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Breast Papillary Ductal Carcinoma In Situ

MedGen UID:
87227
•Concept ID:
C0334372
•
Neoplastic Process
Synonyms: Breast Intraductal Papillary Carcinoma; Breast Papillary DCIS; DCIS, papillary; Ductal carcinoma in situ, papillary; Intraductal papillary adenocarcinoma; Intraductal Papillary Adenocarcinoma; Intraductal Papillary Breast Adenocarcinoma; Intraductal Papillary Breast Carcinoma; Intraductal papillary carcinoma; Intraductal Papillary Carcinoma; Non-infiltrating intraductal papillary adenocarcinoma; Non-Infiltrating Intraductal Papillary Adenocarcinoma; Non-infiltrating intraductal papillary carcinoma; Non-Infiltrating Intraductal Papillary Carcinoma; Non-Infiltrating Papillary Breast Adenocarcinoma; Non-Infiltrating Papillary Breast Carcinoma; Non-Invasive Intraductal Papillary Adenocarcinoma; Non-Invasive Intraductal Papillary Carcinoma; Non-Invasive Papillary Breast Adenocarcinoma; Non-Invasive Papillary Breast Carcinoma; Noninfiltrating intraductal papillary adenocarcinoma; Noninfiltrating intraductal papillary carcinoma; Papillary DCIS; Papillary Ductal Carcinoma In Situ
SNOMED CT: Non-infiltrating intraductal papillary adenocarcinoma (30566004); Non-infiltrating intraductal papillary carcinoma (30566004); Ductal carcinoma in situ, papillary (30566004); DCIS, papillary (30566004); Noninfiltrating intraductal papillary adenocarcinoma (30566004); Noninfiltrating intraductal papillary carcinoma (30566004); Intraductal papillary adenocarcinoma (30566004); Intraductal papillary carcinoma (30566004)

Definition

Breast ductal carcinoma in situ characterized by the presence of filiform arborizing fibrovascular cores lined by neoplastic ductal epithelium. (WHO 2019) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Papillary Ductal Carcinoma In Situ

Professional guidelines

PubMed

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Pathological criteria and practical issues in papillary lesions of the breast - a review.
Ni YB, Tse GM
Histopathology 2016 Jan;68(1):22-32. doi: 10.1111/his.12866. PMID: 26768027

Recent clinical studies

Etiology

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Intraductal Papillomas.
Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944

Diagnosis

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Intraductal Papillomas.
Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367

Therapy

Intraductal papillary carcinoma of breast with invasion: A nomogram and survival from the analysis of the SEER database.
Liu C, Liu S, Zhao L, Zheng W, Wang K, Tian Y, Gui Z, Zhang L
Cancer Med 2023 Jan;12(2):1305-1318. Epub 2022 Jul 15 doi: 10.1002/cam4.5007. PMID: 35837839Free PMC Article
Neuroendocrine breast tumours: breast cancer or neuroendocrine cancer presenting in the breast?
Adams RW, Dyson P, Barthelmes L
Breast 2014 Apr;23(2):120-7. Epub 2013 Dec 15 doi: 10.1016/j.breast.2013.11.005. PMID: 24342375
Intracystic papillary carcinoma of the breast: differential diagnosis and management.
Mugler KC, Marshall C, Hardesty L, Finlayson C, Singh M
Oncology (Williston Park) 2007 Jun;21(7):871-6. PMID: 17722745
Estrogen receptors and hormone dependency in human breast cancer.
Wittliff JL, Beatty BW, Savlov ED, Patterson WB, Cooper RA Jr
Recent Results Cancer Res 1976;(57):59-77. doi: 10.1007/978-3-642-81043-5_7. PMID: 189375
Hypophysectomy as compared with adrenalectomy in the treatment of advanced carcinoma of the breast.
Fracchia AA, Farrow JH, Miller TR, Tollefsen RH, Greenberg EJ, Knapper WH
Surg Gynecol Obstet 1971 Aug;133(2):241-6. PMID: 4105232

Prognosis

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
The Spectrum of Mucinous Lesions of the Breast.
Joneja U, Palazzo J
Arch Pathol Lab Med 2023 Jan 1;147(1):19-29. doi: 10.5858/arpa.2022-0054-RA. PMID: 36577093
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889

Clinical prediction guides

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Sonographic prediction of intraductal papillary carcinoma with partially cystic breast lesions.
Gao L, Lai X, Zhang J, Jiang Y, Li J
BMC Med Imaging 2023 Jan 6;23(1):3. doi: 10.1186/s12880-022-00934-y. PMID: 36609236Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
MR imaging findings of benign and malignant circumscribed breast masses: part 2. Cystic circumscribed masses.
Uematsu T, Kasami M
Jpn J Radiol 2009 Dec;27(10):405-9. Epub 2009 Dec 25 doi: 10.1007/s11604-009-0360-1. PMID: 20035411

Recent systematic reviews

Cytological study of 44 cases with solid papillary carcinoma and a systemic review of solid papillary carcinoma and neuroendocrine tumor of the breast.
Yamada M, Otsuki Y, Ikeya T, Shimizu SI, Tanioka F, Ogawa H, Kobayashi H
Diagn Cytopathol 2023 Jun;51(6):341-348. Epub 2023 Feb 7 doi: 10.1002/dc.25112. PMID: 36748676
The positive predictive value of vacuum assisted biopsy (VAB) in predicting final histological diagnosis for breast lesions of uncertain malignancy (B3 lesions): A systematic review & meta-analysis.
Cullinane C, Byrne J, Kelly L, O Sullivan M, Antony Corrigan M, Paul Redmond H
Eur J Surg Oncol 2022 Jul;48(7):1464-1474. Epub 2022 Apr 15 doi: 10.1016/j.ejso.2022.04.005. PMID: 35491362

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