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Hepatocellular clear cell carcinoma

MedGen UID:
690059
•Concept ID:
C1266020
•
Neoplastic Process
Synonyms: Clear Cell Carcinoma of Liver Cells; clear cell carcinoma of liver cells; Clear Cell Carcinoma of the Liver Cells; clear cell carcinoma of the liver cells; clear cell hepatocellular cancer; Clear Cell Hepatocellular Carcinoma; clear cell hepatocellular carcinoma; Hepatocellular carcinoma, clear cell type; Hepatocellular Clear Cell Carcinoma; hepatocellular clear cell carcinoma; Liver Cell Clear Cell Carcinoma; liver cell clear cell carcinoma
SNOMED CT: Hepatocellular carcinoma, clear cell type (128649001)
 
Monarch Initiative: MONDO:0003243

Definition

A morphologic variant of hepatocellular carcinoma characterized by the presence of clear cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatocellular clear cell carcinoma

Professional guidelines

PubMed

Roles of BMI1 in the Initiation, Progression, and Treatment of Hepatocellular Carcinoma.
Wang R, Fan H, Sun M, Lv Z, Yi W
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338211070689. doi: 10.1177/15330338211070689. PMID: 35072573Free PMC Article
Therapeutic vaccination for treatment of chronic hepatitis B.
Cargill T, Barnes E
Clin Exp Immunol 2021 Aug;205(2):106-118. Epub 2021 Jun 8 doi: 10.1111/cei.13614. PMID: 33969474Free PMC Article
Sorafenib for treatment of hepatocellular carcinoma: a systematic review.
Xie B, Wang DH, Spechler SJ
Dig Dis Sci 2012 May;57(5):1122-9. Epub 2012 Mar 27 doi: 10.1007/s10620-012-2136-1. PMID: 22451120Free PMC Article

Recent clinical studies

Etiology

Site-Specifically Conjugated Single-Domain Antibody Successfully Identifies Glypican-3-Expressing Liver Cancer by Immuno-PET.
Fayn S, King AP, Gutsche NT, Duan Z, Buffington J, Olkowski CP, Fu Y, Hong J, Sail D, Baidoo KE, Swenson RE, Cheloha RW, Ho M, Choyke PL, Escorcia FE
J Nucl Med 2023 Jul;64(7):1017-1023. Epub 2023 Mar 30 doi: 10.2967/jnumed.122.265171. PMID: 36997331Free PMC Article
The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation.
Zhang W, Zhangyuan G, Wang F, Jin K, Shen H, Zhang L, Yuan X, Wang J, Zhang H, Yu W, Huang R, Xu X, Yin Y, Zhong G, Lin A, Sun B
Immunity 2021 Jun 8;54(6):1168-1185.e8. Epub 2021 May 25 doi: 10.1016/j.immuni.2021.04.027. PMID: 34038747
Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma.
Ahn JC, Teng PC, Chen PJ, Posadas E, Tseng HR, Lu SC, Yang JD
Hepatology 2021 Jan;73(1):422-436. Epub 2021 Jan 18 doi: 10.1002/hep.31165. PMID: 32017145Free PMC Article
Role of ion channels in gastrointestinal cancer.
Anderson KJ, Cormier RT, Scott PM
World J Gastroenterol 2019 Oct 14;25(38):5732-5772. doi: 10.3748/wjg.v25.i38.5732. PMID: 31636470Free PMC Article
Nonalcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression From NAFLD to NASH.
Pierantonelli I, Svegliati-Baroni G
Transplantation 2019 Jan;103(1):e1-e13. doi: 10.1097/TP.0000000000002480. PMID: 30300287

Diagnosis

Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma.
Ahn JC, Teng PC, Chen PJ, Posadas E, Tseng HR, Lu SC, Yang JD
Hepatology 2021 Jan;73(1):422-436. Epub 2021 Jan 18 doi: 10.1002/hep.31165. PMID: 32017145Free PMC Article
Circulating Tumor DNA and Hepatocellular Carcinoma.
Yang JD, Liu MC, Kisiel JB
Semin Liver Dis 2019 Nov;39(4):452-462. Epub 2019 Jun 21 doi: 10.1055/s-0039-1688503. PMID: 31226727Free PMC Article
Alcoholic liver disease: Utility of animal models.
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article
Annexin A4 and cancer.
Wei B, Guo C, Liu S, Sun MZ
Clin Chim Acta 2015 Jul 20;447:72-8. Epub 2015 Jun 3 doi: 10.1016/j.cca.2015.05.016. PMID: 26048190
Malignant liver tumors.
Ros PR, Rasmussen JF
Curr Probl Diagn Radiol 1989 May-Jun;18(3):95-124. doi: 10.1016/0363-0188(89)90026-1. PMID: 2544348

