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Increased mean corpuscular hemoglobin concentration

MedGen UID:
605654
•Concept ID:
C0427444
•
Finding
Synonym: Increased mean corpuscular hemoglobin
SNOMED CT: MCHC - raised (165448003); Mean corpuscular hemoglobin concentration (MCHC) - raised (165448003); Mean corpuscular hemoglobin concentration raised (165448003); Mean corpuscular hemoglobin concentration above reference range (165448003)
 
HPO: HP:0025548

Definition

An elevation over the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased mean corpuscular hemoglobin concentration

Conditions with this feature

Dehydrated hereditary stomatocytosis 2
MedGen UID:
908701
•Concept ID:
C4225242
•
Disease or Syndrome
In dehydrated hereditary stomatocytosis (DHS), also known as hereditary xerocytosis, red blood cells exhibit altered intracellular cation content and cellular dehydration, resulting in increased erythrocyte mean corpuscular hemoglobin concentration (MCHC) and decreased erythrocyte osmotic fragility. Blood films show various cell shape abnormalities, the most characteristic being the stomatocyte, with a straight or crescent-shaped central pallor (summary by Rapetti-Mauss et al., 2015). For discussion of clinical and genetic heterogeneity of the stomatocytoses, see DHS1 (194380).
See: Condition Record
Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema
MedGen UID:
1638271
•Concept ID:
C4551512
•
Disease or Syndrome
See: Condition Record
Dehydrated hereditary stomatocytosis 2
Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema

Professional guidelines

PubMed

Diagnosis of hereditary spherocytosis in newborn infants.
Schröter W, Kahsnitz E
J Pediatr 1983 Sep;103(3):460-3. doi: 10.1016/s0022-3476(83)80428-4. PMID: 6886914

Recent clinical studies

Etiology

A novel PIEZO1 mutation in a patient with dehydrated hereditary stomatocytosis: a case report and a brief review of literature.
Zama D, Giulietti G, Muratore E, Andolfo I, Russo R, Iolascon A, Pession A
Ital J Pediatr 2020 Jul 23;46(1):102. doi: 10.1186/s13052-020-00864-x. PMID: 32703298Free PMC Article
Iron profile and dietary pattern of primary school obese Egyptian children.
Abd-El Wahed MA, Mohamed MH, Ibrahim SS, El-Naggar WA
J Egypt Public Health Assoc 2014 Aug;89(2):53-9. doi: 10.1097/01.EPX.0000451827.84315.5c. PMID: 25162735
A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malaria.
Diallo DA, Doumbo OK, Dicko A, Guindo A, Coulibaly D, Kayentao K, Djimdé AA, Théra MA, Fairhurst RM, Plowe CV, Wellems TE
Acta Trop 2004 May;90(3):295-9. doi: 10.1016/j.actatropica.2004.02.005. PMID: 15099817
Diagnosis of hereditary spherocytosis in newborn infants.
Schröter W, Kahsnitz E
J Pediatr 1983 Sep;103(3):460-3. doi: 10.1016/s0022-3476(83)80428-4. PMID: 6886914
Effects of ultra-marathon training and racing on hematologic parameters and serum ferritin levels in well-trained athletes.
Dickson DN, Wilkinson RL, Noakes TD
Int J Sports Med 1982 May;3(2):111-7. doi: 10.1055/s-2008-1026073. PMID: 7107103

Diagnosis

Increased MCHC*RDW-SD interaction values: indicators of neurological impairment in lead-poisoned children.
Ying Q, Ye M, Zhang T, Xia Z, Chen H
PeerJ 2024;12:e17017. Epub 2024 Feb 28 doi: 10.7717/peerj.17017. PMID: 38436014Free PMC Article
A novel PIEZO1 mutation in a patient with dehydrated hereditary stomatocytosis: a case report and a brief review of literature.
Zama D, Giulietti G, Muratore E, Andolfo I, Russo R, Iolascon A, Pession A
Ital J Pediatr 2020 Jul 23;46(1):102. doi: 10.1186/s13052-020-00864-x. PMID: 32703298Free PMC Article
A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malaria.
Diallo DA, Doumbo OK, Dicko A, Guindo A, Coulibaly D, Kayentao K, Djimdé AA, Théra MA, Fairhurst RM, Plowe CV, Wellems TE
Acta Trop 2004 May;90(3):295-9. doi: 10.1016/j.actatropica.2004.02.005. PMID: 15099817
Sodium-potassium pump, ion fluxes, and cellular dehydration in sickle cell anemia.
Izumo H, Lear S, Williams M, Rosa R, Epstein FH
J Clin Invest 1987 Jun;79(6):1621-8. doi: 10.1172/JCI112998. PMID: 3034977Free PMC Article
Diagnosis of hereditary spherocytosis in newborn infants.
Schröter W, Kahsnitz E
J Pediatr 1983 Sep;103(3):460-3. doi: 10.1016/s0022-3476(83)80428-4. PMID: 6886914

Clinical prediction guides

Increased MCHC*RDW-SD interaction values: indicators of neurological impairment in lead-poisoned children.
Ying Q, Ye M, Zhang T, Xia Z, Chen H
PeerJ 2024;12:e17017. Epub 2024 Feb 28 doi: 10.7717/peerj.17017. PMID: 38436014Free PMC Article
A novel PIEZO1 mutation in a patient with dehydrated hereditary stomatocytosis: a case report and a brief review of literature.
Zama D, Giulietti G, Muratore E, Andolfo I, Russo R, Iolascon A, Pession A
Ital J Pediatr 2020 Jul 23;46(1):102. doi: 10.1186/s13052-020-00864-x. PMID: 32703298Free PMC Article
Genomewide search for dehydrated hereditary stomatocytosis (hereditary xerocytosis): mapping of locus to chromosome 16 (16q23-qter).
Carella M, Stewart G, Ajetunmobi JF, Perrotta S, Grootenboer S, Tchernia G, Delaunay J, Totaro A, Zelante L, Gasparini P, Iolascon A
Am J Hum Genet 1998 Sep;63(3):810-6. doi: 10.1086/302024. PMID: 9718354Free PMC Article
Membrane-bound immunoglobulins and complement components on young and old red cells.
Freedman J
Transfusion 1984 Nov-Dec;24(6):477-81. doi: 10.1046/j.1537-2995.1984.24685066804.x. PMID: 6506177

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