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Indeterminate colitis

MedGen UID:
87418
•Concept ID:
C0341332
•
Disease or Syndrome
Synonyms: Colitis of Indeterminate Type; colitis of indeterminate type; indeterminate colitis
SNOMED CT: Indeterminate colitis (235746007)
 
Monarch Initiative: MONDO:0006038

Definition

It describes patients in whom a diagnosis of ulcerative colitis or Crohn's disease cannot be made based on standard clinical testing, including colonoscopy, imaging, laboratory tests, and biopsy. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIndeterminate colitis

Professional guidelines

PubMed

Diagnosis and Treatment of Iron Deficiency and Anemia in Youth With Inflammatory Bowel Disease.
Smith J, Jacobson-Kelly A, Donegan A, Boyle B, Maltz RM, Michel HK, Dotson JL
J Pediatr Gastroenterol Nutr 2023 Mar 1;76(3):313-318. Epub 2022 Nov 30 doi: 10.1097/MPG.0000000000003673. PMID: 36730097
Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview.
M'Koma AE
Medicina (Kaunas) 2022 Apr 21;58(5) doi: 10.3390/medicina58050567. PMID: 35629984Free PMC Article

Recent clinical studies

Etiology

Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview.
M'Koma AE
Medicina (Kaunas) 2022 Apr 21;58(5) doi: 10.3390/medicina58050567. PMID: 35629984Free PMC Article
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Colorectal cancer in inflammatory bowel disease: results of the 3rd ECCO pathogenesis scientific workshop (I).
Sebastian S, Hernández V, Myrelid P, Kariv R, Tsianos E, Toruner M, Marti-Gallostra M, Spinelli A, van der Meulen-de Jong AE, Yuksel ES, Gasche C, Ardizzone S, Danese S
J Crohns Colitis 2014 Jan;8(1):5-18. Epub 2013 May 9 doi: 10.1016/j.crohns.2013.04.008. PMID: 23664897
Inflammatory bowel disease.
Chutkan RK
Prim Care 2001 Sep;28(3):539-56, vi. doi: 10.1016/s0095-4543(05)70052-x. PMID: 11483443

Diagnosis

Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview.
M'Koma AE
Medicina (Kaunas) 2022 Apr 21;58(5) doi: 10.3390/medicina58050567. PMID: 35629984Free PMC Article
Clinical presentation of Crohn's, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes.
Yu YR, Rodriguez JR
Semin Pediatr Surg 2017 Dec;26(6):349-355. Epub 2017 Oct 5 doi: 10.1053/j.sempedsurg.2017.10.003. PMID: 29126502
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Indeterminate colitis.
Hale W, Floch M, Burakoff R, Itzkowitz S, Warren B, Plevy S
J Clin Gastroenterol 2004 May-Jun;38(5 Suppl 1):S57. doi: 10.1097/01.mcg.0000123989.55626.38. PMID: 15115934
Indeterminate colitis.
Nicholls RJ, Wells AD
Baillieres Clin Gastroenterol 1992 Mar;6(1):105-12. doi: 10.1016/0950-3528(92)90021-6. PMID: 1586764

Therapy

Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
The histopathological mimics of inflammatory bowel disease: a critical appraisal.
Woodman I, Schofield JB, Haboubi N
Tech Coloproctol 2015 Dec;19(12):717-27. Epub 2015 Sep 18 doi: 10.1007/s10151-015-1372-8. PMID: 26385573
Colorectal cancer in inflammatory bowel disease: results of the 3rd ECCO pathogenesis scientific workshop (I).
Sebastian S, Hernández V, Myrelid P, Kariv R, Tsianos E, Toruner M, Marti-Gallostra M, Spinelli A, van der Meulen-de Jong AE, Yuksel ES, Gasche C, Ardizzone S, Danese S
J Crohns Colitis 2014 Jan;8(1):5-18. Epub 2013 May 9 doi: 10.1016/j.crohns.2013.04.008. PMID: 23664897
Is indeterminate colitis really indeterminate?
Ngatchu T, Cash D, Langman G
Gut 2010 Sep;59(9):1177. Epub 2010 Jun 11 doi: 10.1136/gut.2009.188318. PMID: 20542860
Indeterminate colitis.
Hale W, Floch M, Burakoff R, Itzkowitz S, Warren B, Plevy S
J Clin Gastroenterol 2004 May-Jun;38(5 Suppl 1):S57. doi: 10.1097/01.mcg.0000123989.55626.38. PMID: 15115934

