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Adenomyoma

MedGen UID:
64617
•Concept ID:
C0206622
•
Neoplastic Process
Synonym: Adenomyomas
SNOMED CT: Adenomyoma (40293003)
 
Monarch Initiative: MONDO:0005635

Definition

A benign neoplasm characterized by the presence of a glandular and a mesenchymal (fibromyomatous) component. It occurs in the uterine corpus, cervix, and uterine ligaments. A variant of adenomyoma associated with glandular architectural complexity is called atypical polypoid adenomyoma. Simple polypectomy is usually curative. Atypical polypoid adenomyoma may recur following polypectomy. [from NCI]

Professional guidelines

PubMed

Minimally invasive treatment of adenomyosis.
Dueholm M
Best Pract Res Clin Obstet Gynaecol 2018 Aug;51:119-137. Epub 2018 Feb 15 doi: 10.1016/j.bpobgyn.2018.01.016. PMID: 29555380
Medical treatment for adenomyosis and/or adenomyoma.
Tsui KH, Lee WL, Chen CY, Sheu BC, Yen MS, Chang TC, Wang PH
Taiwan J Obstet Gynecol 2014 Dec;53(4):459-65. doi: 10.1016/j.tjog.2014.04.024. PMID: 25510683
Benign and malignant tumor of the uterine body with broccoli sign: MR imaging features for differential diagnosis.
Kozawa E, Takahashi M, Meguro S, Yasuda M, Iwasa N, Fujiwara K, Kimura F
Jpn J Radiol 2013 Jul;31(7):437-43. Epub 2013 May 30 doi: 10.1007/s11604-013-0215-7. PMID: 23719762

Recent clinical studies

Etiology

Cystic adenomyoma surgery.
Kerbage Y, Dericquebourg S, Collinet P, Verpillat P, Giraudet G, Rubod C
J Gynecol Obstet Hum Reprod 2022 Mar;51(3):102313. Epub 2022 Jan 11 doi: 10.1016/j.jogoh.2022.102313. PMID: 35031510
Uterine adenomyosis and adenomyoma: the surgical approach.
Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853
Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
Adenomyomatosis Concomitant with Primary Gallbladder Carcinoma.
Morikawa T, Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Saisaka Y, Tokumaru T, Sui K, Iwata J, Matsumoto M, Morita S, Nishioka Y
Acta Med Okayama 2017 Apr;71(2):113-118. doi: 10.18926/AMO/54979. PMID: 28420892
Stepwise approach and surgery for gallbladder adenomyomatosis: a mini-review.
Pellino G, Sciaudone G, Candilio G, Perna G, Santoriello A, Canonico S, Selvaggi F
Hepatobiliary Pancreat Dis Int 2013 Apr;12(2):136-42. doi: 10.1016/s1499-3872(13)60022-3. PMID: 23558066

Diagnosis

Atypical Polypoid Adenomyoma (APAM).
Javed L, Ashraf N, Sabqat M, Zareen A
J Coll Physicians Surg Pak 2021 Jun;31(6):719-721. doi: 10.29271/jcpsp.2021.06.719. PMID: 34102788
Atypical polypoid adenomyoma.
Grindstaff S, Banet N
Int J Gynecol Cancer 2021 Apr;31(4):639-640. doi: 10.1136/ijgc-2020-001886. PMID: 33795408
Uterine adenomyosis and adenomyoma: the surgical approach.
Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853
Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
Adenomyomatosis.
Nguyen MS, Voci S
Ultrasound Q 2013 Sep;29(3):215-7. doi: 10.1097/RUQ.0b013e3182a0aea9. PMID: 23945484

Therapy

The "freeze-all" strategy seems to improve the chances of birth in adenomyosis-affected women.
Bourdon M, Santulli P, Maignien C, Bordonne C, Millischer AE, Chargui A, Marcellin L, Mantelet LM, Fouque Gadol L, Chapron C
Fertil Steril 2024 Mar;121(3):460-469. Epub 2023 Dec 4 doi: 10.1016/j.fertnstert.2023.11.039. PMID: 38056519
Uterine adenomyosis and adenomyoma: the surgical approach.
Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853
Minimally invasive treatment of adenomyosis.
Dueholm M
Best Pract Res Clin Obstet Gynaecol 2018 Aug;51:119-137. Epub 2018 Feb 15 doi: 10.1016/j.bpobgyn.2018.01.016. PMID: 29555380
Placenta accreta following laparoscopic adenomyomectomy: a case report.
Matsuzaki S, Yoshino K, Tomimatsu T, Takiuchi T, Kumasawa K, Kimura T
Clin Exp Obstet Gynecol 2016;43(5):763-765. PMID: 30074335
Medical treatment for adenomyosis and/or adenomyoma.
Tsui KH, Lee WL, Chen CY, Sheu BC, Yen MS, Chang TC, Wang PH
Taiwan J Obstet Gynecol 2014 Dec;53(4):459-65. doi: 10.1016/j.tjog.2014.04.024. PMID: 25510683

