U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Childhood Craniopharyngioma

MedGen UID:
75847
•Concept ID:
C0278652
•
Neoplastic Process
Synonyms: Benign Childhood Neoplasm of Rathke's Pouch; Benign Childhood Rathke's Pouch Neoplasm; Benign Childhood Rathke's Pouch Tumor; Benign Childhood Tumor of Rathke's Pouch; Benign Pediatric Neoplasm of Rathke's Pouch; Benign Pediatric Rathke's Pouch Neoplasm; Benign Pediatric Rathke's Pouch Tumor; Benign Pediatric Tumor of Rathke's Pouch; Childhood Neoplasm of Rathke's Pouch; Childhood Rathke's Pouch Neoplasm; Childhood Rathke's Pouch Tumor; Childhood Tumor of Rathke's Pouch; Pediatric Craniopharyngioma; Pediatric Neoplasm of Rathke's Pouch; Pediatric Rathke's Pouch Neoplasm; Pediatric Rathke's Pouch Tumor; Pediatric Tumor of Rathke's Pouch

Definition

A craniopharyngioma that occurs during childhood. The vast majority of cases are adamantinomatous craniopharyngiomas. Clinical signs and symptoms include endocrine deficiencies and visual disturbances. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Craniopharyngioma

Professional guidelines

PubMed

Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma.
van Schaik J, Hoving EW, Müller HL, van Santen HM
Front Horm Res 2021;54:47-57. Epub 2021 May 7 doi: 10.1159/000515318. PMID: 33965963
Childhood craniopharyngioma - current status and recent perspectives in diagnostics and treatment.
Müller HL
J Pediatr Endocrinol Metab 2015 Jan;28(1-2):1-2. doi: 10.1515/jpem-2014-0416. PMID: 25503668
More or less? Treatment strategies in childhood craniopharyngioma.
Müller HL
Childs Nerv Syst 2006 Feb;22(2):156-7. doi: 10.1007/s00381-005-1192-7. PMID: 16320024

Recent clinical studies

Etiology

Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma.
van Schaik J, Hoving EW, Müller HL, van Santen HM
Front Horm Res 2021;54:47-57. Epub 2021 May 7 doi: 10.1159/000515318. PMID: 33965963
Craniopharyngioma in Children: Long-term Outcomes.
Steinbok P
Neurol Med Chir (Tokyo) 2015;55(9):722-6. Epub 2015 Sep 4 doi: 10.2176/nmc.ra.2015-0099. PMID: 26345668Free PMC Article
Consensus and perspectives on treatment strategies in childhood craniopharyngioma: results of a meeting of the Craniopharyngioma Study Group (SIOP), Genova, 2004.
Müller HL, Albanese A, Calaminus G, Hargrave D, Garré ML, Gebhardt U, Saran F, Sörensen N, Spoudeas HA
J Pediatr Endocrinol Metab 2006 Apr;19 Suppl 1:453-4. PMID: 16700324
The present and future management of childhood craniopharyngioma.
Hayward R
Childs Nerv Syst 1999 Nov;15(11-12):764-9. doi: 10.1007/s003810050468. PMID: 10603020
Postsurgical IQ and behavioral data on twenty patients with a history of childhood craniopharyngioma.
Clopper RR, Meyer WJ 3rd, Udvarhelyi GB, Money J, Aarabi B, Mulvihill JJ, Piasio M
Psychoneuroendocrinology 1977 Oct;2(4):365-72. doi: 10.1016/0306-4530(77)90006-3. PMID: 601173

Diagnosis

Childhood craniopharyngioma - current status and recent perspectives in diagnostics and treatment.
Müller HL
J Pediatr Endocrinol Metab 2015 Jan;28(1-2):1-2. doi: 10.1515/jpem-2014-0416. PMID: 25503668
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Childhood craniopharyngioma.
Müller HL
Pituitary 2013 Mar;16(1):56-67. doi: 10.1007/s11102-012-0401-0. PMID: 22678820
Childhood craniopharyngioma: current controversies on management in diagnostics, treatment and follow-up.
Müller HL
Expert Rev Neurother 2010 Apr;10(4):515-24. doi: 10.1586/ern.10.15. PMID: 20367205
Neuroimaging of childhood craniopharyngioma.
Harwood-Nash DC
Pediatr Neurosurg 1994;21 Suppl 1:2-10. doi: 10.1159/000120853. PMID: 7841074

