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gastroenteritis

MedGen UID:
8967
Concept ID:
C0017160
Disease or Syndrome
Synonyms: Gastroenteritides; Gastroenteritis
SNOMED CT: Gastroenteritis (25374005); Inflammation of stomach and intestine (25374005); GE - Gastroenteritis (25374005)
 
Monarch Initiative: MONDO:0002269

Definition

An inflammatory disorder that affects the upper and lower gastrointestinal tract. Most commonly, this is attributed to viruses; however bacteria, parasites or adverse reactions can also be the culprit. Symptoms include acute diarrhea and vomiting. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVgastroenteritis

Professional guidelines

PubMed

Li K, Ruan G, Liu S, Xu T, Guan K, Li J, Li J
Chin Med J (Engl) 2023 Apr 20;136(8):899-909. Epub 2023 Apr 6 doi: 10.1097/CM9.0000000000002511. PMID: 37022943Free PMC Article
Szajewska H, Berni Canani R, Domellöf M, Guarino A, Hojsak I, Indrio F, Lo Vecchio A, Mihatsch WA, Mosca A, Orel R, Salvatore S, Shamir R, van den Akker CHP, van Goudoever JB, Vandenplas Y, Weizman Z; ESPGHAN Special Interest Group on Gut Microbiota and Modifications
J Pediatr Gastroenterol Nutr 2023 Feb 1;76(2):232-247. Epub 2022 Oct 11 doi: 10.1097/MPG.0000000000003633. PMID: 36219218
Brandt KG, Castro Antunes MM, Silva GA
J Pediatr (Rio J) 2015 Nov-Dec;91(6 Suppl 1):S36-43. Epub 2015 Sep 6 doi: 10.1016/j.jped.2015.06.002. PMID: 26351768

Recent clinical studies

Etiology

Ghoshal UC
Gut Liver 2022 May 15;16(3):331-340. doi: 10.5009/gnl210208. PMID: 34789582Free PMC Article
Guarino A, Aguilar J, Berkley J, Broekaert I, Vazquez-Frias R, Holtz L, Lo Vecchio A, Meskini T, Moore S, Rivera Medina JF, Sandhu B, Smarrazzo A, Szajewska H, Treepongkaruna S
J Pediatr Gastroenterol Nutr 2020 May;70(5):694-701. doi: 10.1097/MPG.0000000000002669. PMID: 32079974Free PMC Article
Esona MD, Gautam R
Clin Lab Med 2015 Jun;35(2):363-91. doi: 10.1016/j.cll.2015.02.012. PMID: 26004648
Pigott DC
Emerg Med Clin North Am 2008 May;26(2):475-97, x. doi: 10.1016/j.emc.2008.01.009. PMID: 18406984
Galanis E
CMAJ 2007 Sep 11;177(6):570-1. doi: 10.1503/cmaj.070660. PMID: 17846438Free PMC Article

Diagnosis

Meier JL
Gastroenterol Clin North Am 2021 Jun;50(2):305-322. Epub 2021 Apr 23 doi: 10.1016/j.gtc.2021.02.003. PMID: 34024443
Fleckenstein JM, Matthew Kuhlmann F, Sheikh A
Gastroenterol Clin North Am 2021 Jun;50(2):283-304. Epub 2021 Apr 23 doi: 10.1016/j.gtc.2021.02.002. PMID: 34024442Free PMC Article
Zhang H, Morrison S, Tang YW
Clin Lab Med 2015 Jun;35(2):461-86. Epub 2015 Apr 4 doi: 10.1016/j.cll.2015.02.006. PMID: 26004652Free PMC Article
Graves NS
Prim Care 2013 Sep;40(3):727-41. Epub 2013 Jul 19 doi: 10.1016/j.pop.2013.05.006. PMID: 23958366Free PMC Article
Elliott EJ
BMJ 2007 Jan 6;334(7583):35-40. doi: 10.1136/bmj.39036.406169.80. PMID: 17204802Free PMC Article

