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Iron metabolism disease

MedGen UID:
8438
•Concept ID:
C0012715
•
Disease or Syndrome
Synonym: iron metabolism disorder
SNOMED CT: Disorder of iron metabolism (30913008)
 
Monarch Initiative: MONDO:0002279

Definition

Disorders in the processing of iron in the body: its absorption, transport, storage, and utilization. [from MONDO]

Professional guidelines

PubMed

Iron deficiency anaemia: pathophysiology, assessment, practical management.
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ
BMJ Open Gastroenterol 2022 Jan;9(1) doi: 10.1136/bmjgast-2021-000759. PMID: 34996762Free PMC Article
Anaemia of chronic diseases: Pathophysiology, diagnosis and treatment.
de Las Cuevas Allende R, Díaz de Entresotos L, Conde Díez S
Med Clin (Barc) 2021 Mar 12;156(5):235-242. Epub 2020 Dec 24 doi: 10.1016/j.medcli.2020.07.035. PMID: 33358297
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P; ESC Scientific Document Group
Eur Heart J 2016 Jul 14;37(27):2129-2200. Epub 2016 May 20 doi: 10.1093/eurheartj/ehw128. PMID: 27206819

Recent clinical studies

Etiology

Are the Soluble Receptors sRAGE, sRANKL, and Osteoprotegerin Associated with Anemia in Rheumatoid Arthritis?
Stefanova K, Delcheva G, Stankova T
Int J Mol Sci 2024 Nov 27;25(23) doi: 10.3390/ijms252312729. PMID: 39684440Free PMC Article
Regression of Fibrosis Stage With Treatment Reduces Long-Term Risk of Liver Cancer in Patients With Hemochromatosis Caused by Mutation in HFE.
Bardou-Jacquet E, Morandeau E, Anderson GJ, Ramm GA, Ramm LE, Morcet J, Bouzille G, Dixon J, Clouston AD, Lainé F, Turlin B, Powell LW, Deugnier YM
Clin Gastroenterol Hepatol 2020 Jul;18(8):1851-1857. Epub 2019 Oct 14 doi: 10.1016/j.cgh.2019.10.010. PMID: 31622736
Impact of Preoperative Iron Deficiency on Blood Transfusion in Elective Cardiac Surgery.
Hubert M, Gaudriot B, Biedermann S, Gouezec H, Sylvestre E, Bouzille G, Verhoye JP, Flecher E, Ecoffey C
J Cardiothorac Vasc Anesth 2019 Aug;33(8):2141-2150. Epub 2019 Feb 11 doi: 10.1053/j.jvca.2019.02.006. PMID: 30857851
Variable expressivity of HJV related hemochromatosis: "Juvenile" hemochromatosis?
Hamdi-Rozé H, Ben Ali Z, Ropert M, Detivaud L, Aggoune S, Simon D, Pelletier G, Deugnier Y, David V, Bardou-Jacquet E
Blood Cells Mol Dis 2019 Feb;74:30-33. Epub 2018 Oct 22 doi: 10.1016/j.bcmd.2018.10.006. PMID: 30389309

Diagnosis

New Mutations in HFE2 and TFR2 Genes Causing Non HFE-Related Hereditary Hemochromatosis.
Hernández G, Ferrer-Cortès X, Venturi V, Musri M, Pilquil MF, Torres PMM, Rodríguez IH, Mínguez MÀR, Kelleher NJ, Pelucchi S, Piperno A, Alberca EP, Ricós GG, Giró EC, Pérez-Montero S, Tornador C, Villà-Freixa J, Sánchez M
Genes (Basel) 2021 Dec 13;12(12) doi: 10.3390/genes12121980. PMID: 34946929Free PMC Article
Regression of Fibrosis Stage With Treatment Reduces Long-Term Risk of Liver Cancer in Patients With Hemochromatosis Caused by Mutation in HFE.
Bardou-Jacquet E, Morandeau E, Anderson GJ, Ramm GA, Ramm LE, Morcet J, Bouzille G, Dixon J, Clouston AD, Lainé F, Turlin B, Powell LW, Deugnier YM
Clin Gastroenterol Hepatol 2020 Jul;18(8):1851-1857. Epub 2019 Oct 14 doi: 10.1016/j.cgh.2019.10.010. PMID: 31622736
Impact of Preoperative Iron Deficiency on Blood Transfusion in Elective Cardiac Surgery.
Hubert M, Gaudriot B, Biedermann S, Gouezec H, Sylvestre E, Bouzille G, Verhoye JP, Flecher E, Ecoffey C
J Cardiothorac Vasc Anesth 2019 Aug;33(8):2141-2150. Epub 2019 Feb 11 doi: 10.1053/j.jvca.2019.02.006. PMID: 30857851
Variable expressivity of HJV related hemochromatosis: "Juvenile" hemochromatosis?
Hamdi-Rozé H, Ben Ali Z, Ropert M, Detivaud L, Aggoune S, Simon D, Pelletier G, Deugnier Y, David V, Bardou-Jacquet E
Blood Cells Mol Dis 2019 Feb;74:30-33. Epub 2018 Oct 22 doi: 10.1016/j.bcmd.2018.10.006. PMID: 30389309

Therapy

Impact of Preoperative Iron Deficiency on Blood Transfusion in Elective Cardiac Surgery.
Hubert M, Gaudriot B, Biedermann S, Gouezec H, Sylvestre E, Bouzille G, Verhoye JP, Flecher E, Ecoffey C
J Cardiothorac Vasc Anesth 2019 Aug;33(8):2141-2150. Epub 2019 Feb 11 doi: 10.1053/j.jvca.2019.02.006. PMID: 30857851

Clinical prediction guides

Are the Soluble Receptors sRAGE, sRANKL, and Osteoprotegerin Associated with Anemia in Rheumatoid Arthritis?
Stefanova K, Delcheva G, Stankova T
Int J Mol Sci 2024 Nov 27;25(23) doi: 10.3390/ijms252312729. PMID: 39684440Free PMC Article
Regression of Fibrosis Stage With Treatment Reduces Long-Term Risk of Liver Cancer in Patients With Hemochromatosis Caused by Mutation in HFE.
Bardou-Jacquet E, Morandeau E, Anderson GJ, Ramm GA, Ramm LE, Morcet J, Bouzille G, Dixon J, Clouston AD, Lainé F, Turlin B, Powell LW, Deugnier YM
Clin Gastroenterol Hepatol 2020 Jul;18(8):1851-1857. Epub 2019 Oct 14 doi: 10.1016/j.cgh.2019.10.010. PMID: 31622736
Impact of Preoperative Iron Deficiency on Blood Transfusion in Elective Cardiac Surgery.
Hubert M, Gaudriot B, Biedermann S, Gouezec H, Sylvestre E, Bouzille G, Verhoye JP, Flecher E, Ecoffey C
J Cardiothorac Vasc Anesth 2019 Aug;33(8):2141-2150. Epub 2019 Feb 11 doi: 10.1053/j.jvca.2019.02.006. PMID: 30857851

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