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Corneal disorder

MedGen UID:
3617
•Concept ID:
C0010034
•
Disease or Syndrome
Synonym: Corneal disease
SNOMED CT: Corneal disorder (15250008); Disorder of cornea (15250008)
 
Monarch Initiative: MONDO:0000942

Definition

A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorneal disorder

Professional guidelines

PubMed

Refractive surgical correction and treatment of keratoconus.
D'Oria F, Bagaglia SA, Alio Del Barrio JL, Alessio G, Alio JL, Mazzotta C
Surv Ophthalmol 2024 Jan-Feb;69(1):122-139. Epub 2023 Sep 27 doi: 10.1016/j.survophthal.2023.09.005. PMID: 37774800
Preferred practice pattern and observed outcome of deep anterior lamellar keratoplasty - A survey of Indian corneal surgeons.
Fogla R, Sahay P, Sharma N
Indian J Ophthalmol 2021 Jun;69(6):1553-1558. doi: 10.4103/ijo.IJO_3067_20. PMID: 34011739Free PMC Article
Neurotrophic keratopathy; its pathophysiology and treatment.
Okada Y, Reinach PS, Kitano A, Shirai K, Kao WW, Saika S
Histol Histopathol 2010 Jun;25(6):771-80. doi: 10.14670/HH-25.771. PMID: 20376784

Recent clinical studies

Etiology

Quantitative interocular comparison of total corneal surface area and corneal diameter in patients with highly asymmetric keratoconus.
Crahay FX, Debellemanière G, Tobalem S, Ghazal W, Moran S, Gatinel D
Sci Rep 2022 Mar 11;12(1):4276. doi: 10.1038/s41598-022-08021-6. PMID: 35277548Free PMC Article
Association of Variants in TMEM45A With Keratoglobus.
Weiner C, Hecht I, Kotlyar A, Shoshany N, Zadok D, Elbaz U, Segev F, Maytal A, Hachmo Y, Michiels C, De Backer O, Shomron N, Einan-Lifshitz A, Pras E
JAMA Ophthalmol 2021 Oct 1;139(10):1089-1095. doi: 10.1001/jamaophthalmol.2021.3172. PMID: 34410316Free PMC Article
Quantitative comparison of corneal surface areas in keratoconus and normal eyes.
Crahay FX, Debellemanière G, Tobalem S, Ghazal W, Moran S, Gatinel D
Sci Rep 2021 Mar 25;11(1):6840. doi: 10.1038/s41598-021-86185-3. PMID: 33767220Free PMC Article
Corneal and conjunctival injury seen in urgent care centres in Israel.
Zimmerman DR, Shneor E, Millodot M, Gordon-Shaag A
Ophthalmic Physiol Opt 2019 Jan;39(1):46-52. doi: 10.1111/opo.12600. PMID: 30628742Free PMC Article
Review: keratoconus in Asia.
Kok YO, Tan GF, Loon SC
Cornea 2012 May;31(5):581-93. doi: 10.1097/ICO.0b013e31820cd61d. PMID: 22314815

Diagnosis

Harboyan Syndrome.
Javaid A, Orakzai AA
J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(Suppl 1)(4):S701-S703. PMID: 33754535
Simplifying and understanding various topographic indices for keratoconus using Scheimpflug based topographers.
Doctor K, Vunnava KP, Shroff R, Kaweri L, Lalgudi VG, Gupta K, Kundu G
Indian J Ophthalmol 2020 Dec;68(12):2732-2743. doi: 10.4103/ijo.IJO_2111_20. PMID: 33229649Free PMC Article
Fuchs Endothelial Corneal Dystrophy: Clinical, Genetic, Pathophysiologic, and Therapeutic Aspects.
Matthaei M, Hribek A, Clahsen T, Bachmann B, Cursiefen C, Jun AS
Annu Rev Vis Sci 2019 Sep 15;5:151-175. doi: 10.1146/annurev-vision-091718-014852. PMID: 31525145
Pellucid marginal degeneration: Detection, discrimination from other corneal ectatic disorders and progression.
Martínez-Abad A, Piñero DP
Cont Lens Anterior Eye 2019 Aug;42(4):341-349. Epub 2018 Nov 22 doi: 10.1016/j.clae.2018.11.010. PMID: 30473322
Review: keratoconus in Asia.
Kok YO, Tan GF, Loon SC
Cornea 2012 May;31(5):581-93. doi: 10.1097/ICO.0b013e31820cd61d. PMID: 22314815

