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Legionella infection

MedGen UID:: 7292
•Concept ID:: C0023240
•: Disease or Syndrome

Synonym:	Legionellosis
SNOMED CT:	Legionella infection (26726000); Legionellosis (26726000)
Modes of inheritance:	Not genetically inherited MedGen UID: 988794 •Concept ID: CN307044 • Finding Source: Orphanet clinical entity without genetic inheritance. See: This record Not genetically inherited (Orphanet)

Related gene: Gene(s) associated with related conditions. For conditions in a hierarchy, the parent condition will list the genes associated with the children conditions.	TLR5

Monarch Initiative:	MONDO:0005823
Orphanet:	ORPHA549

Definition

Legionellosis or Legionnaires' disease (LD) is a bacterial lung infection characterized by a potentially fatal pneumonia. [from ORDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLegionella infection
- CROGVLegionnaires disease
  - CROGVLegionnaire disease, susceptibility to
- CROGVPontiac fever

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Cause
    - Infection
      - Bacterial Infections and Mycoses
        Bacterial infectious disease
        Legionella infection
        Legionnaires disease
        Legionnaire disease, susceptibility to
        Pontiac fever

Professional guidelines

PubMed

New trends in the prevention and management of community-acquired pneumonia.

Postma DF, van Werkhoven CH, Huijts SM, Bolkenbaas M, Oosterheert JJ, Bonten MJ
Neth J Med 2012 Oct;70(8):337-48. PMID: 23065981

Nosocomial legionellosis: prevention and management.

Levin AS
Expert Rev Anti Infect Ther 2009 Feb;7(1):57-68. doi: 10.1586/14787210.7.1.57. PMID: 19622057

Treatment strategies for Legionella infection.

Pedro-Botet ML, Yu VL
Expert Opin Pharmacother 2009 May;10(7):1109-21. doi: 10.1517/14656560902900820. PMID: 19405787

See all (10)

Recent clinical studies

Etiology

Overview and comparison of Legionella regulations worldwide.

Van Kenhove E, Dinne K, Janssens A, Laverge J
Am J Infect Control 2019 Aug;47(8):968-978. Epub 2019 Jan 9 doi: 10.1016/j.ajic.2018.10.006. PMID: 30638676

Legionnaire's Disease and Immunosuppressive Drugs.

Htwe TH, Khardori NM
Infect Dis Clin North Am 2017 Mar;31(1):29-42. Epub 2016 Dec 12 doi: 10.1016/j.idc.2016.10.003. PMID: 27979686

Could it be Legionella?

Darby J, Buising K
Aust Fam Physician 2008 Oct;37(10):812-5. PMID: 19002299

Legionella and immunosuppression.

Schlossberg D, Bonoan J
Semin Respir Infect 1998 Jun;13(2):128-31. PMID: 9643390

Legionella infection.

Nguyen ML, Yu VL
Clin Chest Med 1991 Jun;12(2):257-68. PMID: 1855370

See all (99)

Diagnosis

Incidence and influence of hyperCKemia in Legionella infection.

Hill J, Li J, Li Y
J Neurol Sci 2022 May 15;436:120252. Epub 2022 Apr 6 doi: 10.1016/j.jns.2022.120252. PMID: 35405618

Could it be Legionella?

Darby J, Buising K
Aust Fam Physician 2008 Oct;37(10):812-5. PMID: 19002299

Legionellosis.

Pedro-Botet ML, Sabrià M
Semin Respir Crit Care Med 2005 Dec;26(6):625-34. doi: 10.1055/s-2005-925526. PMID: 16388431

Diagnosis of Legionella infection in Legionnaires' disease.

Den Boer JW, Yzerman EP
Eur J Clin Microbiol Infect Dis 2004 Dec;23(12):871-8. doi: 10.1007/s10096-004-1248-8. PMID: 15599647

Legionella infection.

Nguyen ML, Yu VL
Clin Chest Med 1991 Jun;12(2):257-68. PMID: 1855370

See all (143)

Therapy

Legionnaire's Disease and Immunosuppressive Drugs.

Htwe TH, Khardori NM
Infect Dis Clin North Am 2017 Mar;31(1):29-42. Epub 2016 Dec 12 doi: 10.1016/j.idc.2016.10.003. PMID: 27979686

Legionellosis.

