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Malignant giant cell tumor of soft parts

MedGen UID:
90807
•Concept ID:
C0334554
•
Neoplastic Process
Synonyms: giant cell fibrous histiocytoma; giant cell malignant fibrous histiocytoma; malignant giant cell neoplasm of soft parts; malignant giant cell tumor of soft parts; malignant giant cell tumor of soft parts (morphologic abnormality); Malignant giant cell tumor of soft tissue; malignant giant cell tumour of soft parts (morphologic abnormality); malignant Osteoclastoma; Undifferentiated Pleomorphic Sarcoma with Osteoclast-Like Giant Cells; undifferentiated pleomorphic sarcoma with osteoclast-like giant cells
SNOMED CT: Malignant giant cell tumor of soft tissue (48460009); Malignant giant cell tumor of soft parts (48460009)
 
Monarch Initiative: MONDO:0003561

Definition

An undifferentiated pleomorphic sarcoma characterized by the presence of osteoclast-like giant cells and cellular pleomorphism. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant giant cell tumor of soft parts

Professional guidelines

PubMed

RNAscope CSF1 chromogenic in situ hybridization: a potentially useful tool in the differential diagnosis of tenosynovial giant cell tumors.
Thangaiah JJ, Koepplin JW, Folpe AL
Hum Pathol 2021 Sep;115:1-9. Epub 2021 May 28 doi: 10.1016/j.humpath.2021.05.010. PMID: 34058245
Management of tumors and tumor-like lesions of the hand: a review of 191 patients.
Sağlık Y, Atalar H, Armangil M, Başarır K, Yıldız Y, Bilgin S
Eklem Hastalik Cerrahisi 2013;24(3):149-55. doi: 10.5606/ehc.2013.33. PMID: 24191880

Recent clinical studies

Etiology

Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts.
Folpe AL, Morris RJ, Weiss SW
Mod Pathol 1999 Sep;12(9):894-902. PMID: 10496598
Malignant giant cell tumor of soft parts. An analysis of 32 cases.
Guccion JG, Enzinger FM
Cancer 1972 Jun;29(6):1518-29. doi: 10.1002/1097-0142(197206)29:6<1518::aid-cncr2820290616>3.0.co;2-#. PMID: 5031245

Diagnosis

Disseminated malignant fibrous histiocytoma (giant cell rich): a case report.
Rao S, Arcot R, Pai V, Prathiba D
Indian J Pathol Microbiol 2007 Oct;50(4):795-7. PMID: 18306558
Malignant giant cell tumor of soft parts.
Dodd LG, Major N, Brigman B
Skeletal Radiol 2004 May;33(5):295-9. Epub 2004 Mar 3 doi: 10.1007/s00256-003-0744-8. PMID: 14997349
Malignant giant cell tumor of soft parts presenting as a skin tumor.
Gould E, Albores-Saavedra J, Rothe M, Mnaymneh W, Menendez-Aponte S
Am J Dermatopathol 1989 Jun;11(3):197-201. doi: 10.1097/00000372-198906000-00001. PMID: 2658646
Bronchogenic sarcomatoid squamous cell carcinoma with osteoclast-like giant cells.
Love GL, Daroca PJ Jr
Hum Pathol 1983 Nov;14(11):1004-6. doi: 10.1016/s0046-8177(83)80181-6. PMID: 6195080
Ovarian mucinous tumors with sarcoma-like mural nodules: a report of seven cases.
Prat J, Scully RE
Cancer 1979 Oct;44(4):1332-44. doi: 10.1002/1097-0142(197910)44:4<1332::aid-cncr2820440426>3.0.co;2-#. PMID: 498014

Therapy

Metastatic Giant Cell Tumor Causing Small Bowel Intussusception on 18 F-FDG PET/CT.
Walcutt JE, Johnson CM, Ly QP, Downey RT
Clin Nucl Med 2022 Nov 1;47(11):963-964. Epub 2022 Jul 6 doi: 10.1097/RLU.0000000000004287. PMID: 35777978

Prognosis

Disseminated malignant fibrous histiocytoma (giant cell rich): a case report.
Rao S, Arcot R, Pai V, Prathiba D
Indian J Pathol Microbiol 2007 Oct;50(4):795-7. PMID: 18306558
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts.
Eisen RN, Tallini G
Cancer 1993 Jul 15;72(2):462-8. doi: 10.1002/1097-0142(19930715)72:2<462::aid-cncr2820720223>3.0.co;2-d. PMID: 8319177
Ovarian mucinous tumors with sarcoma-like mural nodules: a report of seven cases.
Prat J, Scully RE
Cancer 1979 Oct;44(4):1332-44. doi: 10.1002/1097-0142(197910)44:4<1332::aid-cncr2820440426>3.0.co;2-#. PMID: 498014
Malignant giant cell tumor of soft parts. An analysis of 32 cases.
Guccion JG, Enzinger FM
Cancer 1972 Jun;29(6):1518-29. doi: 10.1002/1097-0142(197206)29:6<1518::aid-cncr2820290616>3.0.co;2-#. PMID: 5031245

Clinical prediction guides

Atypical fibroxanthoma with osteoclast-like multinucleated giant cells.
Khan ZM, Cockerell CJ
Am J Dermatopathol 1997 Apr;19(2):174-9. doi: 10.1097/00000372-199704000-00012. PMID: 9129703
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts.
Eisen RN, Tallini G
Cancer 1993 Jul 15;72(2):462-8. doi: 10.1002/1097-0142(19930715)72:2<462::aid-cncr2820720223>3.0.co;2-d. PMID: 8319177
Mucinous ovarian tumors with giant cell mural nodules. A report of two cases.
Russell P, Wills EJ, Schweitzer P, Bannatyne PM
Diagn Gynecol Obstet 1981 Fall;3(3):233-49. PMID: 6276116

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