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Bone cancer

MedGen UID:
79002
Concept ID:
C0279530
Neoplastic Process
Synonyms: Bone Cancer; Cancer of Bone; Cancer of the Bone
SNOMED CT: Malignant neoplasm of bone (428281000)
 
Monarch Initiative: MONDO:0002129

Definition

A primary or metastatic malignant neoplasm affecting the bone or articular cartilage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone cancer

Professional guidelines

PubMed

Ferguson JL, Turner SP
Am Fam Physician 2018 Aug 15;98(4):205-213. PMID: 30215968
Biermann JS, Adkins DR, Benjamin RS, Brigman B, Chow W, Conrad EU 3rd, Frassica DA, Frassica FJ, George S, Hande KR, Hornicek FJ, Letson GD, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, Somaiah N, Yasko AW; National Comprehensive Cancer Network Bone Cancer Panel
J Natl Compr Canc Netw 2010 Jun;8(6):688-712. doi: 10.6004/jnccn.2010.0051. PMID: 20581300
Biermann JS, Adkins D, Benjamin R, Brigman B, Chow W, Conrad EU 3rd, Frassica D, Frassica FJ, George S, Healey JH, Heck R Jr, Letson GD, Mayerson J, McGarry SV, O'Donnell RJ, Patt J, Randall RL, Santana V, Satcher RL, Schmidt RG, Siegel HJ, Wong MK, Yasko AW; National Comprehensive Cancer Network
J Natl Compr Canc Netw 2007 Apr;5(4):420-37. doi: 10.6004/jnccn.2007.0037. PMID: 17442233

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024

Recent clinical studies

Etiology

Naseri A, Sanaie S, Hamzehzadeh S, Seyedi-Sahebari S, Hosseini MS, Gholipour-Khalili E, Rezazadeh-Gavgani E, Majidazar R, Seraji P, Daneshvar S, Rezazadeh-Gavgani E
J Basic Clin Physiol Pharmacol 2023 Mar 1;34(2):151-160. Epub 2022 Dec 7 doi: 10.1515/jbcpp-2022-0252. PMID: 36474458
Suh E, Stratton KL, Leisenring WM, Nathan PC, Ford JS, Freyer DR, McNeer JL, Stock W, Stovall M, Krull KR, Sklar CA, Neglia JP, Armstrong GT, Oeffinger KC, Robison LL, Henderson TO
Lancet Oncol 2020 Mar;21(3):421-435. Epub 2020 Feb 14 doi: 10.1016/S1470-2045(19)30800-9. PMID: 32066543Free PMC Article
Imran M, Salehi B, Sharifi-Rad J, Aslam Gondal T, Saeed F, Imran A, Shahbaz M, Tsouh Fokou PV, Umair Arshad M, Khan H, Guerreiro SG, Martins N, Estevinho LM
Molecules 2019 Jun 19;24(12) doi: 10.3390/molecules24122277. PMID: 31248102Free PMC Article
Gnoli M, Ponti F, Sangiorgi L
Surg Pathol Clin 2017 Sep;10(3):749-764. doi: 10.1016/j.path.2017.04.009. PMID: 28797512
Gluth MB
Otolaryngol Clin North Am 2015 Apr;48(2):375-90. Epub 2015 Jan 31 doi: 10.1016/j.otc.2014.12.010. PMID: 25650231

Diagnosis

Karele EN, Paze AN
Biochim Biophys Acta Rev Cancer 2022 Sep;1877(5):188796. Epub 2022 Sep 9 doi: 10.1016/j.bbcan.2022.188796. PMID: 36089204
Jafari F, Javdansirat S, Sanaie S, Naseri A, Shamekh A, Rostamzadeh D, Dolati S
Ann Diagn Pathol 2020 Dec;49:151654. Epub 2020 Oct 25 doi: 10.1016/j.anndiagpath.2020.151654. PMID: 33130384
Am Fam Physician 2018 Aug 15;98(4):Online. PMID: 30215985
Ferguson JL, Turner SP
Am Fam Physician 2018 Aug 15;98(4):205-213. PMID: 30215968
Biermann JS, Adkins DR, Benjamin RS, Brigman B, Chow W, Conrad EU 3rd, Frassica DA, Frassica FJ, George S, Hande KR, Hornicek FJ, Letson GD, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, Somaiah N, Yasko AW; National Comprehensive Cancer Network Bone Cancer Panel
J Natl Compr Canc Netw 2010 Jun;8(6):688-712. doi: 10.6004/jnccn.2010.0051. PMID: 20581300

Therapy

Gounder M, Ratan R, Alcindor T, Schöffski P, van der Graaf WT, Wilky BA, Riedel RF, Lim A, Smith LM, Moody S, Attia S, Chawla S, D'Amato G, Federman N, Merriam P, Van Tine BA, Vincenzi B, Benson C, Bui NQ, Chugh R, Tinoco G, Charlson J, Dileo P, Hartner L, Lapeire L, Mazzeo F, Palmerini E, Reichardt P, Stacchiotti S, Bailey HH, Burgess MA, Cote GM, Davis LE, Deshpande H, Gelderblom H, Grignani G, Loggers E, Philip T, Pressey JG, Kummar S, Kasper B
N Engl J Med 2023 Mar 9;388(10):898-912. doi: 10.1056/NEJMoa2210140. PMID: 36884323Free PMC Article
Naseri A, Sanaie S, Hamzehzadeh S, Seyedi-Sahebari S, Hosseini MS, Gholipour-Khalili E, Rezazadeh-Gavgani E, Majidazar R, Seraji P, Daneshvar S, Rezazadeh-Gavgani E
J Basic Clin Physiol Pharmacol 2023 Mar 1;34(2):151-160. Epub 2022 Dec 7 doi: 10.1515/jbcpp-2022-0252. PMID: 36474458
Lv Z, Guo Y
Front Endocrinol (Lausanne) 2020;11:191. Epub 2020 Apr 16 doi: 10.3389/fendo.2020.00191. PMID: 32425881Free PMC Article
Am Fam Physician 2018 Aug 15;98(4):Online. PMID: 30215985
Brown HK, Tellez-Gabriel M, Heymann D
Cancer Lett 2017 Feb 1;386:189-195. Epub 2016 Nov 25 doi: 10.1016/j.canlet.2016.11.019. PMID: 27894960

