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Nummular keratitis

MedGen UID:
543239
•Concept ID:
C0271261
•
Disease or Syndrome
SNOMED CT: Nummular keratitis (12570008)
 
HPO: HP:6000912

Definition

Nummular keratitis consists of multiple scattered small round anterior corneal superficial stromal infiltrates. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNummular keratitis

Professional guidelines

PubMed

Combined intrastromal injection of ganciclovir and depot betamethasone for the management of nummular keratitis: Case series.
Arenas E, Mieth A, Muñoz D
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):347-351. Epub 2019 Mar 4 doi: 10.1016/j.oftal.2019.01.009. PMID: 30846248
Emerging prevalence of microsporidial keratitis in Singapore: epidemiology, clinical features, and management.
Loh RS, Chan CM, Ti SE, Lim L, Chan KS, Tan DT
Ophthalmology 2009 Dec;116(12):2348-53. Epub 2009 Oct 7 doi: 10.1016/j.ophtha.2009.05.004. PMID: 19815287
The differential diagnosis of nummular keratitis (Dimmer) and epidemic keratoconjunctivitis.
PILLAT A
Am J Ophthalmol 1957 Apr;43(4 Part 2):58-63. doi: 10.1016/0002-9394(57)91479-4. PMID: 13411130

Recent clinical studies

Etiology

Stromal Keratitis After Varicella in Children.
Denier M, Gabison E, Sahyoun M, Labetoulle M, Dureau P, Cochereau I, Doan S
Cornea 2020 Jun;39(6):680-684. doi: 10.1097/ICO.0000000000002281. PMID: 32118671
Combined intrastromal injection of ganciclovir and depot betamethasone for the management of nummular keratitis: Case series.
Arenas E, Mieth A, Muñoz D
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):347-351. Epub 2019 Mar 4 doi: 10.1016/j.oftal.2019.01.009. PMID: 30846248
Clinical and demographic study of microsporidial keratoconjunctivitis in South India: a 3-year study (2013-2015).
Agashe R, Radhakrishnan N, Pradhan S, Srinivasan M, Prajna VN, Lalitha P
Br J Ophthalmol 2017 Oct;101(10):1436-1439. Epub 2017 Feb 22 doi: 10.1136/bjophthalmol-2016-309845. PMID: 28228409
Emerging prevalence of microsporidial keratitis in Singapore: epidemiology, clinical features, and management.
Loh RS, Chan CM, Ti SE, Lim L, Chan KS, Tan DT
Ophthalmology 2009 Dec;116(12):2348-53. Epub 2009 Oct 7 doi: 10.1016/j.ophtha.2009.05.004. PMID: 19815287
Clinical profile of herpes zoster ophthalmicus.
Nigam P, Kumar A, Kapoor KK, Sarkari NB, Gupta AK, Lal BB, Mukhija RD
J Indian Med Assoc 1991 May;89(5):117-9. PMID: 1748774

Diagnosis

Ointment tacrolimus for steroid resistant adenoviral nummular keratitis.
Jamaluddin Ahmad M, Lott PW, Khaliddin N, Singh S
Med J Malaysia 2020 Jul;75(4):461-463. PMID: 32724020
Nummular Keratitis: An Uncommon Manifestation of Ocular Sarcoidosis.
Dao D, Sen HN, Kodati S
Ophthalmology 2020 May;127(5):581. doi: 10.1016/j.ophtha.2020.02.010. PMID: 32327129
Stromal Keratitis After Varicella in Children.
Denier M, Gabison E, Sahyoun M, Labetoulle M, Dureau P, Cochereau I, Doan S
Cornea 2020 Jun;39(6):680-684. doi: 10.1097/ICO.0000000000002281. PMID: 32118671
Neuro-ophthalmic manifestations of Lyme disease.
Balcer LJ, Winterkorn JM, Galetta SL
J Neuroophthalmol 1997 Jun;17(2):108-21. PMID: 9176782
The differential diagnosis of nummular keratitis (Dimmer) and epidemic keratoconjunctivitis.
PILLAT A
Am J Ophthalmol 1957 Apr;43(4 Part 2):58-63. doi: 10.1016/0002-9394(57)91479-4. PMID: 13411130