Pedro-Botet ML, Sabrià M
Semin Respir Crit Care Med 2005 Dec;26(6):625-34. doi: 10.1055/s-2005-925526. PMID: 16388431

Legionella infection and control in occupational and environmental health.

Fujii J, Yoshida S
Rev Environ Health 1998 Oct-Dec;13(4):179-203. doi: 10.1515/reveh.1998.13.4.179. PMID: 9987814

Legionella and immunosuppression.

Schlossberg D, Bonoan J
Semin Respir Infect 1998 Jun;13(2):128-31. PMID: 9643390

Legionella infection.

Nguyen ML, Yu VL
Clin Chest Med 1991 Jun;12(2):257-68. PMID: 1855370

See all (58)

Prognosis

Incidence and influence of hyperCKemia in Legionella infection.

Hill J, Li J, Li Y
J Neurol Sci 2022 May 15;436:120252. Epub 2022 Apr 6 doi: 10.1016/j.jns.2022.120252. PMID: 35405618

Legionnaire's Disease and Influenza.

Magira EE, Zakynthinos S
Infect Dis Clin North Am 2017 Mar;31(1):137-153. doi: 10.1016/j.idc.2016.10.010. PMID: 28159173

Diagnostic and typing methods for investigating Legionella infection.

Blyth CC, Adams DN, Chen SC
N S W Public Health Bull 2009 Sep-Oct;20(9-10):157-61. doi: 10.1071/nb08062. PMID: 19917208

Legionnaires' disease: a rational approach to therapy.

Roig J, Rello J
J Antimicrob Chemother 2003 May;51(5):1119-29. Epub 2003 Mar 28 doi: 10.1093/jac/dkg191. PMID: 12668578

Legionella prosthetic-valve endocarditis.

Tompkins LS, Roessler BJ, Redd SC, Markowitz LE, Cohen ML
N Engl J Med 1988 Mar 3;318(9):530-5. doi: 10.1056/NEJM198803033180902. PMID: 3340136

See all (53)

Clinical prediction guides

Significance of Hypophosphatemia in Patients with Pneumonia.

Morimoto Y, Ishiguro T, Uozumi R, Takano K, Kobayashi Y, Kobayashi Y, Shimizu Y, Takayanagi N
Intern Med 2022;61(7):979-988. Epub 2022 Apr 1 doi: 10.2169/internalmedicine.6949-20. PMID: 35370255 Free PMC Article

Global Perspective of Legionella Infection in Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Observational Studies.

Graham FF, Finn N, White P, Hales S, Baker MG
Int J Environ Res Public Health 2022 Feb 8;19(3) doi: 10.3390/ijerph19031907. PMID: 35162928 Free PMC Article

Overview and comparison of Legionella regulations worldwide.

Van Kenhove E, Dinne K, Janssens A, Laverge J
Am J Infect Control 2019 Aug;47(8):968-978. Epub 2019 Jan 9 doi: 10.1016/j.ajic.2018.10.006. PMID: 30638676

Nosocomial legionellosis: prevention and management.

Levin AS
Expert Rev Anti Infect Ther 2009 Feb;7(1):57-68. doi: 10.1586/14787210.7.1.57. PMID: 19622057

Legionellosis.

Pedro-Botet ML, Sabrià M
Semin Respir Crit Care Med 2005 Dec;26(6):625-34. doi: 10.1055/s-2005-925526. PMID: 16388431

See all (28)

Recent systematic reviews

Can legionellosis be considered an occupational risk in the healthcare sector? A systematic review and meta-analysis.

Bongiovanni A, Colazingari V, Messineo A, Del Cimmuto A, De Giusti M, La Torre G
Public Health 2023 Jan;214:31-37. Epub 2022 Dec 1 doi: 10.1016/j.puhe.2022.10.027. PMID: 36463752

Global Perspective of Legionella Infection in Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Observational Studies.

Graham FF, Finn N, White P, Hales S, Baker MG
Int J Environ Res Public Health 2022 Feb 8;19(3) doi: 10.3390/ijerph19031907. PMID: 35162928 Free PMC Article

Accuracy of diagnostic tests for Legionnaires' disease: a systematic review.

Cristovam E, Almeida D, Caldeira D, Ferreira JJ, Marques T
J Med Microbiol 2017 Apr;66(4):485-489. doi: 10.1099/jmm.0.000454. PMID: 28463665

See all (3)

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Legionella infection

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Recent activity