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Adrenal Cortical Glomerulosa Cell Adenoma

MedGen UID:
90765
•Concept ID:
C0334335
•
Neoplastic Process
Synonyms: Adrenal Cortex Glomerulosa Cell Adenoma; Adrenal cortical adenoma - glomerulosa cell; Adrenal cortical adenoma, glomerulosa cell; Adrenal Gland Glomerulosa Cell Adenoma; Glomerulosa Cell Adrenal Cortex Adenoma; Glomerulosa Cell Adrenal Cortical Adenoma; Glomerulosa Cell Adrenocortical Adenoma
SNOMED CT: Adrenal cortical adenoma - glomerulosa cell (19329008); Adrenal cortical adenoma, glomerulosa cell (19329008)

Definition

An adenoma of the adrenal cortex composed of neoplastic cells with cytologic features of glomerulosa cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdrenal Cortical Glomerulosa Cell Adenoma

Professional guidelines

PubMed

Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.
Gong S, Sun N, Meyer LS, Tetti M, Koupourtidou C, Krebs S, Masserdotti G, Blum H, Rainey WE, Reincke M, Walch A, Williams TA
Hypertension 2023 Jul;80(7):1555-1567. Epub 2023 May 1 doi: 10.1161/HYPERTENSIONAHA.123.20921. PMID: 37125608Free PMC Article
Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism.
Harashima S, Yamazaki Y, Motomura N, Ono Y, Omata K, Tezuka Y, Morimoto R, Nakamura Y, Satoh F, Suzuki H, Kwon GE, Choi MH, Sasano H
J Steroid Biochem Mol Biol 2022 Jul;221:106116. Epub 2022 May 6 doi: 10.1016/j.jsbmb.2022.106116. PMID: 35533918
Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors.
Azizan EA, Lam BY, Newhouse SJ, Zhou J, Kuc RE, Clarke J, Happerfield L, Marker A, Hoffman GJ, Brown MJ
J Clin Endocrinol Metab 2012 May;97(5):E819-29. Epub 2012 Mar 22 doi: 10.1210/jc.2011-2965. PMID: 22442279

Recent clinical studies

Etiology

Disordered CYP11B2 Expression in Primary Aldosteronism.
Gomez-Sanchez CE, Kuppusamy M, Reincke M, Williams TA
Horm Metab Res 2017 Dec;49(12):957-962. Epub 2017 Dec 4 doi: 10.1055/s-0043-122238. PMID: 29202495
Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.
Nishimoto K, Koga M, Seki T, Oki K, Gomez-Sanchez EP, Gomez-Sanchez CE, Naruse M, Sakaguchi T, Morita S, Kosaka T, Oya M, Ogishima T, Yasuda M, Suematsu M, Kabe Y, Omura M, Nishikawa T, Mukai K
Mol Cell Endocrinol 2017 Feb 5;441:124-133. Epub 2016 Oct 14 doi: 10.1016/j.mce.2016.10.014. PMID: 27751767Free PMC Article
KCNJ5 mutations in aldosterone producing adenoma and relationship with adrenal cortex remodeling.
Boulkroun S, Golib Dzib JF, Samson-Couterie B, Rosa FL, Rickard AJ, Meatchi T, Amar L, Benecke A, Zennaro MC
Mol Cell Endocrinol 2013 May 22;371(1-2):221-7. Epub 2013 Jan 30 doi: 10.1016/j.mce.2013.01.018. PMID: 23376008
Primary aldosteronism.
Gordon RD
J Endocrinol Invest 1995 Jul-Aug;18(7):495-511. doi: 10.1007/BF03349761. PMID: 9221268
Mineralocorticoid production of adrenal cortical adenomas.
Gláz E, Rácz K, Varga I, Kiss R, Tóth M, Fütö L
J Steroid Biochem Mol Biol 1993 Apr;45(1-3):57-64. doi: 10.1016/0960-0760(93)90122-d. PMID: 8481352

Diagnosis

The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications.
Seccia TM, Caroccia B, Gomez-Sanchez EP, Gomez-Sanchez CE, Rossi GP
Endocr Rev 2018 Dec 1;39(6):1029-1056. doi: 10.1210/er.2018-00060. PMID: 30007283Free PMC Article
Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.
Nishimoto K, Koga M, Seki T, Oki K, Gomez-Sanchez EP, Gomez-Sanchez CE, Naruse M, Sakaguchi T, Morita S, Kosaka T, Oya M, Ogishima T, Yasuda M, Suematsu M, Kabe Y, Omura M, Nishikawa T, Mukai K
Mol Cell Endocrinol 2017 Feb 5;441:124-133. Epub 2016 Oct 14 doi: 10.1016/j.mce.2016.10.014. PMID: 27751767Free PMC Article
Aldosterone-producing adenoma formation in the adrenal cortex involves expression of stem/progenitor cell markers.
Boulkroun S, Samson-Couterie B, Golib-Dzib JF, Amar L, Plouin PF, Sibony M, Lefebvre H, Louiset E, Jeunemaitre X, Meatchi T, Benecke A, Lalli E, Zennaro MC
Endocrinology 2011 Dec;152(12):4753-63. Epub 2011 Oct 4 doi: 10.1210/en.2011-1205. PMID: 21971159
Neuroendocrine differentiation and nerves in human adrenal cortex and cortical lesions.
Li Q, Johansson H, Kjellman M, Grimelius L
APMIS 1998 Aug;106(8):807-17. doi: 10.1111/j.1699-0463.1998.tb00227.x. PMID: 9744767
Primary aldosteronism.
Gordon RD
J Endocrinol Invest 1995 Jul-Aug;18(7):495-511. doi: 10.1007/BF03349761. PMID: 9221268

