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Mucinous cystadenocarcinoma

MedGen UID:
60211
•Concept ID:
C0206699
•
Neoplastic Process
Synonyms: Cystadenocarcinoma, Mucinous; Cystadenocarcinomas, Mucinous; Mucinous Cystadenocarcinoma; Mucinous Cystadenocarcinomas
SNOMED CT: Mucinous cystadenocarcinoma (79143006); Pseudomucinous adenocarcinoma (79143006); Pseudomucinous cystadenocarcinoma (79143006)
 
Monarch Initiative: MONDO:0005858

Definition

An invasive adenocarcinoma characterized by cystic changes and the presence of malignant glandular cells which contain intracytoplasmic mucin. It may arise from the ovary, pancreas, appendix, and lung. [from NCI]

Professional guidelines

PubMed

Ovarian needle aspiration in the diagnosis and management of ovarian masses.
Nagamine K, Kondo J, Kaneshiro R, Tauchi-Nishi P, Terada K
J Gynecol Oncol 2017 Jul;28(4):e40. doi: 10.3802/jgo.2017.28.e40. PMID: 28541632Free PMC Article
Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment.
Grützmann R, Niedergethmann M, Pilarsky C, Klöppel G, Saeger HD
Oncologist 2010;15(12):1294-309. Epub 2010 Dec 8 doi: 10.1634/theoncologist.2010-0151. PMID: 21147870Free PMC Article
Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis.
van der Waaij LA, van Dullemen HM, Porte RJ
Gastrointest Endosc 2005 Sep;62(3):383-9. doi: 10.1016/s0016-5107(05)01581-6. PMID: 16111956

Recent clinical studies

Etiology

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Therapeutic Approach to Cystic Neoplasms of the Pancreas.
Al Efishat M, Allen PJ
Surg Oncol Clin N Am 2016 Apr;25(2):351-61. doi: 10.1016/j.soc.2015.11.006. PMID: 27013369Free PMC Article
Pathobiology of ovarian carcinomas.
Devouassoux-Shisheboran M, Genestie C
Chin J Cancer 2015 Jan;34(1):50-5. doi: 10.5732/cjc.014.10273. PMID: 25556618Free PMC Article
The inhibins and ovarian cancer.
Burger HG, Fuller PJ, Chu S, Mamers P, Drummond A, Susil B, Neva P, Robertson DM
Mol Cell Endocrinol 2001 Jun 30;180(1-2):145-8. doi: 10.1016/s0303-7207(01)00519-6. PMID: 11451584
Mucosal hyperplasia, mucinous cystadenoma, and mucinous cystadenocarcinoma of the appendix. A re-evaluation of appendiceal "mucocele".
Higa E, Rosai J, Pizzimbono CA, Wise L
Cancer 1973 Dec;32(6):1525-41. doi: 10.1002/1097-0142(197312)32:6<1525::aid-cncr2820320632>3.0.co;2-c. PMID: 4757938

Diagnosis

Choroid Metastasis of Retroperitoneal Mucinous Cystadenocarcinoma.
Raimondo CD, Konstantinou EK, Shields CL
Ophthalmology 2024 Sep;131(9):1082. Epub 2023 Nov 8 doi: 10.1016/j.ophtha.2023.10.002. PMID: 37943192
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
Pancreatic neoplasms.
Levy MJ, Wiersema MJ
Gastrointest Endosc Clin N Am 2005 Jan;15(1):117-42, x. doi: 10.1016/j.giec.2004.07.014. PMID: 15555956
Intraductal papillary mucinous tumor of the bile ducts.
Lim JH, Yoon KH, Kim SH, Kim HY, Lim HK, Song SY, Nam KJ
Radiographics 2004 Jan-Feb;24(1):53-66; discussion 66-7. doi: 10.1148/rg.241035002. PMID: 14730036

