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Disseminated Oka Varicella Zoster Virus Infection

MedGen UID:
823214
•Concept ID:
C3830466
•
Disease or Syndrome
Synonyms: Disseminated Oka VZV Infection; Disseminated Varicella Zoster Vaccine Virus Infection

Definition

A rare systemic and life-threatening infection associated with vaccination with the live attenuated strain of the Varicella-zoster virus, Oka. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisseminated Oka Varicella Zoster Virus Infection

Recent clinical studies

Etiology

Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
Coralie R, Ziad C, Christian R, Pierre T, Chantal B, Bruce T, Philippe O
Pediatr Transplant 2023 Sep;27(6):e14562. Epub 2023 Jul 3 doi: 10.1111/petr.14562. PMID: 37395442
Protocol of a randomised controlled trial characterising the immune responses induced by varicella-zoster virus (VZV) vaccination in healthy Kenyan women: setting the stage for a potential VZV-based HIV vaccine.
Perciani CT, Jaoko W, Walmsley S, Farah B, Mahmud SM, Ostrowski M, Anzala O, Team KI, MacDonald KS
BMJ Open 2017 Sep 21;7(9):e017391. doi: 10.1136/bmjopen-2017-017391. PMID: 28939581Free PMC Article
Chickenpox vaccines: new drugs. A favourable risk-benefit balance in some situations.
Prescrire Int 2005 Jun;14(77):85-91. PMID: 15977369
Viral strain identification in varicella vaccinees with disseminated rashes.
LaRussa P, Steinberg SP, Shapiro E, Vazquez M, Gershon AA
Pediatr Infect Dis J 2000 Nov;19(11):1037-9. doi: 10.1097/00006454-200011000-00002. PMID: 11099082
Varicella vaccine in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma.
Yeung CY, Liang DC
Pediatr Hematol Oncol 1992 Jan-Mar;9(1):29-34. doi: 10.3109/08880019209006393. PMID: 1313688

Diagnosis

Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
Fashina OA, Chuang TM, Galardy PJ, Huskins WC, Levy ER, Streck NT, Chakraborty R
BMC Infect Dis 2024 Nov 14;24(1):1296. doi: 10.1186/s12879-024-09776-1. PMID: 39543470Free PMC Article
Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
Coralie R, Ziad C, Christian R, Pierre T, Chantal B, Bruce T, Philippe O
Pediatr Transplant 2023 Sep;27(6):e14562. Epub 2023 Jul 3 doi: 10.1111/petr.14562. PMID: 37395442
Live zoster vaccination in an immunocompromised patient leading to death secondary to disseminated varicella zoster virus infection.
Alexander KE, Tong PL, Macartney K, Beresford R, Sheppeard V, Gupta M
Vaccine 2018 Jun 22;36(27):3890-3893. Epub 2018 May 25 doi: 10.1016/j.vaccine.2018.05.078. PMID: 29807711
Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: a case report and review of the literature.
Maves RC, Tripp MS, Dell TG, Bennett JW, Ahluwalia JS, Tamminga C, Baldwin JC, Starr CR, Grinkemeyer MD, Dempsey MP
J Clin Virol 2014 Jan;59(1):63-6. Epub 2013 Nov 1 doi: 10.1016/j.jcv.2013.10.027. PMID: 24257110
Varicella zoster virus.
McCrary ML, Severson J, Tyring SK
J Am Acad Dermatol 1999 Jul;41(1):1-14; quiz 15-6. doi: 10.1016/s0190-9622(99)70398-1. PMID: 10411403

