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Pituitary gonadotropic cell adenoma

MedGen UID:
866771
•Concept ID:
C4021122
•
Neoplastic Process
Synonym: Pituitary gonadotropinoma
 
HPO: HP:0011759

Definition

A type of pituitary adenoma that produces gonadotropins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPituitary gonadotropic cell adenoma

Professional guidelines

PubMed

Effects of long-term treatment with the gonadotropin-releasing hormone analog nafarelin in patients with non-functioning pituitary adenomas.
Colombo P, Ambrosi B, Saccomanno K, Bassetti M, Cortelazzi D, Faglia G
Eur J Endocrinol 1994 Apr;130(4):339-45. doi: 10.1530/eje.0.1300339. PMID: 8162161

Recent clinical studies

Etiology

Nonfunctioning Pituitary Adenoma Recurrence and Its Relationship with Sex, Size, and Hormonal Immunohistochemical Profile.
Batista RL, Trarbach EB, Marques MD, Cescato VA, da Silva GO, Herkenhoff CGB, Cunha-Neto MB, Musolino NR
World Neurosurg 2018 Dec;120:e241-e246. Epub 2018 Aug 20 doi: 10.1016/j.wneu.2018.08.043. PMID: 30138730
Management of non-functioning pituitary adenomas: surgery.
Penn DL, Burke WT, Laws ER
Pituitary 2018 Apr;21(2):145-153. doi: 10.1007/s11102-017-0854-2. PMID: 29280026
Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma--Review.
Halupczok J, Kluba-Szyszka A, Bidzińska-Speichert B, Knychalski B
Adv Clin Exp Med 2015 Jul-Aug;24(4):695-703. doi: 10.17219/acem/25212. PMID: 26469116
Clinical review: Functioning gonadotroph adenomas.
Ntali G, Capatina C, Grossman A, Karavitaki N
J Clin Endocrinol Metab 2014 Dec;99(12):4423-33. doi: 10.1210/jc.2014-2362. PMID: 25166722
Giant pituitary adenomas: pathologic-radiographic correlations and lack of role for p53 and MIB-1 labeling.
Madsen H, Borges TM, Knox AJ, Michaelis KA, Xu M, Lillehei KO, Wierman ME, Kleinschmidt-DeMasters BK
Am J Surg Pathol 2011 Aug;35(8):1204-13. doi: 10.1097/PAS.0b013e31821e8c96. PMID: 21753697

Diagnosis

Functioning gonadotroph adenoma.
Zhao Y, Lian W, Xing B, Feng M, Ma WB
Chin Med J (Engl) 2019 Apr 20;132(8):1003-1004. doi: 10.1097/CM9.0000000000000184. PMID: 30958450Free PMC Article
Management of non-functioning pituitary adenomas: surgery.
Penn DL, Burke WT, Laws ER
Pituitary 2018 Apr;21(2):145-153. doi: 10.1007/s11102-017-0854-2. PMID: 29280026
Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma--Review.
Halupczok J, Kluba-Szyszka A, Bidzińska-Speichert B, Knychalski B
Adv Clin Exp Med 2015 Jul-Aug;24(4):695-703. doi: 10.17219/acem/25212. PMID: 26469116
Clinically non-functioning pituitary adenoma.
Jaffe CA
Pituitary 2006;9(4):317-21. doi: 10.1007/s11102-006-0412-9. PMID: 17082898
Cell-specific expression of estrogen receptor in the human pituitary and its adenomas.
Zafar M, Ezzat S, Ramyar L, Pan N, Smyth HS, Asa SL
J Clin Endocrinol Metab 1995 Dec;80(12):3621-7. doi: 10.1210/jcem.80.12.8530610. PMID: 8530610

Therapy

Functioning gonadotroph adenoma with severe ovarian hyperstimulation syndrome: A new emergency in pituitary adenoma surgery? Surgical considerations and literature review.
Graillon T, Castinetti F, Chabert-Orsini V, Morange I, Cuny T, Albarel F, Brue T, Dufour H
Ann Endocrinol (Paris) 2019 Apr;80(2):122-127. Epub 2019 Feb 7 doi: 10.1016/j.ando.2018.11.007. PMID: 30825998
Gonadotroph pituitary macroadenoma inducing ovarian hyperstimulation syndrome: successful response to octreotide therapy.
Karapanou O, Tzanela M, Tamouridis N, Tsagarakis S
Hormones (Athens) 2012 Apr-Jun;11(2):199-202. doi: 10.14310/horm.2002.1347. PMID: 22801566
Sellar collision tumor involving pituitary gonadotroph adenoma and chondroma: a potential clinical diagnosis.
Sahli R, Christ E, Kuhlen D, Giger O, Vajtai I
Pituitary 2011 Dec;14(4):405-8. Epub 2009 Sep 17 doi: 10.1007/s11102-009-0199-6. PMID: 19760170
A double pituitary adenoma presenting as a prolactin-secreting tumor with partial response to medical therapy. Case report.
Coiré CI, Smyth HS, Rosso D, Horvath E, Kovacs K
Endocr Pathol 2010 Jun;21(2):135-8. doi: 10.1007/s12022-009-9104-0. PMID: 20058099
Responses to gonadotropin releasing hormone agonist and antagonist administration in patients with gonadotroph cell adenomas.
Chanson P, Lahlou N, Warnet A, Roger M, Sassolas G, Lubetzi J, Schaison G, Bouchard P
J Endocrinol Invest 1994 Feb;17(2):91-8. doi: 10.1007/BF03347692. PMID: 8006338

