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New or Worsening Symptom

MedGen UID:: 857733
•Concept ID:: C3898139
•: Sign or Symptom

Definition

The subjective evidence of disease perceived by the patient that can be classified as new or worsening [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNew or Worsening Symptom

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Sign or Symptom
    - Symptom
      - New or Worsening Symptom

Professional guidelines

PubMed

Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations.

Northrup H, Aronow ME, Bebin EM, Bissler J, Darling TN, de Vries PJ, Frost MD, Fuchs Z, Gosnell ES, Gupta N, Jansen AC, Jóźwiak S, Kingswood JC, Knilans TK, McCormack FX, Pounders A, Roberds SL, Rodriguez-Buritica DF, Roth J, Sampson JR, Sparagana S, Thiele EA, Weiner HL, Wheless JW, Towbin AJ, Krueger DA; International Tuberous Sclerosis Complex Consensus Group
Pediatr Neurol 2021 Oct;123:50-66. Epub 2021 Jul 24 doi: 10.1016/j.pediatrneurol.2021.07.011. PMID: 34399110

Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases.

Garcia-Pavia P, Rapezzi C, Adler Y, Arad M, Basso C, Brucato A, Burazor I, Caforio ALP, Damy T, Eriksson U, Fontana M, Gillmore JD, Gonzalez-Lopez E, Grogan M, Heymans S, Imazio M, Kindermann I, Kristen AV, Maurer MS, Merlini G, Pantazis A, Pankuweit S, Rigopoulos AG, Linhart A
Eur Heart J 2021 Apr 21;42(16):1554-1568. doi: 10.1093/eurheartj/ehab072. PMID: 33825853 Free PMC Article

Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.

Wolraich ML, Hagan JF Jr, Allan C, Chan E, Davison D, Earls M, Evans SW, Flinn SK, Froehlich T, Frost J, Holbrook JR, Lehmann CU, Lessin HR, Okechukwu K, Pierce KL, Winner JD, Zurhellen W; SUBCOMMITTEE ON CHILDREN AND ADOLESCENTS WITH ATTENTION-DEFICIT/HYPERACTIVE DISORDER
Pediatrics 2019 Oct;144(4) doi: 10.1542/peds.2019-2528. PMID: 31570648 Free PMC Article

See all (151531)

Recent clinical studies

Etiology

Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial.

Basch E, Schrag D, Henson S, Jansen J, Ginos B, Stover AM, Carr P, Spears PA, Jonsson M, Deal AM, Bennett AV, Thanarajasingam G, Rogak LJ, Reeve BB, Snyder C, Bruner D, Cella D, Kottschade LA, Perlmutter J, Geoghegan C, Samuel-Ryals CA, Given B, Mazza GL, Miller R, Strasser JF, Zylla DM, Weiss A, Blinder VS, Dueck AC
JAMA 2022 Jun 28;327(24):2413-2422. doi: 10.1001/jama.2022.9265. PMID: 35661856 Free PMC Article

Trajectories of antenatal depression and adverse pregnancy outcomes.

Miller ES, Saade GR, Simhan HN, Monk C, Haas DM, Silver RM, Mercer BM, Parry S, Wing DA, Reddy UM, Grobman WA
Am J Obstet Gynecol 2022 Jan;226(1):108.e1-108.e9. Epub 2021 Jul 17 doi: 10.1016/j.ajog.2021.07.007. PMID: 34280383 Free PMC Article

Restless Legs Syndrome: Contemporary Diagnosis and Treatment.

Gossard TR, Trotti LM, Videnovic A, St Louis EK
Neurotherapeutics 2021 Jan;18(1):140-155. Epub 2021 Apr 20 doi: 10.1007/s13311-021-01019-4. PMID: 33880737 Free PMC Article

Antipyretic drugs in patients with fever and infection: literature review.

Ludwig J, McWhinnie H
Br J Nurs 2019 May 23;28(10):610-618. doi: 10.12968/bjon.2019.28.10.610. PMID: 31116598

Symptom Monitoring With Patient-Reported Outcomes During Routine Cancer Treatment: A Randomized Controlled Trial.

