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Benign neoplasm of lacrimal gland

MedGen UID:
57813
•Concept ID:
C0154024
•
Neoplastic Process
Synonyms: Benign Lacrimal Gland Neoplasm; benign lacrimal gland neoplasm; Benign Lacrimal Gland Tumor; benign lacrimal gland tumor; benign lacrimal gland tumour; Benign Neoplasm of Lacrimal Gland; benign neoplasm of lacrimal gland; Benign Neoplasm of the Lacrimal Gland; benign neoplasm of the lacrimal gland; Benign tumor of lacrimal gland; Benign Tumor of Lacrimal Gland; benign tumor of lacrimal gland; Benign Tumor of the Lacrimal Gland; benign tumor of the lacrimal gland; benign tumour of lacrimal gland; benign tumour of the lacrimal gland; lacrimal gland benign neoplasm
SNOMED CT: Benign tumor of lacrimal gland (92169007); Benign neoplasm of lacrimal gland (92169007)
 
Monarch Initiative: MONDO:0021488

Definition

A neoplasm that arises from the lacrimal gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of lacrimal gland

Professional guidelines

PubMed

Re: "Does Multimodal Treatment Improve Eye and Life Salvage in Adenoid Cystic Carcinoma of the Lacrimal Gland?".
Rose GE
Ophthalmic Plast Reconstr Surg 2022 Jul-Aug 01;38(4):406. Epub 2022 Jul 5 doi: 10.1097/IOP.0000000000002211. PMID: 35797665
Re: "Multidisciplinary management of lacrimal sac/nasolacrimal duct carcinomas".
Valenzuela AA, McNab A, Sullivan TJ
Ophthalmic Plast Reconstr Surg 2014 Nov-Dec;30(6):531-2. doi: 10.1097/IOP.0000000000000318. PMID: 25383578
The red eye: evaluation and management.
Sethuraman U, Kamat D
Clin Pediatr (Phila) 2009 Jul;48(6):588-600. Epub 2009 Apr 8 doi: 10.1177/0009922809333094. PMID: 19357422

Recent clinical studies

Etiology

A single-institution review of lacrimal gland biopsies between 1962 and 2017.
Choi CJ, Tran AQ, Anagnostopoulos AG, Zhou HW, Tse DT, Dubovy SR
Orbit 2023 Apr;42(2):148-156. Epub 2022 Mar 17 doi: 10.1080/01676830.2022.2052113. PMID: 35298320
Krause's accessory lacrimal gland dacryops - case report and literature review.
Alsulaiman HM, Fatani DR, Al Sheikh O, Elkhamary S, Maktabi A, Alkatan HM, Schellini SA
Orbit 2020 Dec;39(6):441-445. Epub 2020 Jan 8 doi: 10.1080/01676830.2019.1704796. PMID: 31914837
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Lacrimal Sac Tumors--A Review.
Krishna Y, Coupland SE
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):173-178. doi: 10.22608/APO.201713. PMID: 28399337
Primary lymphocytic lymphoma of lacrimal gland.
Romero-Caballero MD, Lozano-García I, Gómez-Molina C, Gil-Liñán AI, Arcas I
Arch Soc Esp Oftalmol 2017 Feb;92(2):82-85. Epub 2016 Jun 3 doi: 10.1016/j.oftal.2016.04.007. PMID: 27268701

Diagnosis

The punctum sign in epidermal cyst.
Borg Grech S, Mintoff D, Scerri L
Clin Exp Dermatol 2024 Feb 14;49(3):275-276. doi: 10.1093/ced/llad380. PMID: 37952189
Complication of Ectopic Lacrimal Gland Tumor on Long-term Follow-up: A Case Report.
Choi JY, Jang YK, Han JC
Korean J Ophthalmol 2023 Aug;37(4):348-349. Epub 2023 Jun 19 doi: 10.3341/kjo.2023.0035. PMID: 37336510Free PMC Article
Management of a Case of Congenital Dacryocystocele.
de Beaufort H, Dumitrescu AV, Kipp MA, Wagner RS
J Pediatr Ophthalmol Strabismus 2020 Jul 1;57(4):208-209. doi: 10.3928/01913913-20200416-02. PMID: 32687201
Bilateral Blue Masses.
Bou Ghannam AS, Mhanna CJ, Atallah M, Alameddine RM
J Pediatr Ophthalmol Strabismus 2019 Jan 23;56(1):8. doi: 10.3928/01913913-20181206-01. PMID: 30673100
Congenital dacryocystocele.
Pujari A
BMJ Case Rep 2016 Dec 9;2016 doi: 10.1136/bcr-2016-218029. PMID: 27941115Free PMC Article

