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Borderline Ovarian Mucinous Adenofibroma

MedGen UID:
690121
•Concept ID:
C1266154
•
Neoplastic Process
Synonyms: Mucinous adenofibroma of borderline malignancy; Mucinous cystadenofibroma of borderline malignancy; Ovarian Mucinous Adenofibroma of Borderline Malignancy
SNOMED CT: Mucinous cystadenofibroma of borderline malignancy (128887007); Mucinous adenofibroma of borderline malignancy (128887007)

Definition

A low malignant potential adenofibroma of the ovary It is characterized by an atypical epithelial hyperplasia. The epithelial cells contain intracytoplasmic mucin. There is no evidence of stromal destructive invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Ovarian Mucinous Adenofibroma

Recent clinical studies

Etiology

When to Worry about Cancer: Concurrent Carcinoma and Recurrence in Borderline Ovarian Tumors.
Sullivan MW, Modesitt SC
South Med J 2019 Dec;112(12):634-638. doi: 10.14423/SMJ.0000000000001048. PMID: 31796975
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Eosinophilic Cells, Autoimplants, Degree of Cellular Proliferation, and Adenofibroma Pattern are Important Histologic Findings in Ovarian Borderline Tumors.
Karpathiou G, Venet M, Chauleur C, Honeyman F, Casteillo F, Peoc'h M
Int J Gynecol Pathol 2017 Sep;36(5):447-452. doi: 10.1097/PGP.0000000000000361. PMID: 28796659
Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome.
Bartosch C, Pires-Luís AS, Meireles C, Baptista M, Gouveia A, Pinto C, Shannon KM, Jerónimo C, Teixeira MR, Lopes JM, Oliva E
Am J Surg Pathol 2016 Sep;40(9):1177-91. doi: 10.1097/PAS.0000000000000684. PMID: 27340747
Clinical value of human epididymis protein 4 and the Risk of Ovarian Malignancy Algorithm in differentiating borderline pelvic tumors from epithelial ovarian cancer in early stages.
Kotowicz B, Fuksiewicz M, Sobiczewski P, Spiewankiewicz B, Jonska-Gmyrek J, Skrzypczak M, Kowalska M
Eur J Obstet Gynecol Reprod Biol 2015 Nov;194:141-6. Epub 2015 Sep 12 doi: 10.1016/j.ejogrb.2015.09.008. PMID: 26398337

Diagnosis

Müllerian Mucinous Cystadenomas of the Ovary: A Report of 25 Cases of an Unheralded Benign Ovarian Neoplasm Often Associated With Endometriosis and a Brief Consideration of Neoplasms Arising From the Latter.
Watkins JC, Young RH
Int J Gynecol Pathol 2022 Jan 1;41(1):68-75. doi: 10.1097/PGP.0000000000000765. PMID: 33577227
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Mucinous Neoplasms of the Ovary: Radiologic-Pathologic Correlation.
Marko J, Marko KI, Pachigolla SL, Crothers BA, Mattu R, Wolfman DJ
Radiographics 2019 Jul-Aug;39(4):982-997. doi: 10.1148/rg.2019180221. PMID: 31283462Free PMC Article
Eosinophilic Cells, Autoimplants, Degree of Cellular Proliferation, and Adenofibroma Pattern are Important Histologic Findings in Ovarian Borderline Tumors.
Karpathiou G, Venet M, Chauleur C, Honeyman F, Casteillo F, Peoc'h M
Int J Gynecol Pathol 2017 Sep;36(5):447-452. doi: 10.1097/PGP.0000000000000361. PMID: 28796659
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826

Prognosis

Mucinous Neoplasms of the Ovary: Radiologic-Pathologic Correlation.
Marko J, Marko KI, Pachigolla SL, Crothers BA, Mattu R, Wolfman DJ
Radiographics 2019 Jul-Aug;39(4):982-997. doi: 10.1148/rg.2019180221. PMID: 31283462Free PMC Article
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Eosinophilic Cells, Autoimplants, Degree of Cellular Proliferation, and Adenofibroma Pattern are Important Histologic Findings in Ovarian Borderline Tumors.
Karpathiou G, Venet M, Chauleur C, Honeyman F, Casteillo F, Peoc'h M
Int J Gynecol Pathol 2017 Sep;36(5):447-452. doi: 10.1097/PGP.0000000000000361. PMID: 28796659
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Ovarian epithelial tumours of borderline malignancy: pathological features and current status.
Br J Obstet Gynaecol 1983 Aug;90(8):743-50. doi: 10.1111/j.1471-0528.1983.tb09305.x. PMID: 6309211

Clinical prediction guides

Premature Classification of Early-stage Endometrioid Ovarian Carcinoma With Mesonephric-like Differentiation as Mesonephric-like Adenocarcinoma.
Miyama Y, Ogasawara A, Hasegawa K, Yasuda M
Int J Gynecol Pathol 2024 Jul 1;43(4):362-372. Epub 2024 Mar 4 doi: 10.1097/PGP.0000000000001002. PMID: 38870078
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome.
Bartosch C, Pires-Luís AS, Meireles C, Baptista M, Gouveia A, Pinto C, Shannon KM, Jerónimo C, Teixeira MR, Lopes JM, Oliva E
Am J Surg Pathol 2016 Sep;40(9):1177-91. doi: 10.1097/PAS.0000000000000684. PMID: 27340747
Clinical value of human epididymis protein 4 and the Risk of Ovarian Malignancy Algorithm in differentiating borderline pelvic tumors from epithelial ovarian cancer in early stages.
Kotowicz B, Fuksiewicz M, Sobiczewski P, Spiewankiewicz B, Jonska-Gmyrek J, Skrzypczak M, Kowalska M
Eur J Obstet Gynecol Reprod Biol 2015 Nov;194:141-6. Epub 2015 Sep 12 doi: 10.1016/j.ejogrb.2015.09.008. PMID: 26398337
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826

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