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Emotional dearth

MedGen UID:
68571
Concept ID:
C0233469
Mental or Behavioral Dysfunction
Synonym: Emotional blunting
SNOMED CT: Blunted affect (6140007); Emotional blunting (6140007); Blunting of mood (6140007)
 
HPO: HP:0030213

Definition

The inability to feel or express emotions. It is generally recognized by the person who often complains that they are unable to feel anything; sadness, joy, or contentment are not experienced, rather a sense of nothingness prevails. This may be dimensional, ranging from limited ability to experience emotions to the perceived complete inability to feel emotions. [from HPO]

Term Hierarchy

Conditions with this feature

Pick disease
MedGen UID:
116020
Concept ID:
C0236642
Disease or Syndrome
Pick disease refers to the neuropathologic finding of 'Pick bodies,' which are argyrophilic, intraneuronal inclusions, and 'Pick cells,' which are enlarged neurons. The clinical correlates of Pick disease of brain include those of frontotemporal dementia, which encompass the behavioral variant of FTD, semantic dementia, and progressive nonfluent aphasia (summary by Piguet et al., 2011). Kertesz (2003) suggested the term 'Pick complex' to represent the overlapping syndromes of FTD, primary progressive aphasia (PPA), corticobasal degeneration (CBD), progressive supranuclear palsy (601104), and FTD with motor neuron disease. He noted that frontotemporal dementia may also be referred to as 'clinical Pick disease,' and that the term 'Pick disease' should be restricted to the pathologic finding of Pick bodies.

Professional guidelines

PubMed

Koh HMD, Lee CSC, Anna C, Lau Y
Int Nurs Rev 2022 Jun;69(2):201-210. Epub 2021 Jun 3 doi: 10.1111/inr.12691. PMID: 34081323
Yatham LN, Chakrabarty T, Bond DJ, Schaffer A, Beaulieu S, Parikh SV, McIntyre RS, Milev RV, Alda M, Vazquez G, Ravindran AV, Frey BN, Sharma V, Goldstein BI, Rej S, O'Donovan C, Tourjman V, Kozicky JM, Kauer-Sant'Anna M, Malhi G, Suppes T, Vieta E, Kapczinski F, Kanba S, Lam RW, Kennedy SH, Calabrese J, Berk M, Post R
Bipolar Disord 2021 Dec;23(8):767-788. Epub 2021 Nov 1 doi: 10.1111/bdi.13135. PMID: 34599629
Goldstein I, Komisaruk BR, Pukall CF, Kim NN, Goldstein AT, Goldstein SW, Hartzell-Cushanick R, Kellogg-Spadt S, Kim CW, Jackowich RA, Parish SJ, Patterson A, Peters KM, Pfaus JG
J Sex Med 2021 Apr;18(4):665-697. Epub 2021 Feb 19 doi: 10.1016/j.jsxm.2021.01.172. PMID: 33612417

Recent clinical studies

Etiology

Khan AA, Hashimoto K, Kwon CHD, Fujiki M, Ahmad M, Esfeh JM
Transplantation 2023 Apr 1;107(4):849-854. Epub 2022 Nov 29 doi: 10.1097/TP.0000000000004397. PMID: 36445920
Yatham LN, Chakrabarty T, Bond DJ, Schaffer A, Beaulieu S, Parikh SV, McIntyre RS, Milev RV, Alda M, Vazquez G, Ravindran AV, Frey BN, Sharma V, Goldstein BI, Rej S, O'Donovan C, Tourjman V, Kozicky JM, Kauer-Sant'Anna M, Malhi G, Suppes T, Vieta E, Kapczinski F, Kanba S, Lam RW, Kennedy SH, Calabrese J, Berk M, Post R
Bipolar Disord 2021 Dec;23(8):767-788. Epub 2021 Nov 1 doi: 10.1111/bdi.13135. PMID: 34599629
Peralta-Carcelen M, Schwartz J, Carcelen AC
Clin Perinatol 2018 Sep;45(3):529-546. Epub 2018 Jun 18 doi: 10.1016/j.clp.2018.05.003. PMID: 30144853
Leeners B, Geary N, Tobler PN, Asarian L
Hum Reprod Update 2017 May 1;23(3):300-321. doi: 10.1093/humupd/dmw045. PMID: 28333235Free PMC Article
Ionescu DF, Niciu MJ, Mathews DC, Richards EM, Zarate CA Jr
Depress Anxiety 2013 Apr;30(4):374-85. Epub 2013 Mar 11 doi: 10.1002/da.22095. PMID: 23495126Free PMC Article

Diagnosis

Yatham LN, Chakrabarty T, Bond DJ, Schaffer A, Beaulieu S, Parikh SV, McIntyre RS, Milev RV, Alda M, Vazquez G, Ravindran AV, Frey BN, Sharma V, Goldstein BI, Rej S, O'Donovan C, Tourjman V, Kozicky JM, Kauer-Sant'Anna M, Malhi G, Suppes T, Vieta E, Kapczinski F, Kanba S, Lam RW, Kennedy SH, Calabrese J, Berk M, Post R
Bipolar Disord 2021 Dec;23(8):767-788. Epub 2021 Nov 1 doi: 10.1111/bdi.13135. PMID: 34599629
Goldstein I, Komisaruk BR, Pukall CF, Kim NN, Goldstein AT, Goldstein SW, Hartzell-Cushanick R, Kellogg-Spadt S, Kim CW, Jackowich RA, Parish SJ, Patterson A, Peters KM, Pfaus JG
J Sex Med 2021 Apr;18(4):665-697. Epub 2021 Feb 19 doi: 10.1016/j.jsxm.2021.01.172. PMID: 33612417
Rashid A, Tahir I
J Cross Cult Gerontol 2015 Mar;30(1):69-85. doi: 10.1007/s10823-014-9248-3. PMID: 25349019
Hamiwka L, Jones JE, Salpekar J, Caplan R
Epilepsy Behav 2011 Sep;22(1):38-46. Epub 2011 Mar 26 doi: 10.1016/j.yebeh.2011.02.013. PMID: 21441073
El-Mallakh RS, Abraham HD
Ann Clin Psychiatry 2007 Jan-Mar;19(1):45-52. doi: 10.1080/10401230601163592. PMID: 17453661

