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Beta-Catenin-Activated Hepatocellular Adenoma

MedGen UID:
474642
•Concept ID:
C3273009
•
Neoplastic Process

Definition

A hepatocellular adenoma caused by activating mutations of beta-catenin. It is characterized by the presence of nuclear atypia and absence of inflammation or steatosis. There is an increased risk of malignant transformation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBeta-Catenin-Activated Hepatocellular Adenoma

Professional guidelines

PubMed

A Scoping Review of the Classification, Diagnosis, and Management of Hepatic Adenomas.
Aziz H, Brown ZJ, Eskander MF, Aquina CT, Baghdadi A, Kamel IR, Pawlik TM
J Gastrointest Surg 2022 Apr;26(4):965-978. Epub 2022 Jan 26 doi: 10.1007/s11605-022-05246-8. PMID: 35083725
Current Approaches in the Management of Hepatic Adenomas.
Tsilimigras DI, Rahnemai-Azar AA, Ntanasis-Stathopoulos I, Gavriatopoulou M, Moris D, Spartalis E, Cloyd JM, Weber SM, Pawlik TM
J Gastrointest Surg 2019 Jan;23(1):199-209. Epub 2018 Aug 14 doi: 10.1007/s11605-018-3917-4. PMID: 30109469
Management of Hepatocellular Adenoma: Recent Advances.
Agrawal S, Agarwal S, Arnason T, Saini S, Belghiti J
Clin Gastroenterol Hepatol 2015 Jul;13(7):1221-30. Epub 2014 Jun 5 doi: 10.1016/j.cgh.2014.05.023. PMID: 24909909

Recent clinical studies

Etiology

Beta-catenin-activated hepatocellular adenoma in a male.
Ishida R, Yano Y, Yamamoto A, Yasutomi E, Hatazawa Y, Hayashi H, Shiomi Y, Gon H, Omiya S, Kanzawa M, Itoh T, Ueda Y, Kodama Y
Clin J Gastroenterol 2021 Jun;14(3):831-835. Epub 2021 Mar 2 doi: 10.1007/s12328-021-01372-z. PMID: 33651269
Hepatocellular nodules resulting from congenital extrahepatic portosystemic shunts can differentiate into potentially malignant hepatocellular adenomas.
Sanada Y, Mizuta K, Niki T, Tashiro M, Hirata Y, Okada N, Yamada N, Ihara Y, Urahashi T, Soejima Y, Fukusato T, Kondo F
J Hepatobiliary Pancreat Sci 2015 Oct;22(10):746-56. Epub 2015 Aug 3 doi: 10.1002/jhbp.277. PMID: 26138244

Diagnosis

Hepatocellular Adenoma: Report of 2 Cases That Highlight the Relevance of Phenotype-Genotype Correlation in the Pediatric Population.
Jiao J, Finberg KE, Jain D, Morotti R
Pediatr Dev Pathol 2023 Jul-Aug;26(4):394-403. Epub 2023 Jun 19 doi: 10.1177/10935266231175426. PMID: 37334553
Beta-catenin-activated hepatocellular adenoma in a male.
Ishida R, Yano Y, Yamamoto A, Yasutomi E, Hatazawa Y, Hayashi H, Shiomi Y, Gon H, Omiya S, Kanzawa M, Itoh T, Ueda Y, Kodama Y
Clin J Gastroenterol 2021 Jun;14(3):831-835. Epub 2021 Mar 2 doi: 10.1007/s12328-021-01372-z. PMID: 33651269
Hepatocellular adenoma in a woman who was undergoing testosterone treatment for gender identity disorder.
Kato K, Abe H, Hanawa N, Fukuzawa J, Matsuo R, Yonezawa T, Itoh S, Sato Y, Ika M, Shimizu S, Endo S, Hano H, Izu A, Sugitani M, Tsubota A
Clin J Gastroenterol 2018 Oct;11(5):401-410. Epub 2018 Mar 27 doi: 10.1007/s12328-018-0854-4. PMID: 29589251
Hepatocellular nodules resulting from congenital extrahepatic portosystemic shunts can differentiate into potentially malignant hepatocellular adenomas.
Sanada Y, Mizuta K, Niki T, Tashiro M, Hirata Y, Okada N, Yamada N, Ihara Y, Urahashi T, Soejima Y, Fukusato T, Kondo F
J Hepatobiliary Pancreat Sci 2015 Oct;22(10):746-56. Epub 2015 Aug 3 doi: 10.1002/jhbp.277. PMID: 26138244

Therapy

Hepatocellular adenoma in a woman who was undergoing testosterone treatment for gender identity disorder.
Kato K, Abe H, Hanawa N, Fukuzawa J, Matsuo R, Yonezawa T, Itoh S, Sato Y, Ika M, Shimizu S, Endo S, Hano H, Izu A, Sugitani M, Tsubota A
Clin J Gastroenterol 2018 Oct;11(5):401-410. Epub 2018 Mar 27 doi: 10.1007/s12328-018-0854-4. PMID: 29589251
Hepatocellular nodules resulting from congenital extrahepatic portosystemic shunts can differentiate into potentially malignant hepatocellular adenomas.
Sanada Y, Mizuta K, Niki T, Tashiro M, Hirata Y, Okada N, Yamada N, Ihara Y, Urahashi T, Soejima Y, Fukusato T, Kondo F
J Hepatobiliary Pancreat Sci 2015 Oct;22(10):746-56. Epub 2015 Aug 3 doi: 10.1002/jhbp.277. PMID: 26138244

Prognosis

Hepatocellular Adenoma: Report of 2 Cases That Highlight the Relevance of Phenotype-Genotype Correlation in the Pediatric Population.
Jiao J, Finberg KE, Jain D, Morotti R
Pediatr Dev Pathol 2023 Jul-Aug;26(4):394-403. Epub 2023 Jun 19 doi: 10.1177/10935266231175426. PMID: 37334553
Hepatocellular nodules resulting from congenital extrahepatic portosystemic shunts can differentiate into potentially malignant hepatocellular adenomas.
Sanada Y, Mizuta K, Niki T, Tashiro M, Hirata Y, Okada N, Yamada N, Ihara Y, Urahashi T, Soejima Y, Fukusato T, Kondo F
J Hepatobiliary Pancreat Sci 2015 Oct;22(10):746-56. Epub 2015 Aug 3 doi: 10.1002/jhbp.277. PMID: 26138244

Clinical prediction guides

Hepatocellular adenoma in a woman who was undergoing testosterone treatment for gender identity disorder.
Kato K, Abe H, Hanawa N, Fukuzawa J, Matsuo R, Yonezawa T, Itoh S, Sato Y, Ika M, Shimizu S, Endo S, Hano H, Izu A, Sugitani M, Tsubota A
Clin J Gastroenterol 2018 Oct;11(5):401-410. Epub 2018 Mar 27 doi: 10.1007/s12328-018-0854-4. PMID: 29589251

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