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Adult pineal parenchymal tumor

MedGen UID:
83710
•Concept ID:
C0280794
•
Neoplastic Process
Synonyms: Adult Pineal Gland Neoplasm; adult pineal gland neoplasm; Adult Pineal Gland Tumor; adult pineal gland tumor; adult pineal gland tumour; Adult Pineal Parenchymal Cell Neoplasm; adult pineal parenchymal cell neoplasm; Adult Pineal Parenchymal Cell Tumor; adult pineal parenchymal cell tumor; adult pineal parenchymal cell tumour; Adult Pineal Parenchymal Neoplasm; adult pineal parenchymal neoplasm; Adult Pineal Parenchymal Tumor; adult pineal parenchymal tumor; Parenchymal Neoplasm of Adult Pineal Gland; parenchymal neoplasm of adult pineal gland; Parenchymal Neoplasm of the Adult Pineal Gland; parenchymal neoplasm of the adult pineal gland; Parenchymal Tumor of Adult Pineal Gland; parenchymal tumor of adult pineal gland; Parenchymal Tumor of the Adult Pineal Gland; parenchymal tumor of the adult pineal gland; parenchymal tumour of adult pineal gland; parenchymal tumour of the adult pineal gland; pineal parenchymal cell neoplasm of adults
 
Monarch Initiative: MONDO:0003248

Definition

A pineal parenchymal cell neoplasm (pineocytoma or pineoblastoma) occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult pineal parenchymal tumor

Professional guidelines

PubMed

Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Pineal Region Glioblastomas: Clinical Characteristics, Treatment, and Survival Outcome.
Niu X, Wang C, Zhou X, Yang Y, Liu Y, Zhang Y, Mao Q
World Neurosurg 2021 Feb;146:e799-e810. Epub 2020 Nov 10 doi: 10.1016/j.wneu.2020.11.016. PMID: 33186787
Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India.
Biswas A, Mallick S, Purkait S, Gandhi A, Sarkar C, Singh M, Julka PK, Rath GK
Childs Nerv Syst 2015 Aug;31(8):1291-304. Epub 2015 Jun 4 doi: 10.1007/s00381-015-2751-1. PMID: 26040934

Recent clinical studies

Etiology

Pineal/germ cell tumors and pineal parenchymal tumors.
Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Melatonin Therapy Improves Cardiac Autonomic Modulation in Pinealectomized Patients.
Campos LA, Bueno C, Barcelos IP, Halpern B, Brito LC, Amaral FG, Baltatu OC, Cipolla-Neto J
Front Endocrinol (Lausanne) 2020;11:239. Epub 2020 Apr 30 doi: 10.3389/fendo.2020.00239. PMID: 32431667Free PMC Article
Metastases to the pineal gland.
Lassman AB, Bruce JN, Fetell MR
Neurology 2006 Oct 10;67(7):1303-4. doi: 10.1212/01.wnl.0000238516.29603.33. PMID: 17030775
Extragonadal and pediatric germ cell tumors.
Nichols CR, Fox EP
Hematol Oncol Clin North Am 1991 Dec;5(6):1189-209. PMID: 1663939
Apudomas.
Nakano PH, Bloom RR, Brown BC, Gray SW, Skandalakis JE, Kibbe JM
Am Surg 1987 Sep;53(9):505-9. PMID: 2820286

Diagnosis

Pineal/germ cell tumors and pineal parenchymal tumors.
Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Adult Brain Tumors and Pseudotumors: Interesting (Bizarre) Cases.
Causil LD, Ames R, Puac P, Castillo M
Neuroimaging Clin N Am 2016 Nov;26(4):667-689. doi: 10.1016/j.nic.2016.06.012. PMID: 27712799
Pineal region myeloid sarcoma.
Wilson TJ, Than KD, Parmar HA, Lieberman AP, Valdivia JM, Sullivan SE
J Clin Neurosci 2012 Jul;19(7):1037-9. Epub 2012 May 2 doi: 10.1016/j.jocn.2011.11.014. PMID: 22560847
Pinealoma.
Backman HA
Am J Optom Physiol Opt 1987 Jul;64(7):543-4. doi: 10.1097/00006324-198707000-00011. PMID: 3631213
Pineal region tumors.
Boyd MC, Steinbok P
Can J Neurol Sci 1985 Feb;12(1):35-8. doi: 10.1017/s0317167100046552. PMID: 3978473

