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Congenital cytomegalovirus infection

MedGen UID:
57644
•Concept ID:
C0158945
•
Disease or Syndrome
Synonyms: CMV Infection, Congenital; Congenital CMV Infection; Congenital CMV Infections; Congenital Cytomegalovirus Infection; Congenital Cytomegalovirus Infections; Cytomegalovirus Infection, Congenital; Infection, Congenital CMV; Infection, Congenital Cytomegalovirus
SNOMED CT: Congenital cytomegalovirus infection (59527008); Neonatal cytomegaloviral disease (59527008)

Definition

An infection with the Cytomegalovirus that is present from birth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital cytomegalovirus infection

Professional guidelines

PubMed

Congenital cytomegalovirus infection diagnostics and management.
Pinninti S, Boppana S
Curr Opin Infect Dis 2022 Oct 1;35(5):436-441. Epub 2022 Aug 19 doi: 10.1097/QCO.0000000000000874. PMID: 35984001Free PMC Article
Congenital Cytomegalovirus Infection: Epidemiology, Timely Diagnosis, and Management.
Jenks CM, Hoff SR, Mithal LB
Neoreviews 2021 Sep;22(9):e606-e613. doi: 10.1542/neo.22-9-e606. PMID: 34470762
Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.
Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, Daly K, Doutré S, Gibson L, Giles ML, Greenlee J, Hamilton ST, Harrison GJ, Hui L, Jones CA, Palasanthiran P, Schleiss MR, Shand AW, van Zuylen WJ
Lancet Infect Dis 2017 Jun;17(6):e177-e188. Epub 2017 Mar 11 doi: 10.1016/S1473-3099(17)30143-3. PMID: 28291720

Recent clinical studies

Etiology

Congenital cytomegalovirus infection diagnostics and management.
Pinninti S, Boppana S
Curr Opin Infect Dis 2022 Oct 1;35(5):436-441. Epub 2022 Aug 19 doi: 10.1097/QCO.0000000000000874. PMID: 35984001Free PMC Article
Congenital Cytomegalovirus Infection.
Kabani N, Ross SA
J Infect Dis 2020 Mar 5;221(Suppl 1):S9-S14. doi: 10.1093/infdis/jiz446. PMID: 32134480Free PMC Article
Congenital and perinatal infections.
Ostrander B, Bale JF
Handb Clin Neurol 2019;162:133-153. doi: 10.1016/B978-0-444-64029-1.00006-0. PMID: 31324308
Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.
Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, Daly K, Doutré S, Gibson L, Giles ML, Greenlee J, Hamilton ST, Harrison GJ, Hui L, Jones CA, Palasanthiran P, Schleiss MR, Shand AW, van Zuylen WJ
Lancet Infect Dis 2017 Jun;17(6):e177-e188. Epub 2017 Mar 11 doi: 10.1016/S1473-3099(17)30143-3. PMID: 28291720
Congenital cytomegalovirus infection.
Jones CA
Curr Probl Pediatr Adolesc Health Care 2003 Mar;33(3):70-93. doi: 10.1067/mps.2003.3. PMID: 12605193

Diagnosis

Congenital cytomegalovirus infection.
Pesch MH, Kuboushek K, McKee MM, Thorne MC, Weinberg JB
BMJ 2021 Jun 3;373:n1212. doi: 10.1136/bmj.n1212. PMID: 34083180
Congenital Cytomegalovirus Infection.
Kabani N, Ross SA
J Infect Dis 2020 Mar 5;221(Suppl 1):S9-S14. doi: 10.1093/infdis/jiz446. PMID: 32134480Free PMC Article
Congenital cytomegalovirus infection.
Fowler KB, Boppana SB
Semin Perinatol 2018 Apr;42(3):149-154. Epub 2018 Mar 2 doi: 10.1053/j.semperi.2018.02.002. PMID: 29503048
Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.
Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, Daly K, Doutré S, Gibson L, Giles ML, Greenlee J, Hamilton ST, Harrison GJ, Hui L, Jones CA, Palasanthiran P, Schleiss MR, Shand AW, van Zuylen WJ
Lancet Infect Dis 2017 Jun;17(6):e177-e188. Epub 2017 Mar 11 doi: 10.1016/S1473-3099(17)30143-3. PMID: 28291720
Congenital cytomegalovirus infection.
Jones CA
Curr Probl Pediatr Adolesc Health Care 2003 Mar;33(3):70-93. doi: 10.1067/mps.2003.3. PMID: 12605193