Therapy

Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial.
Yuen MF, Heo J, Jang JW, Yoon JH, Kweon YO, Park SJ, Tami Y, You S, Yates P, Tao Y, Cremer J, Campbell F, Elston R, Theodore D, Paff M, Bennett CF, Kwoh TJ
Nat Med 2021 Oct;27(10):1725-1734. Epub 2021 Oct 12 doi: 10.1038/s41591-021-01513-4. PMID: 34642494Free PMC Article
Therapeutic vaccination for treatment of chronic hepatitis B.
Cargill T, Barnes E
Clin Exp Immunol 2021 Aug;205(2):106-118. Epub 2021 Jun 8 doi: 10.1111/cei.13614. PMID: 33969474Free PMC Article
Role of ion channels in gastrointestinal cancer.
Anderson KJ, Cormier RT, Scott PM
World J Gastroenterol 2019 Oct 14;25(38):5732-5772. doi: 10.3748/wjg.v25.i38.5732. PMID: 31636470Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Nonalcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression From NAFLD to NASH.
Pierantonelli I, Svegliati-Baroni G
Transplantation 2019 Jan;103(1):e1-e13. doi: 10.1097/TP.0000000000002480. PMID: 30300287

Prognosis

Single-cell tumor heterogeneity landscape of hepatocellular carcinoma: unraveling the pro-metastatic subtype and its interaction loop with fibroblasts.
Guo DZ, Zhang X, Zhang SQ, Zhang SY, Zhang XY, Yan JY, Dong SY, Zhu K, Yang XR, Fan J, Zhou J, Huang A
Mol Cancer 2024 Aug 2;23(1):157. doi: 10.1186/s12943-024-02062-3. PMID: 39095854Free PMC Article
FGF19/FGFR4-mediated elevation of ETV4 facilitates hepatocellular carcinoma metastasis by upregulating PD-L1 and CCL2.
Xie M, Lin Z, Ji X, Luo X, Zhang Z, Sun M, Chen X, Zhang B, Liang H, Liu D, Feng Y, Wang Y, Li Y, Liu B, Huang W, Xia L
J Hepatol 2023 Jul;79(1):109-125. Epub 2023 Mar 11 doi: 10.1016/j.jhep.2023.02.036. PMID: 36907560
Bioinformatics analysis of prognostic value and immunological role of MeCP2 in pan-cancer.
Wang Y, Zhang Y, Wang F, Li T, Song X, Shi H, Du J, Zhang H, Jing H, Han J, Tong D, Zhang J
Sci Rep 2022 Nov 2;12(1):18518. doi: 10.1038/s41598-022-21328-8. PMID: 36323715Free PMC Article
Role of ion channels in gastrointestinal cancer.
Anderson KJ, Cormier RT, Scott PM
World J Gastroenterol 2019 Oct 14;25(38):5732-5772. doi: 10.3748/wjg.v25.i38.5732. PMID: 31636470Free PMC Article
Alcoholic liver disease: Utility of animal models.
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article

Clinical prediction guides

Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression.
Masclef L, Ahmed O, Estavoyer B, Larrivée B, Labrecque N, Nijnik A, Affar EB
Cell Death Differ 2021 Feb;28(2):606-625. Epub 2021 Jan 18 doi: 10.1038/s41418-020-00709-4. PMID: 33462414Free PMC Article
Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma.
Ahn JC, Teng PC, Chen PJ, Posadas E, Tseng HR, Lu SC, Yang JD
Hepatology 2021 Jan;73(1):422-436. Epub 2021 Jan 18 doi: 10.1002/hep.31165. PMID: 32017145Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Alcoholic liver disease: Utility of animal models.
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article

Recent systematic reviews

PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic Review.
Van de Wiele C, Sathekge M, de Spiegeleer B, de Jonghe PJ, Beels L, Maes A
Int J Mol Sci 2019 Oct 2;20(19) doi: 10.3390/ijms20194886. PMID: 31581638Free PMC Article
Annexin A2 and cancer: A systematic review.
Christensen MV, Høgdall CK, Jochumsen KM, Høgdall EVS
Int J Oncol 2018 Jan;52(1):5-18. Epub 2017 Nov 8 doi: 10.3892/ijo.2017.4197. PMID: 29115416
Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review.
Fiorino S, Bacchi-Reggiani L, de Biase D, Fornelli A, Masetti M, Tura A, Grizzi F, Zanello M, Mastrangelo L, Lombardi R, Acquaviva G, di Tommaso L, Bondi A, Visani M, Sabbatani S, Pontoriero L, Fabbri C, Cuppini A, Pession A, Jovine E
World J Gastroenterol 2015 Dec 7;21(45):12896-953. doi: 10.3748/wjg.v21.i45.12896. PMID: 26668515Free PMC Article
Sorafenib for treatment of hepatocellular carcinoma: a systematic review.
Xie B, Wang DH, Spechler SJ
Dig Dis Sci 2012 May;57(5):1122-9. Epub 2012 Mar 27 doi: 10.1007/s10620-012-2136-1. PMID: 22451120Free PMC Article

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