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Abnormal sadness

MedGen UID:
739046
•Concept ID:
C1688635
•
Finding
Synonyms: Feeling sad; Feeling unhappy; Sad; Unhappy
SNOMED CT: Feeling unhappy (420038007); Unhappy (420038007); Feeling sad (420038007)
 
HPO: HP:5200273

Definition

Experience of intense or excessively negative feelings that may include profound unhappiness, feeling low, down, or sorrowful and are beyond cultural or societal norms. Commonly associated with a low self-attitude and grim outlook. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal sadness

Professional guidelines

PubMed

How family physicians address diagnosis and management of depression in palliative care patients.
Warmenhoven F, van Rijswijk E, van Hoogstraten E, van Spaendonck K, Lucassen P, Prins J, Vissers K, van Weel C
Ann Fam Med 2012 Jul-Aug;10(4):330-6. doi: 10.1370/afm.1373. PMID: 22778121Free PMC Article

Recent clinical studies

Etiology

The Origin of Our Modern Concept of Depression-The History of Melancholia From 1780-1880: A Review.
Kendler KS
JAMA Psychiatry 2020 Aug 1;77(8):863-868. doi: 10.1001/jamapsychiatry.2019.4709. PMID: 31995137
Anaemia of cancer: impact on patient fatigue and long-term outcome.
Harper P, Littlewood T
Oncology 2005;69 Suppl 2:2-7. Epub 2005 Oct 21 doi: 10.1159/000088282. PMID: 16244504
Suicide behavior in persons with intellectual disability.
Merrick J, Merrick E, Lunsky Y, Kandel I
ScientificWorldJournal 2005 Sep 8;5:729-35. doi: 10.1100/tsw.2005.91. PMID: 16155687Free PMC Article
Vagal withdrawal to a sad film predicts subsequent recovery from depression.
Rottenberg J, Salomon K, Gross JJ, Gotlib IH
Psychophysiology 2005 May;42(3):277-81. doi: 10.1111/j.1469-8986.2005.00289.x. PMID: 15943681
Self-inflicted burn injuries.
Erzurum VZ, Varcellotti J
J Burn Care Rehabil 1999 Jan-Feb;20(1 Pt 1):22-4. doi: 10.1097/00004630-199901001-00004. PMID: 9934632

Diagnosis

The Origin of Our Modern Concept of Depression-The History of Melancholia From 1780-1880: A Review.
Kendler KS
JAMA Psychiatry 2020 Aug 1;77(8):863-868. doi: 10.1001/jamapsychiatry.2019.4709. PMID: 31995137
Conflicting cultural perspectives: meanings and experiences of postnatal depression among women in Indian communities.
Jain A, Levy D
Health Care Women Int 2013;34(11):966-79. Epub 2013 Aug 2 doi: 10.1080/07399332.2013.807258. PMID: 23909400
Depression symptomatology and neurobiology.
Gelenberg AJ
J Clin Psychiatry 2010 Jan;71(1):e02. doi: 10.4088/JCP.8001tx16c. PMID: 20129000
Anaemia of cancer: impact on patient fatigue and long-term outcome.
Harper P, Littlewood T
Oncology 2005;69 Suppl 2:2-7. Epub 2005 Oct 21 doi: 10.1159/000088282. PMID: 16244504
Self-inflicted burn injuries.
Erzurum VZ, Varcellotti J
J Burn Care Rehabil 1999 Jan-Feb;20(1 Pt 1):22-4. doi: 10.1097/00004630-199901001-00004. PMID: 9934632

Therapy

Unfolding the Role of BDNF as a Biomarker for Treatment of Depression.
Rana T, Behl T, Sehgal A, Srivastava P, Bungau S
J Mol Neurosci 2021 Oct;71(10):2008-2021. Epub 2020 Nov 23 doi: 10.1007/s12031-020-01754-x. PMID: 33230708
Biased Perception of Mean Emotion in Abstinent Heroin Abusers.
Zhang M, Wang X, Hu C, Liao H, Yang T, Shen M
J Psychoactive Drugs 2015 Nov-Dec;47(5):382-92. Epub 2015 Nov 23 doi: 10.1080/02791072.2015.1101181. PMID: 26595559
Anaemia of cancer: impact on patient fatigue and long-term outcome.
Harper P, Littlewood T
Oncology 2005;69 Suppl 2:2-7. Epub 2005 Oct 21 doi: 10.1159/000088282. PMID: 16244504
Vagal withdrawal to a sad film predicts subsequent recovery from depression.
Rottenberg J, Salomon K, Gross JJ, Gotlib IH
Psychophysiology 2005 May;42(3):277-81. doi: 10.1111/j.1469-8986.2005.00289.x. PMID: 15943681
Differential amygdala activation in schizophrenia during sadness.
Schneider F, Weiss U, Kessler C, Salloum JB, Posse S, Grodd W, Müller-Gärtner HW
Schizophr Res 1998 Nov 30;34(3):133-42. doi: 10.1016/s0920-9964(98)00085-1. PMID: 9850979

