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Widespread Alveolar Pneumocyte Damage Present

MedGen UID:
474298
•Concept ID:
C3272665
•
Finding

Definition

A morphologic finding indicating the presence of extensive injury of the alveolar pneumocytes in a lung tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWidespread Alveolar Pneumocyte Damage Present

Professional guidelines

PubMed

Pulmonary administration of phosphoinositide 3-kinase inhibitor is a curative treatment for chronic obstructive pulmonary disease by alveolar regeneration.
Horiguchi M, Oiso Y, Sakai H, Motomura T, Yamashita C
J Control Release 2015 Sep 10;213:112-119. Epub 2015 Jul 6 doi: 10.1016/j.jconrel.2015.07.004. PMID: 26160307

Recent clinical studies

Etiology

Pulmonary administration of phosphoinositide 3-kinase inhibitor is a curative treatment for chronic obstructive pulmonary disease by alveolar regeneration.
Horiguchi M, Oiso Y, Sakai H, Motomura T, Yamashita C
J Control Release 2015 Sep 10;213:112-119. Epub 2015 Jul 6 doi: 10.1016/j.jconrel.2015.07.004. PMID: 26160307

Diagnosis

Drug-induced pneumonitis: the role of methotrexate.
Zisman DA, McCune WJ, Tino G, Lynch JP 3rd
Sarcoidosis Vasc Diffuse Lung Dis 2001 Oct;18(3):243-52. PMID: 11587095

Therapy

Pulmonary administration of phosphoinositide 3-kinase inhibitor is a curative treatment for chronic obstructive pulmonary disease by alveolar regeneration.
Horiguchi M, Oiso Y, Sakai H, Motomura T, Yamashita C
J Control Release 2015 Sep 10;213:112-119. Epub 2015 Jul 6 doi: 10.1016/j.jconrel.2015.07.004. PMID: 26160307
Oxidative damage in human epithelial alveolar cells exposed in vitro to oil fly ash transition metals.
Di Pietro A, Visalli G, Munaò F, Baluce B, La Maestra S, Primerano P, Corigliano F, De Flora S
Int J Hyg Environ Health 2009 Mar;212(2):196-208. Epub 2008 Jul 29 doi: 10.1016/j.ijheh.2008.05.005. PMID: 18667355
Drug-induced pneumonitis: the role of methotrexate.
Zisman DA, McCune WJ, Tino G, Lynch JP 3rd
Sarcoidosis Vasc Diffuse Lung Dis 2001 Oct;18(3):243-52. PMID: 11587095

Prognosis

Drug-induced pneumonitis: the role of methotrexate.
Zisman DA, McCune WJ, Tino G, Lynch JP 3rd
Sarcoidosis Vasc Diffuse Lung Dis 2001 Oct;18(3):243-52. PMID: 11587095
Proliferation, C-myc, and cyclin D1 expression in diffuse alveolar damage: potential roles in pathogenesis and implications for prognosis.
Adamson A, Perkins S, Brambilla E, Tripp S, Holden J, Travis W, Guinee D Jr
Hum Pathol 1999 Sep;30(9):1050-7. doi: 10.1016/s0046-8177(99)90222-8. PMID: 10492039

Clinical prediction guides

Oxidative damage in human epithelial alveolar cells exposed in vitro to oil fly ash transition metals.
Di Pietro A, Visalli G, Munaò F, Baluce B, La Maestra S, Primerano P, Corigliano F, De Flora S
Int J Hyg Environ Health 2009 Mar;212(2):196-208. Epub 2008 Jul 29 doi: 10.1016/j.ijheh.2008.05.005. PMID: 18667355
Proliferation, C-myc, and cyclin D1 expression in diffuse alveolar damage: potential roles in pathogenesis and implications for prognosis.
Adamson A, Perkins S, Brambilla E, Tripp S, Holden J, Travis W, Guinee D Jr
Hum Pathol 1999 Sep;30(9):1050-7. doi: 10.1016/s0046-8177(99)90222-8. PMID: 10492039

Supplemental Content

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    Practice guidelines

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