Therapy

Ointment tacrolimus for steroid resistant adenoviral nummular keratitis.
Jamaluddin Ahmad M, Lott PW, Khaliddin N, Singh S
Med J Malaysia 2020 Jul;75(4):461-463. PMID: 32724020
Nummular Keratitis: An Uncommon Manifestation of Ocular Sarcoidosis.
Dao D, Sen HN, Kodati S
Ophthalmology 2020 May;127(5):581. doi: 10.1016/j.ophtha.2020.02.010. PMID: 32327129
Stromal Keratitis After Varicella in Children.
Denier M, Gabison E, Sahyoun M, Labetoulle M, Dureau P, Cochereau I, Doan S
Cornea 2020 Jun;39(6):680-684. doi: 10.1097/ICO.0000000000002281. PMID: 32118671
Nummular keratitis associated with infectious mononucleosis.
Pinnolis M, McCulley JP, Urman JD
Am J Ophthalmol 1980 Jun;89(6):791-4. doi: 10.1016/0002-9394(80)90167-1. PMID: 6247917
Deep stromal involvement in Dimmer's nummular keratitis.
Valenton MJ
Am J Ophthalmol 1974 Dec;78(6):897-902. doi: 10.1016/0002-9394(74)90799-5. PMID: 4440723

Prognosis

Delayed-onset Bilateral Peripheral Posterior Interstitial Keratitis Associated with Epstein-Barr Virus-Induced Infectious Mononucleosis.
Iovieno A, Coassin M, Viscogliosi F, Adani C, Cimino L, Fontana L
Ocul Immunol Inflamm 2022 Feb 17;30(2):290-293. Epub 2020 Sep 18 doi: 10.1080/09273948.2020.1811351. PMID: 32946296
Stromal Keratitis After Varicella in Children.
Denier M, Gabison E, Sahyoun M, Labetoulle M, Dureau P, Cochereau I, Doan S
Cornea 2020 Jun;39(6):680-684. doi: 10.1097/ICO.0000000000002281. PMID: 32118671
Combined intrastromal injection of ganciclovir and depot betamethasone for the management of nummular keratitis: Case series.
Arenas E, Mieth A, Muñoz D
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):347-351. Epub 2019 Mar 4 doi: 10.1016/j.oftal.2019.01.009. PMID: 30846248
Clinical and demographic study of microsporidial keratoconjunctivitis in South India: a 3-year study (2013-2015).
Agashe R, Radhakrishnan N, Pradhan S, Srinivasan M, Prajna VN, Lalitha P
Br J Ophthalmol 2017 Oct;101(10):1436-1439. Epub 2017 Feb 22 doi: 10.1136/bjophthalmol-2016-309845. PMID: 28228409
Emerging prevalence of microsporidial keratitis in Singapore: epidemiology, clinical features, and management.
Loh RS, Chan CM, Ti SE, Lim L, Chan KS, Tan DT
Ophthalmology 2009 Dec;116(12):2348-53. Epub 2009 Oct 7 doi: 10.1016/j.ophtha.2009.05.004. PMID: 19815287

Clinical prediction guides

Delayed-onset Bilateral Peripheral Posterior Interstitial Keratitis Associated with Epstein-Barr Virus-Induced Infectious Mononucleosis.
Iovieno A, Coassin M, Viscogliosi F, Adani C, Cimino L, Fontana L
Ocul Immunol Inflamm 2022 Feb 17;30(2):290-293. Epub 2020 Sep 18 doi: 10.1080/09273948.2020.1811351. PMID: 32946296
Emerging prevalence of microsporidial keratitis in Singapore: epidemiology, clinical features, and management.
Loh RS, Chan CM, Ti SE, Lim L, Chan KS, Tan DT
Ophthalmology 2009 Dec;116(12):2348-53. Epub 2009 Oct 7 doi: 10.1016/j.ophtha.2009.05.004. PMID: 19815287
Clinical profile of herpes zoster ophthalmicus.
Nigam P, Kumar A, Kapoor KK, Sarkari NB, Gupta AK, Lal BB, Mukhija RD
J Indian Med Assoc 1991 May;89(5):117-9. PMID: 1748774

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