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Microcystic adnexal carcinoma

MedGen UID:
83399
•Concept ID:
C0346027
•
Neoplastic Process
Synonym: Malignant syringoma
SNOMED CT: Eccrine epithelioma (400135003); Syringomatous carcinoma (128896007); Microcystic adnexal carcinoma (128896007); Sclerosing sweat duct carcinoma (128896007); Eccrine epithelioma of skin (254722001); Microcystic adnexal carcinoma of skin (254712007); Malignant syringoma (254712007); Syringoid eccrine carcinoma (254712007); Syringomatous sweat duct carcinoma (254712007); Sclerosing sweat duct carcinoma (254712007); Microcystic adnexal carcinoma (254712007); Eccrine epithelioma (254722001)
 
Monarch Initiative: MONDO:0003519

Definition

A low grade adenocarcinoma with ductal differentiation, arising from the sweat glands. It presents as a scar usually in the face. It is characterized by the formation of small ducts and it frequently involves nerves and perineural spaces. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrocystic adnexal carcinoma

Professional guidelines

PubMed

Microcystic adnexal carcinoma of the head and neck: Characteristics, treatment, and survival statistics.
Behbahani S, Yeh CJ, Pinto JO, Wassef D, Povolotskiy R, Joseph N, Lambert WC, Schwartz RA
Dermatol Ther 2021 Jan;34(1):e14559. Epub 2020 Dec 3 doi: 10.1111/dth.14559. PMID: 33210380
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Determinants of Microcystic Adnexal Carcinoma Management and Outcomes in British Columbia.
Burleigh A, Zloty D, Crawford RI
J Cutan Med Surg 2020 Sep/Oct;24(5):536-537. Epub 2020 Jun 25 doi: 10.1177/1203475420936646. PMID: 32584171

Recent clinical studies

Etiology

Plaque-Type Syringoma Masquerading as Microcystic Adnexal Carcinoma: Review of the Literature and Description of a Novel Technique That Emphasizes Lesion Architecture to Help Make the Diagnosis.
Clark M, Duprey C, Sutton A, Pelster MW, Maher IA, Hurley MY, Vidal C
Am J Dermatopathol 2019 Sep;41(9):e98-e101. doi: 10.1097/DAD.0000000000001415. PMID: 30921007
Demographics and outcomes of microcystic adnexal carcinoma.
King BJ, Tolkachjov SN, Winchester DS, Baum CL, Brewer JD, Arpey CJ, Otley CC, Roenigk RK
J Am Acad Dermatol 2018 Oct;79(4):756-758. Epub 2018 Mar 17 doi: 10.1016/j.jaad.2018.03.010. PMID: 29559397
Longstanding microcystic adnexal carcinoma in a child.
Rohani P, Ramirez R, Maluf H, Kelly KJ
Int J Dermatol 2017 Jul;56(7):782-783. Epub 2017 May 23 doi: 10.1111/ijd.13657. PMID: 28542906
Extrafacial microcystic adnexal carcinoma: case report and review of the literature.
Hansen T, Kingsley M, Mallatt BD, Krishnan R
Dermatol Surg 2009 Nov;35(11):1835-9. Epub 2009 Aug 18 doi: 10.1111/j.1524-4725.2009.01301.x. PMID: 19691664
Microcystic adnexal carcinoma.
Delshad E, Ratner D
Skinmed 2004 Nov-Dec;3(6):341-3. doi: 10.1111/j.1540-9740.2004.03010.x. PMID: 15538086

Diagnosis

Microcystic Adnexal Carcinoma with Xanthomatous Reaction.
Fujii K, Arimura A, Ibusuki A, Uchida Y, Kanekura T
Acta Derm Venereol 2021 Apr 26;101(4):adv00436. doi: 10.2340/00015555-3792. PMID: 33734422Free PMC Article
Microcystic adnexal carcinoma.
Kura MM, Aliporewala VM, Bolde S, Bijwe S
Indian J Dermatol Venereol Leprol 2020 Sep-Oct;86(5):595-596. doi: 10.4103/ijdvl.IJDVL_677_18. PMID: 31347515
Plaque-Type Syringoma Masquerading as Microcystic Adnexal Carcinoma: Review of the Literature and Description of a Novel Technique That Emphasizes Lesion Architecture to Help Make the Diagnosis.
Clark M, Duprey C, Sutton A, Pelster MW, Maher IA, Hurley MY, Vidal C
Am J Dermatopathol 2019 Sep;41(9):e98-e101. doi: 10.1097/DAD.0000000000001415. PMID: 30921007
Diagnosis of pigmented microcystic adnexal carcinoma.
Lan XM, Zhong BY, Yan H, Feng L, Tan H, Yang XC
G Ital Dermatol Venereol 2016 Oct;151(5):564-5. PMID: 27595204
Microcystic adnexal carcinoma.
Adamson T
Dermatol Nurs 2004 Aug;16(4):365. PMID: 15471052

