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Gliosarcoma

MedGen UID:
64638
•Concept ID:
C0206726
•
Neoplastic Process
Synonym: Sarcomatous glioblastoma
SNOMED CT: Gliosarcoma (35262004); Glioblastoma with sarcomatous component (35262004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016681
Orphanet: ORPHA251576

Definition

A rare histological variant of glioblastoma (WHO grade IV) characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation (WHO). [from NCI]

Professional guidelines

PubMed

Primary gliosarcoma: epidemiology, clinical presentation, management, and survival.
Ma R, Alexe DM, Pereira EA
J Neurosurg Sci 2020 Aug;64(4):341-346. Epub 2017 Nov 20 doi: 10.23736/S0390-5616.17.04077-2. PMID: 29154508
Prognosis and management of gliosarcoma patients: A review of literature.
Saadeh F, El Iskandarani S, Najjar M, Assi HI
Clin Neurol Neurosurg 2019 Jul;182:98-103. Epub 2019 May 14 doi: 10.1016/j.clineuro.2019.05.008. PMID: 31112812
Therapeutic management of gliosarcoma in the temozolomide era.
McAleer MF, Brown PD
CNS Oncol 2015;4(3):171-8. Epub 2015 Apr 23 doi: 10.2217/cns.14.61. PMID: 25905568Free PMC Article

Recent clinical studies

Etiology

PATZ1-Rearranged Tumors of the Central Nervous System: Characterization of a Pediatric Series of Seven Cases.
Rossi S, Barresi S, Colafati GS, Genovese S, Tancredi C, Costabile V, Patrizi S, Giovannoni I, Asioli S, Poliani PL, Gardiman MP, Cardoni A, Del Baldo G, Antonelli M, Gianno F, Piccirilli E, Catino G, Martucci L, Quacquarini D, Toni F, Melchionda F, Viscardi E, Zucchelli M, Dal Pos S, Gatti E, Liserre R, Schiavello E, Diomedi-Camassei F, Carai A, Mastronuzzi A, Gessi M, Giannini C, Novelli A, Onetti Muda A, Miele E, Alesi V, Alaggio R
Mod Pathol 2024 Feb;37(2):100387. Epub 2023 Nov 23 doi: 10.1016/j.modpat.2023.100387. PMID: 38007157
Estimated Prevalence, Tumor Spectrum, and Neurofibromatosis Type 1-Like Phenotype of CDKN2A-Related Melanoma-Astrocytoma Syndrome.
Sargen MR, Kim J, Potjer TP, Velthuizen ME, Martir-Negron AE, Odia Y, Helgadottir H, Hatton JN, Haley JS, Thone G, Widemann BC, Gross AM, Yohe ME, Kaplan RN, Shern JF, Sundby RT, Astiazaran-Symonds E, Yang XR, Carey DJ, Tucker MA, Stewart DR, Goldstein AM
JAMA Dermatol 2023 Oct 1;159(10):1112-1118. doi: 10.1001/jamadermatol.2023.2621. PMID: 37585199Free PMC Article
Usefulness of circulating tumor DNA from cerebrospinal fluid in recurrent high-grade glioma.
Fontanilles M, Deniel A, Marguet F, Beaussire L, Magne N, Derrey S, Blanchard F, Alexandru C, Coutant S, Laquerrière A, Clatot F, Di Fiore F, Sarafan-Vasseur N
Rev Neurol (Paris) 2022 Nov;178(9):975-980. Epub 2022 Jul 21 doi: 10.1016/j.neurol.2022.02.462. PMID: 35871016
Gliosarcoma: MR features.
Dwyer KW, Naul LG, Hise JH
J Comput Assist Tomogr 1996 Sep-Oct;20(5):719-23. doi: 10.1097/00004728-199609000-00006. PMID: 8797900
Radiation-associated gliosarcoma.
Lach M, Wallace CJ, Krcek J, Curry B
Can Assoc Radiol J 1996 Jun;47(3):209-12. PMID: 8640419