Therapy

Savarirayan R, Wilcox WR, Harmatz P, Phillips J 3rd, Polgreen LE, Tofts L, Ozono K, Arundel P, Irving M, Bacino CA, Basel D, Bober MB, Charrow J, Mochizuki H, Kotani Y, Saal HM, Army C, Jeha G, Qi Y, Han L, Fisheleva E, Huntsman-Labed A, Day J
Lancet Child Adolesc Health 2024 Jan;8(1):40-50. Epub 2023 Nov 18 doi: 10.1016/S2352-4642(23)00265-1. PMID: 37984383
Winder N, Gohar S, Muthana M
Viruses 2022 Dec 16;14(12) doi: 10.3390/v14122811. PMID: 36560815Free PMC Article
Li Q, Zhou Q, Florez ID, Mathew JL, Shang L, Zhang G, Tian X, Fu Z, Liu E, Luo Z, Chen Y
JAMA Pediatr 2022 Dec 1;176(12):1199-1207. doi: 10.1001/jamapediatrics.2022.4123. PMID: 36374480Free PMC Article
Hirano I, Furuta GT
Gastroenterology 2020 Mar;158(4):840-851. Epub 2019 Dec 10 doi: 10.1053/j.gastro.2019.09.052. PMID: 31836530Free PMC Article
Suez J, Zmora N, Segal E, Elinav E
Nat Med 2019 May;25(5):716-729. Epub 2019 May 6 doi: 10.1038/s41591-019-0439-x. PMID: 31061539

Prognosis

Henschke N, Bergman H, Hungerford D, Cunliffe NA, Grais RF, Kang G, Parashar UD, Wang SA, Neuzil KM
Vaccine 2022 Mar 15;40(12):1707-1711. Epub 2022 Feb 17 doi: 10.1016/j.vaccine.2022.02.003. PMID: 35184924Free PMC Article
Dalby-Payne JR, Elliott EJ
BMJ Clin Evid 2011 Jul 26;2011 PMID: 21791124Free PMC Article
Canani RB, Terrin G
Curr Opin Gastroenterol 2010 Jan;26(1):31-5. doi: 10.1097/MOG.0b013e328333d781. PMID: 19907324
Mitchell DK
Pediatr Infect Dis J 2002 Nov;21(11):1067-9. doi: 10.1097/00006454-200211000-00018. PMID: 12442031
Kuzemko JA
Postgrad Med J 1969 Nov;45(529):731-5. doi: 10.1136/pgmj.45.529.731. PMID: 4902325Free PMC Article

Clinical prediction guides

Guarino A, Aguilar J, Berkley J, Broekaert I, Vazquez-Frias R, Holtz L, Lo Vecchio A, Meskini T, Moore S, Rivera Medina JF, Sandhu B, Smarrazzo A, Szajewska H, Treepongkaruna S
J Pediatr Gastroenterol Nutr 2020 May;70(5):694-701. doi: 10.1097/MPG.0000000000002669. PMID: 32079974Free PMC Article
Schnadower D, Tarr PI, Casper TC, Gorelick MH, Dean JM, O'Connell KJ, Mahajan P, Levine AC, Bhatt SR, Roskind CG, Powell EC, Rogers AJ, Vance C, Sapien RE, Olsen CS, Metheney M, Dickey VP, Hall-Moore C, Freedman SB
N Engl J Med 2018 Nov 22;379(21):2002-2014. doi: 10.1056/NEJMoa1802598. PMID: 30462938Free PMC Article
Sanchez TR, Corwin MT, Davoodian A, Stein-Wexler R
J Ultrasound Med 2016 Mar;35(3):627-35. Epub 2016 Feb 18 doi: 10.7863/ultra.15.04047. PMID: 26892821
Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition; European Society for Pediatric Infectious Diseases
J Pediatr Gastroenterol Nutr 2014 Jul;59(1):132-52. doi: 10.1097/MPG.0000000000000375. PMID: 24739189
Bernstein DI
Pediatr Infect Dis J 2009 Mar;28(3 Suppl):S50-3. doi: 10.1097/INF.0b013e3181967bee. PMID: 19252423

Recent systematic reviews

Li Q, Zhou Q, Florez ID, Mathew JL, Shang L, Zhang G, Tian X, Fu Z, Liu E, Luo Z, Chen Y
JAMA Pediatr 2022 Dec 1;176(12):1199-1207. doi: 10.1001/jamapediatrics.2022.4123. PMID: 36374480Free PMC Article
Caron B, Jouzeau JY, Miossec P, Petitpain N, Gillet P, Netter P, Peyrin-Biroulet L
Expert Opin Drug Saf 2022 Feb;21(2):223-239. Epub 2021 Aug 6 doi: 10.1080/14740338.2021.1960981. PMID: 34304684
Puckrin R, Saltiel MP, Reynier P, Azoulay L, Yu OHY, Filion KB
Acta Diabetol 2018 May;55(5):503-514. Epub 2018 Feb 27 doi: 10.1007/s00592-018-1116-0. PMID: 29484489
Ahmed SM, Hall AJ, Robinson AE, Verhoef L, Premkumar P, Parashar UD, Koopmans M, Lopman BA
Lancet Infect Dis 2014 Aug;14(8):725-730. Epub 2014 Jun 26 doi: 10.1016/S1473-3099(14)70767-4. PMID: 24981041Free PMC Article
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y
Clin Toxicol (Phila) 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. PMID: 20586571

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