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Pontiac fever

MedGen UID:
575661
•Concept ID:
C0343528
•
Disease or Syndrome
Synonyms: Fever, Pontiac; Pontiac Fever
SNOMED CT: Pontiac fever (240447002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0020487
Orphanet: ORPHA99748

Definition

Pontiac fever (PF) is a mild form of legionellosis (see this term) manifesting with flu-like symptoms such as nausea, myalgia, fever, cough and headache but without pneumonia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Pontiac fever in Orphanet.

Professional guidelines

PubMed

Antimicrobial therapy and patient management for severe Legionnaires' pneumonia.
Rello J, Sabater-Riera J
Eur J Intern Med 2024 Oct;128:136-137. Epub 2024 Aug 13 doi: 10.1016/j.ejim.2024.08.002. PMID: 39142936
Severe Pneumonia Caused by Legionella pneumophila: Differential Diagnosis and Therapeutic Considerations.
Chahin A, Opal SM
Infect Dis Clin North Am 2017 Mar;31(1):111-121. doi: 10.1016/j.idc.2016.10.009. PMID: 28159171Free PMC Article
Pneumonia: classification, diagnosis and nursing management.
Dunn L
Nurs Stand 2005 Jun 29-Jul 5;19(42):50-4. doi: 10.7748/ns2005.06.19.42.50.c3901. PMID: 16013205

Recent clinical studies

Etiology

Outbreaks of Legionnaires' Disease and Pontiac Fever 2006-2017.
Hamilton KA, Prussin AJ 2nd, Ahmed W, Haas CN
Curr Environ Health Rep 2018 Jun;5(2):263-271. doi: 10.1007/s40572-018-0201-4. PMID: 29744757
Legionellosis in the occupational setting.
Principe L, Tomao P, Visca P
Environ Res 2017 Jan;152:485-495. Epub 2016 Oct 4 doi: 10.1016/j.envres.2016.09.018. PMID: 27717486
Legionellosis on the Rise: A Review of Guidelines for Prevention in the United States.
Parr A, Whitney EA, Berkelman RL
J Public Health Manag Pract 2015 Sep-Oct;21(5):E17-26. doi: 10.1097/PHH.0000000000000123. PMID: 25203696Free PMC Article
Investigation of Pontiac-like illness in office workers during an outbreak of Legionnaires' disease, 2008.
Nicolay N, Boland M, Ward M, Hickey L, Collins C, Lynch M, McCarthy M, O'Donnell J
Epidemiol Infect 2010 Nov;138(11):1667-73. Epub 2010 Mar 5 doi: 10.1017/S0950268810000403. PMID: 20202281
An outbreak of Legionnaires' disease in Gloucester.
Hunt DA, Cartwright KA, Smith MC, Middleton J, Bartlett CL, Lee JV, Dennis PJ, Harper D
Epidemiol Infect 1991 Aug;107(1):133-41. doi: 10.1017/s0950268800048767. PMID: 1879480Free PMC Article

Diagnosis

Legionellosis on the rise: A scoping review of sporadic, community-acquired incidence in the United States.
Moffa MA, Rock C, Galiatsatos P, Gamage SD, Schwab KJ, Exum NG
Epidemiol Infect 2023 Jul 28;151:e133. doi: 10.1017/S0950268823001206. PMID: 37503568Free PMC Article
The human LL-37 peptide exerts antimicrobial activity against Legionella micdadei interacting with membrane phospholipids.
Palusińska-Szysz M, Jurak M, Gisch N, Waldow F, Zehethofer N, Nehls C, Schwudke D, Koper P, Mazur A
Biochim Biophys Acta Mol Cell Biol Lipids 2022 Jun;1867(6):159138. Epub 2022 Feb 26 doi: 10.1016/j.bbalip.2022.159138. PMID: 35231605
Atypical Pneumonia: Updates on Legionella, Chlamydophila, and Mycoplasma Pneumonia.
Sharma L, Losier A, Tolbert T, Dela Cruz CS, Marion CR
Clin Chest Med 2017 Mar;38(1):45-58. Epub 2016 Dec 24 doi: 10.1016/j.ccm.2016.11.011. PMID: 28159161Free PMC Article
Investigation of Pontiac-like illness in office workers during an outbreak of Legionnaires' disease, 2008.
Nicolay N, Boland M, Ward M, Hickey L, Collins C, Lynch M, McCarthy M, O'Donnell J
Epidemiol Infect 2010 Nov;138(11):1667-73. Epub 2010 Mar 5 doi: 10.1017/S0950268810000403. PMID: 20202281
Legionella infections.
Ching WT, Meyer RD
Infect Dis Clin North Am 1987 Sep;1(3):595-614. PMID: 3332887

