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Childhood Central Nervous System Neoplasm

MedGen UID:
277990
•Concept ID:
C1377665
•
Neoplastic Process
Synonyms: Childhood Central Nervous System Neoplasms; Childhood Central Nervous System Tumor; Childhood Central Nervous System Tumors; Childhood CNS Neoplasm; Childhood CNS Tumor; Childhood Neoplasm of Central Nervous System; Childhood Neoplasm of CNS; Childhood Neoplasm of the Central Nervous System; Childhood Neoplasm of the CNS; Childhood Tumor of Central Nervous System; Childhood Tumor of CNS; Childhood Tumor of the Central Nervous System; Childhood Tumor of the CNS; Pediatric Central Nervous System Neoplasm; Pediatric Central Nervous System Tumor; Pediatric CNS Neoplasm; Pediatric CNS Tumor; Pediatric Neoplasm of Central Nervous System; Pediatric Neoplasm of CNS; Pediatric Neoplasm of the Central Nervous System; Pediatric Neoplasm of the CNS; Pediatric Tumor of Central Nervous System; Pediatric Tumor of CNS; Pediatric Tumor of the Central Nervous System; Pediatric Tumor of the CNS

Definition

A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in children. Representative examples include posterior fossa astrocytoma, optic pathway glioma, medulloblastoma, ependymoma, and craniopharyngioma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Central Nervous System Neoplasm

Professional guidelines

PubMed

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
EANO-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours.
Le Rhun E, Guckenberger M, Smits M, Dummer R, Bachelot T, Sahm F, Galldiks N, de Azambuja E, Berghoff AS, Metellus P, Peters S, Hong YK, Winkler F, Schadendorf D, van den Bent M, Seoane J, Stahel R, Minniti G, Wesseling P, Weller M, Preusser M; EANO Executive Board and ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2021 Nov;32(11):1332-1347. Epub 2021 Aug 6 doi: 10.1016/j.annonc.2021.07.016. PMID: 34364998
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Recent clinical studies

Etiology

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Epidemiology of Brain and Other CNS Tumors.
Ostrom QT, Francis SS, Barnholtz-Sloan JS
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):68. doi: 10.1007/s11910-021-01152-9. PMID: 34817716Free PMC Article
Brain and other central nervous system tumor statistics, 2021.
Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, Fuchs HE, Waite KA, Jemal A, Siegel RL, Barnholtz-Sloan JS
CA Cancer J Clin 2021 Sep;71(5):381-406. Epub 2021 Aug 24 doi: 10.3322/caac.21693. PMID: 34427324
Radiation-induced meningioma.
Umansky F, Shoshan Y, Rosenthal G, Fraifeld S, Spektor S
Neurosurg Focus 2008;24(5):E7. doi: 10.3171/FOC/2008/24/5/E7. PMID: 18447746
Paediatric surgical oncology. 8--Central nervous system tumours in children.
Pizer B, May P
Eur J Surg Oncol 1997 Dec;23(6):559-64. doi: 10.1016/s0748-7983(97)93269-8. PMID: 9484930

Diagnosis

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Brain and other central nervous system tumor statistics, 2021.
Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, Fuchs HE, Waite KA, Jemal A, Siegel RL, Barnholtz-Sloan JS
CA Cancer J Clin 2021 Sep;71(5):381-406. Epub 2021 Aug 24 doi: 10.3322/caac.21693. PMID: 34427324
Pediatric Neuro-Oncology.
Malbari F
Neurol Clin 2021 Aug;39(3):829-845. Epub 2021 Jun 10 doi: 10.1016/j.ncl.2021.04.005. PMID: 34215389
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW
Neuro Oncol 2021 Aug 2;23(8):1231-1251. doi: 10.1093/neuonc/noab106. PMID: 34185076Free PMC Article
Pediatric Ependymoma.
Vitanza NA, Partap S
J Child Neurol 2016 Oct;31(12):1354-66. Epub 2015 Oct 26 doi: 10.1177/0883073815610428. PMID: 26503805