Therapy

Delayed-onset seesaw nystagmus following brain irradiation.
Fridman G, Distefano A
Digit J Ophthalmol 2021 Jun;27(2):29-32. Epub 2021 May 17 doi: 10.5693/djo.02.2020.12.002. PMID: 34512208Free PMC Article
Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.
Liu APY, Li BK, Pfaff E, Gudenas B, Vasiljevic A, Orr BA, Dufour C, Snuderl M, Karajannis MA, Rosenblum MK, Hwang EI, Ng HK, Hansford JR, Szathmari A, Faure-Conter C, Merchant TE, Levine M, Bouvier N, von Hoff K, Mynarek M, Rutkowski S, Sahm F, Kool M, Hawkins C, Onar-Thomas A, Robinson GW, Gajjar A, Pfister SM, Bouffet E, Northcott PA, Jones DTW, Huang A
Acta Neuropathol 2021 May;141(5):771-785. Epub 2021 Feb 22 doi: 10.1007/s00401-021-02284-5. PMID: 33619588Free PMC Article
Melatonin Therapy Improves Cardiac Autonomic Modulation in Pinealectomized Patients.
Campos LA, Bueno C, Barcelos IP, Halpern B, Brito LC, Amaral FG, Baltatu OC, Cipolla-Neto J
Front Endocrinol (Lausanne) 2020;11:239. Epub 2020 Apr 30 doi: 10.3389/fendo.2020.00239. PMID: 32431667Free PMC Article
Pineal germinoma with a prominent epithelioid cell granuloma component: case report.
Mori R, Nakajima M, Sakai H, Fukunaga M, Abe T
Neurol Med Chir (Tokyo) 2008 Dec;48(12):573-5. doi: 10.2176/nmc.48.573. PMID: 19106497
A case of anorexia.
Br Med J 1973 Apr 21;2(5859):156-61. PMID: 4735516Free PMC Article

Prognosis

Primary pineal rhabdomyosarcoma in an adult male patient: A rare presentation and review of the literature.
Pandey L, Joseph D, Arora R, Singh A, Kassim N, Pasricha R, Gupta M
Clin Neurol Neurosurg 2020 Sep;196:106044. Epub 2020 Jun 24 doi: 10.1016/j.clineuro.2020.106044. PMID: 32604035
Adult Brain Tumors and Pseudotumors: Interesting (Bizarre) Cases.
Causil LD, Ames R, Puac P, Castillo M
Neuroimaging Clin N Am 2016 Nov;26(4):667-689. doi: 10.1016/j.nic.2016.06.012. PMID: 27712799
Pineal germinoma.
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Extragonadal and pediatric germ cell tumors.
Nichols CR, Fox EP
Hematol Oncol Clin North Am 1991 Dec;5(6):1189-209. PMID: 1663939
Pinealoma.
Backman HA
Am J Optom Physiol Opt 1987 Jul;64(7):543-4. doi: 10.1097/00006324-198707000-00011. PMID: 3631213

Clinical prediction guides

Neurosurgical application of pineal region tumor resection with 3D 4K exoscopy via infratentorial approach: a retrospective cohort study.
Hua W, Zhang X, Wang Q, Qiu T, Yang Z, Wang X, Xu H, Zhang J, Yu G, Fu M, Chen L, Zhu W, Mao Y
Int J Surg 2023 Dec 1;109(12):4062-4072. doi: 10.1097/JS9.0000000000000707. PMID: 37755386Free PMC Article
Pathologic Prognostic Factors of Pineal Parenchymal Tumor of Intermediate Differentiation.
Chatterjee D, Lath K, Singla N, Kumar N, Radotra BD
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):210-215. doi: 10.1097/PAI.0000000000000565. PMID: 28800009
MRI of intracranial germ cell tumours.
Sumida M, Uozumi T, Kiya K, Mukada K, Arita K, Kurisu K, Sugiyama K, Onda J, Satoh H, Ikawa F
Neuroradiology 1995 Jan;37(1):32-7. doi: 10.1007/BF00588516. PMID: 7708186
Surgical approach to pineal tumours.
Pluchino F, Broggi G, Fornari M, Franzini A, Solero CL, Allegranza A
Acta Neurochir (Wien) 1989;96(1-2):26-31. doi: 10.1007/BF01403491. PMID: 2929390
Trans-reservoiral ventriculography (TRV).
Suzuki S, Ottomo M, Suzuki M
Acta Neurochir (Wien) 1979;45(3-4):311-8. doi: 10.1007/BF01769144. PMID: 311578

Recent systematic reviews

Good clinical outcomes and the necessity of CSF drainage in patients undergoing simultaneous biopsy and endoscopic third ventriculostomy in the region of pineal tumors: A systematic review and meta-analysis.
Porto Sousa M, Gomes Cabral Junior S, Virgilio Ribeiro F, Nunes Pustilnik H, Yuri Ferreira M, Verly G, Pedro Bittar Sanches J, Snyder Crespo Zavala N, Muszkat Besborodco R, Vinicius Figueredo Almeida C, Oliveira LB, Batista S, Campos Gomes Pinto F, Bertani R
J Clin Neurosci 2024 Aug;126:234-244. Epub 2024 Jul 5 doi: 10.1016/j.jocn.2024.07.001. PMID: 38970969
Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Papillary tumor of the pineal region in pediatric populations: An additional case and systematic review of a rare tumor entity.
Mathkour M, Hanna J, Ibrahim N, Scullen T, Kilgore MD, Werner C, Cormier I, Spencer P, Keen JR, Bui CJ
Clin Neurol Neurosurg 2021 Feb;201:106404. Epub 2020 Dec 8 doi: 10.1016/j.clineuro.2020.106404. PMID: 33360024
Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors.
Yamaki VN, Solla DJF, Ribeiro RR, da Silva SA, Teixeira MJ, Figueiredo EG
Neurosurgery 2019 Sep 1;85(3):E420-E429. doi: 10.1093/neuros/nyz062. PMID: 30989225
Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers.
Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646

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