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Corneal disorder

MedGen UID:: 3617
•Concept ID:: C0010034
•: Disease or Syndrome

Synonym:	Corneal disease
SNOMED CT:	Corneal disorder (15250008); Disorder of cornea (15250008)

Monarch Initiative:	MONDO:0000942

Definition

A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCorneal disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of eye
        Corneal disorder
        Cornea neoplasm
        Benign neoplasm of cornea
        Cornea cancer
        Cornea squamous cell carcinoma
        Corneal Kaposi Sarcoma
        Malignant cornea melanoma
        Corneal intraepithelial neoplasm
        High Grade Corneal Squamous Intraepithelial Neoplasia
        Low Grade Corneal Squamous Intraepithelial Neoplasia
        corneal edema
        Corneal stromal edema
        Fine corneal edema
        Corneal Endothelial Cell Loss
        Corneal neovascularization
        Corneal opacity
        Arcus senilis
        Kayser-Fleischer ring
        Opacification of the corneal epithelium
        Subepithelial corneal opacities
        Sclerocornea
        Corneal Wavefront Aberration
        Hereditary corneal dystrophy
        Fuchs endothelial dystrophy
        Meesmann corneal dystrophy
        Corneal dystrophy, Meesmann, 1
        Corneal dystrophy, Meesmann, 2
        Iridocorneal endothelial syndrome
        Chandler syndrome
        Cogan-Reese syndrome
        Essential iris atrophy
        Keratitis
        Acanthamoeba keratitis
        Corneal infection
        Corneal abscess
        Endotheliitis
        Fungal keratitis
        Herpes simplex dendritic keratitis
        Infectious epithelial keratitis
        Neurotrophic keratopathy
        Stromal keratitis
        Corneal ulceration
        Herpetiform corneal ulceration
        Herpes simplex virus keratitis
        Keratitis caused by infection
        Keratoconjunctivitis
        Epidemic keratoconjunctivitis
        Keratoconjunctivitis sicca
        Keratoconjunctivitis, Infectious
        Nummular keratitis
        Photokeratitis
        Punctate keratitis
        Keratoconus
        Non-Neoplastic Corneal Disorder
        Corneal decompensation
        Corneal dystrophy
        Band-shaped corneal dystrophy
        Corneal endothelial dystrophy
        Gelatinous drop-like dystrophic cornea
        Gelatinous droplike corneal dystrophy
        Granular corneal dystrophy
        Lattice corneal dystrophy
        Marginal corneal dystrophy
        Mosaic corneal dystrophy
        Punctate corneal dystrophy
        Speckled corneal dystrophy
        Syndromic corneal dystrophy
        Keratopathy
        Band-shaped keratopathy
        Bullous keratopathy
        Microcornea
        Trachoma

Professional guidelines

PubMed

Comprehensive Evaluation of the Genetic Basis of Keratoconus: New Perspectives for Clinical Translation.

Cerván-Martín M, Higueras-Serrano I, González-Muñoz S, Guzmán-Jiménez A, Chaves-Urbano B, Palomino-Morales RJ, Poo-López A, Fernández-Vega-Cueto L, Merayo-Lloves J, Alcalde I, Bossini-Castillo L, Carmona FD
Invest Ophthalmol Vis Sci 2024 Oct 1;65(12):32. doi: 10.1167/iovs.65.12.32. PMID: 39436372 Free PMC Article

Refractive surgical correction and treatment of keratoconus.

D'Oria F, Bagaglia SA, Alio Del Barrio JL, Alessio G, Alio JL, Mazzotta C
Surv Ophthalmol 2024 Jan-Feb;69(1):122-139. Epub 2023 Sep 27 doi: 10.1016/j.survophthal.2023.09.005. PMID: 37774800

Optometric practices and attitudes in keratoconus patient management in Latin America.

Braga Vieira S, Rivadeneira-Bueno D, Ortiz-Toquero S, Martin R
Clin Exp Optom 2023 May;106(4):386-394. Epub 2022 Mar 17 doi: 10.1080/08164622.2022.2048997. PMID: 35298892

See all (6)

Recent clinical studies

Etiology

Trio-based exome sequencing broaden the genetic spectrum in keratoconus.

