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Microcystic adenoma

MedGen UID:
64420
•Concept ID:
C0205648
•
Neoplastic Process
Synonyms: Adenoma, Microcystic; Adenomas, Microcystic; Microcystic Adenoma; Microcystic Adenomas
SNOMED CT: Microcystic adenoma (79494009)
 
Monarch Initiative: MONDO:0003435

Definition

A benign epithelial neoplasm characterized by a microcystic pattern. The cystic spaces are lined by small cuboidal cells without evidence of significant cytologic atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrocystic adenoma

Professional guidelines

PubMed

Magnetic resonance imaging of cystic pancreatic lesions in adults: an update in current diagnostic features and management.
Barral M, Soyer P, Dohan A, Laurent V, Hoeffel C, Fishman EK, Boudiaf M
Abdom Imaging 2014 Feb;39(1):48-65. doi: 10.1007/s00261-013-0048-y. PMID: 24263208
Comments and illustrations regarding the guidelines and good clinical practice recommendations for contrast-enhanced ultrasound (CEUS)--update 2008.
Dietrich CF
Ultraschall Med 2008 Sep;29 Suppl 4:S188-202. Epub 2008 Oct 2 doi: 10.1055/s-2008-1027799. PMID: 18833497

Recent clinical studies

Etiology

A disseminated variant of pancreatic serous cystadenoma causing obstructive jaundice, a very rare entity: a case report and review of the literature.
Al-Jiffry BO, Rayzah F, Khayat SH
BMC Res Notes 2014 Oct 22;7:749. doi: 10.1186/1756-0500-7-749. PMID: 25338636Free PMC Article
Cystic tumors of the pancreas: ultrasound, computed tomography, and magnetic resonance imaging features.
Sidden CR, Mortele KJ
Semin Ultrasound CT MR 2007 Oct;28(5):339-56. doi: 10.1053/j.sult.2007.07.001. PMID: 17970551
Microcystic adenoma of the pancreas: clinical, radiologic, and cytologic features.
Lal A, Bourtsos EP, DeFrias DV, Nemcek AA, Nayar R
Cancer 2004 Oct 25;102(5):288-94. doi: 10.1002/cncr.20487. PMID: 15559952
Management decisions for unusual periampullary tumors.
Todd KE, Lewis MP, Gloor B, Kusske AM, Ashley SW, Reber HA
Am Surg 1997 Oct;63(10):927-32. PMID: 9322675
Pancreatic cystic neoplasms.
Mathieu D, Guigui B, Valette PJ, Dao TH, Bruneton JN, Bruel JM, Pringot J, Vasile N
Radiol Clin North Am 1989 Jan;27(1):163-76. PMID: 2642272

Diagnosis

A disseminated variant of pancreatic serous cystadenoma causing obstructive jaundice, a very rare entity: a case report and review of the literature.
Al-Jiffry BO, Rayzah F, Khayat SH
BMC Res Notes 2014 Oct 22;7:749. doi: 10.1186/1756-0500-7-749. PMID: 25338636Free PMC Article
Cystic tumors of the pancreas: imaging and management.
Dewhurst CE, Mortele KJ
Radiol Clin North Am 2012 May;50(3):467-86. Epub 2012 Mar 28 doi: 10.1016/j.rcl.2012.03.001. PMID: 22560692
Cystic tumors of the pancreas: ultrasound, computed tomography, and magnetic resonance imaging features.
Sidden CR, Mortele KJ
Semin Ultrasound CT MR 2007 Oct;28(5):339-56. doi: 10.1053/j.sult.2007.07.001. PMID: 17970551
Serous microcystic adenoma of the pancreas: case report and review of the literature.
Köksal AS, Asil M, Turhan N, Yolcu OF, Küçükay F, Akoğlu M, Sahin B
Turk J Gastroenterol 2004 Sep;15(3):183-6. PMID: 15492919
Microcystic adenoma of the pancreas: report of a case and review of the literature.
Balsalobre C, Marcial MA, Marcial-Seoane RA, Collazo V, Rodríguez-Pérez D
Bol Asoc Med P R 1988 Nov;80(11):413-6. PMID: 3064760

