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Avascular Placental Villi

MedGen UID:
859581
•Concept ID:
C3899987
•
Finding

Definition

Focus of two or more placental terminal villi showing a total loss of villous capillaries and bland hyaline fibrosis of the villous stroma. Stromal karyorrhexis may or may not be evident. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAvascular Placental Villi

Professional guidelines

PubMed

Fetal thrombotic vasculopathy: significance in liveborn children using proposed society for pediatric pathology diagnostic criteria.
Chisholm KM, Heerema-McKenney A
Am J Surg Pathol 2015 Feb;39(2):274-80. doi: 10.1097/PAS.0000000000000334. PMID: 25321333
Placental histologic criteria for diagnosis of cord accident: sensitivity and specificity.
Ryan WD, Trivedi N, Benirschke K, Lacoursiere DY, Parast MM
Pediatr Dev Pathol 2012 Jul-Aug;15(4):275-80. Epub 2012 Mar 8 doi: 10.2350/11-12-1127-OA.1. PMID: 22400796
Placental histologic criteria for umbilical blood flow restriction in unexplained stillbirth.
Parast MM, Crum CP, Boyd TK
Hum Pathol 2008 Jun;39(6):948-53. Epub 2008 Apr 21 doi: 10.1016/j.humpath.2007.10.032. PMID: 18430456

Recent clinical studies

Etiology

Placental Pathology and Its Associations With Clinical Signs in Different Subtypes of Fetal Growth Restriction.
Dankó I, Kelemen E, Tankó A, Cserni G
Pediatr Dev Pathol 2023 Sep-Oct;26(5):437-446. Epub 2023 Jun 19 doi: 10.1177/10935266231179587. PMID: 37334814
Correlations of Placental Histopathology, Neonatal Outcome, and Cardiotocogram Baseline Variability and Acceleration Patterns in the Growth Restricted Preterm Population.
Dankó I, Kelemen E, Tankó A, Cserni G
Pediatr Dev Pathol 2023 Sep-Oct;26(5):447-457. Epub 2023 Jun 19 doi: 10.1177/10935266231178615. PMID: 37334626
Fetal vascular malperfusion (FVM): diagnostic implications and clinical associations.
Ravikumar G, Mascarenhas D, Suman Rao PN, Crasta J
J Matern Fetal Neonatal Med 2022 Dec;35(23):4526-4533. Epub 2020 Dec 1 doi: 10.1080/14767058.2020.1854215. PMID: 33261528
Fetal Vascular Malperfusion.
Heider A
Arch Pathol Lab Med 2017 Nov;141(11):1484-1489. doi: 10.5858/arpa.2017-0212-RA. PMID: 29072954
Multifocal chorangiomatosis.
Bagby C, Redline RW
Pediatr Dev Pathol 2011 Jan-Feb;14(1):38-44. Epub 2010 Jun 28 doi: 10.2350/10-05-0832-OA.1. PMID: 20583896

Diagnosis

Correlations of Placental Histopathology, Neonatal Outcome, and Cardiotocogram Baseline Variability and Acceleration Patterns in the Growth Restricted Preterm Population.
Dankó I, Kelemen E, Tankó A, Cserni G
Pediatr Dev Pathol 2023 Sep-Oct;26(5):447-457. Epub 2023 Jun 19 doi: 10.1177/10935266231178615. PMID: 37334626
Placental pathology predicts infantile neurodevelopment.
Ueda M, Tsuchiya KJ, Yaguchi C, Furuta-Isomura N, Horikoshi Y, Matsumoto M, Suzuki M, Oda T, Kawai K, Itoh T, Matsuya M, Narumi M, Kohmura-Kobayashi Y, Tamura N, Uchida T, Itoh H
Sci Rep 2022 Feb 16;12(1):2578. doi: 10.1038/s41598-022-06300-w. PMID: 35173199Free PMC Article
Placental Cytomegalovirus Infection.
Lindholm K, O'Keefe M
Arch Pathol Lab Med 2019 May;143(5):639-642. Epub 2018 Nov 30 doi: 10.5858/arpa.2017-0421-RS. PMID: 30500287
Fetal Vascular Malperfusion.
Heider A
Arch Pathol Lab Med 2017 Nov;141(11):1484-1489. doi: 10.5858/arpa.2017-0212-RA. PMID: 29072954
Hydatidiform moles.
Heath JM, Bu TH, Brereton WF
Am Fam Physician 1985 May;31(5):123-31. PMID: 2581433