Diagnosis

Update on Circumscribed Gliomas and Glioneuronal Tumors.
Chen J, Dahiya SM
Surg Pathol Clin 2020 Jun;13(2):249-266. doi: 10.1016/j.path.2020.02.004. PMID: 32389265
Brain tumors in Li-Fraumeni syndrome: a commentary and a case of a gliosarcoma patient.
Guidi M, Giunti L, Lucchesi M, Scoccianti S, Giglio S, Favre C, Oliveri G, Sardi I
Future Oncol 2017 Jan;13(1):9-12. Epub 2016 Aug 15 doi: 10.2217/fon-2016-0236. PMID: 27523101
An unusual case of intraventricular gliosarcoma.
Govindan A, Bhat DI, Mahadevan A, Chakraborti S, Sampath S, Chandramouli BA, Shankar SK
Clin Neuropathol 2009 Sep-Oct;28(5):379-83. doi: 10.5414/npp28379. PMID: 19788054
Infantile gliosarcoma.
Melo JR, Souza AL, Reis RC, Almeida MA
Arq Neuropsiquiatr 2008 Mar;66(1):88-9. doi: 10.1590/s0004-282x2008000100022. PMID: 18392424
Glioblastoma.
Miller CR, Perry A
Arch Pathol Lab Med 2007 Mar;131(3):397-406. doi: 10.5858/2007-131-397-G. PMID: 17516742

Therapy

Photodynamic effect of protoporphyrin IX in gliosarcoma 9l/lacZ cell line.
Fontana LC, Pinto JG, Vitorio GDS, Ferreira I, Pacheco-Soares C, Mamone LA, Strixino JF
Photodiagnosis Photodyn Ther 2022 Mar;37:102669. Epub 2021 Dec 2 doi: 10.1016/j.pdpdt.2021.102669. PMID: 34863947
Rapid In Situ MRI Traceable Gel-forming Dual-drug Delivery for Synergistic Therapy of Brain Tumor.
Lin FW, Chen PY, Wei KC, Huang CY, Wang CK, Yang HW
Theranostics 2017;7(9):2524-2536. Epub 2017 Jun 25 doi: 10.7150/thno.19856. PMID: 28744332Free PMC Article
Therapeutic management of gliosarcoma in the temozolomide era.
McAleer MF, Brown PD
CNS Oncol 2015;4(3):171-8. Epub 2015 Apr 23 doi: 10.2217/cns.14.61. PMID: 25905568Free PMC Article
Extraneural metastases of primary brain tumors.
Schweitzer T, Vince GH, Herbold C, Roosen K, Tonn JC
J Neurooncol 2001 Jun;53(2):107-14. doi: 10.1023/a:1012245115209. PMID: 11716064
Radiation-associated gliosarcoma.
Lach M, Wallace CJ, Krcek J, Curry B
Can Assoc Radiol J 1996 Jun;47(3):209-12. PMID: 8640419

Prognosis

Gliosarcoma in a Young Filipino Woman: A Case Report and Review of the Literature.
Langlois AM, Alarfaj AK, Sagga A, Findlay JM, Das S
Am J Case Rep 2019 Jun 27;20:914-919. doi: 10.12659/AJCR.916020. PMID: 31243260Free PMC Article
An unusual case of intraventricular gliosarcoma.
Govindan A, Bhat DI, Mahadevan A, Chakraborti S, Sampath S, Chandramouli BA, Shankar SK
Clin Neuropathol 2009 Sep-Oct;28(5):379-83. doi: 10.5414/npp28379. PMID: 19788054
Infantile gliosarcoma.
Melo JR, Souza AL, Reis RC, Almeida MA
Arq Neuropsiquiatr 2008 Mar;66(1):88-9. doi: 10.1590/s0004-282x2008000100022. PMID: 18392424
Glioblastoma.
Miller CR, Perry A
Arch Pathol Lab Med 2007 Mar;131(3):397-406. doi: 10.5858/2007-131-397-G. PMID: 17516742
Radiation-induced gliosarcoma. Case report and review of the literature.
Kaschten B, Flandroy P, Reznik M, Hainaut H, Stevenaert A
J Neurosurg 1995 Jul;83(1):154-62. doi: 10.3171/jns.1995.83.1.0154. PMID: 7782835

