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Warty Carcinoma

MedGen UID:
757679
•Concept ID:
C3251817
•
Neoplastic Process
Synonyms: Condylomatous carcinoma; Warty (condylomatous) carcinoma; Warty carcinoma
SNOMED CT: Warty (condylomatous) carcinoma (399408005); Condylomatous carcinoma (399408005); Warty carcinoma (399408005)

Definition

A squamous cell carcinoma characterized by a papillary growth pattern, hyperkeratosis, and koilocytosis. [from NCI]

Professional guidelines

PubMed

Detection of variable genotypes in common human papillomavirus-associated invasive penile squamous cell carcinomas: a study of 177 human papillomavirus-positive cases.
Sanchez DF, Fernández-Nestosa MJ, Alemany L, Cañete-Portillo S, Lloveras B, Clavero O, Rodríguez I, Quint W, Muñoz N, de Sanjosé S, Bosch FX, Cubilla AL; HPV VVAP Study Group
Hum Pathol 2023 Sep;139:65-72. Epub 2023 Jul 8 doi: 10.1016/j.humpath.2023.07.001. PMID: 37429448
Distribution of human papillomavirus genotypes in invasive squamous carcinoma of the vulva.
Sutton BC, Allen RA, Moore WE, Dunn ST
Mod Pathol 2008 Mar;21(3):345-54. Epub 2008 Jan 11 doi: 10.1038/modpathol.3801010. PMID: 18192967

Recent clinical studies

Etiology

Detection of variable genotypes in common human papillomavirus-associated invasive penile squamous cell carcinomas: a study of 177 human papillomavirus-positive cases.
Sanchez DF, Fernández-Nestosa MJ, Alemany L, Cañete-Portillo S, Lloveras B, Clavero O, Rodríguez I, Quint W, Muñoz N, de Sanjosé S, Bosch FX, Cubilla AL; HPV VVAP Study Group
Hum Pathol 2023 Sep;139:65-72. Epub 2023 Jul 8 doi: 10.1016/j.humpath.2023.07.001. PMID: 37429448
Penile warty mucoepidermoid carcinoma with features of stratified mucin-producing intra-epithelial lesion and invasive stratified mucin-producing carcinoma.
Yorita K, Kuroda N, Naroda T, Tamura M, Ohe C, Divatia M, Amin MB, Cubilla AL, Kazakov DV, Hes O, Michal M, Michal M
Histopathology 2018 Apr;72(5):867-873. Epub 2018 Jan 14 doi: 10.1111/his.13438. PMID: 29144557
Warty (condylomatous) carcinoma of the cervix. A review of 3 cases with emphasis on thin-layer cytology and molecular analysis for HPV.
Ng WK, Cheung LK, Li AS
Acta Cytol 2003 Mar-Apr;47(2):159-66. doi: 10.1159/000326497. PMID: 12685182
Basaloid and warty carcinomas of the vulva. Distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses.
Kurman RJ, Toki T, Schiffman MH
Am J Surg Pathol 1993 Feb;17(2):133-45. doi: 10.1097/00000478-199302000-00005. PMID: 8380681
Early invasive and in situ warty carcinoma of the vulva: clinical, histologic, and electron microscopic study with particular reference to viral association.
Rastkar G, Okagaki T, Twiggs LB, Clark BA
Am J Obstet Gynecol 1982 Aug 1;143(7):814-20. doi: 10.1016/0002-9378(82)90015-1. PMID: 6285742

Diagnosis

Not all penile cancers are created equal.
Choi K, Hale N, Olsen D, Deem S
Can J Urol 2015 Oct;22(5):8003-5. PMID: 26432973
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
Warty (condylomatous) carcinoma of the cervix. A review of 3 cases with emphasis on thin-layer cytology and molecular analysis for HPV.
Ng WK, Cheung LK, Li AS
Acta Cytol 2003 Mar-Apr;47(2):159-66. doi: 10.1159/000326497. PMID: 12685182
Warty carcinoma of the oral mucosa in an HIV+ patient.
Piattelli A, Rubini C, Fioroni M, Iezzi T
Oral Oncol 2001 Dec;37(8):665-7. doi: 10.1016/s1368-8375(00)00118-4. PMID: 11590077
Early invasive and in situ warty carcinoma of the vulva: clinical, histologic, and electron microscopic study with particular reference to viral association.
Rastkar G, Okagaki T, Twiggs LB, Clark BA
Am J Obstet Gynecol 1982 Aug 1;143(7):814-20. doi: 10.1016/0002-9378(82)90015-1. PMID: 6285742