Prognosis

Significance of stromal markers in atypical polypoid adenomyoma.
Travaglino A, Raffone A, Gencarelli A, Zullo F, Di Spiezio Sardo A, Insabato L
Pathol Res Pract 2020 Nov;216(11):153133. Epub 2020 Aug 1 doi: 10.1016/j.prp.2020.153133. PMID: 32823231
Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
A literature review of radiological findings to guide the diagnosis of gallbladder adenomyomatosis.
Hammad AY, Miura JT, Turaga KK, Johnston FM, Hohenwalter MD, Gamblin TC
HPB (Oxford) 2016 Feb;18(2):129-135. Epub 2016 Jan 6 doi: 10.1016/j.hpb.2015.09.006. PMID: 26902131Free PMC Article
Stepwise approach and surgery for gallbladder adenomyomatosis: a mini-review.
Pellino G, Sciaudone G, Candilio G, Perna G, Santoriello A, Canonico S, Selvaggi F
Hepatobiliary Pancreat Dis Int 2013 Apr;12(2):136-42. doi: 10.1016/s1499-3872(13)60022-3. PMID: 23558066
Carcinomas of the breast showing myoepithelial cell differentiation. A review of the literature.
Foschini MP, Eusebi V
Virchows Arch 1998 Apr;432(4):303-10. doi: 10.1007/s004280050170. PMID: 9565338

Clinical prediction guides

The "freeze-all" strategy seems to improve the chances of birth in adenomyosis-affected women.
Bourdon M, Santulli P, Maignien C, Bordonne C, Millischer AE, Chargui A, Marcellin L, Mantelet LM, Fouque Gadol L, Chapron C
Fertil Steril 2024 Mar;121(3):460-469. Epub 2023 Dec 4 doi: 10.1016/j.fertnstert.2023.11.039. PMID: 38056519
A literature review of radiological findings to guide the diagnosis of gallbladder adenomyomatosis.
Hammad AY, Miura JT, Turaga KK, Johnston FM, Hohenwalter MD, Gamblin TC
HPB (Oxford) 2016 Feb;18(2):129-135. Epub 2016 Jan 6 doi: 10.1016/j.hpb.2015.09.006. PMID: 26902131Free PMC Article
Stepwise approach and surgery for gallbladder adenomyomatosis: a mini-review.
Pellino G, Sciaudone G, Candilio G, Perna G, Santoriello A, Canonico S, Selvaggi F
Hepatobiliary Pancreat Dis Int 2013 Apr;12(2):136-42. doi: 10.1016/s1499-3872(13)60022-3. PMID: 23558066
History of adenomyosis.
Benagiano G, Brosens I
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):449-63. Epub 2006 Mar 2 doi: 10.1016/j.bpobgyn.2006.01.007. PMID: 16515887
Magnetic resonance imaging for diagnosing adenomyomata.
Phillips DR, Nathanson HG, Milim SJ, Haselkorn JS
J Am Assoc Gynecol Laparosc 1996 Feb;3(2):245-50. doi: 10.1016/s1074-3804(96)80330-6. PMID: 9050634

Recent systematic reviews

The Effect of Uterine Adenomyosis on IVF Outcomes: a Systematic Review and Meta-analysis.
Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F
Reprod Sci 2022 Nov;29(11):3177-3193. Epub 2022 Jan 3 doi: 10.1007/s43032-021-00818-6. PMID: 34981458
Atypical polypoid adenomyoma follow-up and management: Systematic review of case reports and series and meta-analysis.
Biasioli A, Londero AP, Orsaria M, Scrimin F, Mangino FP, Bertozzi S, Mariuzzi L, Cagnacci A
Medicine (Baltimore) 2020 Jun 26;99(26):e20491. doi: 10.1097/MD.0000000000020491. PMID: 32590732Free PMC Article
Systematic review shows that pathological lead points are important and frequent in intussusception and are not limited to infants.
Fiegel H, Gfroerer S, Rolle U
Acta Paediatr 2016 Nov;105(11):1275-1279. doi: 10.1111/apa.13567. PMID: 27588829
Uterus-sparing operative treatment for adenomyosis.
Grimbizis GF, Mikos T, Tarlatzis B
Fertil Steril 2014 Feb;101(2):472-87. Epub 2013 Nov 26 doi: 10.1016/j.fertnstert.2013.10.025. PMID: 24289992
Stepwise approach and surgery for gallbladder adenomyomatosis: a mini-review.
Pellino G, Sciaudone G, Candilio G, Perna G, Santoriello A, Canonico S, Selvaggi F
Hepatobiliary Pancreat Dis Int 2013 Apr;12(2):136-42. doi: 10.1016/s1499-3872(13)60022-3. PMID: 23558066

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