Therapy

CD34 immunostain increases the sensitivity of placental examination for distal fetal vascular malperfusion in liveborn infants.
Stanek J
Placenta 2023 Sep 7;140:117-124. Epub 2023 Aug 3 doi: 10.1016/j.placenta.2023.08.004. PMID: 37573725
Cesarean section per se is not a risk factor for non-anatomical placenta creta.
Stanek J
Int J Gynaecol Obstet 2023 Mar;160(3):969-977. Epub 2022 Sep 5 doi: 10.1002/ijgo.14415. PMID: 35993138
Placental pathology predicts infantile neurodevelopment.
Ueda M, Tsuchiya KJ, Yaguchi C, Furuta-Isomura N, Horikoshi Y, Matsumoto M, Suzuki M, Oda T, Kawai K, Itoh T, Matsuya M, Narumi M, Kohmura-Kobayashi Y, Tamura N, Uchida T, Itoh H
Sci Rep 2022 Feb 16;12(1):2578. doi: 10.1038/s41598-022-06300-w. PMID: 35173199Free PMC Article
Segmental villous mineralization: A placental feature of fetal vascular malperfusion.
Stanek J
Placenta 2019 Oct;86:20-27. Epub 2019 Jul 24 doi: 10.1016/j.placenta.2019.07.011. PMID: 31358342
The Placenta in Neonatal Encephalopathy: A Case-Control Study.
Vik T, Redline R, Nelson KB, Bjellmo S, Vogt C, Ng P, Strand KM, Nu TNT, Oskoui M
J Pediatr 2018 Nov;202:77-85.e3. Epub 2018 Jun 29 doi: 10.1016/j.jpeds.2018.06.005. PMID: 30369428

Prognosis

Correlations of Placental Histopathology, Neonatal Outcome, and Cardiotocogram Baseline Variability and Acceleration Patterns in the Growth Restricted Preterm Population.
Dankó I, Kelemen E, Tankó A, Cserni G
Pediatr Dev Pathol 2023 Sep-Oct;26(5):447-457. Epub 2023 Jun 19 doi: 10.1177/10935266231178615. PMID: 37334626
Placental pathology of preeclampsia from a clinical point of view: Correlation between placental histopathology, clinical signs of preeclampsia and neonatal outcome.
Dankó I, Tankó A, Kelemen E, Cserni G
J Obstet Gynaecol Res 2023 Jun;49(6):1471-1480. Epub 2023 Mar 25 doi: 10.1111/jog.15641. PMID: 36965061
Cesarean section per se is not a risk factor for non-anatomical placenta creta.
Stanek J
Int J Gynaecol Obstet 2023 Mar;160(3):969-977. Epub 2022 Sep 5 doi: 10.1002/ijgo.14415. PMID: 35993138
Placental pathology predicts infantile neurodevelopment.
Ueda M, Tsuchiya KJ, Yaguchi C, Furuta-Isomura N, Horikoshi Y, Matsumoto M, Suzuki M, Oda T, Kawai K, Itoh T, Matsuya M, Narumi M, Kohmura-Kobayashi Y, Tamura N, Uchida T, Itoh H
Sci Rep 2022 Feb 16;12(1):2578. doi: 10.1038/s41598-022-06300-w. PMID: 35173199Free PMC Article
The Placenta in Neonatal Encephalopathy: A Case-Control Study.
Vik T, Redline R, Nelson KB, Bjellmo S, Vogt C, Ng P, Strand KM, Nu TNT, Oskoui M
J Pediatr 2018 Nov;202:77-85.e3. Epub 2018 Jun 29 doi: 10.1016/j.jpeds.2018.06.005. PMID: 30369428

Clinical prediction guides

Correlations of Placental Histopathology, Neonatal Outcome, and Cardiotocogram Baseline Variability and Acceleration Patterns in the Growth Restricted Preterm Population.
Dankó I, Kelemen E, Tankó A, Cserni G
Pediatr Dev Pathol 2023 Sep-Oct;26(5):447-457. Epub 2023 Jun 19 doi: 10.1177/10935266231178615. PMID: 37334626
The impact of SARS-CoV-2 infection on term placentae.
Karthikeyan TM, Sundari AA, Veenaa NN, Shivapriya R, Prema N
Indian J Pathol Microbiol 2023 Apr-Jun;66(2):301-306. doi: 10.4103/ijpm.ijpm_237_21. PMID: 37077072
Correlation between Pregnancy Outcome and Placental Pathology in COVID-19 Pregnant Women.
Al-Rawaf SA, Mousa ET, Kareem NM
Infect Dis Obstet Gynecol 2022;2022:8061112. Epub 2022 Aug 21 doi: 10.1155/2022/8061112. PMID: 36046178Free PMC Article
Placental pathology predicts infantile neurodevelopment.
Ueda M, Tsuchiya KJ, Yaguchi C, Furuta-Isomura N, Horikoshi Y, Matsumoto M, Suzuki M, Oda T, Kawai K, Itoh T, Matsuya M, Narumi M, Kohmura-Kobayashi Y, Tamura N, Uchida T, Itoh H
Sci Rep 2022 Feb 16;12(1):2578. doi: 10.1038/s41598-022-06300-w. PMID: 35173199Free PMC Article
Altered fetal growth, placental abnormalities, and stillbirth.
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Stillbirth Collaborative Research Network (SCRN)
PLoS One 2017;12(8):e0182874. Epub 2017 Aug 18 doi: 10.1371/journal.pone.0182874. PMID: 28820889Free PMC Article

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