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Abnormal mean corpuscular hemoglobin concentration

MedGen UID:
663424
•Concept ID:
C0580549
•
Finding
Synonym: Abnormal mean corpuscular hemoglobin
SNOMED CT: MCH - abnormal (165442002); Mean corpuscular hemoglobin (MCH) - abnormal (165442002); Mean corpuscular hemoglobin abnormal (165442002); Mean corpuscular hemoglobin outside reference range (165442002)
 
HPO: HP:0025546

Definition

A deviation from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal mean corpuscular hemoglobin concentration

Professional guidelines

PubMed

Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus.
Guler Kazanci E, Buyuktiryaki M, Unsal H, Tayman C
Am J Perinatol 2019 Dec;36(14):1521-1527. Epub 2019 May 14 doi: 10.1055/s-0039-1688821. PMID: 31087312
The role of automated measurement of RBC subpopulations in differential diagnosis of microcytic anemia and β-thalassemia screening.
Urrechaga E, Borque L, Escanero JF
Am J Clin Pathol 2011 Mar;135(3):374-9. doi: 10.1309/AJCPJRH1I0XTNFGA. PMID: 21350090
Adults with cyanotic congenital heart disease: hematologic management.
Perloff JK, Rosove MH, Child JS, Wright GB
Ann Intern Med 1988 Sep 1;109(5):406-13. doi: 10.7326/0003-4819-109-5-406. PMID: 3044212

Recent clinical studies

Etiology

Mild macrocytosis in Williams-Beuren syndrome.
Yu E, Feinn R, Bona R, Brink B, Sindhar S, Kozel BA, Pober BR
Eur J Med Genet 2020 Mar;63(3):103740. Epub 2019 Aug 14 doi: 10.1016/j.ejmg.2019.103740. PMID: 31419598
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
Red blood cell distribution width: A simple parameter with multiple clinical applications.
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G
Crit Rev Clin Lab Sci 2015;52(2):86-105. Epub 2014 Dec 23 doi: 10.3109/10408363.2014.992064. PMID: 25535770
Alpha and beta thalassemia.
Muncie HL Jr, Campbell J
Am Fam Physician 2009 Aug 15;80(4):339-44. PMID: 19678601
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968

Diagnosis

Iron Deficiency Anemia in Pregnancy.
James AH
Obstet Gynecol 2021 Oct 1;138(4):663-674. doi: 10.1097/AOG.0000000000004559. PMID: 34623079
Red blood cell distribution width: A simple parameter with multiple clinical applications.
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G
Crit Rev Clin Lab Sci 2015;52(2):86-105. Epub 2014 Dec 23 doi: 10.3109/10408363.2014.992064. PMID: 25535770
Red blood cell morphology.
Ford J
Int J Lab Hematol 2013 Jun;35(3):351-7. Epub 2013 Mar 9 doi: 10.1111/ijlh.12082. PMID: 23480230
Alpha and beta thalassemia.
Muncie HL Jr, Campbell J
Am Fam Physician 2009 Aug 15;80(4):339-44. PMID: 19678601
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968

Therapy

Iron Deficiency Anemia in Pregnancy.
James AH
Obstet Gynecol 2021 Oct 1;138(4):663-674. doi: 10.1097/AOG.0000000000004559. PMID: 34623079
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968
Alcoholic macrocytosis--is there a role for acetaldehyde and adducts?
Niemelä O, Parkkila S
Addict Biol 2004 Mar;9(1):3-10. doi: 10.1080/13556210410001674031. PMID: 15203433
Hematologic alterations in diabetes mellitus.
Jones RL, Peterson CM
Am J Med 1981 Feb;70(2):339-52. doi: 10.1016/0002-9343(81)90771-3. PMID: 7008587

Prognosis

The prognostic impact of preoperative mean corpuscular volume in colorectal cancer.
Nakamura K, Seishima R, Matsui S, Shigeta K, Okabayashi K, Kitagawa Y
Jpn J Clin Oncol 2022 May 31;52(6):562-570. doi: 10.1093/jjco/hyac023. PMID: 35253057
Red blood cell distribution width: A simple parameter with multiple clinical applications.
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G
Crit Rev Clin Lab Sci 2015;52(2):86-105. Epub 2014 Dec 23 doi: 10.3109/10408363.2014.992064. PMID: 25535770
Mean corpuscular volume predicts prognosis in MDS patients with abnormal karyotypes.
Wang H, Wang X, Xu X, Lin G
Ann Hematol 2010 Jul;89(7):671-9. Epub 2010 Feb 24 doi: 10.1007/s00277-010-0912-6. PMID: 20179929
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968
Refractory anemia in the elderly.
Gardner FH
Adv Intern Med 1987;32:155-75. PMID: 3548248

Clinical prediction guides

Mild macrocytosis in Williams-Beuren syndrome.
Yu E, Feinn R, Bona R, Brink B, Sindhar S, Kozel BA, Pober BR
Eur J Med Genet 2020 Mar;63(3):103740. Epub 2019 Aug 14 doi: 10.1016/j.ejmg.2019.103740. PMID: 31419598
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
Red blood cell distribution width: A simple parameter with multiple clinical applications.
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G
Crit Rev Clin Lab Sci 2015;52(2):86-105. Epub 2014 Dec 23 doi: 10.3109/10408363.2014.992064. PMID: 25535770
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968
Refractory anemia in the elderly.
Gardner FH
Adv Intern Med 1987;32:155-75. PMID: 3548248

Recent systematic reviews

Folate supplementation in people with sickle cell disease.
Dixit R, Nettem S, Madan SS, Soe HHK, Abas AB, Vance LD, Stover PJ
Cochrane Database Syst Rev 2018 Mar 16;3(3):CD011130. doi: 10.1002/14651858.CD011130.pub3. PMID: 29546732Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
Folate supplementation in people with sickle cell disease.
Dixit R, Nettem S, Madan SS, Soe HH, Abas AB, Vance LD, Stover PJ
Cochrane Database Syst Rev 2016 Feb 16;2:CD011130. doi: 10.1002/14651858.CD011130.pub2. PMID: 26880182Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2012 Jul 11;(7):CD003426. doi: 10.1002/14651858.CD003426.pub4. PMID: 22786485
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2010 Jan 20;(1):CD003426. doi: 10.1002/14651858.CD003426.pub3. PMID: 20091545

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