Therapy

Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety.
Vitanza NA, Wilson AL, Huang W, Seidel K, Brown C, Gustafson JA, Yokoyama JK, Johnson AJ, Baxter BA, Koning RW, Reid AN, Meechan M, Biery MC, Myers C, Rawlings-Rhea SD, Albert CM, Browd SR, Hauptman JS, Lee A, Ojemann JG, Berens ME, Dun MD, Foster JB, Crotty EE, Leary SES, Cole BL, Perez FA, Wright JN, Orentas RJ, Chour T, Newell EW, Whiteaker JR, Zhao L, Paulovich AG, Pinto N, Gust J, Gardner RA, Jensen MC, Park JR
Cancer Discov 2023 Jan 9;13(1):114-131. doi: 10.1158/2159-8290.CD-22-0750. PMID: 36259971Free PMC Article
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Radiation-induced meningioma.
Umansky F, Shoshan Y, Rosenthal G, Fraifeld S, Spektor S
Neurosurg Focus 2008;24(5):E7. doi: 10.3171/FOC/2008/24/5/E7. PMID: 18447746
Neonatal brain tumors: a review.
Mazewski CM, Hudgins RJ, Reisner A, Geyer JR
Semin Perinatol 1999 Aug;23(4):286-98. doi: 10.1016/s0146-0005(99)80037-8. PMID: 10475542
Pediatric central nervous system tumors.
Reddy AT, Packer RJ
Curr Opin Oncol 1998 May;10(3):186-93. doi: 10.1097/00001622-199805000-00003. PMID: 9619353

Prognosis

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Epidemiology of Brain and Other CNS Tumors.
Ostrom QT, Francis SS, Barnholtz-Sloan JS
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):68. doi: 10.1007/s11910-021-01152-9. PMID: 34817716Free PMC Article
EANO-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours.
Le Rhun E, Guckenberger M, Smits M, Dummer R, Bachelot T, Sahm F, Galldiks N, de Azambuja E, Berghoff AS, Metellus P, Peters S, Hong YK, Winkler F, Schadendorf D, van den Bent M, Seoane J, Stahel R, Minniti G, Wesseling P, Weller M, Preusser M; EANO Executive Board and ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2021 Nov;32(11):1332-1347. Epub 2021 Aug 6 doi: 10.1016/j.annonc.2021.07.016. PMID: 34364998
Pediatric Neuro-Oncology.
Malbari F
Neurol Clin 2021 Aug;39(3):829-845. Epub 2021 Jun 10 doi: 10.1016/j.ncl.2021.04.005. PMID: 34215389
Pediatric central nervous system tumors.
Reddy AT, Packer RJ
Curr Opin Oncol 1998 May;10(3):186-93. doi: 10.1097/00001622-199805000-00003. PMID: 9619353

Clinical prediction guides

TULIPs decorate the three-dimensional genome of PFA ependymoma.
Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M
Cell 2024 Sep 5;187(18):4926-4945.e22. Epub 2024 Jul 9 doi: 10.1016/j.cell.2024.06.023. PMID: 38986619
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995
Craniopharyngioma in childhood.
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867
Radiation-induced meningiomas.
Boljesíkova E, Chorvath M
Neoplasma 2001;48(6):442-4. PMID: 11949834

Recent systematic reviews

Brain and Brain Stem Necrosis After Reirradiation for Recurrent Childhood Primary Central Nervous System Tumors: A PENTEC Comprehensive Review.
Ajithkumar T, Avanzo M, Yorke E, Tsang DS, Milano MT, Olch AJ, Merchant TE, Dieckmann K, Mahajan A, Fuji H, Paulino AC, Timmermann B, Marks LB, Bentzen SM, Jackson A, Constine LS
Int J Radiat Oncol Biol Phys 2024 Jun 1;119(2):655-668. Epub 2024 Feb 1 doi: 10.1016/j.ijrobp.2023.12.043. PMID: 38300187
Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.
Onyije FM, Dolatkhah R, Olsson A, Bouaoun L, Deltour I, Erdmann F, Bonaventure A, Scheurer ME, Clavel J, Schüz J
Cancer Epidemiol 2024 Feb;88:102510. Epub 2023 Dec 5 doi: 10.1016/j.canep.2023.102510. PMID: 38056243Free PMC Article
Fusiform Dilatation of the Internal Carotid Artery in Childhood-Onset Craniopharyngioma: A Systematic Review.
Jamshidi AM, Soldozy S, Elarjani T, Burks JD, Luther E, Starke RM
World Neurosurg 2022 Jun;162:77-84. Epub 2021 Sep 20 doi: 10.1016/j.wneu.2021.09.058. PMID: 34555575
Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia.
Richards S, Pui CH, Gayon P; Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG)
Pediatr Blood Cancer 2013 Feb;60(2):185-95. Epub 2012 Jun 12 doi: 10.1002/pbc.24228. PMID: 22693038Free PMC Article
Is there a role for high dose chemotherapy with hematopoietic stem cell rescue in patients with relapsed supratentorial PNET?
Raghuram CP, Moreno L, Zacharoulis S
J Neurooncol 2012 Feb;106(3):441-7. Epub 2011 Aug 18 doi: 10.1007/s11060-011-0690-6. PMID: 21850536

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