U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Symptom

MedGen UID:
306142
•Concept ID:
C1457887
•
Sign or Symptom

Definition

Subjective evidence of disease perceived by the patient. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSymptom

Professional guidelines

PubMed

Neck Pain: Initial Evaluation and Management.
Childress MA, Stuek SJ
Am Fam Physician 2020 Aug 1;102(3):150-156. PMID: 32735440
Clinical Practice Guideline: Sudden Hearing Loss (Update).
Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, Hollingsworth DB, Kelley DM, Kmucha ST, Moonis G, Poling GL, Roberts JK, Stachler RJ, Zeitler DM, Corrigan MD, Nnacheta LC, Satterfield L
Otolaryngol Head Neck Surg 2019 Aug;161(1_suppl):S1-S45. doi: 10.1177/0194599819859885. PMID: 31369359
Clinical guideline: management of gastroparesis.
Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L; American College of Gastroenterology
Am J Gastroenterol 2013 Jan;108(1):18-37; quiz 38. Epub 2012 Nov 13 doi: 10.1038/ajg.2012.373. PMID: 23147521Free PMC Article

Recent clinical studies

Etiology

Prevalence of anxiety symptom and depressive symptom among college students during COVID-19 pandemic: A meta-analysis.
Chang JJ, Ji Y, Li YH, Pan HF, Su PY
J Affect Disord 2021 Sep 1;292:242-254. Epub 2021 Jun 4 doi: 10.1016/j.jad.2021.05.109. PMID: 34134022Free PMC Article
Complementary and Alternative Medicine in Hospice and Palliative Care: A Systematic Review.
Zeng YS, Wang C, Ward KE, Hume AL
J Pain Symptom Manage 2018 Nov;56(5):781-794.e4. Epub 2018 Aug 2 doi: 10.1016/j.jpainsymman.2018.07.016. PMID: 30076965
Approach to MPN Symptom Assessment.
Geyer H, Mesa RA
Curr Hematol Malig Rep 2017 Oct;12(5):381-388. doi: 10.1007/s11899-017-0399-5. PMID: 28942516Free PMC Article
Advancing Symptom Science Through Symptom Cluster Research: Expert Panel Proceedings and Recommendations.
Miaskowski C, Barsevick A, Berger A, Casagrande R, Grady PA, Jacobsen P, Kutner J, Patrick D, Zimmerman L, Xiao C, Matocha M, Marden S
J Natl Cancer Inst 2017 Apr;109(4) Epub 2017 Jan 24 doi: 10.1093/jnci/djw253. PMID: 28119347Free PMC Article
The Edmonton Symptom Assessment System 25 Years Later: Past, Present, and Future Developments.
Hui D, Bruera E
J Pain Symptom Manage 2017 Mar;53(3):630-643. Epub 2016 Dec 29 doi: 10.1016/j.jpainsymman.2016.10.370. PMID: 28042071Free PMC Article

Diagnosis

The effectiveness of symptom management interventions based on electronic patient-reported outcomes (ePROs) for symptom burden, quality of life, and overall survival among patients with cancer: A meta-analysis of randomized controlled trials.
Li Y, Li J, Hu X
Int J Nurs Stud 2023 Nov;147:104588. Epub 2023 Aug 17 doi: 10.1016/j.ijnurstu.2023.104588. PMID: 37690275
Prevalence of anxiety symptom and depressive symptom among college students during COVID-19 pandemic: A meta-analysis.
Chang JJ, Ji Y, Li YH, Pan HF, Su PY
J Affect Disord 2021 Sep 1;292:242-254. Epub 2021 Jun 4 doi: 10.1016/j.jad.2021.05.109. PMID: 34134022Free PMC Article
Research on Somatization and Somatic Symptom Disorders: Ars longa, vita brevis.
Dimsdale JE
Psychosom Med 2017 Nov/Dec;79(9):971-973. doi: 10.1097/PSY.0000000000000533. PMID: 28976443Free PMC Article
Approach to MPN Symptom Assessment.
Geyer H, Mesa RA
Curr Hematol Malig Rep 2017 Oct;12(5):381-388. doi: 10.1007/s11899-017-0399-5. PMID: 28942516Free PMC Article
Cancer Symptom Cluster Management.
Kwekkeboom KL
Semin Oncol Nurs 2016 Nov;32(4):373-382. Epub 2016 Oct 24 doi: 10.1016/j.soncn.2016.08.004. PMID: 27789073Free PMC Article