Prognosis

Wu YY, Law YY, Huang YW, Tran NB, Lin CY, Lai CY, Huang YL, Tsai CH, Ko CY, Chou MC, Huang WC, Cheng FJ, Fong YC, Tang CH
Int J Biol Sci 2023;19(16):5174-5186. Epub 2023 Oct 9 doi: 10.7150/ijbs.86116. PMID: 37928274Free PMC Article
Tornín J, Gallego B, Rey V, Murillo D, Huergo C, Rodríguez A, Canal C, Rodríguez R
Free Radic Biol Med 2023 Nov 20;209(Pt 1):127-134. Epub 2023 Oct 14 doi: 10.1016/j.freeradbiomed.2023.10.394. PMID: 37844652
Karele EN, Paze AN
Biochim Biophys Acta Rev Cancer 2022 Sep;1877(5):188796. Epub 2022 Sep 9 doi: 10.1016/j.bbcan.2022.188796. PMID: 36089204
Ferguson JL, Turner SP
Am Fam Physician 2018 Aug 15;98(4):205-213. PMID: 30215968
Brown HK, Tellez-Gabriel M, Heymann D
Cancer Lett 2017 Feb 1;386:189-195. Epub 2016 Nov 25 doi: 10.1016/j.canlet.2016.11.019. PMID: 27894960

Clinical prediction guides

Zhang Q, Xu Z, Han R, Wang Y, Ye Z, Zhu J, Cai Y, Zhang F, Zhao J, Yao B, Qin Z, Qiao N, Huang R, Feng J, Wang Y, Rui W, He F, Zhao Y, Ding C
Nat Commun 2024 Sep 27;15(1):8338. doi: 10.1038/s41467-024-52285-7. PMID: 39333076Free PMC Article
Gounder M, Ratan R, Alcindor T, Schöffski P, van der Graaf WT, Wilky BA, Riedel RF, Lim A, Smith LM, Moody S, Attia S, Chawla S, D'Amato G, Federman N, Merriam P, Van Tine BA, Vincenzi B, Benson C, Bui NQ, Chugh R, Tinoco G, Charlson J, Dileo P, Hartner L, Lapeire L, Mazzeo F, Palmerini E, Reichardt P, Stacchiotti S, Bailey HH, Burgess MA, Cote GM, Davis LE, Deshpande H, Gelderblom H, Grignani G, Loggers E, Philip T, Pressey JG, Kummar S, Kasper B
N Engl J Med 2023 Mar 9;388(10):898-912. doi: 10.1056/NEJMoa2210140. PMID: 36884323Free PMC Article
Naseri A, Sanaie S, Hamzehzadeh S, Seyedi-Sahebari S, Hosseini MS, Gholipour-Khalili E, Rezazadeh-Gavgani E, Majidazar R, Seraji P, Daneshvar S, Rezazadeh-Gavgani E
J Basic Clin Physiol Pharmacol 2023 Mar 1;34(2):151-160. Epub 2022 Dec 7 doi: 10.1515/jbcpp-2022-0252. PMID: 36474458
Cole S, Gianferante DM, Zhu B, Mirabello L
Cancer 2022 Jun 1;128(11):2107-2118. Epub 2022 Feb 28 doi: 10.1002/cncr.34163. PMID: 35226758Free PMC Article
Tsantoulas C
Curr Opin Support Palliat Care 2015 Jun;9(2):147-54. doi: 10.1097/SPC.0000000000000131. PMID: 25872119

Recent systematic reviews

Hajduga N, Subramanian MP, Brown H, McNally R, Zohoori V, Rand V
Bone 2025 Jan;190:117320. Epub 2024 Nov 5 doi: 10.1016/j.bone.2024.117320. PMID: 39510434
Ruivo J, Tavares I, Pozza DH
J Mol Med (Berl) 2024 Sep;102(9):1063-1088. Epub 2024 Jun 28 doi: 10.1007/s00109-024-02464-2. PMID: 38940936Free PMC Article
Tattersall L, Gagui DC, Tippett VL, Latif NBA, Shah KM, Gartland A
Front Biosci (Landmark Ed) 2022 Apr 2;27(4):122. doi: 10.31083/j.fbl2704122. PMID: 35468681
Tan GJS, Gerrand CH, Rankin KS
Pediatr Blood Cancer 2019 Jan;66(1):e27462. Epub 2018 Sep 24 doi: 10.1002/pbc.27462. PMID: 30251311
Fernandes RS, Dos Santos Ferreira D, de Aguiar Ferreira C, Giammarile F, Rubello D, de Barros ALB
Biomed Pharmacother 2016 Oct;83:1253-1264. Epub 2016 Aug 24 doi: 10.1016/j.biopha.2016.08.039. PMID: 27565848

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024

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