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Abnormal morphology of myocardial trabeculae

MedGen UID:: 892696
•Concept ID:: C4073289
•: Anatomical Abnormality

HPO:	HP:0030681

Definition

Any structural anomaly of the muscular columns which project from the inner surface of the right and left ventricles of the heart (cardiac trabeculae, trabeculae carneae). [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal morphology of myocardial trabeculae

Disorder by Site
- Disorder of cardiovascular system
  - Abnormality of the cardiovascular system
    - Abnormal cardiovascular system morphology
      - Abnormal heart morphology
        Abnormal myocardium morphology
        Abnormal morphology of myocardial trabeculae
        Abnormal morphology of left ventricular trabeculae
        Apical hypertrabeculation of the left ventricle
        Increased density of left ventricular trabeculae
        Left ventricular noncompaction
        Thin myocardium compact layer
        Abnormal morphology of right ventricular trabeculae

Recent clinical studies

Etiology

Late gadolinium enhancement on CMRI in patients with LV noncompaction: An overestimated phenomenon?

Asmakutlu O, Alis D, Topel C, Sahin A
Clin Imaging 2020 Oct;66:121-126. Epub 2020 May 4 doi: 10.1016/j.clinimag.2020.04.024. PMID: 32480266

Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart.

Panzer AA, Regmi SD, Cormier D, Danzo MT, Chen ID, Winston JB, Hutchinson AK, Salm D, Schulkey CE, Cochran RS, Wilson DB, Jay PY
Sci Rep 2017 Apr 13;7:46438. doi: 10.1038/srep46438. PMID: 28406175 Free PMC Article

Feasibility of ferumoxytol-enhanced neonatal and young infant cardiac MRI without general anesthesia.

Lai LM, Cheng JY, Alley MT, Zhang T, Lustig M, Vasanawala SS
J Magn Reson Imaging 2017 May;45(5):1407-1418. Epub 2016 Sep 28 doi: 10.1002/jmri.25482. PMID: 27678106 Free PMC Article

Quantification of left ventricular trabeculae using fractal analysis.

Captur G, Muthurangu V, Cook C, Flett AS, Wilson R, Barison A, Sado DM, Anderson S, McKenna WJ, Mohun TJ, Elliott PM, Moon JC
J Cardiovasc Magn Reson 2013 May 10;15(1):36. doi: 10.1186/1532-429X-15-36. PMID: 23663522 Free PMC Article

Pathology and pathogenesis of arrhythmogenic right ventricular cardiomyopathy.

Thiene G, Basso C, Calabrese F, Angelini A, Valente M
Herz 2000 May;25(3):210-5. doi: 10.1007/s000590050008. PMID: 10904840

See all (20)

Diagnosis

Fetal Noncompaction Cardiomyopathy and Histologic Diagnosis of Spongy Myocardium: Case Report and Review of the Literature.

Nappi L, Vasciaveo L, Sorrentino F, Scutiero G, Iannone P, Greco P
Rev Bras Ginecol Obstet 2018 Nov;40(11):722-725. Epub 2018 Oct 11 doi: 10.1055/s-0038-1673677. PMID: 30308683 Free PMC Article

Left Ventricular Noncompaction: A Distinct Genetic Cardiomyopathy?

Arbustini E, Favalli V, Narula N, Serio A, Grasso M
J Am Coll Cardiol 2016 Aug 30;68(9):949-66. doi: 10.1016/j.jacc.2016.05.096. PMID: 27561770

Formation and Malformation of Cardiac Trabeculae: Biological Basis, Clinical Significance, and Special Yield of Magnetic Resonance Imaging in Assessment.

Captur G, Syrris P, Obianyo C, Limongelli G, Moon JC
Can J Cardiol 2015 Nov;31(11):1325-37. Epub 2015 Jul 8 doi: 10.1016/j.cjca.2015.07.003. PMID: 26440509

Abnormal cardiac formation in hypertrophic cardiomyopathy: fractal analysis of trabeculae and preclinical gene expression.

