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Negative for Neoplasia

MedGen UID:
474277
•Concept ID:
C3272644
•
Finding

Definition

A microscopic finding indicating the absence of neoplastic cells in a tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNegative for Neoplasia

Professional guidelines

PubMed

Human papillomavirus-specific genotypes in cervical lesions of women referred for smears with atypical glandular cells or adenocarcinoma in situ.
Rabelo-Santos SH, Derchain SF, Villa LL, Costa MC, Sarian LO, do Amaral Westin MC, Kornegay J, Zeferino LC
Int J Gynecol Pathol 2009 May;28(3):272-8. doi: 10.1097/PGP.0b013e318190ed27. PMID: 19620946
Diagnostic criteria for gastrointestinal carcinomas in Japan and Western countries: proposal for a new classification system of gastrointestinal epithelial neoplasia.
Schlemper RJ, Kato Y, Stolte M
J Gastroenterol Hepatol 2000 Oct;15 Suppl:G49-57. doi: 10.1046/j.1440-1746.2000.02266.x. PMID: 11100994
Role of second look laparotomy in multidisciplinary treatment and in the follow up of advanced ovarian cancer.
Maggino T, Tredese F, Valente S, Marchesoni D, Brandes A, Menighetti M, Onnis GL
Eur J Gynaecol Oncol 1983;4(1):26-9. PMID: 6861774

Recent clinical studies

Etiology

Classification of Vulvar Squamous Cell Carcinoma and Precursor Lesions by p16 and p53 Immunohistochemistry: Considerations, Caveats, and an Algorithmic Approach.
Yang H, Almadani N, Thompson EF, Tessier-Cloutier B, Chen J, Ho J, Senz J, McConechy MK, Chow C, Ta M, Cheng A, Karnezis A, Huvila J, McAlpine JN, Gilks B, Jamieson A, Hoang LN
Mod Pathol 2023 Jun;36(6):100145. Epub 2023 Feb 22 doi: 10.1016/j.modpat.2023.100145. PMID: 36828360
Update on the clinical management of multiple endocrine neoplasia type 1.
Pieterman CRC, Valk GD
Clin Endocrinol (Oxf) 2022 Oct;97(4):409-423. Epub 2022 Apr 1 doi: 10.1111/cen.14727. PMID: 35319130Free PMC Article
Cytology versus HPV testing for cervical cancer screening in the general population.
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Interval colorectal carcinoma: An unsolved debate.
Benedict M, Galvao Neto A, Zhang X
World J Gastroenterol 2015 Dec 7;21(45):12735-41. doi: 10.3748/wjg.v21.i45.12735. PMID: 26668498Free PMC Article
Basal-like and triple-negative breast cancers: searching for positives among many negatives.
Alluri P, Newman LA
Surg Oncol Clin N Am 2014 Jul;23(3):567-77. doi: 10.1016/j.soc.2014.03.003. PMID: 24882351Free PMC Article

