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Uterine polyp

MedGen UID:
57628
•Concept ID:
C0156369
•
Neoplastic Process
Synonyms: endometrial/uterine polyp; Intrauterine polyp; Polyp of corpus uteri; polyp of corpus uteri; Polyp of the Uterus; polyp of the uterus; Polyp of Uterus; polyp of uterus; polyp, uterus; Uterine Polyp; uterine polyp; Uterus Polyp; uterus polyp
SNOMED CT: Intrauterine polyp (11314008); Polyp of corpus uteri (11314008); Uterine polyp (11314008)
 
Monarch Initiative: MONDO:0004701

Definition

A benign protruding lesion arising either from the endometrial cavity (endometrial polyp) or the endocervix (endocervical polyp). It may occasionally recur following complete resection. [from NCI]

Professional guidelines

PubMed

Evaluation and management of abnormal uterine bleeding.
Achanna KS, Nanda J
Med J Malaysia 2022 May;77(3):374-383. PMID: 35638495
Endometrial polyps. An evidence-based diagnosis and management guide.
Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J; From the Global Community of Hysteroscopy Guidelines Committee
Eur J Obstet Gynecol Reprod Biol 2021 May;260:70-77. Epub 2021 Mar 13 doi: 10.1016/j.ejogrb.2021.03.017. PMID: 33756339
Evaluation and Management of Abnormal Uterine Bleeding.
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128

Recent clinical studies

Etiology

Postmarketing adverse events of tamoxifen in male and female patients with breast cancer.
Ke C, Chen M, Lin L, Huang Y
Int J Cancer 2025 Feb 15;156(4):734-743. Epub 2024 Sep 21 doi: 10.1002/ijc.35193. PMID: 39305475
Nonelectric shaving of endometrial polyp by hysteroscopy - A new technique to eliminate thermal damage.
Sharon A, Zidane M, Aiob A, Apel-Sarid L, Bornstein J
Eur J Obstet Gynecol Reprod Biol 2023 Jun;285:170-174. Epub 2023 Apr 27 doi: 10.1016/j.ejogrb.2023.04.018. PMID: 37146506
Prediction of endometrial cancer recurrence by using a novel machine learning algorithm: An Israeli gynecologic oncology group study.
Houri O, Gil Y, Gemer O, Helpman L, Vaknin Z, Lavie O, Arie AB, Amit A, Levy T, Namazov A, Shachar IB, Atlas I, Bruchim I, Eitan R
J Gynecol Obstet Hum Reprod 2022 Nov;51(9):102466. Epub 2022 Aug 28 doi: 10.1016/j.jogoh.2022.102466. PMID: 36041694
Clinical application of Lin's biopsy grasper for intrauterine targeted biopsy and polypectomy during office hysteroscopy.
Cheng HY, Lin BL, Tseng JY, Ueno K, Nakada S
Taiwan J Obstet Gynecol 2018 Jun;57(3):379-382. doi: 10.1016/j.tjog.2018.04.009. PMID: 29880169
Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study.
Cooper NA, Clark TJ, Middleton L, Diwakar L, Smith P, Denny E, Roberts T, Stobert L, Jowett S, Daniels J; OPT Trial Collaborative Group
BMJ 2015 Mar 23;350:h1398. doi: 10.1136/bmj.h1398. PMID: 25801579Free PMC Article

Diagnosis

Metastatic malignant melanoma in an endometrial polyp.
Ulmer K, Powers J, Alrwashdeh A, Hardy-Fairbanks A
Dermatol Online J 2021 Apr 15;27(4) PMID: 33999583
Two-Step Office-Based Hysteroscopic Operation for Submucosal Myoma.
Oh ST, Ryu HK
JSLS 2019 Jul-Sep;23(3) doi: 10.4293/JSLS.2019.00028. PMID: 31488942Free PMC Article
Clinicopathological and immunohistochemical features of uterine adenomyomatous polyps.
Strickland KC, Yuan L, Quade BJ, Nucci MR, Howitt BE
Hum Pathol 2019 Feb;84:239-245. Epub 2018 Oct 16 doi: 10.1016/j.humpath.2018.10.002. PMID: 30339971
Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study.
Cooper NA, Clark TJ, Middleton L, Diwakar L, Smith P, Denny E, Roberts T, Stobert L, Jowett S, Daniels J; OPT Trial Collaborative Group
BMJ 2015 Mar 23;350:h1398. doi: 10.1136/bmj.h1398. PMID: 25801579Free PMC Article
The natural course of endometrial polyps: could they vanish when left untreated?
Haimov-Kochman R, Deri-Hasid R, Hamani Y, Voss E
Fertil Steril 2009 Aug;92(2):828.e11-2. Epub 2009 Jun 13 doi: 10.1016/j.fertnstert.2009.04.054. PMID: 19524890