Basch E, Deal AM, Kris MG, Scher HI, Hudis CA, Sabbatini P, Rogak L, Bennett AV, Dueck AC, Atkinson TM, Chou JF, Dulko D, Sit L, Barz A, Novotny P, Fruscione M, Sloan JA, Schrag D
J Clin Oncol 2016 Feb 20;34(6):557-65. Epub 2015 Dec 7 doi: 10.1200/JCO.2015.63.0830. PMID: 26644527 Free PMC Article

See all (906334)

Diagnosis

Idiopathic pulmonary fibrosis: state of the art for 2023.

Podolanczuk AJ, Thomson CC, Remy-Jardin M, Richeldi L, Martinez FJ, Kolb M, Raghu G
Eur Respir J 2023 Apr;61(4) Epub 2023 Apr 20 doi: 10.1183/13993003.00957-2022. PMID: 36702498

Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial.

Abdominal Wall Pain: Clinical Evaluation, Differential Diagnosis, and Treatment.

Shian B, Larson ST
Am Fam Physician 2018 Oct 1;98(7):429-436. PMID: 30252418

Post-fundoplication symptoms and complications: Diagnostic approach and treatment.

Sobrino-Cossío S, Soto-Pérez JC, Coss-Adame E, Mateos-Pérez G, Teramoto Matsubara O, Tawil J, Vallejo-Soto M, Sáez-Ríos A, Vargas-Romero JA, Zárate-Guzmán AM, Galvis-García ES, Morales-Arámbula M, Quiroz-Castro O, Carrasco-Rojas A, Remes-Troche JM
Rev Gastroenterol Mex 2017 Jul-Sep;82(3):234-247. Epub 2017 Jan 5 doi: 10.1016/j.rgmx.2016.08.005. PMID: 28065591

Recognition and Differential Diagnosis of Psychosis in Primary Care.

Griswold KS, Del Regno PA, Berger RC
Am Fam Physician 2015 Jun 15;91(12):856-63. PMID: 26131945

See all (647271)

Therapy

Antipyretic drugs in patients with fever and infection: literature review.

Ludwig J, McWhinnie H
Br J Nurs 2019 May 23;28(10):610-618. doi: 10.12968/bjon.2019.28.10.610. PMID: 31116598

Randomization in clinical studies.

Lim CY, In J
Korean J Anesthesiol 2019 Jun;72(3):221-232. Epub 2019 Apr 1 doi: 10.4097/kja.19049. PMID: 30929415 Free PMC Article

Randomization and allocation concealment: a practical guide for researchers.

Doig GS, Simpson F
J Crit Care 2005 Jun;20(2):187-91; discussion 191-3. doi: 10.1016/j.jcrc.2005.04.005. PMID: 16139163

Stratified randomization for clinical trials.

Kernan WN, Viscoli CM, Makuch RW, Brass LM, Horwitz RI
J Clin Epidemiol 1999 Jan;52(1):19-26. doi: 10.1016/s0895-4356(98)00138-3. PMID: 9973070

Coronary artery surgery study (CASS): a randomized trial of coronary artery bypass surgery. Survival data.

Circulation 1983 Nov;68(5):939-50. doi: 10.1161/01.cir.68.5.939. PMID: 6137292

See all (680997)

Prognosis

Global burden of primary liver cancer in 2020 and predictions to 2040.

Rumgay H, Arnold M, Ferlay J, Lesi O, Cabasag CJ, Vignat J, Laversanne M, McGlynn KA, Soerjomataram I
J Hepatol 2022 Dec;77(6):1598-1606. Epub 2022 Oct 5 doi: 10.1016/j.jhep.2022.08.021. PMID: 36208844 Free PMC Article

Cancer Statistics, 2021.

Siegel RL, Miller KD, Fuchs HE, Jemal A
CA Cancer J Clin 2021 Jan;71(1):7-33. Epub 2021 Jan 12 doi: 10.3322/caac.21654. PMID: 33433946

Progress in cancer mortality, incidence, and survival: a global overview.

Santucci C, Carioli G, Bertuccio P, Malvezzi M, Pastorino U, Boffetta P, Negri E, Bosetti C, La Vecchia C
Eur J Cancer Prev 2020 Sep;29(5):367-381. doi: 10.1097/CEJ.0000000000000594. PMID: 32740162

Global stroke statistics.

