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Childhood Ovarian Mixed Germ Cell Tumor

MedGen UID:
896650
•Concept ID:
C4086167
•
Neoplastic Process

Definition

A mixed germ cell tumor that arises from the ovary and occurs in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Ovarian Mixed Germ Cell Tumor

Recent clinical studies

Etiology

Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors.
Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Sex-Cord Stromal Tumors in Children and Teenagers: Results of the TGM-95 Study.
Fresneau B, Orbach D, Faure-Conter C, Verité C, Castex MP, Kalfa N, Martelli H, Patte C
Pediatr Blood Cancer 2015 Dec;62(12):2114-9. Epub 2015 Jul 23 doi: 10.1002/pbc.25614. PMID: 26206391
Molecular genetic analysis of bilateral ovarian germ cell tumors.
Hennes E, Zahn S, Lopes LF, Schönberger S, Leuschner I, Göbel U, Calaminus G, Schneider DT
Klin Padiatr 2012 Oct;224(6):359-65. Epub 2012 Nov 9 doi: 10.1055/s-0032-1327606. PMID: 23143763
Ovarian germ cell tumours: a 17-year study in a single unit.
Panteli C, Curry J, Kiely E, Pierro A, de Coppi P, Anderson J, Sebire N, Drake D
Eur J Pediatr Surg 2009 Apr;19(2):96-100. Epub 2009 Apr 9 doi: 10.1055/s-0029-1202372. PMID: 19360543
Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols.
Schneider DT, Calaminus G, Koch S, Teske C, Schmidt P, Haas RJ, Harms D, Göbel U
Pediatr Blood Cancer 2004 Feb;42(2):169-75. doi: 10.1002/pbc.10321. PMID: 14752882

Diagnosis

Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors.
Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Ovarian germ cell tumours: a 17-year study in a single unit.
Panteli C, Curry J, Kiely E, Pierro A, de Coppi P, Anderson J, Sebire N, Drake D
Eur J Pediatr Surg 2009 Apr;19(2):96-100. Epub 2009 Apr 9 doi: 10.1055/s-0029-1202372. PMID: 19360543
Ovarian germ cell tumors in children: a clinical study of 66 patients.
De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW
Pediatr Blood Cancer 2006 Apr;46(4):459-64. doi: 10.1002/pbc.20633. PMID: 16206211
Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols.
Schneider DT, Calaminus G, Koch S, Teske C, Schmidt P, Haas RJ, Harms D, Göbel U
Pediatr Blood Cancer 2004 Feb;42(2):169-75. doi: 10.1002/pbc.10321. PMID: 14752882
Childhood malignant ovarian germ cell tumors: a monoinstitutional experience.
Terenziani M, Massimino M, Casanova M, Cefalo G, Ferrari A, Luksch R, Spreafico F, Polastri D, Fontanelli R, Piva L, Fossati-Bellani F
Gynecol Oncol 2001 Jun;81(3):436-40. doi: 10.1006/gyno.2001.6177. PMID: 11371135

Therapy

Sex-Cord Stromal Tumors in Children and Teenagers: Results of the TGM-95 Study.
Fresneau B, Orbach D, Faure-Conter C, Verité C, Castex MP, Kalfa N, Martelli H, Patte C
Pediatr Blood Cancer 2015 Dec;62(12):2114-9. Epub 2015 Jul 23 doi: 10.1002/pbc.25614. PMID: 26206391
Ovarian germ cell tumours: a 17-year study in a single unit.
Panteli C, Curry J, Kiely E, Pierro A, de Coppi P, Anderson J, Sebire N, Drake D
Eur J Pediatr Surg 2009 Apr;19(2):96-100. Epub 2009 Apr 9 doi: 10.1055/s-0029-1202372. PMID: 19360543
Ovarian germ cell tumors in children: a clinical study of 66 patients.
De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW
Pediatr Blood Cancer 2006 Apr;46(4):459-64. doi: 10.1002/pbc.20633. PMID: 16206211
Paediatric extracranial germ cell tumours: a retrospective review.
Lim LP, Tan AM, Chan MY, Rajalingam V, Lou J, Tan CL
Ann Acad Med Singap 2002 Mar;31(2):206-11. PMID: 11957559
Childhood malignant ovarian germ cell tumors: a monoinstitutional experience.
Terenziani M, Massimino M, Casanova M, Cefalo G, Ferrari A, Luksch R, Spreafico F, Polastri D, Fontanelli R, Piva L, Fossati-Bellani F
Gynecol Oncol 2001 Jun;81(3):436-40. doi: 10.1006/gyno.2001.6177. PMID: 11371135

Prognosis

Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors.
Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Sex-Cord Stromal Tumors in Children and Teenagers: Results of the TGM-95 Study.
Fresneau B, Orbach D, Faure-Conter C, Verité C, Castex MP, Kalfa N, Martelli H, Patte C
Pediatr Blood Cancer 2015 Dec;62(12):2114-9. Epub 2015 Jul 23 doi: 10.1002/pbc.25614. PMID: 26206391
Molecular genetic analysis of bilateral ovarian germ cell tumors.
Hennes E, Zahn S, Lopes LF, Schönberger S, Leuschner I, Göbel U, Calaminus G, Schneider DT
Klin Padiatr 2012 Oct;224(6):359-65. Epub 2012 Nov 9 doi: 10.1055/s-0032-1327606. PMID: 23143763
Ovarian germ cell tumours: a 17-year study in a single unit.
Panteli C, Curry J, Kiely E, Pierro A, de Coppi P, Anderson J, Sebire N, Drake D
Eur J Pediatr Surg 2009 Apr;19(2):96-100. Epub 2009 Apr 9 doi: 10.1055/s-0029-1202372. PMID: 19360543
Ovarian germ cell tumors in children: a clinical study of 66 patients.
De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW
Pediatr Blood Cancer 2006 Apr;46(4):459-64. doi: 10.1002/pbc.20633. PMID: 16206211

Clinical prediction guides

Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors.
Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Ovarian germ cell tumors in children: a clinical study of 66 patients.
De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW
Pediatr Blood Cancer 2006 Apr;46(4):459-64. doi: 10.1002/pbc.20633. PMID: 16206211
Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols.
Schneider DT, Calaminus G, Koch S, Teske C, Schmidt P, Haas RJ, Harms D, Göbel U
Pediatr Blood Cancer 2004 Feb;42(2):169-75. doi: 10.1002/pbc.10321. PMID: 14752882
Teratomas in infancy and childhood at Tygerberg Hospital, South Africa, 1973 to 1992.
Bezuidenhout J, Schneider JW, Hugo F, Wessels G
Arch Pathol Lab Med 1997 May;121(5):499-502. PMID: 9167604

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