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Normal breast-like subtype of breast carcinoma

MedGen UID:
771111
•Concept ID:
C3642471
•
Neoplastic Process
Synonyms: Normal Breast-Like Subtype of Breast Cancer; normal breast-like subtype of breast cancer; Normal Breast-Like Subtype of Breast Carcinoma; normal breast-like subtype of breast carcinoma
 
Monarch Initiative: MONDO:0006324

Definition

A biologic subset of breast carcinoma defined by high expression of many genes expressed by adipose and other non-epithelial tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNormal breast-like subtype of breast carcinoma

Professional guidelines

PubMed

Antiprogestins in breast cancer treatment: are we ready?
Lanari C, Wargon V, Rojas P, Molinolo AA
Endocr Relat Cancer 2012 Jun;19(3):R35-50. Epub 2012 May 3 doi: 10.1530/ERC-11-0378. PMID: 22351709
The changing role of pathology in breast cancer diagnosis and treatment.
Leong AS, Zhuang Z
Pathobiology 2011;78(2):99-114. Epub 2011 Jun 14 doi: 10.1159/000292644. PMID: 21677473Free PMC Article
Clinical relevance of the triple-negative breast cancer concept: genetic basis and clinical utility of the concept.
Linn SC, Van 't Veer LJ
Eur J Cancer 2009 Sep;45 Suppl 1:11-26. doi: 10.1016/S0959-8049(09)70012-7. PMID: 19775601

Recent clinical studies

Etiology

Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer.
Wu HJ, Chu PY
Int J Mol Sci 2021 Jan 10;22(2) doi: 10.3390/ijms22020636. PMID: 33435254Free PMC Article
Deconstructing the molecular portraits of breast cancer.
Prat A, Perou CM
Mol Oncol 2011 Feb;5(1):5-23. Epub 2010 Nov 24 doi: 10.1016/j.molonc.2010.11.003. PMID: 21147047Free PMC Article
Systems biology and genomics of breast cancer.
Perou CM, Børresen-Dale AL
Cold Spring Harb Perspect Biol 2011 Feb 1;3(2) doi: 10.1101/cshperspect.a003293. PMID: 21047916Free PMC Article
Clinical relevance of the triple-negative breast cancer concept: genetic basis and clinical utility of the concept.
Linn SC, Van 't Veer LJ
Eur J Cancer 2009 Sep;45 Suppl 1:11-26. doi: 10.1016/S0959-8049(09)70012-7. PMID: 19775601
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article

Diagnosis

Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer.
Wu HJ, Chu PY
Int J Mol Sci 2021 Jan 10;22(2) doi: 10.3390/ijms22020636. PMID: 33435254Free PMC Article
Immunohistochemical Surrogates for Molecular Classification of Breast Carcinoma: A 2015 Update.
Tang P, Tse GM
Arch Pathol Lab Med 2016 Aug;140(8):806-14. doi: 10.5858/arpa.2015-0133-RA. PMID: 27472239
Antiprogestins in breast cancer treatment: are we ready?
Lanari C, Wargon V, Rojas P, Molinolo AA
Endocr Relat Cancer 2012 Jun;19(3):R35-50. Epub 2012 May 3 doi: 10.1530/ERC-11-0378. PMID: 22351709
The changing role of pathology in breast cancer diagnosis and treatment.
Leong AS, Zhuang Z
Pathobiology 2011;78(2):99-114. Epub 2011 Jun 14 doi: 10.1159/000292644. PMID: 21677473Free PMC Article
Systems biology and genomics of breast cancer.
Perou CM, Børresen-Dale AL
Cold Spring Harb Perspect Biol 2011 Feb 1;3(2) doi: 10.1101/cshperspect.a003293. PMID: 21047916Free PMC Article

Therapy

Antiprogestins in breast cancer treatment: are we ready?
Lanari C, Wargon V, Rojas P, Molinolo AA
Endocr Relat Cancer 2012 Jun;19(3):R35-50. Epub 2012 May 3 doi: 10.1530/ERC-11-0378. PMID: 22351709
Clinical relevance of the triple-negative breast cancer concept: genetic basis and clinical utility of the concept.
Linn SC, Van 't Veer LJ
Eur J Cancer 2009 Sep;45 Suppl 1:11-26. doi: 10.1016/S0959-8049(09)70012-7. PMID: 19775601
Contemplating chemosensitivity of basal-like breast cancer based on BRCA1 dysfunction.
Ohta T, Wu W, Koike A, Asakawa H, Koizumi H, Fukuda M
Breast Cancer 2009;16(4):268-74. Epub 2009 May 21 doi: 10.1007/s12282-009-0115-y. PMID: 19459031

Prognosis

DNAJC9 expression in basal-like and luminal A breast cancer subtypes predicts worse survival.
Incekara O, Acun T
Mol Biol Rep 2023 Sep;50(9):7275-7282. Epub 2023 Jul 8 doi: 10.1007/s11033-023-08654-4. PMID: 37422538
Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer.
Wu HJ, Chu PY
Int J Mol Sci 2021 Jan 10;22(2) doi: 10.3390/ijms22020636. PMID: 33435254Free PMC Article
The changing role of pathology in breast cancer diagnosis and treatment.
Leong AS, Zhuang Z
Pathobiology 2011;78(2):99-114. Epub 2011 Jun 14 doi: 10.1159/000292644. PMID: 21677473Free PMC Article
Systems biology and genomics of breast cancer.
Perou CM, Børresen-Dale AL
Cold Spring Harb Perspect Biol 2011 Feb 1;3(2) doi: 10.1101/cshperspect.a003293. PMID: 21047916Free PMC Article
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article

Clinical prediction guides

DNAJC9 expression in basal-like and luminal A breast cancer subtypes predicts worse survival.
Incekara O, Acun T
Mol Biol Rep 2023 Sep;50(9):7275-7282. Epub 2023 Jul 8 doi: 10.1007/s11033-023-08654-4. PMID: 37422538
Molecular subtyping of breast cancer intrinsic taxonomy with oligonucleotide microarray and NanoString nCounter.
Chen YJ, Huang CS, Phan NN, Lu TP, Liu CY, Huang CJ, Chiu JH, Tseng LM, Huang CC
Biosci Rep 2021 Aug 27;41(8) doi: 10.1042/BSR20211428. PMID: 34387660Free PMC Article
The changing role of pathology in breast cancer diagnosis and treatment.
Leong AS, Zhuang Z
Pathobiology 2011;78(2):99-114. Epub 2011 Jun 14 doi: 10.1159/000292644. PMID: 21677473Free PMC Article
Systems biology and genomics of breast cancer.
Perou CM, Børresen-Dale AL
Cold Spring Harb Perspect Biol 2011 Feb 1;3(2) doi: 10.1101/cshperspect.a003293. PMID: 21047916Free PMC Article
Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma.
Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, Akslen LA, Ragaz J, Gown AM, Gilks CB, van de Rijn M, Perou CM
Clin Cancer Res 2004 Aug 15;10(16):5367-74. doi: 10.1158/1078-0432.CCR-04-0220. PMID: 15328174

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