Therapy

A booster administration of the OKA/SK strain causes fatal disseminated varicella in an immunocompetent child.
Kang HM, Kang KR, Kim YJ, Kang JH, Lee SY
J Med Virol 2023 Sep;95(9):e29108. doi: 10.1002/jmv.29108. PMID: 37715715
Disseminated vaccine-induced varicella infection in a kidney transplant recipient.
Berman MA, Rupp RE
Am J Transplant 2023 Nov;23(11):1806-1810. Epub 2023 Jun 5 doi: 10.1016/j.ajt.2023.05.034. PMID: 37286085
Disseminated varicella zoster virus infection following live attenuated herpes zoster vaccine: descriptive analysis of reports to Australia's spontaneous vaccine pharmacovigilance system, 2016-2020.
Li-Kim-Moy J, Phillips A, Morgan A, Glover C, Jayasinghe S, Hull BP, Dey A, Beard FH, Hickie M, Macartney K
BMJ Open 2023 Jan 27;13(1):e067287. doi: 10.1136/bmjopen-2022-067287. PMID: 36707120Free PMC Article
Prevention of Herpes Zoster: A Focus on the Effectiveness and Safety of Herpes Zoster Vaccines.
Marra Y, Lalji F
Viruses 2022 Nov 29;14(12) doi: 10.3390/v14122667. PMID: 36560671Free PMC Article
Herpes zoster vaccine live: A 10 year review of post-marketing safety experience.
Willis ED, Woodward M, Brown E, Popmihajlov Z, Saddier P, Annunziato PW, Halsey NA, Gershon AA
Vaccine 2017 Dec 19;35(52):7231-7239. Epub 2017 Nov 22 doi: 10.1016/j.vaccine.2017.11.013. PMID: 29174682Free PMC Article

Prognosis

Heightened incidence of adverse events associated with a live attenuated varicella vaccine strain that lacks critical genetic polymorphisms in open reading frame 62.
Kim YJ, Oh D, Kim J, Son J, Moon JY, Kim YK, Ahn B, Kang KR, Park D, Kang HM
Clin Microbiol Infect 2024 Nov;30(11):1466-1473. Epub 2024 Aug 30 doi: 10.1016/j.cmi.2024.08.018. PMID: 39209266
Live zoster vaccination in an immunocompromised patient leading to death secondary to disseminated varicella zoster virus infection.
Alexander KE, Tong PL, Macartney K, Beresford R, Sheppeard V, Gupta M
Vaccine 2018 Jun 22;36(27):3890-3893. Epub 2018 May 25 doi: 10.1016/j.vaccine.2018.05.078. PMID: 29807711
Fatal disseminated varicella zoster infection following zoster vaccination in an immunocompromised patient.
Costa E, Buxton J, Brown J, Templeton KE, Breuer J, Johannessen I
BMJ Case Rep 2016 May 4;2016 doi: 10.1136/bcr-2015-212688. PMID: 27147629Free PMC Article
The safety profile of varicella vaccine: a 10-year review.
Galea SA, Sweet A, Beninger P, Steinberg SP, Larussa PS, Gershon AA, Sharrar RG
J Infect Dis 2008 Mar 1;197 Suppl 2:S165-9. doi: 10.1086/522125. PMID: 18419392

Clinical prediction guides

Heightened incidence of adverse events associated with a live attenuated varicella vaccine strain that lacks critical genetic polymorphisms in open reading frame 62.
Kim YJ, Oh D, Kim J, Son J, Moon JY, Kim YK, Ahn B, Kang KR, Park D, Kang HM
Clin Microbiol Infect 2024 Nov;30(11):1466-1473. Epub 2024 Aug 30 doi: 10.1016/j.cmi.2024.08.018. PMID: 39209266
Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
Coralie R, Ziad C, Christian R, Pierre T, Chantal B, Bruce T, Philippe O
Pediatr Transplant 2023 Sep;27(6):e14562. Epub 2023 Jul 3 doi: 10.1111/petr.14562. PMID: 37395442
Herpes zoster vaccine live: A 10 year review of post-marketing safety experience.
Willis ED, Woodward M, Brown E, Popmihajlov Z, Saddier P, Annunziato PW, Halsey NA, Gershon AA
Vaccine 2017 Dec 19;35(52):7231-7239. Epub 2017 Nov 22 doi: 10.1016/j.vaccine.2017.11.013. PMID: 29174682Free PMC Article
Varicella vaccine in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma.
Yeung CY, Liang DC
Pediatr Hematol Oncol 1992 Jan-Mar;9(1):29-34. doi: 10.3109/08880019209006393. PMID: 1313688

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