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Iris cancer

MedGen UID:
91103
Concept ID:
C0346372
Neoplastic Process
Synonyms: cancer of iris; iris cancer; Malignant Iris Neoplasm; malignant iris neoplasm; Malignant Iris Tumor; malignant iris tumor; malignant iris tumour; Malignant neoplasm of iris; Malignant Neoplasm of Iris; malignant neoplasm of iris; Malignant Neoplasm of the Iris; malignant neoplasm of the iris; Malignant tumor of iris; Malignant Tumor of Iris; malignant tumor of iris; Malignant Tumor of the Iris; malignant tumor of the iris; malignant tumour of iris; malignant tumour of the iris
SNOMED CT: Malignant neoplasm of iris (188264002); Malignant tumor of iris (188264002)
 
Monarch Initiative: MONDO:0002658

Definition

A malignant neoplasm that affects the iris. This category includes primary iris melanoma and metastatic malignant neoplasms in the iris. [from NCI]

Professional guidelines

PubMed

Gehlhaus MW 3rd, Gift JS, Hogan KA, Kopylev L, Schlosser PM, Kadry AR
Toxicol Appl Pharmacol 2011 Jul 15;254(2):170-80. Epub 2010 Oct 27 doi: 10.1016/j.taap.2010.10.019. PMID: 21034767

Recent clinical studies

Etiology

Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Anderson JL, Gutmann DH
Handb Clin Neurol 2015;132:75-86. doi: 10.1016/B978-0-444-62702-5.00004-4. PMID: 26564071
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Diagnosis

Kakkassery V MD, PhD, Coupland SE MD, PhD, Heindl LM MD, PhD, MSc
Surv Ophthalmol 2021 Jan-Feb;66(1):41-53. Epub 2020 Jun 23 doi: 10.1016/j.survophthal.2020.06.003. PMID: 32585164
Yeaney GA, Platt S, Singh AD
Surv Ophthalmol 2017 May-Jun;62(3):366-370. Epub 2016 Nov 24 doi: 10.1016/j.survophthal.2016.11.007. PMID: 27890619
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12 doi: 10.1016/j.survophthal.2015.07.005. PMID: 26277063
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Therapy

Géraud A, Hueso T, Laparra A, Bige N, Ouali K, Cauquil C, Stoclin A, Danlos FX, Hollebecque A, Ribrag V, Gazzah A, Goldschmidt V, Baldini C, Suzzoni S, Bahleda R, Besse B, Barlesi F, Lambotte O, Massard C, Marabelle A, Castilla-Llorente C, Champiat S, Michot JM
Eur J Cancer 2024 Jul;205:114075. Epub 2024 May 4 doi: 10.1016/j.ejca.2024.114075. PMID: 38733717
Lyon AR, López-Fernández T, Couch LS, Asteggiano R, Aznar MC, Bergler-Klein J, Boriani G, Cardinale D, Cordoba R, Cosyns B, Cutter DJ, de Azambuja E, de Boer RA, Dent SF, Farmakis D, Gevaert SA, Gorog DA, Herrmann J, Lenihan D, Moslehi J, Moura B, Salinger SS, Stephens R, Suter TM, Szmit S, Tamargo J, Thavendiranathan P, Tocchetti CG, van der Meer P, van der Pal HJH; ESC Scientific Document Group
Eur Heart J 2022 Nov 1;43(41):4229-4361. doi: 10.1093/eurheartj/ehac244. PMID: 36017568
Wen PY, Stein A, van den Bent M, De Greve J, Wick A, de Vos FYFL, von Bubnoff N, van Linde ME, Lai A, Prager GW, Campone M, Fasolo A, Lopez-Martin JA, Kim TM, Mason WP, Hofheinz RD, Blay JY, Cho DC, Gazzah A, Pouessel D, Yachnin J, Boran A, Burgess P, Ilankumaran P, Gasal E, Subbiah V
Lancet Oncol 2022 Jan;23(1):53-64. Epub 2021 Nov 24 doi: 10.1016/S1470-2045(21)00578-7. PMID: 34838156
Hochhaus A, Larson RA, Guilhot F, Radich JP, Branford S, Hughes TP, Baccarani M, Deininger MW, Cervantes F, Fujihara S, Ortmann CE, Menssen HD, Kantarjian H, O'Brien SG, Druker BJ; IRIS Investigators
N Engl J Med 2017 Mar 9;376(10):917-927. doi: 10.1056/NEJMoa1609324. PMID: 28273028Free PMC Article
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article