Diagnosis

Classification of Vulvar Squamous Cell Carcinoma and Precursor Lesions by p16 and p53 Immunohistochemistry: Considerations, Caveats, and an Algorithmic Approach.
Yang H, Almadani N, Thompson EF, Tessier-Cloutier B, Chen J, Ho J, Senz J, McConechy MK, Chow C, Ta M, Cheng A, Karnezis A, Huvila J, McAlpine JN, Gilks B, Jamieson A, Hoang LN
Mod Pathol 2023 Jun;36(6):100145. Epub 2023 Feb 22 doi: 10.1016/j.modpat.2023.100145. PMID: 36828360
Update on the clinical management of multiple endocrine neoplasia type 1.
Pieterman CRC, Valk GD
Clin Endocrinol (Oxf) 2022 Oct;97(4):409-423. Epub 2022 Apr 1 doi: 10.1111/cen.14727. PMID: 35319130Free PMC Article
Cytology versus HPV testing for cervical cancer screening in the general population.
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Interval colorectal carcinoma: An unsolved debate.
Benedict M, Galvao Neto A, Zhang X
World J Gastroenterol 2015 Dec 7;21(45):12735-41. doi: 10.3748/wjg.v21.i45.12735. PMID: 26668498Free PMC Article
The Vienna classification of gastrointestinal epithelial neoplasia.
Schlemper RJ, Riddell RH, Kato Y, Borchard F, Cooper HS, Dawsey SM, Dixon MF, Fenoglio-Preiser CM, Fléjou JF, Geboes K, Hattori T, Hirota T, Itabashi M, Iwafuchi M, Iwashita A, Kim YI, Kirchner T, Klimpfinger M, Koike M, Lauwers GY, Lewin KJ, Oberhuber G, Offner F, Price AB, Rubio CA, Shimizu M, Shimoda T, Sipponen P, Solcia E, Stolte M, Watanabe H, Yamabe H
Gut 2000 Aug;47(2):251-5. doi: 10.1136/gut.47.2.251. PMID: 10896917Free PMC Article

Therapy

Targeting PP2A for cancer therapeutic modulation.
Ronk H, Rosenblum JS, Kung T, Zhuang Z
Cancer Biol Med 2022 Nov 1;19(10):1428-39. doi: 10.20892/j.issn.2095-3941.2022.0330. PMID: 36342229Free PMC Article
A Problematic Biomarker Trial Design.
Freidlin B, Korn EL
J Natl Cancer Inst 2022 Feb 7;114(2):187-190. doi: 10.1093/jnci/djab144. PMID: 34289052Free PMC Article
Sacituzumab Govitecan for Metastatic Triple-Negative Breast Cancer: Clinical Overview and Management of Potential Toxicities.
Spring LM, Nakajima E, Hutchinson J, Viscosi E, Blouin G, Weekes C, Rugo H, Moy B, Bardia A
Oncologist 2021 Oct;26(10):827-834. Epub 2021 Jul 10 doi: 10.1002/onco.13878. PMID: 34176192Free PMC Article
Targeting the PI3-kinase pathway in triple-negative breast cancer.
Pascual J, Turner NC
Ann Oncol 2019 Jul 1;30(7):1051-1060. doi: 10.1093/annonc/mdz133. PMID: 31050709
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.
Platten M, Nollen EAA, Röhrig UF, Fallarino F, Opitz CA
Nat Rev Drug Discov 2019 May;18(5):379-401. doi: 10.1038/s41573-019-0016-5. PMID: 30760888

Prognosis

Cancer incidence, patterns, and genotype-phenotype associations in individuals with pathogenic or likely pathogenic germline TP53 variants: an observational cohort study.
de Andrade KC, Khincha PP, Hatton JN, Frone MN, Wegman-Ostrosky T, Mai PL, Best AF, Savage SA
Lancet Oncol 2021 Dec;22(12):1787-1798. Epub 2021 Nov 12 doi: 10.1016/S1470-2045(21)00580-5. PMID: 34780712Free PMC Article
Worldwide trends in cervical cancer incidence and mortality, with predictions for the next 15 years.
Lin S, Gao K, Gu S, You L, Qian S, Tang M, Wang J, Chen K, Jin M
Cancer 2021 Nov 1;127(21):4030-4039. Epub 2021 Aug 9 doi: 10.1002/cncr.33795. PMID: 34368955
Pediatric Thyroid Microcarcinoma.
Lerner J, Goldfarb M
Ann Surg Oncol 2015 Dec;22(13):4187-92. Epub 2015 Apr 9 doi: 10.1245/s10434-015-4546-8. PMID: 25854844
Health disparities in breast cancer.
Brawley OW
Obstet Gynecol Clin North Am 2013 Sep;40(3):513-23. doi: 10.1016/j.ogc.2013.06.001. PMID: 24021254
Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation.
Fisher B, Jeong JH, Anderson S, Bryant J, Fisher ER, Wolmark N
N Engl J Med 2002 Aug 22;347(8):567-75. doi: 10.1056/NEJMoa020128. PMID: 12192016