Therapy

Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Plaque-Type Syringoma Masquerading as Microcystic Adnexal Carcinoma: Review of the Literature and Description of a Novel Technique That Emphasizes Lesion Architecture to Help Make the Diagnosis.
Clark M, Duprey C, Sutton A, Pelster MW, Maher IA, Hurley MY, Vidal C
Am J Dermatopathol 2019 Sep;41(9):e98-e101. doi: 10.1097/DAD.0000000000001415. PMID: 30921007
Treatments for microcystic adnexal carcinoma--A review.
Chaudhari SP, Mortazie MB, Blattner CM, Garelik J, Wolff M, Daulat J, Chaudhari PJ
J Dermatolog Treat 2016;27(3):278-84. Epub 2015 Nov 11 doi: 10.3109/09546634.2015.1089351. PMID: 26331917
Microcystic adnexal carcinoma induced by multiple radiation therapy.
Schwarze HP, Loche F, Lamant L, Kuchta J, Bazex J
Int J Dermatol 2000 May;39(5):369-72. doi: 10.1046/j.1365-4362.2000.00841-2.x. PMID: 10849130
Microcystic adnexal carcinoma: report of a case.
Robinson ML, Knibbe MA, Roberson JB
J Oral Maxillofac Surg 1995 Jul;53(7):846-9. doi: 10.1016/0278-2391(95)90347-x. PMID: 7595804

Prognosis

Plaque-Type Syringoma Masquerading as Microcystic Adnexal Carcinoma: Review of the Literature and Description of a Novel Technique That Emphasizes Lesion Architecture to Help Make the Diagnosis.
Clark M, Duprey C, Sutton A, Pelster MW, Maher IA, Hurley MY, Vidal C
Am J Dermatopathol 2019 Sep;41(9):e98-e101. doi: 10.1097/DAD.0000000000001415. PMID: 30921007
Demographics and outcomes of microcystic adnexal carcinoma.
King BJ, Tolkachjov SN, Winchester DS, Baum CL, Brewer JD, Arpey CJ, Otley CC, Roenigk RK
J Am Acad Dermatol 2018 Oct;79(4):756-758. Epub 2018 Mar 17 doi: 10.1016/j.jaad.2018.03.010. PMID: 29559397
Microcystic Adnexal Carcinoma: A Review of the Literature.
Gordon S, Fischer C, Martin A, Rosman IS, Council ML
Dermatol Surg 2017 Aug;43(8):1012-1016. doi: 10.1097/DSS.0000000000001142. PMID: 28654578
Longstanding microcystic adnexal carcinoma in a child.
Rohani P, Ramirez R, Maluf H, Kelly KJ
Int J Dermatol 2017 Jul;56(7):782-783. Epub 2017 May 23 doi: 10.1111/ijd.13657. PMID: 28542906
Microcystic adnexal carcinoma.
Delshad E, Ratner D
Skinmed 2004 Nov-Dec;3(6):341-3. doi: 10.1111/j.1540-9740.2004.03010.x. PMID: 15538086

Clinical prediction guides

Expression of Hedgehog signalling molecules in microcystic adnexal carcinoma.
Gambichler T, Hartenstein I, Dreißigacker M, Stockfleth E, Stücker M, Schaller J, Schulze HJ, Becker JC, Käfferlein HU, Brüning T, Lang K
Clin Exp Dermatol 2021 Aug;46(6):1052-1057. Epub 2021 May 1 doi: 10.1111/ced.14634. PMID: 33714217
Microcystic adnexal carcinoma with multiple areas of follicular differentiation toward germinative cells and specific follicular stroma (trichoblastomatous areas).
Kazakov DV, Kacerovska D, Michal M
Am J Dermatopathol 2011 Jun;33(4):e47-9. doi: 10.1097/DAD.0b013e3181ea1385. PMID: 21252639
Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge.
Wetter R, Goldstein GD
Dermatol Ther 2008 Nov-Dec;21(6):452-8. doi: 10.1111/j.1529-8019.2008.00246.x. PMID: 19076623
Microcystic adnexal carcinoma. Immunohistologic observations suggesting dual (pilar and eccrine) differentiation.
Nickoloff BJ, Fleischmann HE, Carmel J, Wood CC, Roth RJ
Arch Dermatol 1986 Mar;122(3):290-4. doi: 10.1001/archderm.122.3.290. PMID: 3513708
Microcystic adnexal carcinoma.
Cooper PH, Mills SE
J Am Acad Dermatol 1984 May;10(5 Pt 2):908-14. doi: 10.1016/s0190-9622(84)80445-4. PMID: 6725679

Recent systematic reviews

A Systematic Review of the Epidemiology, Clinical Characteristics, Treatment, and Outcomes for Desmoplastic Trichoepithelioma: Underscoring Mohs Micrographic Surgery in Management.
Nanda R, Srivastava D, Nijhawan RI
Dermatol Surg 2024 Aug 1;50(8):695-698. Epub 2024 Apr 9 doi: 10.1097/DSS.0000000000004194. PMID: 38595132
Emerging therapies for rare cutaneous cancers: A systematic review.
Garcia A, Nelson K, Patel V
Cancer Treat Rev 2021 Nov;100:102266. Epub 2021 Aug 16 doi: 10.1016/j.ctrv.2021.102266. PMID: 34418780

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