Prognosis

Kuksin M, Morel D, Aglave M, Danlos FX, Marabelle A, Zinovyev A, Gautheret D, Verlingue L
Eur J Cancer 2021 May;149:193-210. Epub 2021 Apr 15 doi: 10.1016/j.ejca.2021.03.005. PMID: 33866228
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588

Clinical prediction guides

Kuksin M, Morel D, Aglave M, Danlos FX, Marabelle A, Zinovyev A, Gautheret D, Verlingue L
Eur J Cancer 2021 May;149:193-210. Epub 2021 Apr 15 doi: 10.1016/j.ejca.2021.03.005. PMID: 33866228
Pashayan N, Antoniou AC, Ivanus U, Esserman LJ, Easton DF, French D, Sroczynski G, Hall P, Cuzick J, Evans DG, Simard J, Garcia-Closas M, Schmutzler R, Wegwarth O, Pharoah P, Moorthie S, De Montgolfier S, Baron C, Herceg Z, Turnbull C, Balleyguier C, Rossi PG, Wesseling J, Ritchie D, Tischkowitz M, Broeders M, Reisel D, Metspalu A, Callender T, de Koning H, Devilee P, Delaloge S, Schmidt MK, Widschwendter M
Nat Rev Clin Oncol 2020 Nov;17(11):687-705. Epub 2020 Jun 18 doi: 10.1038/s41571-020-0388-9. PMID: 32555420Free PMC Article
Georgalas I, Petrou P, Papaconstantinou D, Brouzas D, Koutsandrea C, Kanakis M
Surv Ophthalmol 2018 May-Jun;63(3):347-364. Epub 2017 Sep 5 doi: 10.1016/j.survophthal.2017.08.009. PMID: 28882598
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Recent systematic reviews

Melin J, Forslund M, Alesi S, Piltonen T, Romualdi D, Spritzer PM, Tay CT, Pena A, Witchel SF, Mousa A, Teede H
J Clin Endocrinol Metab 2024 Jan 18;109(2):e817-e836. doi: 10.1210/clinem/dgad465. PMID: 37554096Free PMC Article
Soares LR, Vilbert M, Rosa VDL, Oliveira JL, Deus MM, Freitas-Junior R
ESMO Open 2023 Aug;8(4):101613. Epub 2023 Jul 23 doi: 10.1016/j.esmoop.2023.101613. PMID: 37481956Free PMC Article
Forslund M, Melin J, Alesi S, Piltonen T, Romualdi D, Tay CT, Witchel S, Pena A, Mousa A, Teede H
Eur J Endocrinol 2023 Jul 20;189(1):S1-S16. doi: 10.1093/ejendo/lvad082. PMID: 37440702
Krebbers I, Pilz W, Vanbelle S, Verdonschot RJCG, Baijens LWJ
Dysphagia 2023 Feb;38(1):127-144. Epub 2022 Jul 7 doi: 10.1007/s00455-022-10484-8. PMID: 35796877Free PMC Article
Bargiela D, Verkerk MM, Wee I, Welman K, Ng E, Choong AMTL
Eur J Radiol 2018 Mar;100:66-75. Epub 2017 Dec 23 doi: 10.1016/j.ejrad.2017.12.014. PMID: 29496081

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