U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Borderline Ovarian Clear Cell Adenofibroma

MedGen UID:
690067
•Concept ID:
C1266039
•
Neoplastic Process
Synonyms: Clear cell adenofibroma of borderline malignancy; Clear cell borderline tumor; Clear cell cystadenofibroma of borderline malignancy; Clear cell tumor, atypical proliferative
SNOMED CT: Clear cell cystadenofibroma of borderline malignancy (128890001); Clear cell adenofibroma of borderline malignancy (128890001); Clear cell tumor, atypical proliferative (128890001); Clear cell borderline tumor (128890001)

Definition

An epithelial neoplasm with low malignant potential affecting the ovary. It is characterized by the presence of atypical glands and/or cystic spaces lined with clear or hobnail cells. [from NCI]

Recent clinical studies

Etiology

Determining the significance of psammoma bodies in pelvic washings: A 10-year retrospective review.
Sun T, Pitman MB, Torous VF
Cancer Cytopathol 2021 Jan;129(1):83-89. Epub 2020 Sep 15 doi: 10.1002/cncy.22346. PMID: 32931128
Microcystic pattern and shadowing are independent predictors of ovarian borderline tumors and cystadenofibromas in ultrasound.
Zheng X, Lyu G, Gan Y, Hu M, Liu X, Chen S, Wu X, Yang W, Ye F, Yan X, Zhang Y
Eur Radiol 2021 Jan;31(1):45-54. Epub 2020 Aug 11 doi: 10.1007/s00330-020-07113-z. PMID: 32780208
Ovarian masses with papillary projections diagnosed and removed during pregnancy: ultrasound features and histological diagnosis.
Mascilini F, Savelli L, Scifo MC, Exacoustos C, Timor-Tritsch IE, De Blasis I, Moruzzi MC, Pasciuto T, Scambia G, Valentin L, Testa AC
Ultrasound Obstet Gynecol 2017 Jul;50(1):116-123. doi: 10.1002/uog.17216. PMID: 27484484
The feasibility of fertility-sparing surgery in treating advanced-stage borderline ovarian tumors: A meta-analysis.
Huang Y, Zhang W, Wang Y
Taiwan J Obstet Gynecol 2016 Jun;55(3):319-25. doi: 10.1016/j.tjog.2016.04.005. PMID: 27343308
Benign clear cell adenofibroma of the ovary. A case report with literature review.
Paşaoğlu O, Ciftçi E, Tel N, Ozalp S, Acikalin MF
Gynecol Obstet Invest 2007;64(1):36-9. Epub 2007 Jan 5 doi: 10.1159/000098425. PMID: 17202822

Diagnosis

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
Brenner tumors.
Costeira FS, Félix A, Cunha TM
Br J Radiol 2022 Feb 1;95(1130):20210687. Epub 2021 Dec 20 doi: 10.1259/bjr.20210687. PMID: 34928171Free PMC Article
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Role of Imaging Tools for the Diagnosis of Borderline Ovarian Tumors: A Systematic Review and Meta-Analysis.
Borrelli GM, de Mattos LA, Andres MP, Gonçalves MO, Kho RM, Abrão MS
J Minim Invasive Gynecol 2017 Mar-Apr;24(3):353-363. Epub 2016 Dec 24 doi: 10.1016/j.jmig.2016.12.012. PMID: 28027973

Therapy

Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor.
Qian XQ, Hua XP, Wu JH, Shen YM, Cheng XD, Wan XY
Int J Gynecol Cancer 2018 Feb;28(2):279-284. doi: 10.1097/IGC.0000000000001154. PMID: 29194193
Coffee, tea, and caffeine consumption and risk of epithelial ovarian cancer and borderline ovarian tumors: Results from a Danish case-control study.
Gosvig CF, Kjaer SK, Blaakær J, Høgdall E, Høgdall C, Jensen A
Acta Oncol 2015;54(8):1144-51. Epub 2015 Jan 28 doi: 10.3109/0284186X.2014.1001035. PMID: 25629440
An unusual case of a borderline Brenner tumor associated with bilateral serous cystadenoma and endometrial carcinoma.
Cruz-Galarza D, Pérez-Rodríguez O, Laboy-Torres J, Gutiérrez-Rivera S
Bol Asoc Med P R 2014;106(1):54-6. PMID: 24791367
Outpatient minilaparotomy for ovarian cysts.
Flynn MK, Niloff JM
J Reprod Med 1999 May;44(5):399-404. PMID: 10360250

Prognosis

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
Ovarian Clear Cell Tumors Associated With Seromucinous Borderline Tumor: A Case Series.
Vroobel KM, McCluggage WG
Int J Gynecol Pathol 2022 Jan 1;41(1):76-81. doi: 10.1097/PGP.0000000000000768. PMID: 33741765
Microcystic pattern and shadowing are independent predictors of ovarian borderline tumors and cystadenofibromas in ultrasound.
Zheng X, Lyu G, Gan Y, Hu M, Liu X, Chen S, Wu X, Yang W, Ye F, Yan X, Zhang Y
Eur Radiol 2021 Jan;31(1):45-54. Epub 2020 Aug 11 doi: 10.1007/s00330-020-07113-z. PMID: 32780208
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Benign clear cell adenofibroma of the ovary. A case report with literature review.
Paşaoğlu O, Ciftçi E, Tel N, Ozalp S, Acikalin MF
Gynecol Obstet Invest 2007;64(1):36-9. Epub 2007 Jan 5 doi: 10.1159/000098425. PMID: 17202822

Clinical prediction guides

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
A case of ovarian serous cystadenofibroma with scattered lesions in pelvic cavity, like malignant disseminations.
Fujita K, Ogawa C, Sako T, Utsumi F, Inada KI, Shibata K
J Obstet Gynaecol Res 2021 Dec;47(12):4496-4501. Epub 2021 Sep 6 doi: 10.1111/jog.15018. PMID: 34490687Free PMC Article
Microcystic pattern and shadowing are independent predictors of ovarian borderline tumors and cystadenofibromas in ultrasound.
Zheng X, Lyu G, Gan Y, Hu M, Liu X, Chen S, Wu X, Yang W, Ye F, Yan X, Zhang Y
Eur Radiol 2021 Jan;31(1):45-54. Epub 2020 Aug 11 doi: 10.1007/s00330-020-07113-z. PMID: 32780208
Ovarian masses with papillary projections diagnosed and removed during pregnancy: ultrasound features and histological diagnosis.
Mascilini F, Savelli L, Scifo MC, Exacoustos C, Timor-Tritsch IE, De Blasis I, Moruzzi MC, Pasciuto T, Scambia G, Valentin L, Testa AC
Ultrasound Obstet Gynecol 2017 Jul;50(1):116-123. doi: 10.1002/uog.17216. PMID: 27484484
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826

Recent systematic reviews

Role of Imaging Tools for the Diagnosis of Borderline Ovarian Tumors: A Systematic Review and Meta-Analysis.
Borrelli GM, de Mattos LA, Andres MP, Gonçalves MO, Kho RM, Abrão MS
J Minim Invasive Gynecol 2017 Mar-Apr;24(3):353-363. Epub 2016 Dec 24 doi: 10.1016/j.jmig.2016.12.012. PMID: 28027973
Accuracy of serum human epididymis protein 4 in ovarian cancer diagnosis: a systematic review and meta-analysis.
Macedo AC, da Rosa MI, Lumertz S, Medeiros LR
Int J Gynecol Cancer 2014 Sep;24(7):1222-31. doi: 10.1097/IGC.0000000000000192. PMID: 25078339

Supplemental Content

Table of contents

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...