U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Congenital Varicella Zoster Infection

MedGen UID:
859096
•Concept ID:
C3899502
•
Disease or Syndrome

Definition

An infection, characterized by the rash of chickenpox or shingles, that is caused by the varicella-zoster virus transmitted directly from the mother to the fetus or neonate during late pregnancy or childbirth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital Varicella Zoster Infection

Professional guidelines

PubMed

Monkeypox in pregnancy: virology, clinical presentation, and obstetric management.
Dashraath P, Nielsen-Saines K, Rimoin A, Mattar CNZ, Panchaud A, Baud D
Am J Obstet Gynecol 2022 Dec;227(6):849-861.e7. Epub 2022 Aug 17 doi: 10.1016/j.ajog.2022.08.017. PMID: 35985514Free PMC Article
Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.
Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L
Biochim Biophys Acta Mol Basis Dis 2021 Oct 1;1867(10):166198. Epub 2021 Jun 10 doi: 10.1016/j.bbadis.2021.166198. PMID: 34118406Free PMC Article
Herpesviridae Infection: Prevention, Screening, and Management.
Subramaniam A, Britt WJ
Clin Obstet Gynecol 2018 Mar;61(1):157-176. doi: 10.1097/GRF.0000000000000335. PMID: 29283902

Recent clinical studies

Etiology

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.
Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L
Biochim Biophys Acta Mol Basis Dis 2021 Oct 1;1867(10):166198. Epub 2021 Jun 10 doi: 10.1016/j.bbadis.2021.166198. PMID: 34118406Free PMC Article
Viral causes of hearing loss: a review for hearing health professionals.
Cohen BE, Durstenfeld A, Roehm PC
Trends Hear 2014 Jul 29;18 doi: 10.1177/2331216514541361. PMID: 25080364Free PMC Article
Varicella-zoster virus infection in pregnancy.
Enders G
Prog Med Virol 1984;29:166-96. PMID: 6322232
Viral infections.
Dudgeon JA
J Clin Pathol Suppl (R Coll Pathol) 1976;10:99-106. PMID: 184117Free PMC Article

Diagnosis

Acute Oral Lesions.
France K, Villa A
Dermatol Clin 2020 Oct;38(4):441-450. doi: 10.1016/j.det.2020.05.005. PMID: 32892853
Intracranial calcifications in childhood: Part 1.
Gonçalves FG, Caschera L, Teixeira SR, Viaene AN, Pinelli L, Mankad K, Alves CAPF, Ortiz-Gonzalez XR, Andronikou S, Vossough A
Pediatr Radiol 2020 Sep;50(10):1424-1447. Epub 2020 Jul 30 doi: 10.1007/s00247-020-04721-1. PMID: 32734340
Perinatal varicella.
Cobelli Kett J
Pediatr Rev 2013 Jan;34(1):49-51. doi: 10.1542/pir.34-1-49. PMID: 23281363
Congenital infection.
Henderson JL, Weiner CP
Curr Opin Obstet Gynecol 1995 Apr;7(2):130-4. doi: 10.1097/00001703-199504000-00010. PMID: 7787122
Varicella-zoster virus infection in pregnancy.
Enders G
Prog Med Virol 1984;29:166-96. PMID: 6322232

Therapy

Varicella in the 21st Century.
Obi OA
Neoreviews 2024 May 1;25(5):e274-e281. doi: 10.1542/neo.25-5-e274. PMID: 38688890
40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Advances in antiviral therapy: acyclovir.
Chadwick EG, Shulman ST
Pediatr Dermatol 1984 Jul;2(1):64-70. doi: 10.1111/j.1525-1470.1984.tb00445.x. PMID: 6095238
Renal complications of infectious diseases.
Eknoyan G, Dillman RO
Med Clin North Am 1978 Sep;62(5):979-1003. doi: 10.1016/s0025-7125(16)31750-3. PMID: 366299
Herpes simplex and zoster.
Juel-Jensen BE
Br Med J 1973 Feb 17;1(5850):406-10. doi: 10.1136/bmj.1.5850.406. PMID: 4347938Free PMC Article

Prognosis

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Skin infections in pregnancy.
Müllegger RR, Häring NS, Glatz M
Clin Dermatol 2016 May-Jun;34(3):368-77. Epub 2016 Feb 9 doi: 10.1016/j.clindermatol.2016.02.009. PMID: 27265075
Congenital Varicella Syndrome.
Kodur VV, Hegde DG
Indian Pediatr 2016 Mar;53(3):269. PMID: 27029702
Viral causes of hearing loss: a review for hearing health professionals.
Cohen BE, Durstenfeld A, Roehm PC
Trends Hear 2014 Jul 29;18 doi: 10.1177/2331216514541361. PMID: 25080364Free PMC Article
Congenital varicella.
Chakraborty B
J Indian Med Assoc 1995 Oct;93(10):401. PMID: 9053427

Clinical prediction guides

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.
Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L
Biochim Biophys Acta Mol Basis Dis 2021 Oct 1;1867(10):166198. Epub 2021 Jun 10 doi: 10.1016/j.bbadis.2021.166198. PMID: 34118406Free PMC Article
Lights and Shadows of TORCH Infection Proteomics.
Macedo-da-Silva J, Marinho CRF, Palmisano G, Rosa-Fernandes L
Genes (Basel) 2020 Aug 5;11(8) doi: 10.3390/genes11080894. PMID: 32764347Free PMC Article
Childhood peripheral facial palsy.
Karalok ZS, Taskin BD, Ozturk Z, Gurkas E, Koc TB, Guven A
Childs Nerv Syst 2018 May;34(5):911-917. Epub 2018 Feb 9 doi: 10.1007/s00381-018-3742-9. PMID: 29427137
Antenatal assessment of neurological impairment.
Taylor WG, Walkinshaw SA, Thomson MA
Arch Dis Child 1993 May;68(5 Spec No):604-5. doi: 10.1136/adc.68.5_spec_no.604. PMID: 8323367Free PMC Article

Recent systematic reviews

Congenital varicella syndrome: A systematic review.
Ahn KH, Park YJ, Hong SC, Lee EH, Lee JS, Oh MJ, Kim HJ
J Obstet Gynaecol 2016 Jul;36(5):563-6. Epub 2016 Mar 10 doi: 10.3109/01443615.2015.1127905. PMID: 26965725
Incidence and use of resources for chickenpox and herpes zoster in Latin America and the Caribbean--a systematic review and meta-analysis.
Bardach A, Cafferata ML, Klein K, Cormick G, Gibbons L, Ruvinsky S
Pediatr Infect Dis J 2012 Dec;31(12):1263-8. doi: 10.1097/INF.0b013e31826ff3a5. PMID: 23188098
Sonographic findings in fetal viral infections: a systematic review.
Degani S
Obstet Gynecol Surv 2006 May;61(5):329-36. doi: 10.1097/01.ogx.0000216518.85796.88. PMID: 16635273

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...