Prognosis

Detection of variable genotypes in common human papillomavirus-associated invasive penile squamous cell carcinomas: a study of 177 human papillomavirus-positive cases.
Sanchez DF, Fernández-Nestosa MJ, Alemany L, Cañete-Portillo S, Lloveras B, Clavero O, Rodríguez I, Quint W, Muñoz N, de Sanjosé S, Bosch FX, Cubilla AL; HPV VVAP Study Group
Hum Pathol 2023 Sep;139:65-72. Epub 2023 Jul 8 doi: 10.1016/j.humpath.2023.07.001. PMID: 37429448
Characteristics of penile cancer in Japan: An analysis of nationwide hospital-based cancer registry data.
Tanaka K, Kandori S, Nitta S, Chihara I, Kojo K, Nagumo Y, Kimura T, Kojima T, Kawai K, Okuyama A, Higashi T, Nishiyama H
Int J Urol 2020 Jun;27(6):538-542. Epub 2020 Apr 19 doi: 10.1111/iju.14247. PMID: 32307745
Penile warty mucoepidermoid carcinoma with features of stratified mucin-producing intra-epithelial lesion and invasive stratified mucin-producing carcinoma.
Yorita K, Kuroda N, Naroda T, Tamura M, Ohe C, Divatia M, Amin MB, Cubilla AL, Kazakov DV, Hes O, Michal M, Michal M
Histopathology 2018 Apr;72(5):867-873. Epub 2018 Jan 14 doi: 10.1111/his.13438. PMID: 29144557
Squamous Cell Carcinoma of the Vulva: A Subclassification of 97 Cases by Clinicopathologic, Immunohistochemical, and Molecular Features (p16, p53, and EGFR).
Dong F, Kojiro S, Borger DR, Growdon WB, Oliva E
Am J Surg Pathol 2015 Aug;39(8):1045-53. doi: 10.1097/PAS.0000000000000454. PMID: 26171917
Basaloid and warty carcinomas of the vulva. Distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses.
Kurman RJ, Toki T, Schiffman MH
Am J Surg Pathol 1993 Feb;17(2):133-45. doi: 10.1097/00000478-199302000-00005. PMID: 8380681

Clinical prediction guides

Squamous Cell Carcinoma of the Vulva: A Subclassification of 97 Cases by Clinicopathologic, Immunohistochemical, and Molecular Features (p16, p53, and EGFR).
Dong F, Kojiro S, Borger DR, Growdon WB, Oliva E
Am J Surg Pathol 2015 Aug;39(8):1045-53. doi: 10.1097/PAS.0000000000000454. PMID: 26171917
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
Warty (condylomatous) carcinoma of the cervix. A review of 3 cases with emphasis on thin-layer cytology and molecular analysis for HPV.
Ng WK, Cheung LK, Li AS
Acta Cytol 2003 Mar-Apr;47(2):159-66. doi: 10.1159/000326497. PMID: 12685182
Warty carcinoma of the oral mucosa in an HIV+ patient.
Piattelli A, Rubini C, Fioroni M, Iezzi T
Oral Oncol 2001 Dec;37(8):665-7. doi: 10.1016/s1368-8375(00)00118-4. PMID: 11590077
Early invasive and in situ warty carcinoma of the vulva: clinical, histologic, and electron microscopic study with particular reference to viral association.
Rastkar G, Okagaki T, Twiggs LB, Clark BA
Am J Obstet Gynecol 1982 Aug 1;143(7):814-20. doi: 10.1016/0002-9378(82)90015-1. PMID: 6285742

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