Therapy

Refractive surgical correction and treatment of keratoconus.
D'Oria F, Bagaglia SA, Alio Del Barrio JL, Alessio G, Alio JL, Mazzotta C
Surv Ophthalmol 2024 Jan-Feb;69(1):122-139. Epub 2023 Sep 27 doi: 10.1016/j.survophthal.2023.09.005. PMID: 37774800
Review on the Use of Topical Ocular Hypertonic Saline in Corneal Edema.
Chow SC, Chan JC
Cornea 2021 Apr;40(4):533-539. doi: 10.1097/ICO.0000000000002652. PMID: 33470681
Autologous Serum and Serum Components.
Higuchi A
Invest Ophthalmol Vis Sci 2018 Nov 1;59(14):DES121-DES129. doi: 10.1167/iovs.17-23760. PMID: 30481816
Neurotrophic keratopathy; its pathophysiology and treatment.
Okada Y, Reinach PS, Kitano A, Shirai K, Kao WW, Saika S
Histol Histopathol 2010 Jun;25(6):771-80. doi: 10.14670/HH-25.771. PMID: 20376784
Update on phototherapeutic keratectomy.
Stasi K, Chuck RS
Curr Opin Ophthalmol 2009 Jul;20(4):272-5. doi: 10.1097/ICU.0b013e32832b4f44. PMID: 19381088

Prognosis

Whole mitochondrial genome analysis in Chinese patients with keratoconus.
Xu L, Yang K, Fan Q, Zhao D, Pang C, Ren S
Mol Vis 2021;27:270-282. Epub 2021 May 8 PMID: 34012229Free PMC Article
Corneal and conjunctival injury seen in urgent care centres in Israel.
Zimmerman DR, Shneor E, Millodot M, Gordon-Shaag A
Ophthalmic Physiol Opt 2019 Jan;39(1):46-52. doi: 10.1111/opo.12600. PMID: 30628742Free PMC Article
The Association of Refractive Error with Glaucoma in a Multiethnic Population.
Shen L, Melles RB, Metlapally R, Barcellos L, Schaefer C, Risch N, Herrinton LJ, Wildsoet C, Jorgenson E
Ophthalmology 2016 Jan;123(1):92-101. Epub 2015 Aug 8 doi: 10.1016/j.ophtha.2015.07.002. PMID: 26260281Free PMC Article
Fuchs endothelial corneal dystrophy.
Elhalis H, Azizi B, Jurkunas UV
Ocul Surf 2010 Oct;8(4):173-84. doi: 10.1016/s1542-0124(12)70232-x. PMID: 20964980Free PMC Article
Congenital hereditary endothelial dystrophy with progressive sensorineural deafness (Harboyan syndrome).
Desir J, Abramowicz M
Orphanet J Rare Dis 2008 Oct 15;3:28. doi: 10.1186/1750-1172-3-28. PMID: 18922146Free PMC Article

Clinical prediction guides

Experimental models for keratoconus: Insights and challenges.
Shankar S, Deshmukh R, Pingali T, Sonar R, Basu S, Singh V
Exp Eye Res 2024 Nov;248:110122. Epub 2024 Oct 10 doi: 10.1016/j.exer.2024.110122. PMID: 39395558
Whole mitochondrial genome analysis in Chinese patients with keratoconus.
Xu L, Yang K, Fan Q, Zhao D, Pang C, Ren S
Mol Vis 2021;27:270-282. Epub 2021 May 8 PMID: 34012229Free PMC Article
Autologous Serum and Serum Components.
Higuchi A
Invest Ophthalmol Vis Sci 2018 Nov 1;59(14):DES121-DES129. doi: 10.1167/iovs.17-23760. PMID: 30481816
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.
Afshari NA, Igo RP Jr, Morris NJ, Stambolian D, Sharma S, Pulagam VL, Dunn S, Stamler JF, Truitt BJ, Rimmler J, Kuot A, Croasdale CR, Qin X, Burdon KP, Riazuddin SA, Mills R, Klebe S, Minear MA, Zhao J, Balajonda E, Rosenwasser GO, Baratz KH, Mootha VV, Patel SV, Gregory SG, Bailey-Wilson JE, Price MO, Price FW Jr, Craig JE, Fingert JH, Gottsch JD, Aldave AJ, Klintworth GK, Lass JH, Li YJ, Iyengar SK
Nat Commun 2017 Mar 30;8:14898. doi: 10.1038/ncomms14898. PMID: 28358029Free PMC Article
The Association of Refractive Error with Glaucoma in a Multiethnic Population.
Shen L, Melles RB, Metlapally R, Barcellos L, Schaefer C, Risch N, Herrinton LJ, Wildsoet C, Jorgenson E
Ophthalmology 2016 Jan;123(1):92-101. Epub 2015 Aug 8 doi: 10.1016/j.ophtha.2015.07.002. PMID: 26260281Free PMC Article

Recent systematic reviews

Efficacy comparison of combining cross-linking and refractive laser ablation in progressive keratoconus: systematic review and meta-analysis.
Achiron A, Yahalomi T, Knyazer B, Hecht I, Elbaz U, Spierer O, Livny E, Akowuah PK, Tuuminen R, Avadhanam VS
Can J Ophthalmol 2024 Dec;59(6):e661-e672. Epub 2024 Mar 18 doi: 10.1016/j.jcjo.2024.02.017. PMID: 38513713
Lenticule addition keratoplasty for the treatment of keratoconus: A systematic review and critical considerations.
Liu Y, He Y, Deng Y, Wang L
Indian J Ophthalmol 2024 Feb 1;72(Suppl 2):S167-S175. Epub 2024 Jan 25 doi: 10.4103/IJO.IJO_695_23. PMID: 38271413

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