Therapy

Primary Retroperitoneal Mucinous Cystadenocarcinoma during Long-term Administration of Infliximab for the Treatment of Crohn's Disease.
Morihisa Y, Urai S, Iwagami H, Shimoyama M, Ogino S, Terashita T, Morimura H, Akamatsu T, Uenoyama Y, Yamashita Y
Intern Med 2023 Dec 15;62(24):3619-3624. Epub 2023 May 10 doi: 10.2169/internalmedicine.1593-23. PMID: 37164674Free PMC Article
Primary Mucinous Cystadenocarcinoma of the Breast: A Rare Case Report With Review of Literature.
Jain E, Kumar A, Jain R, Sharma S
Int J Surg Pathol 2021 Oct;29(7):740-746. Epub 2021 Feb 26 doi: 10.1177/1066896921991650. PMID: 33635116
Cyst features and risk of malignancy in intraductal papillary mucinous neoplasms of the pancreas: a meta-analysis.
Anand N, Sampath K, Wu BU
Clin Gastroenterol Hepatol 2013 Aug;11(8):913-21; quiz e59-60. Epub 2013 Feb 13 doi: 10.1016/j.cgh.2013.02.010. PMID: 23416279
Molecular abnormalities in ovarian carcinoma: clinical, morphological and therapeutic correlates.
Gurung A, Hung T, Morin J, Gilks CB
Histopathology 2013 Jan;62(1):59-70. doi: 10.1111/his.12033. PMID: 23240670
Pseudomyxoma Peritonei arising from a mucinous borderline ovarian tumour: Case report and literature review.
Saluja M, Kenwright DN, Keating JP
Aust N Z J Obstet Gynaecol 2010 Aug;50(4):399-403. doi: 10.1111/j.1479-828X.2010.01189.x. PMID: 20716272

Prognosis

The Spectrum of Mucinous Lesions of the Breast.
Joneja U, Palazzo J
Arch Pathol Lab Med 2023 Jan 1;147(1):19-29. doi: 10.5858/arpa.2022-0054-RA. PMID: 36577093
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
Therapeutic Approach to Cystic Neoplasms of the Pancreas.
Al Efishat M, Allen PJ
Surg Oncol Clin N Am 2016 Apr;25(2):351-61. doi: 10.1016/j.soc.2015.11.006. PMID: 27013369Free PMC Article
Peritoneal pseudomyxoma arising from the urachus.
Martínez A, Ferron G, Mery E, Gladieff L, Delord JP, Querleu D
Surg Oncol 2012 Mar;21(1):1-5. Epub 2010 Feb 26 doi: 10.1016/j.suronc.2009.12.004. PMID: 20189378
Mucosal hyperplasia, mucinous cystadenoma, and mucinous cystadenocarcinoma of the appendix. A re-evaluation of appendiceal "mucocele".
Higa E, Rosai J, Pizzimbono CA, Wise L
Cancer 1973 Dec;32(6):1525-41. doi: 10.1002/1097-0142(197312)32:6<1525::aid-cncr2820320632>3.0.co;2-c. PMID: 4757938

Clinical prediction guides

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Therapeutic Approach to Cystic Neoplasms of the Pancreas.
Al Efishat M, Allen PJ
Surg Oncol Clin N Am 2016 Apr;25(2):351-61. doi: 10.1016/j.soc.2015.11.006. PMID: 27013369Free PMC Article
Prolapse into the bile duct and expansive growth is characteristic behavior of mucinous cystic neoplasm of the liver: report of two cases and review of the literature.
Takano Y, Nagahama M, Yamamura E, Maruoka N, Mizukami H, Tanaka J, Ohike N, Takahashi H
Clin J Gastroenterol 2015 Jun;8(3):148-55. Epub 2015 May 8 doi: 10.1007/s12328-015-0569-8. PMID: 25951998Free PMC Article
Primary pancreatic cystic neoplasms revisited: part II. Mucinous cystic neoplasms.
Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG
Surg Oncol 2011 Jun;20(2):e93-101. Epub 2011 Jan 19 doi: 10.1016/j.suronc.2010.12.003. PMID: 21251815
The inhibins and ovarian cancer.
Burger HG, Fuller PJ, Chu S, Mamers P, Drummond A, Susil B, Neva P, Robertson DM
Mol Cell Endocrinol 2001 Jun 30;180(1-2):145-8. doi: 10.1016/s0303-7207(01)00519-6. PMID: 11451584

Recent systematic reviews

Pregnancy-associated mucinous cystic neoplasms of the pancreas - A systematic review.
Dhamor D, Irrinki S, Naik A, Kurdia KC, Rastogi P, Gupta P, Kapoor VK
Am J Surg 2023 Apr;225(4):630-638. Epub 2022 Nov 17 doi: 10.1016/j.amjsurg.2022.11.002. PMID: 36424200
Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa): a systematic review of the literature and meta-analysis.
Myriokefalitaki E, Luqman I, Potdar N, Brown L, Steward W, Moss EL
Arch Gynecol Obstet 2016 Apr;293(4):709-20. Epub 2015 Dec 17 doi: 10.1007/s00404-015-3975-8. PMID: 26681306
Does smoking increase risk of ovarian cancer? A systematic review.
Jordan SJ, Whiteman DC, Purdie DM, Green AC, Webb PM
Gynecol Oncol 2006 Dec;103(3):1122-9. Epub 2006 Sep 26 doi: 10.1016/j.ygyno.2006.08.012. PMID: 17005245

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