Xu L, Yang K, Zhu M, Yin S, Gu Y, Fan Q, Wang Y, Pang C, Ren S
Exp Eye Res 2023 Jan;226:109342. Epub 2022 Dec 9 doi: 10.1016/j.exer.2022.109342. PMID: 36502923

Association of Variants in TMEM45A With Keratoglobus.

Weiner C, Hecht I, Kotlyar A, Shoshany N, Zadok D, Elbaz U, Segev F, Maytal A, Hachmo Y, Michiels C, De Backer O, Shomron N, Einan-Lifshitz A, Pras E
JAMA Ophthalmol 2021 Oct 1;139(10):1089-1095. doi: 10.1001/jamaophthalmol.2021.3172. PMID: 34410316 Free PMC Article

Quantitative comparison of corneal surface areas in keratoconus and normal eyes.

Crahay FX, Debellemanière G, Tobalem S, Ghazal W, Moran S, Gatinel D
Sci Rep 2021 Mar 25;11(1):6840. doi: 10.1038/s41598-021-86185-3. PMID: 33767220 Free PMC Article

The Association of Refractive Error with Glaucoma in a Multiethnic Population.

Shen L, Melles RB, Metlapally R, Barcellos L, Schaefer C, Risch N, Herrinton LJ, Wildsoet C, Jorgenson E
Ophthalmology 2016 Jan;123(1):92-101. Epub 2015 Aug 8 doi: 10.1016/j.ophtha.2015.07.002. PMID: 26260281 Free PMC Article

Review: keratoconus in Asia.

Kok YO, Tan GF, Loon SC
Cornea 2012 May;31(5):581-93. doi: 10.1097/ICO.0b013e31820cd61d. PMID: 22314815

See all (33)

Diagnosis

Neurotrophic keratopathy: General features and new therapies.

Vera-Duarte GR, Jimenez-Collado D, Kahuam-López N, Ramirez-Miranda A, Graue-Hernandez EO, Navas A, Rosenblatt MI
Surv Ophthalmol 2024 Sep-Oct;69(5):789-804. Epub 2024 Apr 26 doi: 10.1016/j.survophthal.2024.04.004. PMID: 38679146

Harboyan Syndrome.

Javaid A, Orakzai AA
J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(Suppl 1)(4):S701-S703. PMID: 33754535

Fuchs Endothelial Corneal Dystrophy: Clinical, Genetic, Pathophysiologic, and Therapeutic Aspects.

Matthaei M, Hribek A, Clahsen T, Bachmann B, Cursiefen C, Jun AS
Annu Rev Vis Sci 2019 Sep 15;5:151-175. doi: 10.1146/annurev-vision-091718-014852. PMID: 31525145

Review: keratoconus in Asia.

Kok YO, Tan GF, Loon SC
Cornea 2012 May;31(5):581-93. doi: 10.1097/ICO.0b013e31820cd61d. PMID: 22314815

A review of selected inherited corneal dystrophies associated with systemic diseases.

Birth Defects Orig Artic Ser 1971 Mar;7(3):13-25. PMID: 5006138

See all (37)

Therapy

Refractive surgical correction and treatment of keratoconus.

D'Oria F, Bagaglia SA, Alio Del Barrio JL, Alessio G, Alio JL, Mazzotta C
Surv Ophthalmol 2024 Jan-Feb;69(1):122-139. Epub 2023 Sep 27 doi: 10.1016/j.survophthal.2023.09.005. PMID: 37774800

Safety and activity of anti-mesothelin antibody-drug conjugate anetumab ravtansine in combination with pegylated-liposomal doxorubicin in platinum-resistant ovarian cancer: multicenter, phase Ib dose escalation and expansion study.

Santin AD, Vergote I, González-Martín A, Moore K, Oaknin A, Romero I, Diab S, Copeland LJ, Monk BJ, Coleman RL, Herzog TJ, Siegel J, Kasten L, Schlicker A, Schulz A, Köchert K, Walter AO, Childs BH, Elbi C, Bulat I
Int J Gynecol Cancer 2023 Apr 3;33(4):562-570. doi: 10.1136/ijgc-2022-003927. PMID: 36564099 Free PMC Article

Anterior pituitary, sex hormones, and keratoconus: Beyond traditional targets.

