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Trabecular Adenoma

MedGen UID:
60000
•Concept ID:
C0205651
•
Neoplastic Process
Synonyms: Adenoma, Trabecular; Adenomas, Trabecular; Trabecular Adenomas
SNOMED CT: Trabecular adenoma (21930005)

Definition

A benign epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrabecular Adenoma

Professional guidelines

PubMed

Hyalinizing trabecular adenoma of the thyroid--morphology and differential diagnosis.
Schmid KW, Mesewinkel F, Böcker W
Acta Med Austriaca 1996;23(1-2):65-8. PMID: 8767518

Recent clinical studies

Etiology

GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland.
Nikiforova MN, Nikitski AV, Panebianco F, Kaya C, Yip L, Williams M, Chiosea SI, Seethala RR, Roy S, Condello V, Santana-Santos L, Wald AI, Carty SE, Ferris RL, El-Naggar AK, Nikiforov YE
Thyroid 2019 Feb;29(2):161-173. doi: 10.1089/thy.2018.0791. PMID: 30648929Free PMC Article
Histopathological study of solitary nodules of thyroid.
Khadilkar UN, Maji P
Kathmandu Univ Med J (KUMJ) 2008 Oct-Dec;6(24):486-90. doi: 10.3126/kumj.v6i4.1740. PMID: 19483430
Accumulated basement membrane material in hyalinizing trabecular tumors of the thyroid.
Katoh R, Kakudo K, Kawaoi A
Mod Pathol 1999 Nov;12(11):1057-61. PMID: 10574603
Hyalinizing trabecular carcinoma of the thyroid gland: report of two cases of follicular cell thyroid carcinoma with hyalinizing trabecular pattern.
González-Cámpora R, Fuentes-Vaamonde E, Hevia-Vázquez A, Otal-Salaverri C, Villar-Rodriguez JL, Galera-Davidson H
Ultrastruct Pathol 1998 Jan-Feb;22(1):39-46. doi: 10.3109/01913129809032256. PMID: 9491214
Hyalinizing trabecular carcinoma of thyroid gland.
McCluggage WG, Sloan JM
Histopathology 1996 Apr;28(4):357-62. doi: 10.1046/j.1365-2559.1996.d01-432.x. PMID: 8732345

Diagnosis

The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
Hyalinizing trabecular adenoma of the thyroid gland.
Bishop JA, Ali SZ
Diagn Cytopathol 2011 Apr;39(4):306-10. Epub 2010 Aug 20 doi: 10.1002/dc.21413. PMID: 20730896
A practical diagnostic approach to solid/trabecular nodules in the thyroid.
Volante M, Papotti M
Endocr Pathol 2008 Summer;19(2):75-81. doi: 10.1007/s12022-008-9023-5. PMID: 18409025
Hyalinizing trabecular adenoma of the thyroid--morphology and differential diagnosis.
Schmid KW, Mesewinkel F, Böcker W
Acta Med Austriaca 1996;23(1-2):65-8. PMID: 8767518
Hyalinizing trabecular adenoma.
Hakata H, Katagiri M, Yasuda K, Fukuya T, Manabe T, Harada T
Thyroidology 1992 Aug;4(2):83-6. PMID: 1285031

Therapy

A case of trabecular adenoma of the thyroid with black pigmentation.
Sharma V, Cui H, Whalen G, Khan A, Torres M
Thyroid 2007 Jun;17(6):593-4. doi: 10.1089/thy.2006.0151. PMID: 17614784
Prevalence and incidence of cytoplasmic yellow bodies in thyroid neoplasms.
Rothenberg HJ, Goellner JR, Carney JA
Arch Pathol Lab Med 2003 Jun;127(6):715-7. doi: 10.5858/2003-127-715-PAIOCY. PMID: 12741896

Prognosis

Hyaline matrix in hyalinizing trabecular tumor: Findings in fine-needle aspiration smears.
Bakuła-Zalewska E, Cameron R, Gałczyński JP, Domanski HA
Diagn Cytopathol 2015 Sep;43(9):710-3. Epub 2014 Oct 29 doi: 10.1002/dc.23224. PMID: 25352467
Histopathological study of solitary nodules of thyroid.
Khadilkar UN, Maji P
Kathmandu Univ Med J (KUMJ) 2008 Oct-Dec;6(24):486-90. doi: 10.3126/kumj.v6i4.1740. PMID: 19483430
Prevalence and incidence of cytoplasmic yellow bodies in thyroid neoplasms.
Rothenberg HJ, Goellner JR, Carney JA
Arch Pathol Lab Med 2003 Jun;127(6):715-7. doi: 10.5858/2003-127-715-PAIOCY. PMID: 12741896
Hyalinizing trabecular adenoma of the thyroid gland.
Hicks MJ, Batsakis JG
Ann Otol Rhinol Laryngol 1993 Mar;102(3 Pt 1):239-40. doi: 10.1177/000348949310200313. PMID: 8457127
Hyalinizing trabecular adenoma of the thyroid (case of the Ullensvang course). Hyalinizing spindle cell tumor of the thyroid with dual differentiation (variant of the so-called hyalinizing trabecular adenoma).
Sambade C, Sarabando F, Nesland JM, Sobrinho Simões M
Ultrastruct Pathol 1989 Mar-Jun;13(2-3):275-80. doi: 10.3109/01913128909057445. PMID: 2734856

Clinical prediction guides

Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma.
Hirokawa M, Matsuse M, Mitsutake N, Suzuki A, Higuchi M, Hayashi T, Kamma H, Miyauchi A, Akamizu T
Diagn Pathol 2023 Jun 20;18(1):74. doi: 10.1186/s13000-023-01361-5. PMID: 37340328Free PMC Article
The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
Hyalinizing trabecular adenoma of the thyroid revisited: a histologic and immunohistochemical study of thyroid lesions with prominent trabecular architecture and sclerosis.
Galgano MT, Mills SE, Stelow EB
Am J Surg Pathol 2006 Oct;30(10):1269-73. doi: 10.1097/01.pas.0000209858.13035.0a. PMID: 17001158
Cytologic features of hyalinizing trabecular adenoma of the thyroid.
Kuma S, Hirokawa M, Miyauchi A, Kakudo K, Katayama S
Acta Cytol 2003 May-Jun;47(3):399-404. doi: 10.1159/000326540. PMID: 12789921
Accumulated basement membrane material in hyalinizing trabecular tumors of the thyroid.
Katoh R, Kakudo K, Kawaoi A
Mod Pathol 1999 Nov;12(11):1057-61. PMID: 10574603

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