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Adverse drug response

MedGen UID:
22562
•Concept ID:
C0041755
•
Pathologic Function
Synonyms: Adverse Drug Event; Adverse Drug Events; Adverse Drug Reaction; Adverse Drug Reactions; Drug Event, Adverse; Drug Events, Adverse; Drug Reaction, Adverse; Drug Reactions, Adverse; Drug Related Side Effects and Adverse Reaction; Drug Related Side Effects and Adverse Reactions; Drug Side Effect; Drug Side Effects; Drug-Related Side Effects and Adverse Reaction; Drug-Related Side Effects and Adverse Reactions; Effects, Drug Side; Reactions, Adverse Drug; Side Effect, Drug; Side Effects of Drugs; Side Effects, Drug
SNOMED CT: Drug reaction (62014003); Adverse drug effect (62014003); Adverse drug reaction (62014003); Adverse reaction caused by drug (62014003); Drug reaction (264519003); Adverse reaction to drug (62014003); ADR - Adverse drug reaction (62014003); Adverse reaction to medication (62014003)
 
HPO: HP:0020172

Definition

An unpleasant or harmful reaction resulting from treatment with a drug. [from HPO]

Professional guidelines

PubMed

A Novel PCR-RFLP Method for Detection of POR*28 Polymorphism and its Genotype/Allele Frequencies in a Turkish Population.
Ozdemir F, Oz MD, Suzen HS
Curr Drug Metab 2019;20(10):845-851. doi: 10.2174/1389200220666190913121052. PMID: 31518218
In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties.
Yucha RW, He K, Shi Q, Cai L, Nakashita Y, Xia CQ, Liao M
Toxicol Sci 2017 Jun 1;157(2):487-499. doi: 10.1093/toxsci/kfx060. PMID: 28369588
Human leukocyte antigen genotypes in carbamazepine-induced severe cutaneous adverse drug response in Japanese patients.
Kashiwagi M, Aihara M, Takahashi Y, Yamazaki E, Yamane Y, Song Y, Muramatsu M, Ikezawa Z
J Dermatol 2008 Oct;35(10):683-5. doi: 10.1111/j.1346-8138.2008.00548.x. PMID: 19017052

Recent clinical studies

Etiology

Pharmacogenes (PGx-genes): Current understanding and future directions.
Katara P, Yadav A
Gene 2019 Nov 15;718:144050. Epub 2019 Aug 16 doi: 10.1016/j.gene.2019.144050. PMID: 31425740
Mouse Population-Based Approaches to Investigate Adverse Drug Reactions.
Mosedale M
Drug Metab Dispos 2018 Nov;46(11):1787-1795. Epub 2018 Jul 25 doi: 10.1124/dmd.118.082834. PMID: 30045843
Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
Brackman DJ, Giacomini KM
Clin Pharmacol Ther 2018 Feb;103(2):233-242. Epub 2017 Nov 28 doi: 10.1002/cpt.903. PMID: 29023674Free PMC Article
Female gender as a susceptibility factor for drug-induced liver injury.
Amacher DE
Hum Exp Toxicol 2014 Sep;33(9):928-39. Epub 2013 Dec 3 doi: 10.1177/0960327113512860. PMID: 24299907
Regulation of drug metabolism and disposition during inflammation and infection.
Renton KW
Expert Opin Drug Metab Toxicol 2005 Dec;1(4):629-40. doi: 10.1517/17425255.1.4.629. PMID: 16863429

Diagnosis

Mouse Population-Based Approaches to Investigate Adverse Drug Reactions.
Mosedale M
Drug Metab Dispos 2018 Nov;46(11):1787-1795. Epub 2018 Jul 25 doi: 10.1124/dmd.118.082834. PMID: 30045843
Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers.
Huo J, Kamalakar A, Yang X, Word B, Stockbridge N, Lyn-Cook B, Pang L
Toxicol Sci 2017 Mar 1;156(1):25-38. doi: 10.1093/toxsci/kfw235. PMID: 28031415
Genetic variants influencing fluoropyrimidine based-therapy and available methods to detect them.
Di Francia R, Cimino L, Berretta M
Eur Rev Med Pharmacol Sci 2012 Mar;16(3):285-98. PMID: 22530343
Genetics of migraine and pharmacogenomics: some considerations.
Piane M, Lulli P, Farinelli I, Simeoni S, De Filippis S, Patacchioli FR, Martelletti P
J Headache Pain 2007 Dec;8(6):334-9. Epub 2007 Dec 5 doi: 10.1007/s10194-007-0427-2. PMID: 18058067Free PMC Article
The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.
Kupershmidt S, Yang IC, Hayashi K, Wei J, Chanthaphaychith S, Petersen CI, Johns DC, George AL Jr, Roden DM, Balser JR
FASEB J 2003 Dec;17(15):2263-5. Epub 2003 Oct 2 doi: 10.1096/fj.02-1057fje. PMID: 14525949