Therapy

Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Congenital cytomegalovirus infection diagnostics and management.
Pinninti S, Boppana S
Curr Opin Infect Dis 2022 Oct 1;35(5):436-441. Epub 2022 Aug 19 doi: 10.1097/QCO.0000000000000874. PMID: 35984001Free PMC Article
Congenital cytomegalovirus infection.
Fowler KB, Boppana SB
Semin Perinatol 2018 Apr;42(3):149-154. Epub 2018 Mar 2 doi: 10.1053/j.semperi.2018.02.002. PMID: 29503048
Preventing Congenital Cytomegalovirus Infection.
Coleman JL, Steele RW
Clin Pediatr (Phila) 2017 Oct;56(12):1085-1094. Epub 2017 Aug 21 doi: 10.1177/0009922817724400. PMID: 28825308
Congenital Cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment.
Marsico C, Kimberlin DW
Ital J Pediatr 2017 Apr 17;43(1):38. doi: 10.1186/s13052-017-0358-8. PMID: 28416012Free PMC Article

Prognosis

Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Congenital Cytomegalovirus Infection: Epidemiology, Timely Diagnosis, and Management.
Jenks CM, Hoff SR, Mithal LB
Neoreviews 2021 Sep;22(9):e606-e613. doi: 10.1542/neo.22-9-e606. PMID: 34470762
Congenital Cytomegalovirus Infection.
Kabani N, Ross SA
J Infect Dis 2020 Mar 5;221(Suppl 1):S9-S14. doi: 10.1093/infdis/jiz446. PMID: 32134480Free PMC Article
Outcome and management of newborns with congenital cytomegalovirus infection.
Nicloux M, Peterman L, Parodi M, Magny JF
Arch Pediatr 2020 Apr;27(3):160-165. Epub 2020 Feb 29 doi: 10.1016/j.arcped.2020.01.006. PMID: 32127242
Congenital Cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment.
Marsico C, Kimberlin DW
Ital J Pediatr 2017 Apr 17;43(1):38. doi: 10.1186/s13052-017-0358-8. PMID: 28416012Free PMC Article

Clinical prediction guides

Universal and Expanded Screening Strategy for Congenital Cytomegalovirus Infection: Is Pool Testing by a Rapid Molecular Test in Saliva a New Choice in Developing Countries?
Izquierdo G, Guerra C, Reyes R, Araya L, Sepulveda B, Cabrera C, Medina P, Mardones E, Villavicencio L, Montecinos L, Tarque F, Acevedo W, Barraza M, Farfán M, Mendez J, Torres JP
Viruses 2024 May 13;16(5) doi: 10.3390/v16050772. PMID: 38793653Free PMC Article
Congenital Cytomegalovirus Infection.
Kabani N, Ross SA
J Infect Dis 2020 Mar 5;221(Suppl 1):S9-S14. doi: 10.1093/infdis/jiz446. PMID: 32134480Free PMC Article
Outcome and management of newborns with congenital cytomegalovirus infection.
Nicloux M, Peterman L, Parodi M, Magny JF
Arch Pediatr 2020 Apr;27(3):160-165. Epub 2020 Feb 29 doi: 10.1016/j.arcped.2020.01.006. PMID: 32127242
Cytomegalovirus infection during pregnancy: state of the science.
Leruez-Ville M, Foulon I, Pass R, Ville Y
Am J Obstet Gynecol 2020 Sep;223(3):330-349. Epub 2020 Feb 24 doi: 10.1016/j.ajog.2020.02.018. PMID: 32105678
New advances in the diagnosis of congenital cytomegalovirus infection.
Lazzarotto T, Varani S, Gabrielli L, Spezzacatena P, Landini MP
Intervirology 1999;42(5-6):390-7. doi: 10.1159/000053976. PMID: 10702722

Recent systematic reviews

Congenital Cytomegalovirus Infection and Hearing Outcomes in Twins: A Systematic Review of Reported Cases.
Cordray H, Liu-Lam O, Tey CS, Alfonso K
Otol Neurotol 2023 Feb 1;44(2):e53-e62. Epub 2022 Dec 21 doi: 10.1097/MAO.0000000000003776. PMID: 36538753
Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Congenital Cytomegalovirus Infection and Ophthalmological Disorders: A Systematic Review.
Gabrani C, Mitsikas D, Giannakou K, Lamnisos D
J Pediatr Ophthalmol Strabismus 2023 Mar-Apr;60(2):86-94. Epub 2022 May 25 doi: 10.3928/01913913-20220426-01. PMID: 35611826
Vestibular and postural impairment in congenital Cytomegalovirus infection.
Corazzi V, Hatzopoulos S, Bianchini C, Skarżyńska MB, Pelucchi S, Skarżyński PH, Ciorba A
Int J Pediatr Otorhinolaryngol 2022 Jan;152:111005. Epub 2021 Dec 7 doi: 10.1016/j.ijporl.2021.111005. PMID: 34894538
Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis.
Maeyama K, Tomioka K, Nagase H, Yoshioka M, Takagi Y, Kato T, Mizobuchi M, Kitayama S, Takada S, Nagai M, Sakakibara N, Nishiyama M, Taniguchi-Ikeda M, Morioka I, Iijima K, Nishimura N
J Autism Dev Disord 2018 May;48(5):1483-1491. doi: 10.1007/s10803-017-3412-x. PMID: 29185167

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