Prognosis

A Comprehensive Approach to Pouch Disorders.
Quinn KP, Lightner AL, Faubion WA, Raffals LE
Inflamm Bowel Dis 2019 Feb 21;25(3):460-471. doi: 10.1093/ibd/izy267. PMID: 30124882
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Colorectal cancer in inflammatory bowel disease: results of the 3rd ECCO pathogenesis scientific workshop (I).
Sebastian S, Hernández V, Myrelid P, Kariv R, Tsianos E, Toruner M, Marti-Gallostra M, Spinelli A, van der Meulen-de Jong AE, Yuksel ES, Gasche C, Ardizzone S, Danese S
J Crohns Colitis 2014 Jan;8(1):5-18. Epub 2013 May 9 doi: 10.1016/j.crohns.2013.04.008. PMID: 23664897
Use of capsule endoscopy for established Crohn's disease.
Legnani P, Abreu MT
Gastrointest Endosc Clin N Am 2006 Apr;16(2):299-306. doi: 10.1016/j.giec.2006.03.001. PMID: 16644458
NOD2/CARD15: relevance in clinical practice.
Vermeire S
Best Pract Res Clin Gastroenterol 2004 Jun;18(3):569-75. doi: 10.1016/j.bpg.2003.12.008. PMID: 15157828

Clinical prediction guides

Reduced Systemic Corticosteroid Use among Pediatric Patients With Inflammatory Bowel Disease in a Large Learning Health System.
Kandavel P, Eder SJ, Adler J; and the ImproveCareNow Network Pediatric IBD Learning Health System
J Pediatr Gastroenterol Nutr 2021 Sep 1;73(3):345-351. doi: 10.1097/MPG.0000000000003182. PMID: 34415262
Diagnostic Modalities for Inflammatory Bowel Disease: Serologic Markers and Endoscopy.
Clark C, Turner J
Surg Clin North Am 2015 Dec;95(6):1123-41, v. Epub 2015 Oct 21 doi: 10.1016/j.suc.2015.07.008. PMID: 26596918
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Is indeterminate colitis determinable?
Tremaine WJ
Curr Gastroenterol Rep 2012 Apr;14(2):162-5. doi: 10.1007/s11894-012-0244-x. PMID: 22314810
Indeterminate colitis.
Guindi M, Riddell RH
J Clin Pathol 2004 Dec;57(12):1233-44. doi: 10.1136/jcp.2003.015214. PMID: 15563659Free PMC Article

Recent systematic reviews

Prevalence of Extraintestinal Manifestations in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Kilic Y, Kamal S, Jaffar F, Sriranganathan D, Quraishi MN, Segal JP
Inflamm Bowel Dis 2024 Feb 1;30(2):230-239. doi: 10.1093/ibd/izad061. PMID: 37042969
Systematic Review of Diagnostic Delay for Children With Inflammatory Bowel Disease.
Vernon-Roberts A, Aluzaite K, Khalilipour B, Day AS
J Pediatr Gastroenterol Nutr 2023 Mar 1;76(3):304-312. Epub 2022 Dec 1 doi: 10.1097/MPG.0000000000003670. PMID: 36730088
COVID-19 and Outcomes in Patients With Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.
Tripathi K, Godoy Brewer G, Thu Nguyen M, Singh Y, Saleh Ismail M, Sauk JS, Parian AM, Limketkai BN
Inflamm Bowel Dis 2022 Aug 1;28(8):1265-1279. doi: 10.1093/ibd/izab236. PMID: 34718595Free PMC Article
Does perioperative biological therapy increase 30-day post-operative complication rates in inflammatory bowel disease patients undergoing intra-abdominal surgery? A systematic review.
Byrne LW, McKay D
Surgeon 2021 Oct;19(5):e153-e167. Epub 2020 Oct 23 doi: 10.1016/j.surge.2020.09.001. PMID: 34581275
Outcome of Ileal Pouch-anal Anastomosis in Patients With Indeterminate Colitis: A Systematic Review and Meta-analysis.
Emile SH, Gilshtein H, Wexner SD
J Crohns Colitis 2020 Jul 30;14(7):1010-1020. doi: 10.1093/ecco-jcc/jjaa002. PMID: 31912129

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