Therapy

Pharmacogenomics of GPCR Drug Targets.
Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM
Cell 2018 Jan 11;172(1-2):41-54.e19. Epub 2017 Dec 14 doi: 10.1016/j.cell.2017.11.033. PMID: 29249361Free PMC Article
Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
Brackman DJ, Giacomini KM
Clin Pharmacol Ther 2018 Feb;103(2):233-242. Epub 2017 Nov 28 doi: 10.1002/cpt.903. PMID: 29023674Free PMC Article
Expectations, validity, and reality in pharmacogenetics.
Limdi NA, Veenstra DL
J Clin Epidemiol 2010 Sep;63(9):960-9. Epub 2009 Dec 7 doi: 10.1016/j.jclinepi.2009.09.006. PMID: 19995676Free PMC Article
Understanding drug-induced torsades de pointes: a genetic stance.
Kannankeril PJ
Expert Opin Drug Saf 2008 May;7(3):231-9. doi: 10.1517/14740338.7.3.231. PMID: 18462182
Genetics of migraine and pharmacogenomics: some considerations.
Piane M, Lulli P, Farinelli I, Simeoni S, De Filippis S, Patacchioli FR, Martelletti P
J Headache Pain 2007 Dec;8(6):334-9. Epub 2007 Dec 5 doi: 10.1007/s10194-007-0427-2. PMID: 18058067Free PMC Article

Prognosis

Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.
Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM
J Pharm Sci 2021 Jan;110(1):347-353. Epub 2020 Sep 7 doi: 10.1016/j.xphs.2020.09.004. PMID: 32910949Free PMC Article
Human cytochrome P450 and personalized medicine.
Chen Q, Wei D
Adv Exp Med Biol 2015;827:341-51. doi: 10.1007/978-94-017-9245-5_20. PMID: 25387974
Advances in human cytochrome p450 and personalized medicine.
Chen Q, Zhang T, Wang JF, Wei DQ
Curr Drug Metab 2011 Jun;12(5):436-44. doi: 10.2174/138920011795495259. PMID: 21453272
Expectations, validity, and reality in pharmacogenetics.
Limdi NA, Veenstra DL
J Clin Epidemiol 2010 Sep;63(9):960-9. Epub 2009 Dec 7 doi: 10.1016/j.jclinepi.2009.09.006. PMID: 19995676Free PMC Article
Understanding drug-induced torsades de pointes: a genetic stance.
Kannankeril PJ
Expert Opin Drug Saf 2008 May;7(3):231-9. doi: 10.1517/14740338.7.3.231. PMID: 18462182

Clinical prediction guides

Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.
Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM
J Pharm Sci 2021 Jan;110(1):347-353. Epub 2020 Sep 7 doi: 10.1016/j.xphs.2020.09.004. PMID: 32910949Free PMC Article
Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
Brackman DJ, Giacomini KM
Clin Pharmacol Ther 2018 Feb;103(2):233-242. Epub 2017 Nov 28 doi: 10.1002/cpt.903. PMID: 29023674Free PMC Article
Human cytochrome P450 and personalized medicine.
Chen Q, Wei D
Adv Exp Med Biol 2015;827:341-51. doi: 10.1007/978-94-017-9245-5_20. PMID: 25387974
Advances in human cytochrome p450 and personalized medicine.
Chen Q, Zhang T, Wang JF, Wei DQ
Curr Drug Metab 2011 Jun;12(5):436-44. doi: 10.2174/138920011795495259. PMID: 21453272
Understanding drug-induced torsades de pointes: a genetic stance.
Kannankeril PJ
Expert Opin Drug Saf 2008 May;7(3):231-9. doi: 10.1517/14740338.7.3.231. PMID: 18462182

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