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Neonatal Spell

MedGen UID:
857740
•Concept ID:
C3898146
•
Disease or Syndrome
Synonym: Neonatal Spells

Definition

Cardiorespiratory events that are characterized by variable combinations of cessation of breathing, decrease in blood oxygen saturation, and decreased heart rate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal Spell

Professional guidelines

PubMed

Childhood-related neural genotype-phenotype in ATP1A3 mutations: comprehensive analysis.
Muthaffar OY, Alqarni A, Shafei JA, Bahowarth SY, Alyazidi AS, Naseer MI
Genes Genomics 2024 Apr;46(4):475-487. Epub 2024 Jan 19 doi: 10.1007/s13258-023-01481-8. PMID: 38243045
Staring Spells: An Age-based Approach Toward Differential Diagnosis.
Goenka A, Reyes I, Fonseca LD, George MC, Stolfi A, Kumar G
J Child Neurol 2023 Feb;38(1-2):64-77. Epub 2022 Nov 13 doi: 10.1177/08830738221134552. PMID: 36373696
Management Issues in Intensive Care Units for Infants and Children with Heart Disease.
Iyer PU
Indian J Pediatr 2015 Dec;82(12):1164-71. Epub 2015 Nov 6 doi: 10.1007/s12098-015-1914-0. PMID: 26542311

Recent clinical studies

Etiology

Cold spell and mortality in 31 Chinese capital cities: Definitions, vulnerability and implications.
Chen J, Yang J, Zhou M, Yin P, Wang B, Liu J, Chen Z, Song X, Ou CQ, Liu Q
Environ Int 2019 Jul;128:271-278. Epub 2019 May 6 doi: 10.1016/j.envint.2019.04.049. PMID: 31071590
A systematic approach to autoinflammatory syndromes: a spelling booklet for the beginner.
Rigante D
Expert Rev Clin Immunol 2017 Jun;13(6):571-597. Epub 2017 Feb 1 doi: 10.1080/1744666X.2017.1280396. PMID: 28064547
Paroxysmal nonepileptic events in infancy, childhood, and adolescence.
Luat AF, Kamat D, Sivaswamy L
Pediatr Ann 2015 Feb;44(2):e18-23. doi: 10.3928/00904481-20150203-07. PMID: 25658214
Pathological findings in SIDS.
Berry PJ
J Clin Pathol 1992 Nov;45(11 Suppl):11-6. PMID: 1474151
Airways and air pollution in childhood: state of the art.
Hoppenbrouwers T
Lung 1990;168 Suppl:335-46. doi: 10.1007/BF02718150. PMID: 2117134

Diagnosis

Paroxysmal nonepileptic events in infancy, childhood, and adolescence.
Luat AF, Kamat D, Sivaswamy L
Pediatr Ann 2015 Feb;44(2):e18-23. doi: 10.3928/00904481-20150203-07. PMID: 25658214
Breath-holding spells.
Breningstall GN
Pediatr Neurol 1996 Feb;14(2):91-7. doi: 10.1016/0887-8994(96)00006-9. PMID: 8703234
Pathological findings in SIDS.
Berry PJ
J Clin Pathol 1992 Nov;45(11 Suppl):11-6. PMID: 1474151
Pertussis in neonates.
Christie CD, Baltimore RS
Am J Dis Child 1989 Oct;143(10):1199-202. doi: 10.1001/archpedi.1989.02150220097027. PMID: 2801662
Pediatric cardiac emergencies.
Fulton DR, Grodin M
Emerg Med Clin North Am 1983 Apr;1(1):45-61. PMID: 6394286

Therapy

Are we over-treating hypoxic spells in preterm infants?
Conlon S, Di Fiore JM, Martin RJ
Semin Fetal Neonatal Med 2021 Jun;26(3):101227. Epub 2021 Mar 8 doi: 10.1016/j.siny.2021.101227. PMID: 33736905
Cold spell and mortality in 31 Chinese capital cities: Definitions, vulnerability and implications.
Chen J, Yang J, Zhou M, Yin P, Wang B, Liu J, Chen Z, Song X, Ou CQ, Liu Q
Environ Int 2019 Jul;128:271-278. Epub 2019 May 6 doi: 10.1016/j.envint.2019.04.049. PMID: 31071590
Update on pertussis in children.
Heininger U
Expert Rev Anti Infect Ther 2010 Feb;8(2):163-73. doi: 10.1586/eri.09.124. PMID: 20109046
Airways and air pollution in childhood: state of the art.
Hoppenbrouwers T
Lung 1990;168 Suppl:335-46. doi: 10.1007/BF02718150. PMID: 2117134
Pediatric cardiac emergencies.
Fulton DR, Grodin M
Emerg Med Clin North Am 1983 Apr;1(1):45-61. PMID: 6394286