Therapy

Bilateral aldosteronoma associated with secondary aldosteronism in a chronic hemodialysis subject.
Ikoma A, Saito T, Murata M, Toyoshima H, Nakamura Y, Kawakami M, Sasano H, Ishikawa SE
Intern Med 2010;49(11):1017-21. Epub 2010 Jun 1 doi: 10.2169/internalmedicine.49.2808. PMID: 20519819
Characterization of serotonin(4) receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro studies.
Lefebvre H, Cartier D, Duparc C, Lihrmann I, Contesse V, Delarue C, Godin M, Fischmeister R, Vaudry H, Kuhn JM
J Clin Endocrinol Metab 2002 Mar;87(3):1211-6. doi: 10.1210/jcem.87.3.8327. PMID: 11889190
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies.
Al Saad KO, Chan NH
Pathology 2001 Nov;33(4):508-10. doi: 10.1080/00313020120083241. PMID: 11827421
Effect of the serotonin 5-HT4 receptor agonist cisapride on aldosterone secretion in corticotropic insufficiency and primary hyperaldosteronism.
Lefebvre H, Dhib M, Godin M, Contesse V, Delarue C, Rieu M, Wolf LM, Vaudry H, Kuhn JM
Neuroendocrinology 1997 Sep;66(3):229-33. doi: 10.1159/000127242. PMID: 9380281
Spironolactone bodies in an adrenal adenoma.
Shrago SS, Waisman J, Cooper PH
Arch Pathol 1975 Aug;99(8):416-20. PMID: 167703

Prognosis

Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors.
Azizan EA, Lam BY, Newhouse SJ, Zhou J, Kuc RE, Clarke J, Happerfield L, Marker A, Hoffman GJ, Brown MJ
J Clin Endocrinol Metab 2012 May;97(5):E819-29. Epub 2012 Mar 22 doi: 10.1210/jc.2011-2965. PMID: 22442279
Histopathological diagnosis and prognostic factors in adrenocortical carcinoma.
Aiba M, Fujibayashi M
Endocr Pathol 2005 Spring;16(1):13-22. doi: 10.1385/ep:16:1:013. PMID: 16000842
Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene.
Honda M, Tsukada T, Horiuchi T, Tanaka R, Yamaguchi K, Obara T, Miyakawa H, Yamaji T, Ishibashi M
Intern Med 2004 Apr;43(4):310-4. doi: 10.2169/internalmedicine.43.310. PMID: 15168774

Clinical prediction guides

Colocalization of Wnt/β-Catenin and ACTH Signaling Pathways and Paracrine Regulation in Aldosterone-producing Adenoma.
De Sousa K, Abdellatif AB, Giscos-Douriez I, Meatchi T, Amar L, Fernandes-Rosa FL, Boulkroun S, Zennaro MC
J Clin Endocrinol Metab 2022 Jan 18;107(2):419-434. doi: 10.1210/clinem/dgab707. PMID: 34570225
Paracrine Regulation of Aldosterone Secretion in Physiological and Pathophysiological Conditions.
Lefebvre H, Duparc C, Naccache A, Lopez AG, Castanet M, Louiset E
Vitam Horm 2019;109:303-339. Epub 2018 Dec 1 doi: 10.1016/bs.vh.2018.10.001. PMID: 30678861
Characterization of serotonin(4) receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro studies.
Lefebvre H, Cartier D, Duparc C, Lihrmann I, Contesse V, Delarue C, Godin M, Fischmeister R, Vaudry H, Kuhn JM
J Clin Endocrinol Metab 2002 Mar;87(3):1211-6. doi: 10.1210/jcem.87.3.8327. PMID: 11889190
Cell proliferation and apoptosis in normal and pathologic human adrenal.
Sasano H, Imatani A, Shizawa S, Suzuki T, Nagura H
Mod Pathol 1995 Jan;8(1):11-7. PMID: 7731935
Mineralocorticoid production of adrenal cortical adenomas.
Gláz E, Rácz K, Varga I, Kiss R, Tóth M, Fütö L
J Steroid Biochem Mol Biol 1993 Apr;45(1-3):57-64. doi: 10.1016/0960-0760(93)90122-d. PMID: 8481352

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