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Toxic myopathy

MedGen UID:
509650
•Concept ID:
C0154769
•
Disease or Syndrome
Synonyms: Myopathy, Toxic; Myotoxicities; Myotoxicity; Toxic Myopathies; Toxic Myopathy
SNOMED CT: Toxic myopathy (66952001)

Definition

Damage to the muscle or its function secondary to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToxic myopathy

Professional guidelines

PubMed

Statin-associated muscle symptoms: A comprehensive exploration of epidemiology, pathophysiology, diagnosis, and clinical management strategies.
Shah M, Shrestha K, Tseng CW, Goyal A, Liewluck T, Gupta L
Int J Rheum Dis 2024 Sep;27(9):e15337. doi: 10.1111/1756-185X.15337. PMID: 39285637
Glucocorticoid-Induced Myopathy: Typology, Pathogenesis, Diagnosis, and Treatment.
Wu M, Liu C, Sun D
Horm Metab Res 2024 May;56(5):341-349. Epub 2024 Jan 15 doi: 10.1055/a-2246-2900. PMID: 38224966

Recent clinical studies

Etiology

Toxic Myopathies.
Doughty CT, Amato AA
Continuum (Minneap Minn) 2019 Dec;25(6):1712-1731. doi: 10.1212/CON.0000000000000806. PMID: 31794468
Statin-associated immune-mediated myopathy: biology and clinical implications.
Christopher-Stine L, Basharat P
Curr Opin Lipidol 2017 Apr;28(2):186-192. doi: 10.1097/MOL.0000000000000399. PMID: 28207435
The spectrum of statin myopathy.
Mohassel P, Mammen AL
Curr Opin Rheumatol 2013 Nov;25(6):747-52. doi: 10.1097/01.bor.0000434673.85515.89. PMID: 24061077
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412

Diagnosis

Drug-induced Myopathies.
Steinmeyer J, Flechtenmacher J
Z Orthop Unfall 2023 Apr;161(2):175-181. Epub 2021 Jul 28 doi: 10.1055/a-1488-6912. PMID: 34320661
Other Myopathies.
Hussain Y, Miller S
Neurol Clin 2020 Aug;38(3):619-635. doi: 10.1016/j.ncl.2020.04.002. PMID: 32703473
Inflammatory and toxic myopathy.
Teener JW
Semin Neurol 2012 Nov;32(5):491-9. Epub 2013 May 15 doi: 10.1055/s-0033-1334467. PMID: 23677656
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412

Therapy

Drug-induced Myopathies.
Steinmeyer J, Flechtenmacher J
Z Orthop Unfall 2023 Apr;161(2):175-181. Epub 2021 Jul 28 doi: 10.1055/a-1488-6912. PMID: 34320661
Is statin-induced myositis part of the polymyositis disease spectrum?
Albayda J, Mammen AL
Curr Rheumatol Rep 2014 Aug;16(8):433. doi: 10.1007/s11926-014-0433-8. PMID: 24996782
Inflammatory and toxic myopathy.
Teener JW
Semin Neurol 2012 Nov;32(5):491-9. Epub 2013 May 15 doi: 10.1055/s-0033-1334467. PMID: 23677656
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412

Prognosis

Statin-associated muscle symptoms: A comprehensive exploration of epidemiology, pathophysiology, diagnosis, and clinical management strategies.
Shah M, Shrestha K, Tseng CW, Goyal A, Liewluck T, Gupta L
Int J Rheum Dis 2024 Sep;27(9):e15337. doi: 10.1111/1756-185X.15337. PMID: 39285637
The spectrum of statin myopathy.
Mohassel P, Mammen AL
Curr Opin Rheumatol 2013 Nov;25(6):747-52. doi: 10.1097/01.bor.0000434673.85515.89. PMID: 24061077
Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment.
Orsucci D, Pizzanelli C, Alì G, Calabrese R, Ricci G, Lenzi P, Petrozzi L, Moretti P, Siciliano G
Neuromuscul Disord 2012 Aug;22(8):767-70. Epub 2012 May 29 doi: 10.1016/j.nmd.2012.04.004. PMID: 22652078
Hydroxychloroquine-induced toxic myopathy causing respiratory failure.
Siddiqui AK, Huberfeld SI, Weidenheim KM, Einberg KR, Efferen LS
Chest 2007 Feb;131(2):588-90. doi: 10.1378/chest.06-1146. PMID: 17296665
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412

Clinical prediction guides

Statin-associated muscle symptoms: A comprehensive exploration of epidemiology, pathophysiology, diagnosis, and clinical management strategies.
Shah M, Shrestha K, Tseng CW, Goyal A, Liewluck T, Gupta L
Int J Rheum Dis 2024 Sep;27(9):e15337. doi: 10.1111/1756-185X.15337. PMID: 39285637
Toxic myopathy with multiple deletions in mitochondrial DNA associated with long-term use of oral anti-viral drugs for hepatitis B: A case study.
Fujii T, Takase KI, Honda H, Kawamura N, Yamasaki R, Urata M, Uchiumi T, Iwaki T, Kira JI
Neuropathology 2019 Apr;39(2):162-167. Epub 2019 Mar 7 doi: 10.1111/neup.12548. PMID: 30847961
Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
Madden L, Juhas M, Kraus WE, Truskey GA, Bursac N
Elife 2015 Jan 9;4:e04885. doi: 10.7554/eLife.04885. PMID: 25575180Free PMC Article
Acute quadriplegic myopathy with loss of thick (myosin) filaments following heart transplantation.
Perea M, Picón M, Miró O, Orús J, Roig E, Grau JM
J Heart Lung Transplant 2001 Oct;20(10):1136-41. doi: 10.1016/s1053-2498(01)00300-x. PMID: 11595571
Drugs and toxins associated with myopathies.
Pascuzzi RM
Curr Opin Rheumatol 1998 Nov;10(6):511-20. doi: 10.1097/00002281-199811000-00003. PMID: 9812211

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