Therapy

Lysova A, Dim EE
Violence Vict 2023 Aug 1;38(4):573-592. Epub 2023 Jun 28 doi: 10.1891/VV-2022-0031. PMID: 37380342
Yatham LN, Chakrabarty T, Bond DJ, Schaffer A, Beaulieu S, Parikh SV, McIntyre RS, Milev RV, Alda M, Vazquez G, Ravindran AV, Frey BN, Sharma V, Goldstein BI, Rej S, O'Donovan C, Tourjman V, Kozicky JM, Kauer-Sant'Anna M, Malhi G, Suppes T, Vieta E, Kapczinski F, Kanba S, Lam RW, Kennedy SH, Calabrese J, Berk M, Post R
Bipolar Disord 2021 Dec;23(8):767-788. Epub 2021 Nov 1 doi: 10.1111/bdi.13135. PMID: 34599629
Glover EM, Jovanovic T, Norrholm SD
Biol Psychiatry 2015 Aug 1;78(3):178-85. Epub 2015 Feb 16 doi: 10.1016/j.biopsych.2015.02.007. PMID: 25796471Free PMC Article
El-Mallakh RS, Abraham HD
Ann Clin Psychiatry 2007 Jan-Mar;19(1):45-52. doi: 10.1080/10401230601163592. PMID: 17453661
Morgan D
Expert Rev Vaccines 2003 Feb;2(1):53-9. doi: 10.1586/14760584.2.1.53. PMID: 12901597

Prognosis

Lysova A, Dim EE
Violence Vict 2023 Aug 1;38(4):573-592. Epub 2023 Jun 28 doi: 10.1891/VV-2022-0031. PMID: 37380342
Horn J, Simpson KN, Simpson AN, Bonilha LF, Bonilha HS
Am J Speech Lang Pathol 2022 Jul 12;31(4):1836-1844. Epub 2022 Jul 5 doi: 10.1044/2022_AJSLP-21-00346. PMID: 35858266Free PMC Article
Starzomska M, Wilkos E, Kucharska K
Psychiatr Pol 2018 Aug 24;52(4):663-672. doi: 10.12740/PP/OnlineFirst/73733. PMID: 30368536
Glover EM, Jovanovic T, Norrholm SD
Biol Psychiatry 2015 Aug 1;78(3):178-85. Epub 2015 Feb 16 doi: 10.1016/j.biopsych.2015.02.007. PMID: 25796471Free PMC Article
Rashid A, Tahir I
J Cross Cult Gerontol 2015 Mar;30(1):69-85. doi: 10.1007/s10823-014-9248-3. PMID: 25349019

Clinical prediction guides

Selekman J, Monforto K, Selekman D
NASN Sch Nurse 2023 Jul;38(4):187-193. Epub 2023 Feb 22 doi: 10.1177/1942602X231154549. PMID: 37403823
Lysova A, Dim EE
Violence Vict 2023 Aug 1;38(4):573-592. Epub 2023 Jun 28 doi: 10.1891/VV-2022-0031. PMID: 37380342
Michaels MS, Parent MC, Torrey CL
Suicide Life Threat Behav 2016 Feb;46(1):23-34. Epub 2015 May 16 doi: 10.1111/sltb.12169. PMID: 25981684
Glover EM, Jovanovic T, Norrholm SD
Biol Psychiatry 2015 Aug 1;78(3):178-85. Epub 2015 Feb 16 doi: 10.1016/j.biopsych.2015.02.007. PMID: 25796471Free PMC Article
Rashid A, Tahir I
J Cross Cult Gerontol 2015 Mar;30(1):69-85. doi: 10.1007/s10823-014-9248-3. PMID: 25349019

Recent systematic reviews

Khan S, Biswas MR, Shah Z
Hum Vaccin Immunother 2023 Dec 15;19(3):2278377. Epub 2023 Nov 20 doi: 10.1080/21645515.2023.2278377. PMID: 37981842Free PMC Article
Golding MA, Batac ALR, Gunnarsson NV, Ahlstedt S, Middelveld R, Protudjer JLP
Pediatr Allergy Immunol 2022 Mar;33(3):e13743. doi: 10.1111/pai.13743. PMID: 35338731
Liyanage S, Saqib K, Khan AF, Thobani TR, Tang WC, Chiarot CB, AlShurman BA, Butt ZA
Int J Environ Res Public Health 2021 Dec 22;19(1) doi: 10.3390/ijerph19010062. PMID: 35010323Free PMC Article
Theys L, Krystallidou D, Salaets H, Wermuth C, Pype P
Patient Educ Couns 2020 Jan;103(1):33-43. Epub 2019 Aug 12 doi: 10.1016/j.pec.2019.08.006. PMID: 31431309
Thomas BE, Shanmugam P, Malaisamy M, Ovung S, Suresh C, Subbaraman R, Adinarayanan S, Nagarajan K
PLoS One 2016;11(1):e0147397. Epub 2016 Jan 25 doi: 10.1371/journal.pone.0147397. PMID: 26807933Free PMC Article

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