Thrift AG, Thayabaranathan T, Howard G, Howard VJ, Rothwell PM, Feigin VL, Norrving B, Donnan GA, Cadilhac DA
Int J Stroke 2017 Jan;12(1):13-32. Epub 2016 Oct 28 doi: 10.1177/1747493016676285. PMID: 27794138

Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842

See all (499834)

Clinical prediction guides

Acute pancreatitis: A review of diagnosis, severity prediction and prognosis assessment from imaging technology, scoring system and artificial intelligence.

Hu JX, Zhao CF, Wang SL, Tu XY, Huang WB, Chen JN, Xie Y, Chen CR
World J Gastroenterol 2023 Oct 7;29(37):5268-5291. doi: 10.3748/wjg.v29.i37.5268. PMID: 37899784 Free PMC Article

The reliability of the Glasgow Coma Scale: a systematic review.

Reith FC, Van den Brande R, Synnot A, Gruen R, Maas AI
Intensive Care Med 2016 Jan;42(1):3-15. Epub 2015 Nov 12 doi: 10.1007/s00134-015-4124-3. PMID: 26564211

Burning mouth syndrome.

Gurvits GE, Tan A
World J Gastroenterol 2013 Feb 7;19(5):665-72. doi: 10.3748/wjg.v19.i5.665. PMID: 23429751 Free PMC Article

Validation of a new coma scale: The FOUR score.

Wijdicks EF, Bamlet WR, Maramattom BV, Manno EM, McClelland RL
Ann Neurol 2005 Oct;58(4):585-93. doi: 10.1002/ana.20611. PMID: 16178024

Reflections on misdiagnosis.

Kirch W, Schafii C
J Intern Med 1994 May;235(5):399-404. doi: 10.1111/j.1365-2796.1994.tb01094.x. PMID: 8182393

See all (620898)

Recent systematic reviews

Muscle strength and osteoarthritis of the knee: a systematic review and meta-analysis of longitudinal studies.

Patterson BE, Girdwood MA, West TJ, Bruder AM, Øiestad BE, Juhl C, Culvenor AG
Skeletal Radiol 2023 Nov;52(11):2085-2097. Epub 2022 Dec 23 doi: 10.1007/s00256-022-04266-4. PMID: 36562820

Patellofemoral Pain Syndrome Risk Associated with Squats: A Systematic Review.

Pereira PM, Baptista JS, Conceição F, Duarte J, Ferraz J, Costa JT
Int J Environ Res Public Health 2022 Jul 28;19(15) doi: 10.3390/ijerph19159241. PMID: 35954598 Free PMC Article

Parkinson's disease and intensive exercise therapy - An updated systematic review and meta-analysis.

Gamborg M, Hvid LG, Dalgas U, Langeskov-Christensen M
Acta Neurol Scand 2022 May;145(5):504-528. Epub 2022 Jan 8 doi: 10.1111/ane.13579. PMID: 34997759

Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.

Pacchiarotti I, Tiihonen J, Kotzalidis GD, Verdolini N, Murru A, Goikolea JM, Valentí M, Aedo A, Vieta E
Eur Neuropsychopharmacol 2019 Apr;29(4):457-470. Epub 2019 Feb 12 doi: 10.1016/j.euroneuro.2019.02.003. PMID: 30770235

Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative.

Ronco C, McCullough P, Anker SD, Anand I, Aspromonte N, Bagshaw SM, Bellomo R, Berl T, Bobek I, Cruz DN, Daliento L, Davenport A, Haapio M, Hillege H, House AA, Katz N, Maisel A, Mankad S, Zanco P, Mebazaa A, Palazzuoli A, Ronco F, Shaw A, Sheinfeld G, Soni S, Vescovo G, Zamperetti N, Ponikowski P; Acute Dialysis Quality Initiative (ADQI) consensus group
Eur Heart J 2010 Mar;31(6):703-11. Epub 2009 Dec 25 doi: 10.1093/eurheartj/ehp507. PMID: 20037146 Free PMC Article

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