Therapy

Postmarketing adverse events of tamoxifen in male and female patients with breast cancer.
Ke C, Chen M, Lin L, Huang Y
Int J Cancer 2025 Feb 15;156(4):734-743. Epub 2024 Sep 21 doi: 10.1002/ijc.35193. PMID: 39305475
Nonelectric shaving of endometrial polyp by hysteroscopy - A new technique to eliminate thermal damage.
Sharon A, Zidane M, Aiob A, Apel-Sarid L, Bornstein J
Eur J Obstet Gynecol Reprod Biol 2023 Jun;285:170-174. Epub 2023 Apr 27 doi: 10.1016/j.ejogrb.2023.04.018. PMID: 37146506
Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study.
Cooper NA, Clark TJ, Middleton L, Diwakar L, Smith P, Denny E, Roberts T, Stobert L, Jowett S, Daniels J; OPT Trial Collaborative Group
BMJ 2015 Mar 23;350:h1398. doi: 10.1136/bmj.h1398. PMID: 25801579Free PMC Article
Pre-cycle saline infusion sonography minimizes assisted reproductive technologies cycle cancellation due to endometrial polyps.
Yauger BJ, Feinberg EC, Levens ED, Gustofson RL, Larsen FW, DeCherney AH
Fertil Steril 2008 Oct;90(4):1324-6. Epub 2007 Dec 21 doi: 10.1016/j.fertnstert.2007.09.050. PMID: 18155202
Fallopian tube presenting as a uterine polyp.
Steigrad SJ, Margin CJ
Aust N Z J Obstet Gynaecol 1978 Nov;18(4):281-3. doi: 10.1111/j.1479-828x.1978.tb00073.x. PMID: 284776

Prognosis

Uterine embryonal rhabdomyosarcoma in adult women: a case report on the challenging diagnosis and treatment.
Pop CF, Stanciu-Pop CM, Jungels C, Chintinne M, Artigas Guix C, Grosu F, Juravle C, Veys I
Rom J Morphol Embryol 2023 Jan-Mar;64(1):83-88. doi: 10.47162/RJME.64.1.10. PMID: 37128795Free PMC Article
Can endometrial thickness at baseline or maximum stimulated levels during IVF predict the presence of endometrial polyps in women with two failed embryo transfers?
Hussaini S, Nayot D, Hartman M, Dahan MH
Arch Gynecol Obstet 2023 May;307(5):1645-1653. Epub 2022 Jun 9 doi: 10.1007/s00404-022-06646-6. PMID: 35680687
Prediction of endometrial cancer recurrence by using a novel machine learning algorithm: An Israeli gynecologic oncology group study.
Houri O, Gil Y, Gemer O, Helpman L, Vaknin Z, Lavie O, Arie AB, Amit A, Levy T, Namazov A, Shachar IB, Atlas I, Bruchim I, Eitan R
J Gynecol Obstet Hum Reprod 2022 Nov;51(9):102466. Epub 2022 Aug 28 doi: 10.1016/j.jogoh.2022.102466. PMID: 36041694
Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study.
Cooper NA, Clark TJ, Middleton L, Diwakar L, Smith P, Denny E, Roberts T, Stobert L, Jowett S, Daniels J; OPT Trial Collaborative Group
BMJ 2015 Mar 23;350:h1398. doi: 10.1136/bmj.h1398. PMID: 25801579Free PMC Article
The natural course of endometrial polyps: could they vanish when left untreated?
Haimov-Kochman R, Deri-Hasid R, Hamani Y, Voss E
Fertil Steril 2009 Aug;92(2):828.e11-2. Epub 2009 Jun 13 doi: 10.1016/j.fertnstert.2009.04.054. PMID: 19524890

Clinical prediction guides

Postmarketing adverse events of tamoxifen in male and female patients with breast cancer.
Ke C, Chen M, Lin L, Huang Y
Int J Cancer 2025 Feb 15;156(4):734-743. Epub 2024 Sep 21 doi: 10.1002/ijc.35193. PMID: 39305475
Can endometrial thickness at baseline or maximum stimulated levels during IVF predict the presence of endometrial polyps in women with two failed embryo transfers?
Hussaini S, Nayot D, Hartman M, Dahan MH
Arch Gynecol Obstet 2023 May;307(5):1645-1653. Epub 2022 Jun 9 doi: 10.1007/s00404-022-06646-6. PMID: 35680687
Prediction of endometrial cancer recurrence by using a novel machine learning algorithm: An Israeli gynecologic oncology group study.
Houri O, Gil Y, Gemer O, Helpman L, Vaknin Z, Lavie O, Arie AB, Amit A, Levy T, Namazov A, Shachar IB, Atlas I, Bruchim I, Eitan R
J Gynecol Obstet Hum Reprod 2022 Nov;51(9):102466. Epub 2022 Aug 28 doi: 10.1016/j.jogoh.2022.102466. PMID: 36041694
Some minor female reproductive system disorders: findings in the Oxford-Family Planning Association contraceptive study.
Vessey M, Yeates D
J Fam Plann Reprod Health Care 2009 Apr;35(2):105-10. doi: 10.1783/147118909787931988. PMID: 19356282

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