Therapy

Childhood craniopharyngioma - current status and recent perspectives in diagnostics and treatment.
Müller HL
J Pediatr Endocrinol Metab 2015 Jan;28(1-2):1-2. doi: 10.1515/jpem-2014-0416. PMID: 25503668
Intracystic interferon therapy in childhood craniopharyngioma: who, when and how?
Bailey S, Parkes J
Clin Endocrinol (Oxf) 2015 Jan;82(1):29-34. Epub 2014 Aug 14 doi: 10.1111/cen.12568. PMID: 25059106
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Childhood craniopharyngioma.
Müller HL
Pituitary 2013 Mar;16(1):56-67. doi: 10.1007/s11102-012-0401-0. PMID: 22678820
The present and future management of childhood craniopharyngioma.
Hayward R
Childs Nerv Syst 1999 Nov;15(11-12):764-9. doi: 10.1007/s003810050468. PMID: 10603020

Prognosis

Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma.
van Schaik J, Hoving EW, Müller HL, van Santen HM
Front Horm Res 2021;54:47-57. Epub 2021 May 7 doi: 10.1159/000515318. PMID: 33965963
Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up.
Bogusz A, Müller HL
Expert Rev Neurother 2018 Oct;18(10):793-806. Epub 2018 Oct 4 doi: 10.1080/14737175.2018.1528874. PMID: 30257123
Preoperative staging in childhood craniopharyngioma: standardization as a first step towards improved outcome.
Müller HL
Endocrine 2016 Jan;51(1):1-3. Epub 2015 Nov 18 doi: 10.1007/s12020-015-0800-x. PMID: 26582066
The present and future management of childhood craniopharyngioma.
Hayward R
Childs Nerv Syst 1999 Nov;15(11-12):764-9. doi: 10.1007/s003810050468. PMID: 10603020
Postsurgical IQ and behavioral data on twenty patients with a history of childhood craniopharyngioma.
Clopper RR, Meyer WJ 3rd, Udvarhelyi GB, Money J, Aarabi B, Mulvihill JJ, Piasio M
Psychoneuroendocrinology 1977 Oct;2(4):365-72. doi: 10.1016/0306-4530(77)90006-3. PMID: 601173

Clinical prediction guides

Treatment and outcome of the Dutch Childhood Craniopharyngioma Cohort study: First results after centralization of care.
Van Schaik J, Schouten-van Meeteren AYN, Vos-Kerkhof E, Janssens GO, Porro GL, Fiocco M, Bakker B, Tissing WJE, Hoving EW, van Santen HM
Neuro Oncol 2023 Dec 8;25(12):2250-2261. doi: 10.1093/neuonc/noad112. PMID: 37381692Free PMC Article
Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up.
Bogusz A, Müller HL
Expert Rev Neurother 2018 Oct;18(10):793-806. Epub 2018 Oct 4 doi: 10.1080/14737175.2018.1528874. PMID: 30257123
Preoperative staging in childhood craniopharyngioma: standardization as a first step towards improved outcome.
Müller HL
Endocrine 2016 Jan;51(1):1-3. Epub 2015 Nov 18 doi: 10.1007/s12020-015-0800-x. PMID: 26582066
Neuropsychological outcome in patients with childhood craniopharyngioma and hypothalamic involvement.
Özyurt J, Thiel CM, Lorenzen A, Gebhardt U, Calaminus G, Warmuth-Metz M, Müller HL
J Pediatr 2014 Apr;164(4):876-881.e4. Epub 2014 Feb 6 doi: 10.1016/j.jpeds.2013.12.010. PMID: 24507865
The present and future management of childhood craniopharyngioma.
Hayward R
Childs Nerv Syst 1999 Nov;15(11-12):764-9. doi: 10.1007/s003810050468. PMID: 10603020

Recent systematic reviews

Visual functions in children with craniopharyngioma at diagnosis: A systematic review.
Nuijts MA, Veldhuis N, Stegeman I, van Santen HM, Porro GL, Imhof SM, Schouten-van Meeteren AYN
PLoS One 2020;15(10):e0240016. Epub 2020 Oct 1 doi: 10.1371/journal.pone.0240016. PMID: 33002047Free PMC Article
A systematic review of cognitive performance in patients with childhood craniopharyngioma.
Özyurt J, Müller HL, Thiel CM
J Neurooncol 2015 Oct;125(1):9-21. Epub 2015 Sep 14 doi: 10.1007/s11060-015-1885-z. PMID: 26369768
Prevalence of neurobehavioral, social, and emotional dysfunction in patients treated for childhood craniopharyngioma: a systematic literature review.
Zada G, Kintz N, Pulido M, Amezcua L
PLoS One 2013;8(11):e76562. Epub 2013 Nov 5 doi: 10.1371/journal.pone.0076562. PMID: 24223703Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...