Therapy

Large outbreak of Legionnaires' disease and Pontiac fever at a military base.
Ambrose J, Hampton LM, Fleming-Dutra KE, Marten C, McClusky C, Perry C, Clemmons NA, McCormic Z, Peik S, Mancuso J, Brown E, Kozak N, Travis T, Lucas C, Fields B, Hicks L, Cersovsky SB
Epidemiol Infect 2014 Nov;142(11):2336-46. doi: 10.1017/S0950268813003440. PMID: 25267405Free PMC Article
Hot tub legionellosis. Legionnaires' disease and Pontiac fever after a point-source exposure to Legionella pneumophila.
Thomas DL, Mundy LM, Tucker PC
Arch Intern Med 1993 Nov 22;153(22):2597-9. doi: 10.1001/archinte.153.22.2597. PMID: 8239853
Legionnaires' disease: respiratory infections caused by Legionella bacteria.
Davis GS, Winn WC Jr
Clin Chest Med 1987 Sep;8(3):419-39. PMID: 3311585
Pneumonic and nonpneumonic forms of legionellosis. The result of a common-source exposure to Legionella pneumophila.
Girod JC, Reichman RC, Winn WC Jr, Klaucke DN, Vogt RL, Dolin R
Arch Intern Med 1982 Mar;142(3):545-7. PMID: 7065789
Legionellosis: Legionnaires' disease; Pontiac fever.
Cordes LG, Fraser DW
Med Clin North Am 1980 May;64(3):395-416. doi: 10.1016/s0025-7125(16)31600-5. PMID: 6993807

Prognosis

Legionellosis in Poland in 2018-2021.
Czerwiński M, Księżak E, Piekarska K
Przegl Epidemiol 2023;77(2):241-250. doi: 10.32394/pe.77.23. PMID: 37861069
Legionellosis on the rise: A scoping review of sporadic, community-acquired incidence in the United States.
Moffa MA, Rock C, Galiatsatos P, Gamage SD, Schwab KJ, Exum NG
Epidemiol Infect 2023 Jul 28;151:e133. doi: 10.1017/S0950268823001206. PMID: 37503568Free PMC Article
Legionellosis in Poland in 2016.
Stypułkowska-Misiurewicz H, Czerwiński M
Przegl Epidemiol 2018;72(2):143-147. PMID: 30111084
Legionellosis in the occupational setting.
Principe L, Tomao P, Visca P
Environ Res 2017 Jan;152:485-495. Epub 2016 Oct 4 doi: 10.1016/j.envres.2016.09.018. PMID: 27717486
Large outbreak of Legionnaires' disease and Pontiac fever at a military base.
Ambrose J, Hampton LM, Fleming-Dutra KE, Marten C, McClusky C, Perry C, Clemmons NA, McCormic Z, Peik S, Mancuso J, Brown E, Kozak N, Travis T, Lucas C, Fields B, Hicks L, Cersovsky SB
Epidemiol Infect 2014 Nov;142(11):2336-46. doi: 10.1017/S0950268813003440. PMID: 25267405Free PMC Article

Clinical prediction guides

Legionellosis in Poland in 2018-2021.
Czerwiński M, Księżak E, Piekarska K
Przegl Epidemiol 2023;77(2):241-250. doi: 10.32394/pe.77.23. PMID: 37861069
The human LL-37 peptide exerts antimicrobial activity against Legionella micdadei interacting with membrane phospholipids.
Palusińska-Szysz M, Jurak M, Gisch N, Waldow F, Zehethofer N, Nehls C, Schwudke D, Koper P, Mazur A
Biochim Biophys Acta Mol Cell Biol Lipids 2022 Jun;1867(6):159138. Epub 2022 Feb 26 doi: 10.1016/j.bbalip.2022.159138. PMID: 35231605
Legionellosis in the occupational setting.
Principe L, Tomao P, Visca P
Environ Res 2017 Jan;152:485-495. Epub 2016 Oct 4 doi: 10.1016/j.envres.2016.09.018. PMID: 27717486
Hot tub legionellosis. Legionnaires' disease and Pontiac fever after a point-source exposure to Legionella pneumophila.
Thomas DL, Mundy LM, Tucker PC
Arch Intern Med 1993 Nov 22;153(22):2597-9. doi: 10.1001/archinte.153.22.2597. PMID: 8239853
Pontiac fever outbreak associated with a cooling tower.
Friedman S, Spitalny K, Barbaree J, Faur Y, McKinney R
Am J Public Health 1987 May;77(5):568-72. PMID: 3565648Free PMC Article

Recent systematic reviews

Legionellosis Associated with Recreational Waters: A Systematic Review of Cases and Outbreaks in Swimming Pools, Spa Pools, and Similar Environments.
Leoni E, Catalani F, Marini S, Dallolio L
Int J Environ Res Public Health 2018 Jul 30;15(8) doi: 10.3390/ijerph15081612. PMID: 30061526Free PMC Article

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