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Late-onset neonatal sepsis

MedGen UID:
853136
•Concept ID:
C1096721
•
Disease or Syndrome
Synonyms: Late-Onset Sepses, Neonatal; Late-Onset Sepsis, Neonatal; Neonatal Late Onset Sepsis; Neonatal Late-Onset Sepses; Neonatal Late-Onset Sepsis; Sepses, Neonatal Late-Onset; Sepsis, Neonatal Late-Onset
SNOMED CT: Late-onset neonatal sepsis (765107002)

Definition

An infectious disorder of newborn infants that is characterized by a systemic inflammatory response beyond 72 hours of life and is most commonly caused by bacteria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLate-onset neonatal sepsis

Professional guidelines

PubMed

Diagnostic capacity of miRNAs in neonatal sepsis: a systematic review and meta-analysis.
Zhao Y, Zhu R, Hu X
J Matern Fetal Neonatal Med 2024 Dec;37(1):2345850. Epub 2024 May 7 doi: 10.1080/14767058.2024.2345850. PMID: 38714508
Updates in Late-Onset Sepsis: Risk Assessment, Therapy, and Outcomes.
Coggins SA, Glaser K
Neoreviews 2022 Nov 1;23(11):738-755. doi: 10.1542/neo.23-10-e738. PMID: 36316254Free PMC Article
Considerations in the pharmacologic treatment and prevention of neonatal sepsis.
Stockmann C, Spigarelli MG, Campbell SC, Constance JE, Courter JD, Thorell EA, Olson J, Sherwin CM
Paediatr Drugs 2014 Feb;16(1):67-81. doi: 10.1007/s40272-013-0057-x. PMID: 24218112

Recent clinical studies

Etiology

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis.
Fleischmann C, Reichert F, Cassini A, Horner R, Harder T, Markwart R, Tröndle M, Savova Y, Kissoon N, Schlattmann P, Reinhart K, Allegranzi B, Eckmanns T
Arch Dis Child 2021 Jul 19;106(8):745-752. doi: 10.1136/archdischild-2020-320217. PMID: 33483376Free PMC Article
Aetiology and frequency of risk factors for late onset neonatal sepsis in a level IIIBb NICU.
Alonso-Ojembarrena A, Marín-Lozano ÁC, Galán-Sánchez F, Rodríguez-Iglesias MA
Enferm Infecc Microbiol Clin (Engl Ed) 2018 Feb;36(2):144-145. Epub 2017 May 19 doi: 10.1016/j.eimc.2017.03.012. PMID: 28532597
Late onset neonatal sepsis caused by group A streptococcus.
Saito R, Kerr-Liddell R, Paul SP
Br J Hosp Med (Lond) 2017 Mar 2;78(3):170-171. doi: 10.12968/hmed.2017.78.3.170. PMID: 28277774

Diagnosis

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Change-point detection for infinite horizon dynamic treatment regimes.
Goldberg Y, Pollak M, Mitelpunkt A, Orlovsky M, Weiss-Meilik A, Gorfine M
Stat Methods Med Res 2017 Aug;26(4):1590-1604. Epub 2017 May 10 doi: 10.1177/0962280217708655. PMID: 28490270
Late onset neonatal sepsis caused by group A streptococcus.
Saito R, Kerr-Liddell R, Paul SP
Br J Hosp Med (Lond) 2017 Mar 2;78(3):170-171. doi: 10.12968/hmed.2017.78.3.170. PMID: 28277774
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article

Therapy

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis.
Fleischmann C, Reichert F, Cassini A, Horner R, Harder T, Markwart R, Tröndle M, Savova Y, Kissoon N, Schlattmann P, Reinhart K, Allegranzi B, Eckmanns T
Arch Dis Child 2021 Jul 19;106(8):745-752. doi: 10.1136/archdischild-2020-320217. PMID: 33483376Free PMC Article
Late onset neonatal sepsis caused by group A streptococcus.
Saito R, Kerr-Liddell R, Paul SP
Br J Hosp Med (Lond) 2017 Mar 2;78(3):170-171. doi: 10.12968/hmed.2017.78.3.170. PMID: 28277774
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article

Prognosis

Diagnostic capacity of miRNAs in neonatal sepsis: a systematic review and meta-analysis.
Zhao Y, Zhu R, Hu X
J Matern Fetal Neonatal Med 2024 Dec;37(1):2345850. Epub 2024 May 7 doi: 10.1080/14767058.2024.2345850. PMID: 38714508
Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis.
Fleischmann C, Reichert F, Cassini A, Horner R, Harder T, Markwart R, Tröndle M, Savova Y, Kissoon N, Schlattmann P, Reinhart K, Allegranzi B, Eckmanns T
Arch Dis Child 2021 Jul 19;106(8):745-752. doi: 10.1136/archdischild-2020-320217. PMID: 33483376Free PMC Article
Aetiology and frequency of risk factors for late onset neonatal sepsis in a level IIIBb NICU.
Alonso-Ojembarrena A, Marín-Lozano ÁC, Galán-Sánchez F, Rodríguez-Iglesias MA
Enferm Infecc Microbiol Clin (Engl Ed) 2018 Feb;36(2):144-145. Epub 2017 May 19 doi: 10.1016/j.eimc.2017.03.012. PMID: 28532597
Malignant Infantile Osteopetrosis.
Gillani S, Abbas Z
J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):350-352. PMID: 28718264
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article

Clinical prediction guides

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
TLR2 and TLR4 expressions in late-onset neonatal sepsis: Is it a potential novel biomarker?
Rohsiswatmo R, Azharry M, Sari TT, Bahasoan Y, Wulandari D
J Neonatal Perinatal Med 2021;14(3):361-367. doi: 10.3233/NPM-200411. PMID: 33164948
Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Malignant Infantile Osteopetrosis.
Gillani S, Abbas Z
J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):350-352. PMID: 28718264

Recent systematic reviews

Diagnostic capacity of miRNAs in neonatal sepsis: a systematic review and meta-analysis.
Zhao Y, Zhu R, Hu X
J Matern Fetal Neonatal Med 2024 Dec;37(1):2345850. Epub 2024 May 7 doi: 10.1080/14767058.2024.2345850. PMID: 38714508
Efficacy of empiric antibiotic treatment of late-onset neonatal sepsis caused by Enterobacteriaceae: A systematic review.
Akselsen AB, Sheth CC, Veses V
Lett Appl Microbiol 2022 Sep;75(3):500-510. Epub 2022 Jan 7 doi: 10.1111/lam.13640. PMID: 34951709
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis.
Fleischmann C, Reichert F, Cassini A, Horner R, Harder T, Markwart R, Tröndle M, Savova Y, Kissoon N, Schlattmann P, Reinhart K, Allegranzi B, Eckmanns T
Arch Dis Child 2021 Jul 19;106(8):745-752. doi: 10.1136/archdischild-2020-320217. PMID: 33483376Free PMC Article
Antibiotics for neonates born through meconium-stained amniotic fluid.
Kelly LE, Shivananda S, Murthy P, Srinivasjois R, Shah PS
Cochrane Database Syst Rev 2017 Jun 28;6(6):CD006183. doi: 10.1002/14651858.CD006183.pub2. PMID: 28658507Free PMC Article

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