Therapy

Modelling ASthma TrEatment Responses (MASTER): Effect of individual patient characteristics on the risk of exacerbation in moderate or severe asthma: A time-to-event analysis of randomized clinical trials.
Oosterholt S, Pavord ID, Brusselle G, Yorgancıoğlu A, Pitrez PM, Pg A, Teli C, Della Pasqua O
Br J Clin Pharmacol 2023 Nov;89(11):3273-3290. Epub 2023 Jul 6 doi: 10.1111/bcp.15801. PMID: 37221636
Efficacy of rimegepant for the acute treatment of migraine based on triptan treatment experience: Pooled results from three phase 3 randomized clinical trials.
Lipton RB, Blumenfeld A, Jensen CM, Croop R, Thiry A, L'Italien G, Morris BA, Coric V, Goadsby PJ
Cephalalgia 2023 Feb;43(2):3331024221141686. doi: 10.1177/03331024221141686. PMID: 36739511
The validity and reproducibility of a work productivity and activity impairment instrument.
Reilly MC, Zbrozek AS, Dukes EM
Pharmacoeconomics 1993 Nov;4(5):353-65. doi: 10.2165/00019053-199304050-00006. PMID: 10146874
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
Kane J, Honigfeld G, Singer J, Meltzer H
Arch Gen Psychiatry 1988 Sep;45(9):789-96. doi: 10.1001/archpsyc.1988.01800330013001. PMID: 3046553
Schizophrenia and dialysis.
Carpenter WT Jr, Sadler JH, Light PD, Hanlon TE, Kurland AA
Artif Organs 1983 Aug;7(3):357-64. doi: 10.1111/j.1525-1594.1983.tb04211.x. PMID: 6625966

Prognosis

Subarachnoid Hemorrhage: Updates in Diagnosis and Management.
Long B, Koyfman A, Runyon MS
Emerg Med Clin North Am 2017 Nov;35(4):803-824. Epub 2017 Aug 24 doi: 10.1016/j.emc.2017.07.001. PMID: 28987430
Disease manifestations and burden of illness in patients with acid sphingomyelinase deficiency (ASMD).
McGovern MM, Avetisyan R, Sanson BJ, Lidove O
Orphanet J Rare Dis 2017 Feb 23;12(1):41. doi: 10.1186/s13023-017-0572-x. PMID: 28228103Free PMC Article
Impact of atrial fibrillation on outcomes in heart failure.
DePasquale EC, Fonarow GC
Heart Fail Clin 2013 Oct;9(4):437-49, viii. doi: 10.1016/j.hfc.2013.07.009. PMID: 24054477
Clinical practice guidelines for the management of delirium in older people in Australia.
Tropea J, Slee JA, Brand CA, Gray L, Snell T
Australas J Ageing 2008 Sep;27(3):150-6. doi: 10.1111/j.1741-6612.2008.00301.x. PMID: 18713175
Early gastric cancer in Europe.
Everett SM, Axon AT
Gut 1997 Aug;41(2):142-50. doi: 10.1136/gut.41.2.142. PMID: 9301490Free PMC Article

Clinical prediction guides

Clinical Outcome Measures in Chiari I Malformation.
Yarbrough CK, Greenberg JK, Park TS
Neurosurg Clin N Am 2015 Oct;26(4):533-41. Epub 2015 Aug 4 doi: 10.1016/j.nec.2015.06.008. PMID: 26408063
Prognostic scores for brain metastasis patients: use in clinical practice and trial design.
Venur VA, Ahluwalia MS
Chin Clin Oncol 2015 Jun;4(2):18. doi: 10.3978/j.issn.2304-3865.2015.06.01. PMID: 26112804
Scoring systems for the post-thrombotic syndrome.
Soosainathan A, Moore HM, Gohel MS, Davies AH
J Vasc Surg 2013 Jan;57(1):254-61. Epub 2012 Nov 20 doi: 10.1016/j.jvs.2012.09.011. PMID: 23182156
A novel approach to defining the relationship between lung function and symptom status in asthma.
Kuntz KM, Kitch BT, Fuhlbrigge AL, Paltiel AD, Weiss ST
J Clin Epidemiol 2002 Jan;55(1):11-8. doi: 10.1016/s0895-4356(01)00412-7. PMID: 11781117
Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification.
Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, Tytgat GN, Wallin L
Gut 1999 Aug;45(2):172-80. doi: 10.1136/gut.45.2.172. PMID: 10403727Free PMC Article

Recent systematic reviews

Prevalence of anxiety symptom and depressive symptom among college students during COVID-19 pandemic: A meta-analysis.
Chang JJ, Ji Y, Li YH, Pan HF, Su PY
J Affect Disord 2021 Sep 1;292:242-254. Epub 2021 Jun 4 doi: 10.1016/j.jad.2021.05.109. PMID: 34134022Free PMC Article
An integrative review of the theory of unpleasant symptoms.
Blakeman JR
J Adv Nurs 2019 May;75(5):946-961. Epub 2019 Jan 15 doi: 10.1111/jan.13906. PMID: 30397941
Complementary and Alternative Medicine in Hospice and Palliative Care: A Systematic Review.
Zeng YS, Wang C, Ward KE, Hume AL
J Pain Symptom Manage 2018 Nov;56(5):781-794.e4. Epub 2018 Aug 2 doi: 10.1016/j.jpainsymman.2018.07.016. PMID: 30076965
Association Between Palliative Care and Patient and Caregiver Outcomes: A Systematic Review and Meta-analysis.
Kavalieratos D, Corbelli J, Zhang D, Dionne-Odom JN, Ernecoff NC, Hanmer J, Hoydich ZP, Ikejiani DZ, Klein-Fedyshin M, Zimmermann C, Morton SC, Arnold RM, Heller L, Schenker Y
JAMA 2016 Nov 22;316(20):2104-2114. doi: 10.1001/jama.2016.16840. PMID: 27893131Free PMC Article
Premenstrual syndrome.
Kwan I, Onwude JL
BMJ Clin Evid 2015 Aug 25;2015 PMID: 26303988Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...