Therapy

Use of expandable metallic biliary stents in resectable pancreatic cancer.
Wasan SM, Ross WA, Staerkel GA, Lee JH
Am J Gastroenterol 2005 Sep;100(9):2056-61. doi: 10.1111/j.1572-0241.2005.42031.x. PMID: 16128952

Prognosis

Synchronous pancreatic cancer and pancreatic serous cystic neoplasm: A case report.
Zong Y, Xiao W, Ma Y, Wang B, Yu W
J Pak Med Assoc 2023 Apr;73(4):901-904. doi: 10.47391/JPMA.5496. PMID: 37052011
A disseminated variant of pancreatic serous cystadenoma causing obstructive jaundice, a very rare entity: a case report and review of the literature.
Al-Jiffry BO, Rayzah F, Khayat SH
BMC Res Notes 2014 Oct 22;7:749. doi: 10.1186/1756-0500-7-749. PMID: 25338636Free PMC Article
Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects.
Adsay NV, Basturk O, Cheng JD, Andea AA
Semin Radiat Oncol 2005 Oct;15(4):254-64. doi: 10.1016/j.semradonc.2005.04.001. PMID: 16183479
Macrocystic serous cystadenoma of the pancreas. Diagnostic, therapeutic and pathological considerations of three cases.
Casadei R, Santini D, Greco VM, Piana S, Okoro HU, Conti A, Marrano D
Ital J Gastroenterol Hepatol 1997 Feb;29(1):54-7. PMID: 9265580
Pancreatic cystic neoplasms.
Mathieu D, Guigui B, Valette PJ, Dao TH, Bruneton JN, Bruel JM, Pringot J, Vasile N
Radiol Clin North Am 1989 Jan;27(1):163-76. PMID: 2642272

Clinical prediction guides

Multifocal/diffuse pancreatic serous cystic neoplasms: Systematic review with a new case.
Wu YHA, Samuels JM, Harnke B, Negrini D, Al-Musawi MH, Meguid C, Ahrendt S, Schulick RD, Del Chiaro M, Oba A
Pancreatology 2020 Jul;20(5):902-909. Epub 2020 May 5 doi: 10.1016/j.pan.2020.04.015. PMID: 32418758
A disseminated variant of pancreatic serous cystadenoma causing obstructive jaundice, a very rare entity: a case report and review of the literature.
Al-Jiffry BO, Rayzah F, Khayat SH
BMC Res Notes 2014 Oct 22;7:749. doi: 10.1186/1756-0500-7-749. PMID: 25338636Free PMC Article
Serous cystadenoma of the pancreas presenting as a third primary neoplasm.
Köksal AS, Ulker A, Asil M, Tunç B, Arda K, Savkilioğlu M, Ozoğul Y, Turhan N
Can J Gastroenterol 2003 Sep;17(9):552-4. doi: 10.1155/2003/784257. PMID: 14532929
Microcystic adenoma of the pancreas: observation or treatment?
Pavlidis TE, Thompson JN, Williamson RC
HPB Surg 1993 Aug;6(4):295-9. doi: 10.1155/1993/63464. PMID: 8217926Free PMC Article
From the Archives of the AFIP. Microcystic adenoma of the pancreas.
Buck JL, Hayes WS
Radiographics 1990 Mar;10(2):313-22. doi: 10.1148/radiographics.10.2.2183300. PMID: 2183300

Recent systematic reviews

Multifocal/diffuse pancreatic serous cystic neoplasms: Systematic review with a new case.
Wu YHA, Samuels JM, Harnke B, Negrini D, Al-Musawi MH, Meguid C, Ahrendt S, Schulick RD, Del Chiaro M, Oba A
Pancreatology 2020 Jul;20(5):902-909. Epub 2020 May 5 doi: 10.1016/j.pan.2020.04.015. PMID: 32418758

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