Clinical prediction guides

Metastatic glioblastoma to the lungs: a case report and literature review.
Yuen CA, Pekmezci M, Bao S, Kong XT
CNS Oncol 2024 Jun 6;13(1):2351789. Epub 2024 Jun 12 doi: 10.1080/20450907.2024.2351789. PMID: 38864820Free PMC Article
Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
Umemura Y, Orringer D, Junck L, Varela ML, West MEJ, Faisal SM, Comba A, Heth J, Sagher O, Leung D, Mammoser A, Hervey-Jumper S, Zamler D, Yadav VN, Dunn P, Al-Holou W, Hollon T, Kim MM, Wahl DR, Camelo-Piragua S, Lieberman AP, Venneti S, McKeever P, Lawrence T, Kurokawa R, Sagher K, Altshuler D, Zhao L, Muraszko K, Castro MG, Lowenstein PR
Lancet Oncol 2023 Sep;24(9):1042-1052. doi: 10.1016/S1470-2045(23)00347-9. PMID: 37657463
Rapid In Situ MRI Traceable Gel-forming Dual-drug Delivery for Synergistic Therapy of Brain Tumor.
Lin FW, Chen PY, Wei KC, Huang CY, Wang CK, Yang HW
Theranostics 2017;7(9):2524-2536. Epub 2017 Jun 25 doi: 10.7150/thno.19856. PMID: 28744332Free PMC Article
Sustained focal antitumor activity of bevacizumab in recurrent glioblastoma.
Bähr O, Harter PN, Weise LM, You SJ, Mittelbronn M, Ronellenfitsch MW, Rieger J, Steinbach JP, Hattingen E
Neurology 2014 Jul 15;83(3):227-34. Epub 2014 Jun 13 doi: 10.1212/WNL.0000000000000594. PMID: 24928118
Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides.
Zhou J, Tryggestad E, Wen Z, Lal B, Zhou T, Grossman R, Wang S, Yan K, Fu DX, Ford E, Tyler B, Blakeley J, Laterra J, van Zijl PC
Nat Med 2011 Jan;17(1):130-4. Epub 2010 Dec 19 doi: 10.1038/nm.2268. PMID: 21170048Free PMC Article

Recent systematic reviews

Primary versus secondary gliosarcoma: a systematic review and meta-analysis.
Vuong HG, Dunn IF
J Neurooncol 2022 Aug;159(1):195-200. Epub 2022 Jun 29 doi: 10.1007/s11060-022-04057-w. PMID: 35768633
Treatments of gliosarcoma of the brain: a systematic review and meta-analysis.
Wang X, Jiang J, Liu M, You C
Acta Neurol Belg 2021 Dec;121(6):1789-1797. Epub 2020 Nov 6 doi: 10.1007/s13760-020-01533-w. PMID: 33156945
Comparative epidemiology of gliosarcoma and glioblastoma and the impact of Race on overall survival: A systematic literature review.
Gerges C, Elder T, Penuela M, Rossetti N, Maynard M, Jeong S, Wright CH, Wright J, Zhou X, Burant C, Sajatovic M, Hodges T
Clin Neurol Neurosurg 2020 Aug;195:106054. Epub 2020 Jun 29 doi: 10.1016/j.clineuro.2020.106054. PMID: 32650210
Xenografting for disease modeling of intramedullary spinal cord tumors: a systematic review.
Rauschenbach L, Kocakavuk E, Pierscianek D, Ahmadipour Y, Kebir S, Glas M, Scheffler B, Sure U, Jabbarli R
Spinal Cord 2019 Jun;57(6):439-448. Epub 2019 Feb 1 doi: 10.1038/s41393-019-0248-6. PMID: 30710121
A Systematic Review on the Characteristics, Treatments and Outcomes of the Patients with Primary Spinal Glioblastomas or Gliosarcomas Reported in Literature until March 2015.
Beyer S, von Bueren AO, Klautke G, Guckenberger M, Kortmann RD, Pietschmann S, Müller K
PLoS One 2016;11(2):e0148312. Epub 2016 Feb 9 doi: 10.1371/journal.pone.0148312. PMID: 26859136Free PMC Article

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