Therapy

Congenital bilateral dacryocystocele.
Carneiro de Sousa P, Neves M, Duarte D, Azevedo P
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Feb;136(1):41-42. Epub 2018 Oct 15 doi: 10.1016/j.anorl.2017.10.006. PMID: 30337239
Intra-arterial Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma.
Zhang M, Fathy C, Breazzano MP, Hollar M, Barahimi B
Int Ophthalmol Clin 2017 Winter;57(1):143-152. doi: 10.1097/IIO.0000000000000158. PMID: 27898620
Sebaceous carcinoma of the ocular region: a review.
Shields JA, Demirci H, Marr BP, Eagle RC Jr, Shields CL
Surv Ophthalmol 2005 Mar-Apr;50(2):103-22. doi: 10.1016/j.survophthal.2004.12.008. PMID: 15749305
Eyelids, lacrimal apparatus, and conjunctiva.
Sexton RR
Arch Ophthalmol 1970 Mar;83(3):361-77. doi: 10.1001/archopht.1970.00990030361016. PMID: 4906255
Eyelids, lacrimal apparatus, and conjunctiva.
Sexton RR
Arch Ophthalmol 1969 Feb;81(2):281-99. doi: 10.1001/archopht.1969.00990010283024. PMID: 4179337

Prognosis

Management of Congenital Dacryocystocele: A Case Series and Literature Review.
Pur DR, Husein M, Makar I
J Pediatr Ophthalmol Strabismus 2023 May;60(3):e31-e34. Epub 2023 May 1 doi: 10.3928/01913913-20230320-01. PMID: 37227990
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Management of graves myopathy: Thyroid-associated orbitopathy: when should we operate?
Seiff SR, Wagner LH
J AAPOS 2018 Aug;22(4):251-252. Epub 2018 Jan 9 doi: 10.1016/j.jaapos.2017.12.002. PMID: 29330045
Lacrimal Sac Tumors--A Review.
Krishna Y, Coupland SE
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):173-178. doi: 10.22608/APO.201713. PMID: 28399337
Avoiding the major complication of ophthalmic pathology: misdiagnosis. A review of three common diagnostic challenges.
Rashid A, Jakobiec FA
Semin Ophthalmol 2014 Sep-Nov;29(5-6):468-74. doi: 10.3109/08820538.2014.959196. PMID: 25325875

Clinical prediction guides

Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
Management of graves myopathy: Thyroid-associated orbitopathy: when should we operate?
Seiff SR, Wagner LH
J AAPOS 2018 Aug;22(4):251-252. Epub 2018 Jan 9 doi: 10.1016/j.jaapos.2017.12.002. PMID: 29330045
Sjögren syndrome.
Brito-Zerón P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M
Nat Rev Dis Primers 2016 Jul 7;2:16047. doi: 10.1038/nrdp.2016.47. PMID: 27383445
Mucoepidermoid carcinoma of the lacrimal sac: a report of two cases, with observations on the histogenesis.
Fliss DM, Freeman JL, Hurwitz JJ, Heathcote JG
Can J Ophthalmol 1993 Aug;28(5):228-35. PMID: 8221372
Canalicular cystocele.
Weinstein GS, Tse DT, Reese PD, Anderson RL
Ophthalmologica 1984;189(1-2):64-8. doi: 10.1159/000309387. PMID: 6472808

Recent systematic reviews

Recurrence rate of pleomorphic adenoma of the lacrimal gland: systematic review and meta-analysis.
Van Swol EG, Gupta A, Nguyen SA, Eiseman AS
Orbit 2024 Apr;43(2):208-216. Epub 2023 Oct 23 doi: 10.1080/01676830.2023.2269252. PMID: 37870812
Holding back the tears: is there a role for marsupialisation?
Chiu SJ, Currie ZI, Tan JH
BMJ Open Ophthalmol 2022 Aug;7(1) doi: 10.1136/bmjophth-2022-000985. PMID: 36161857Free PMC Article
Ectopic Lacrimal Gland Tissue: A Systematic Review.
Nagendran S, Alsamnan M, Strianese D, Malhotra R
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):540-544. doi: 10.1097/IOP.0000000000001621. PMID: 32205779
A systematic review of sinonasal oncocytomas and oncocytic carcinomas: Diagnosis, management, and technical considerations.
Hodzic Z, Rowan NR, Kashiwazaki R, Willson TJ, Wang EW, Lee SE
Int Forum Allergy Rhinol 2017 May;7(5):514-524. Epub 2017 Jan 16 doi: 10.1002/alr.21902. PMID: 28092140
Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma--a systematic review.
Clement SC, Peeters RP, Ronckers CM, Links TP, van den Heuvel-Eibrink MM, Nieveen van Dijkum EJ, van Rijn RR, van der Pal HJ, Neggers SJ, Kremer LC, van Eck-Smit BL, van Santen HM
Cancer Treat Rev 2015 Dec;41(10):925-34. Epub 2015 Sep 10 doi: 10.1016/j.ctrv.2015.09.001. PMID: 26421813

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