Prognosis

Cold spell and mortality in 31 Chinese capital cities: Definitions, vulnerability and implications.
Chen J, Yang J, Zhou M, Yin P, Wang B, Liu J, Chen Z, Song X, Ou CQ, Liu Q
Environ Int 2019 Jul;128:271-278. Epub 2019 May 6 doi: 10.1016/j.envint.2019.04.049. PMID: 31071590
Isolated neonatal swallowing dysfunction: a case series and review of the literature.
Heuschkel RB, Fletcher K, Hill A, Buonomo C, Bousvaros A, Nurko S
Dig Dis Sci 2003 Jan;48(1):30-5. doi: 10.1023/a:1021722012250. PMID: 12645787
Airways and air pollution in childhood: state of the art.
Hoppenbrouwers T
Lung 1990;168 Suppl:335-46. doi: 10.1007/BF02718150. PMID: 2117134
Pertussis in neonates.
Christie CD, Baltimore RS
Am J Dis Child 1989 Oct;143(10):1199-202. doi: 10.1001/archpedi.1989.02150220097027. PMID: 2801662
Sleep apnea in infancy and childhood.
Thach BT
Med Clin North Am 1985 Nov;69(6):1289-315. doi: 10.1016/s0025-7125(16)30988-9. PMID: 3906304

Clinical prediction guides

Natural History of Chiari 1 Deformity.
Venkatakrishna SSB, McClure ME, Andronikou S
J Comput Assist Tomogr 2023 Mar-Apr 01;47(2):301-306. Epub 2022 Dec 13 doi: 10.1097/RCT.0000000000001404. PMID: 36728736
Non-Epileptic Paroxysmal Events: Clinical features and diagnostic differences with epileptic seizures. A Single Tertiary Centre Study.
Sullo F, Venti V, Catania R, Smilari P, Greco F, Pustorino E, Fiumara A, Raucci U, Falsaperla R, Marino S, Pavone P
Clin Neurol Neurosurg 2021 Aug;207:106739. Epub 2021 Jun 8 doi: 10.1016/j.clineuro.2021.106739. PMID: 34157509
Birth weight, neonatal morbidities, and school age outcomes in full-term and preterm infants.
McGrath M, Sullivan M
Issues Compr Pediatr Nurs 2002 Oct-Dec;25(4):231-54. doi: 10.1080/01460860290042611. PMID: 12542885
The Baller-Gerold syndrome.
Van Maldergem L, Verloes A, Lejeune L, Gillerot Y
J Med Genet 1992 Apr;29(4):266-8. doi: 10.1136/jmg.29.4.266. PMID: 1583650Free PMC Article
Airways and air pollution in childhood: state of the art.
Hoppenbrouwers T
Lung 1990;168 Suppl:335-46. doi: 10.1007/BF02718150. PMID: 2117134

Recent systematic reviews

Reading abilities in preterm children: a systematic review and meta-analysis.
Gutiérrez-Ortega M, Álvarez-Bardón A, Vergara-Moragues E, Tubío J, González-Andrade A
Cogn Process 2024 Nov;25(4):545-565. Epub 2024 May 16 doi: 10.1007/s10339-024-01192-2. PMID: 38753253
Gestational diabetes mellitus and its associated factors in Ethiopia: a systematic review and meta-analysis.
Beyene FY, Kassa BG, Mihretie GN, Ayele AD
Eur J Med Res 2023 Mar 15;28(1):125. doi: 10.1186/s40001-023-01088-5. PMID: 36922857Free PMC Article
Cognitive, motor, behavioural and academic performances of children born preterm: a meta-analysis and systematic review involving 64 061 children.
Allotey J, Zamora J, Cheong-See F, Kalidindi M, Arroyo-Manzano D, Asztalos E, van der Post J, Mol BW, Moore D, Birtles D, Khan KS, Thangaratinam S
BJOG 2018 Jan;125(1):16-25. Epub 2017 Oct 11 doi: 10.1111/1471-0528.14832. PMID: 29024294
Impact of ambient temperature on children's health: a systematic review.
Xu Z, Etzel RA, Su H, Huang C, Guo Y, Tong S
Environ Res 2012 Aug;117:120-31. Epub 2012 Jul 23 doi: 10.1016/j.envres.2012.07.002. PMID: 22831555

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