Prognosis

Sequential learning of emotional faces is statistical at 12 months of age.
Mermier J, Quadrelli E, Turati C, Bulf H
Infancy 2022 May;27(3):479-491. Epub 2022 Mar 3 doi: 10.1111/infa.12463. PMID: 35238464
The Origin of Our Modern Concept of Depression-The History of Melancholia From 1780-1880: A Review.
Kendler KS
JAMA Psychiatry 2020 Aug 1;77(8):863-868. doi: 10.1001/jamapsychiatry.2019.4709. PMID: 31995137
Perinatal sadness among Shuar women: support for an evolutionary theory of psychic pain.
Hagen EH, Barrett HC
Med Anthropol Q 2007 Mar;21(1):22-40. doi: 10.1525/maq.2007.21.1.22. PMID: 17405696
Vagal withdrawal to a sad film predicts subsequent recovery from depression.
Rottenberg J, Salomon K, Gross JJ, Gotlib IH
Psychophysiology 2005 May;42(3):277-81. doi: 10.1111/j.1469-8986.2005.00289.x. PMID: 15943681
Knowledge of basic emotions in adolescent and adult individuals with autism.
Muris P, Meesters C, Merckelbach H, Lomme M
Psychol Rep 1995 Feb;76(1):52-4. doi: 10.2466/pr0.1995.76.1.52. PMID: 7770593

Clinical prediction guides

Sequential learning of emotional faces is statistical at 12 months of age.
Mermier J, Quadrelli E, Turati C, Bulf H
Infancy 2022 May;27(3):479-491. Epub 2022 Mar 3 doi: 10.1111/infa.12463. PMID: 35238464
The Origin of Our Modern Concept of Depression-The History of Melancholia From 1780-1880: A Review.
Kendler KS
JAMA Psychiatry 2020 Aug 1;77(8):863-868. doi: 10.1001/jamapsychiatry.2019.4709. PMID: 31995137
Perinatal sadness among Shuar women: support for an evolutionary theory of psychic pain.
Hagen EH, Barrett HC
Med Anthropol Q 2007 Mar;21(1):22-40. doi: 10.1525/maq.2007.21.1.22. PMID: 17405696
Anaemia of cancer: impact on patient fatigue and long-term outcome.
Harper P, Littlewood T
Oncology 2005;69 Suppl 2:2-7. Epub 2005 Oct 21 doi: 10.1159/000088282. PMID: 16244504
Vagal withdrawal to a sad film predicts subsequent recovery from depression.
Rottenberg J, Salomon K, Gross JJ, Gotlib IH
Psychophysiology 2005 May;42(3):277-81. doi: 10.1111/j.1469-8986.2005.00289.x. PMID: 15943681

Recent systematic reviews

Parents' experiences of receiving their child's diagnosis of congenital heart disease: A systematic review and meta-synthesis of the qualitative literature.
Dandy S, Wittkowski A, Murray CD
Br J Health Psychol 2024 May;29(2):351-378. Epub 2023 Nov 15 doi: 10.1111/bjhp.12703. PMID: 37968248
Auditory emotion recognition deficits in schizophrenia: A systematic review and meta-analysis.
Gong B, Li Q, Zhao Y, Wu C
Asian J Psychiatr 2021 Nov;65:102820. Epub 2021 Aug 28 doi: 10.1016/j.ajp.2021.102820. PMID: 34482183
Anaemia of cancer: impact on patient fatigue and long-term outcome.
Harper P, Littlewood T
Oncology 2005;69 Suppl 2:2-7. Epub 2005 Oct 21 doi: 10.1159/000088282. PMID: 16244504

Supplemental Content

Table of contents

    Clinical resources

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