Prognosis

Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis.
Lasolle H, Elsensohn MH, Wierinckx A, Alix E, Bonnefille C, Vasiljevic A, Cortet C, Decoudier B, Sturm N, Gaillard S, Ferrière A, Roy P, Jouanneau E, Bertolino P, Bardel C, Sanlaville D, Raverot G
Acta Neuropathol Commun 2020 Nov 10;8(1):190. doi: 10.1186/s40478-020-01067-5. PMID: 33168091Free PMC Article
Clinical characteristics and outcomes of null-cell versus silent gonadotroph adenomas in a series of 1166 pituitary adenomas from a single institution.
Haddad AF, Young JS, Oh T, Pereira MP, Joshi RS, Pereira KM, Osorio RC, Donohue KC, Peeran Z, Sudhir S, Jain S, Beniwal A, Chopra AS, Sandhu NS, Theodosopoulos PV, Kunwar S, El-Sayed IH, Gurrola J, Blevins LS, Aghi MK
Neurosurg Focus 2020 Jun;48(6):E13. doi: 10.3171/2020.3.FOCUS20114. PMID: 32480370
Nonfunctioning Pituitary Adenoma Recurrence and Its Relationship with Sex, Size, and Hormonal Immunohistochemical Profile.
Batista RL, Trarbach EB, Marques MD, Cescato VA, da Silva GO, Herkenhoff CGB, Cunha-Neto MB, Musolino NR
World Neurosurg 2018 Dec;120:e241-e246. Epub 2018 Aug 20 doi: 10.1016/j.wneu.2018.08.043. PMID: 30138730
Gonadotrope Tumors.
Asa SL, Ezzat S
Prog Mol Biol Transl Sci 2016;143:187-210. Epub 2016 Sep 7 doi: 10.1016/bs.pmbts.2016.08.005. PMID: 27697203
Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma--Review.
Halupczok J, Kluba-Szyszka A, Bidzińska-Speichert B, Knychalski B
Adv Clin Exp Med 2015 Jul-Aug;24(4):695-703. doi: 10.17219/acem/25212. PMID: 26469116

Clinical prediction guides

Clinical characteristics of functioning gonadotroph adenoma in women presenting with ovarian hyperstimulation: Audit of UK pituitary centres.
Papanikolaou N, Millar O, Coulden A, Parker N, Sit L, Kelly C, Cox J, Dhillo WS, Meeran K, Al Memar M, Anderson R, Rees DA, Karavitaki N, Jayasena CN
Clin Endocrinol (Oxf) 2023 Oct;99(4):386-395. Epub 2023 Jul 10 doi: 10.1111/cen.14949. PMID: 37430451
Functioning gonadotroph adenomas in premenopausal women: clinical and molecular characterization and review of the literature.
Wang L, Liang H, Deng C, Yu Q, Gong F, Feng F, You H, Liang Z, Chen B, Deng K, Ma J, Wang R, Yao Y, Zhu H
Pituitary 2022 Jun;25(3):454-467. Epub 2022 Feb 9 doi: 10.1007/s11102-021-01205-9. PMID: 35138520
Gonadotroph Pituitary Adenoma Causing Treatable Infertility and Ovarian Hyperstimulation Syndrome in Female Patients: Neurosurgical, Endocrinologic, Gynecologic, and Reproductive Outcomes.
Hasegawa H, Nesvick CL, Erickson D, Cohen SC, Yolcu YU, Khan Z, Raghunathan A, Nippoldt TB, Atkinson JL, Van Gompel JJ
World Neurosurg 2021 Jun;150:e162-e175. Epub 2021 Mar 5 doi: 10.1016/j.wneu.2021.02.115. PMID: 33684575
Nonfunctioning Pituitary Adenoma Recurrence and Its Relationship with Sex, Size, and Hormonal Immunohistochemical Profile.
Batista RL, Trarbach EB, Marques MD, Cescato VA, da Silva GO, Herkenhoff CGB, Cunha-Neto MB, Musolino NR
World Neurosurg 2018 Dec;120:e241-e246. Epub 2018 Aug 20 doi: 10.1016/j.wneu.2018.08.043. PMID: 30138730
Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma--Review.
Halupczok J, Kluba-Szyszka A, Bidzińska-Speichert B, Knychalski B
Adv Clin Exp Med 2015 Jul-Aug;24(4):695-703. doi: 10.17219/acem/25212. PMID: 26469116

Recent systematic reviews

Gonadotroph Pituitary Adenoma Causing Treatable Infertility and Ovarian Hyperstimulation Syndrome in Female Patients: Neurosurgical, Endocrinologic, Gynecologic, and Reproductive Outcomes.
Hasegawa H, Nesvick CL, Erickson D, Cohen SC, Yolcu YU, Khan Z, Raghunathan A, Nippoldt TB, Atkinson JL, Van Gompel JJ
World Neurosurg 2021 Jun;150:e162-e175. Epub 2021 Mar 5 doi: 10.1016/j.wneu.2021.02.115. PMID: 33684575

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