Clinical prediction guides

Predicting stereotactic radiosurgery outcomes with multi-observer qualitative appearance labelling versus MRI radiomics.
DeVries DA, Tang T, Albweady A, Leung A, Laba J, Johnson C, Lagerwaard F, Zindler J, Hajdok G, Ward AD
Sci Rep 2023 Nov 28;13(1):20977. doi: 10.1038/s41598-023-47702-8. PMID: 38017055Free PMC Article
Use of artificial intelligence for cancer clinical trial enrollment: a systematic review and meta-analysis.
Chow R, Midroni J, Kaur J, Boldt G, Liu G, Eng L, Liu FF, Haibe-Kains B, Lock M, Raman S
J Natl Cancer Inst 2023 Apr 11;115(4):365-374. doi: 10.1093/jnci/djad013. PMID: 36688707Free PMC Article
Ultrasound-based deep learning radiomics in the assessment of pathological complete response to neoadjuvant chemotherapy in locally advanced breast cancer.
Jiang M, Li CL, Luo XM, Chuan ZR, Lv WZ, Li X, Cui XW, Dietrich CF
Eur J Cancer 2021 Apr;147:95-105. Epub 2021 Feb 24 doi: 10.1016/j.ejca.2021.01.028. PMID: 33639324
Impact of Deep Learning Assistance on the Histopathologic Review of Lymph Nodes for Metastatic Breast Cancer.
Steiner DF, MacDonald R, Liu Y, Truszkowski P, Hipp JD, Gammage C, Thng F, Peng L, Stumpe MC
Am J Surg Pathol 2018 Dec;42(12):1636-1646. doi: 10.1097/PAS.0000000000001151. PMID: 30312179Free PMC Article
Borderline breast lesions diagnosed at core needle biopsy: can magnetic resonance mammography rule out associated malignancy? Preliminary results based on 79 surgically excised lesions.
Linda A, Zuiani C, Bazzocchi M, Furlan A, Londero V
Breast 2008 Apr;17(2):125-31. Epub 2008 Feb 20 doi: 10.1016/j.breast.2007.11.002. PMID: 18083514

Recent systematic reviews

Triple-Negative Breast Cancer and Predictive Markers of Response to Neoadjuvant Chemotherapy: A Systematic Review.
van den Ende NS, Nguyen AH, Jager A, Kok M, Debets R, van Deurzen CHM
Int J Mol Sci 2023 Feb 3;24(3) doi: 10.3390/ijms24032969. PMID: 36769287Free PMC Article
Safety of systemic hormone replacement therapy in breast cancer survivors: a systematic review and meta-analysis.
Poggio F, Del Mastro L, Bruzzone M, Ceppi M, Razeti MG, Fregatti P, Ruelle T, Pronzato P, Massarotti C, Franzoi MA, Lambertini M, Tagliamento M
Breast Cancer Res Treat 2022 Jan;191(2):269-275. Epub 2021 Nov 3 doi: 10.1007/s10549-021-06436-9. PMID: 34731351
A systematic review of rehabilitation and exercise recommendations in oncology guidelines.
Stout NL, Santa Mina D, Lyons KD, Robb K, Silver JK
CA Cancer J Clin 2021 Mar;71(2):149-175. Epub 2020 Oct 27 doi: 10.3322/caac.21639. PMID: 33107982Free PMC Article
Cytology versus HPV testing for cervical cancer screening in the general population.
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Effect of BRCA germline mutations on breast cancer prognosis: A systematic review and meta-analysis.
Baretta Z, Mocellin S, Goldin E, Olopade OI, Huo D
Medicine (Baltimore) 2016 Oct;95(40):e4975. doi: 10.1097/MD.0000000000004975. PMID: 27749552Free PMC Article

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