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Malignant Germinomatous Cells Present

MedGen UID:
901326
•Concept ID:
C4086360
•
Finding

Definition

A morphologic finding indicating the presence of germinoma, dysgerminoma, or seminoma germ cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Germinomatous Cells Present

Recent clinical studies

Etiology

Myeloablative chemotherapy and autologous stem cell transplantation in patients with relapsed or progressed central nervous system germ cell tumors: results of Korean Society of Pediatric Neuro-Oncology (KSPNO) S-053 study.
Baek HJ, Park HJ, Sung KW, Lee SH, Han JW, Koh KN, Im HJ, Kang HJ, Park KD
J Neurooncol 2013 Sep;114(3):329-38. Epub 2013 Jul 4 doi: 10.1007/s11060-013-1188-1. PMID: 23824533
Fourth-ventricular immature teratoma.
Furtado SV, Ghosal N, Rokade VB, Hegde AS
J Clin Neurosci 2011 Feb;18(2):296-8. Epub 2010 Oct 27 doi: 10.1016/j.jocn.2010.03.061. PMID: 21030259
Evaluation of residual tissues after adjuvant therapy in germ cell tumors.
Nakamura H, Takeshima H, Makino K, Kuratsu J
Pediatr Neurosurg 2007;43(2):82-91. doi: 10.1159/000098378. PMID: 17337917
Malignant germ cell tumours of childhood: new associations of genomic imbalance.
Palmer RD, Foster NA, Vowler SL, Roberts I, Thornton CM, Hale JP, Schneider DT, Nicholson JC, Coleman N
Br J Cancer 2007 Feb 26;96(4):667-76. Epub 2007 Feb 6 doi: 10.1038/sj.bjc.6603602. PMID: 17285132Free PMC Article

Diagnosis

PD-L1 and PD-1 expression in pediatric central nervous system germ cell tumors.
Woods JK, Lidov HG, Ligon KL, Santagata S, Chi SN, Yeo KK, Alexandrescu S
Mod Pathol 2022 Dec;35(12):1770-1774. Epub 2022 Sep 3 doi: 10.1038/s41379-022-01142-3. PMID: 36057740
Intracranial Germinoma Masquerading as Secondary Granulomatous Hypophysitis: A Case Report and Review of Literature.
Pal R, Rai A, Vaiphei K, Gangadhar P, Gupta P, Mukherjee KK, Singh P, Ray N, Bhansali A, Dutta P
Neuroendocrinology 2020;110(5):422-429. Epub 2019 Jul 4 doi: 10.1159/000501886. PMID: 31269501
Fourth-ventricular immature teratoma.
Furtado SV, Ghosal N, Rokade VB, Hegde AS
J Clin Neurosci 2011 Feb;18(2):296-8. Epub 2010 Oct 27 doi: 10.1016/j.jocn.2010.03.061. PMID: 21030259
Evaluation of residual tissues after adjuvant therapy in germ cell tumors.
Nakamura H, Takeshima H, Makino K, Kuratsu J
Pediatr Neurosurg 2007;43(2):82-91. doi: 10.1159/000098378. PMID: 17337917
Paradoxical response of a pineal immature teratoma to combination chemotherapy.
Lee AC, Chan GC, Fung CF, Leung SY, Lau YL
Med Pediatr Oncol 1995 Jan;24(1):53-7. doi: 10.1002/mpo.2950240112. PMID: 7968794

Therapy

Myeloablative chemotherapy and autologous stem cell transplantation in patients with relapsed or progressed central nervous system germ cell tumors: results of Korean Society of Pediatric Neuro-Oncology (KSPNO) S-053 study.
Baek HJ, Park HJ, Sung KW, Lee SH, Han JW, Koh KN, Im HJ, Kang HJ, Park KD
J Neurooncol 2013 Sep;114(3):329-38. Epub 2013 Jul 4 doi: 10.1007/s11060-013-1188-1. PMID: 23824533
Paradoxical response of a pineal immature teratoma to combination chemotherapy.
Lee AC, Chan GC, Fung CF, Leung SY, Lau YL
Med Pediatr Oncol 1995 Jan;24(1):53-7. doi: 10.1002/mpo.2950240112. PMID: 7968794

Prognosis

PD-L1 and PD-1 expression in pediatric central nervous system germ cell tumors.
Woods JK, Lidov HG, Ligon KL, Santagata S, Chi SN, Yeo KK, Alexandrescu S
Mod Pathol 2022 Dec;35(12):1770-1774. Epub 2022 Sep 3 doi: 10.1038/s41379-022-01142-3. PMID: 36057740
Myeloablative chemotherapy and autologous stem cell transplantation in patients with relapsed or progressed central nervous system germ cell tumors: results of Korean Society of Pediatric Neuro-Oncology (KSPNO) S-053 study.
Baek HJ, Park HJ, Sung KW, Lee SH, Han JW, Koh KN, Im HJ, Kang HJ, Park KD
J Neurooncol 2013 Sep;114(3):329-38. Epub 2013 Jul 4 doi: 10.1007/s11060-013-1188-1. PMID: 23824533
Fourth-ventricular immature teratoma.
Furtado SV, Ghosal N, Rokade VB, Hegde AS
J Clin Neurosci 2011 Feb;18(2):296-8. Epub 2010 Oct 27 doi: 10.1016/j.jocn.2010.03.061. PMID: 21030259
Evaluation of residual tissues after adjuvant therapy in germ cell tumors.
Nakamura H, Takeshima H, Makino K, Kuratsu J
Pediatr Neurosurg 2007;43(2):82-91. doi: 10.1159/000098378. PMID: 17337917
Malignant germ cell tumours of childhood: new associations of genomic imbalance.
Palmer RD, Foster NA, Vowler SL, Roberts I, Thornton CM, Hale JP, Schneider DT, Nicholson JC, Coleman N
Br J Cancer 2007 Feb 26;96(4):667-76. Epub 2007 Feb 6 doi: 10.1038/sj.bjc.6603602. PMID: 17285132Free PMC Article

Clinical prediction guides

Malignant germ cell tumours of childhood: new associations of genomic imbalance.
Palmer RD, Foster NA, Vowler SL, Roberts I, Thornton CM, Hale JP, Schneider DT, Nicholson JC, Coleman N
Br J Cancer 2007 Feb 26;96(4):667-76. Epub 2007 Feb 6 doi: 10.1038/sj.bjc.6603602. PMID: 17285132Free PMC Article

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