Karamichos D, Escandon P, Vasini B, Nicholas SE, Van L, Dang DH, Cunningham RL, Riaz KM
Prog Retin Eye Res 2022 May;88:101016. Epub 2021 Nov 2 doi: 10.1016/j.preteyeres.2021.101016. PMID: 34740824 Free PMC Article

Review on the Use of Topical Ocular Hypertonic Saline in Corneal Edema.

Chow SC, Chan JC
Cornea 2021 Apr;40(4):533-539. doi: 10.1097/ICO.0000000000002652. PMID: 33470681

Autologous Serum and Serum Components.

Higuchi A
Invest Ophthalmol Vis Sci 2018 Nov 1;59(14):DES121-DES129. doi: 10.1167/iovs.17-23760. PMID: 30481816

See all (18)

Prognosis

Corneal and conjunctival injury seen in urgent care centres in Israel.

Zimmerman DR, Shneor E, Millodot M, Gordon-Shaag A
Ophthalmic Physiol Opt 2019 Jan;39(1):46-52. doi: 10.1111/opo.12600. PMID: 30628742 Free PMC Article

The Association of Refractive Error with Glaucoma in a Multiethnic Population.

Fuchs endothelial corneal dystrophy.

Elhalis H, Azizi B, Jurkunas UV
Ocul Surf 2010 Oct;8(4):173-84. doi: 10.1016/s1542-0124(12)70232-x. PMID: 20964980 Free PMC Article

Congenital hereditary endothelial dystrophy with progressive sensorineural deafness (Harboyan syndrome).

Desir J, Abramowicz M
Orphanet J Rare Dis 2008 Oct 15;3:28. doi: 10.1186/1750-1172-3-28. PMID: 18922146 Free PMC Article

CHST6 mutations in North American subjects with macular corneal dystrophy: a comprehensive molecular genetic review.

Klintworth GK, Smith CF, Bowling BL
Mol Vis 2006 Mar 10;12:159-76. PMID: 16568029

See all (14)

Clinical prediction guides

Experimental models for keratoconus: Insights and challenges.

Shankar S, Deshmukh R, Pingali T, Sonar R, Basu S, Singh V
Exp Eye Res 2024 Nov;248:110122. Epub 2024 Oct 10 doi: 10.1016/j.exer.2024.110122. PMID: 39395558

Autologous Serum and Serum Components.

Higuchi A
Invest Ophthalmol Vis Sci 2018 Nov 1;59(14):DES121-DES129. doi: 10.1167/iovs.17-23760. PMID: 30481816

The Association of Refractive Error with Glaucoma in a Multiethnic Population.

Proteomics of Fuchs' endothelial corneal dystrophy support that the extracellular matrix of Descemet's membrane is disordered.

Poulsen ET, Dyrlund TF, Runager K, Scavenius C, Krogager TP, Højrup P, Thøgersen IB, Sanggaard KW, Vorum H, Hjortdal J, Enghild JJ
J Proteome Res 2014 Nov 7;13(11):4659-67. Epub 2014 Jun 27 doi: 10.1021/pr500252r. PMID: 24846694 Free PMC Article

CHST6 mutations in North American subjects with macular corneal dystrophy: a comprehensive molecular genetic review.

Klintworth GK, Smith CF, Bowling BL
Mol Vis 2006 Mar 10;12:159-76. PMID: 16568029

See all (30)

Recent systematic reviews

Efficacy comparison of combining cross-linking and refractive laser ablation in progressive keratoconus: systematic review and meta-analysis.

Achiron A, Yahalomi T, Knyazer B, Hecht I, Elbaz U, Spierer O, Livny E, Akowuah PK, Tuuminen R, Avadhanam VS
Can J Ophthalmol 2024 Dec;59(6):e661-e672. Epub 2024 Mar 18 doi: 10.1016/j.jcjo.2024.02.017. PMID: 38513713

Lenticule addition keratoplasty for the treatment of keratoconus: A systematic review and critical considerations.

Liu Y, He Y, Deng Y, Wang L
Indian J Ophthalmol 2024 Feb 1;72(Suppl 2):S167-S175. Epub 2024 Jan 25 doi: 10.4103/IJO.IJO_695_23. PMID: 38271413 Free PMC Article

See all (2)

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Corneal disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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