Captur G, Lopes LR, Patel V, Li C, Bassett P, Syrris P, Sado DM, Maestrini V, Mohun TJ, McKenna WJ, Muthurangu V, Elliott PM, Moon JC
Circ Cardiovasc Genet 2014 Jun;7(3):241-8. Epub 2014 Apr 5 doi: 10.1161/CIRCGENETICS.113.000362. PMID: 24704860

Noncompaction syndrome of the myocardium: pathophysiology and imaging pearls.

Zenooz NA, Zahka KG, Siwik ES, Gilkeson RC
J Thorac Imaging 2010 Nov;25(4):326-32. doi: 10.1097/RTI.0b013e31819ca93e. PMID: 20216462

See all (37)

Therapy

Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy.

Crocini C, Ferrantini C, Scardigli M, Coppini R, Mazzoni L, Lazzeri E, Pioner JM, Scellini B, Guo A, Song LS, Yan P, Loew LM, Tardiff J, Tesi C, Vanzi F, Cerbai E, Pavone FS, Sacconi L, Poggesi C
J Mol Cell Cardiol 2016 Feb;91:42-51. Epub 2015 Dec 20 doi: 10.1016/j.yjmcc.2015.12.013. PMID: 26714042 Free PMC Article

See all (1)

Prognosis

Myofiber organization in the failing systemic right ventricle.

Campanale CM, Scherrer B, Afacan O, Majeed A, Warfield SK, Sanders SP
J Cardiovasc Magn Reson 2020 Jun 29;22(1):49. doi: 10.1186/s12968-020-00637-9. PMID: 32600420 Free PMC Article

Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart.

Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy.

Captur G, Lopes LR, Mohun TJ, Patel V, Li C, Bassett P, Finocchiaro G, Ferreira VM, Esteban MT, Muthurangu V, Sherrid MV, Day SM, Canter CE, McKenna WJ, Seidman CE, Bluemke DA, Elliott PM, Ho CY, Moon JC
Circ Cardiovasc Imaging 2014 Nov;7(6):863-71. Epub 2014 Sep 16 doi: 10.1161/CIRCIMAGING.114.002411. PMID: 25228707 Free PMC Article

Noncompaction syndrome of the myocardium: pathophysiology and imaging pearls.

Zenooz NA, Zahka KG, Siwik ES, Gilkeson RC
J Thorac Imaging 2010 Nov;25(4):326-32. doi: 10.1097/RTI.0b013e31819ca93e. PMID: 20216462

Primary noncompaction of the ventricular myocardium from the morphogenetic standpoint.

Bartram U, Bauer J, Schranz D
Pediatr Cardiol 2007 Sep-Oct;28(5):325-32. Epub 2007 Jul 12 doi: 10.1007/s00246-006-0054-8. PMID: 17632682

See all (20)

Clinical prediction guides

Late gadolinium enhancement on CMRI in patients with LV noncompaction: An overestimated phenomenon?

Asmakutlu O, Alis D, Topel C, Sahin A
Clin Imaging 2020 Oct;66:121-126. Epub 2020 May 4 doi: 10.1016/j.clinimag.2020.04.024. PMID: 32480266

Feasibility of ferumoxytol-enhanced neonatal and young infant cardiac MRI without general anesthesia.

Lai LM, Cheng JY, Alley MT, Zhang T, Lustig M, Vasanawala SS
J Magn Reson Imaging 2017 May;45(5):1407-1418. Epub 2016 Sep 28 doi: 10.1002/jmri.25482. PMID: 27678106 Free PMC Article

Left Ventricular Noncompaction: A Distinct Genetic Cardiomyopathy?

Arbustini E, Favalli V, Narula N, Serio A, Grasso M
J Am Coll Cardiol 2016 Aug 30;68(9):949-66. doi: 10.1016/j.jacc.2016.05.096. PMID: 27561770

Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy.

Isolated left ventricular noncompaction syndrome.

Stanton C, Bruce C, Connolly H, Brady P, Syed I, Hodge D, Asirvatham S, Friedman P
Am J Cardiol 2009 Oct 15;104(8):1135-8. Epub 2009 Aug 28 doi: 10.1016/j.amjcard.2009.05.062. PMID: 19801037

See all (22)

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Abnormal morphology of myocardial trabeculae

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

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Clinical resources

Consumer resources

Reviews

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