Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Neonatal thyrotoxicosis

MedGen UID:: 510684
•Concept ID:: C0158983
•: Disease or Syndrome

Synonyms:	infantile hyperthyroidism; Neonatal Thyrotoxicosis; neonatal thyrotoxicosis
SNOMED CT:	Neonatal thyrotoxicosis (13795004)

Monarch Initiative:	MONDO:0001555

Definition

A hypermetabolic syndrome characterized by tachycardia, palpitations, tremor, weight loss, and moist skin that is caused by the elevation of thyroid hormone levels in the serum of the newborn infant or thyroid-axis receptor activation, most commonly due to transplacental passage of thyroid stimulating globulins. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeonatal thyrotoxicosis

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
- Neonatal disorder
  - Neonatal thyrotoxicosis

Professional guidelines

PubMed

Neonatal Screening for Hyperthyroidism Proof of Concept.

Banigé M, Kariyawasam D, Gauthereau V, Luton D, Polak M
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1374-e1381. doi: 10.1210/clinem/dgab890. PMID: 34894265

Clinical review: Clinical utility of TSH receptor antibodies.

Barbesino G, Tomer Y
J Clin Endocrinol Metab 2013 Jun;98(6):2247-55. Epub 2013 Mar 28 doi: 10.1210/jc.2012-4309. PMID: 23539719 Free PMC Article

Propranolol in treatment of neonatal thyrotoxicosis.

Smith CS, Howard NJ
J Pediatr 1973 Dec;83(6):1046-8. doi: 10.1016/s0022-3476(73)80548-7. PMID: 4757519

See all (13)

Recent clinical studies

Etiology

Neonatal Screening for Hyperthyroidism Proof of Concept.

Banigé M, Kariyawasam D, Gauthereau V, Luton D, Polak M
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1374-e1381. doi: 10.1210/clinem/dgab890. PMID: 34894265

Thyrotropin Receptor Antibodies-An Overview.

Kotwal A, Stan M
Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S20-S27. doi: 10.1097/IOP.0000000000001052. PMID: 29771756

Maternal Thyrotropin Receptor Antibody Concentration and the Risk of Fetal and Neonatal Thyrotoxicosis: A Systematic Review.

van Dijk MM, Smits IH, Fliers E, Bisschop PH
Thyroid 2018 Feb;28(2):257-264. doi: 10.1089/thy.2017.0413. PMID: 29325496

Thyroid hyperfunction during pregnancy.

Glinoer D
Thyroid 1998 Sep;8(9):859-64. doi: 10.1089/thy.1998.8.859. PMID: 9777758

Endocrinology of the neonate.

Ogilvy-Stuart AL
Br J Hosp Med 1995 Sep 6-19;54(5):207-11; quiz 212-3. PMID: 8528527

See all (28)

Diagnosis

Diagnosis and Management of Fetal and Neonatal Thyrotoxicosis.

Bohîlțea RE, Mihai BM, Szini E, Șucaliuc IA, Badiu C
Medicina (Kaunas) 2022 Dec 23;59(1) doi: 10.3390/medicina59010036. PMID: 36676660 Free PMC Article

Neonatal thyrotoxicosis with maternal hypothyroidism.

Ravindra S, Shetty S
BMJ Case Rep 2022 Mar 9;15(3) doi: 10.1136/bcr-2021-247865. PMID: 35264385 Free PMC Article

Thyrotropin Receptor Antibodies-An Overview.

Kotwal A, Stan M
Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S20-S27. doi: 10.1097/IOP.0000000000001052. PMID: 29771756

Hyperthyroidism in pregnancy.

Cooper DS, Laurberg P
Lancet Diabetes Endocrinol 2013 Nov;1(3):238-49. Epub 2013 Oct 18 doi: 10.1016/S2213-8587(13)70086-X. PMID: 24622372

Neonatal thyrotoxicosis and conjugated hyperbilirubinemia.

Beroukhim RS, Moon TD, Felner EI
J Matern Fetal Neonatal Med 2003 Jun;13(6):426-8. doi: 10.1080/jmf.13.6.426.428. PMID: 12962270

See all (44)

Therapy

Neonatal thyrotoxicosis with maternal hypothyroidism.

Ravindra S, Shetty S
BMJ Case Rep 2022 Mar 9;15(3) doi: 10.1136/bcr-2021-247865. PMID: 35264385 Free PMC Article

Neonatal Thyrotoxicosis.

Samuels SL, Namoc SM, Bauer AJ
Clin Perinatol 2018 Mar;45(1):31-40. Epub 2017 Dec 16 doi: 10.1016/j.clp.2017.10.001. PMID: 29406005

Hyperthyroidism in pregnancy.

Cooper DS, Laurberg P
Lancet Diabetes Endocrinol 2013 Nov;1(3):238-49. Epub 2013 Oct 18 doi: 10.1016/S2213-8587(13)70086-X. PMID: 24622372

Neonatal thyrotoxicosis.

Robards GJ, Davis JR
Med J Aust 1973 Sep 1;2(9):432-4. doi: 10.5694/j.1326-5377.1973.tb115207.x. PMID: 4800423

Neonatal thyrotoxicosis.

Hopton DS, Wade JS
Proc R Soc Med 1969 Aug;62(8):817. PMID: 4185737 Free PMC Article

See all (47)

Prognosis

Diagnosis and Management of Fetal and Neonatal Thyrotoxicosis.

Bohîlțea RE, Mihai BM, Szini E, Șucaliuc IA, Badiu C
Medicina (Kaunas) 2022 Dec 23;59(1) doi: 10.3390/medicina59010036. PMID: 36676660 Free PMC Article

Neonatal thyrotoxicosis with maternal hypothyroidism.

Ravindra S, Shetty S
BMJ Case Rep 2022 Mar 9;15(3) doi: 10.1136/bcr-2021-247865. PMID: 35264385 Free PMC Article

Thyrotropin Receptor Antibodies-An Overview.

Kotwal A, Stan M
Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S20-S27. doi: 10.1097/IOP.0000000000001052. PMID: 29771756

A review of thyroid disease in pregnancy.

Drury MI, Sugrue DD, Drury RM
Clin Exp Obstet Gynecol 1984;11(3):79-89. PMID: 6202441

Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years.

Daneman D, Howard NJ
J Pediatr 1980 Aug;97(2):257-9. doi: 10.1016/s0022-3476(80)80487-2. PMID: 7400892

See all (28)

Clinical prediction guides

Neonatal Screening for Hyperthyroidism Proof of Concept.

Banigé M, Kariyawasam D, Gauthereau V, Luton D, Polak M
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1374-e1381. doi: 10.1210/clinem/dgab890. PMID: 34894265

Thyrotropin Receptor Antibodies-An Overview.

Kotwal A, Stan M
Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S20-S27. doi: 10.1097/IOP.0000000000001052. PMID: 29771756

Measuring TSH receptor antibody to influence treatment choices in Graves' disease.

Hesarghatta Shyamasunder A, Abraham P
Clin Endocrinol (Oxf) 2017 May;86(5):652-657. doi: 10.1111/cen.13327. PMID: 28295509

Clinical review: Clinical utility of TSH receptor antibodies.

Barbesino G, Tomer Y
J Clin Endocrinol Metab 2013 Jun;98(6):2247-55. Epub 2013 Mar 28 doi: 10.1210/jc.2012-4309. PMID: 23539719 Free PMC Article

Thyroid hyperfunction during pregnancy.

Glinoer D
Thyroid 1998 Sep;8(9):859-64. doi: 10.1089/thy.1998.8.859. PMID: 9777758

See all (16)